Clinical trials: Disease Exacerbation
COPD
Early Pulmonary Rehabilitation Following Acute COPD Exacerbation
The principal aim of the study is to evaluate whether attendance at an exercise training and education programme (known as pulmonary rehabilitation) shortly following hospital discharge can lead to a reduction in exacerbations…
- Trial name
- NCT00557115
- Testing
- Early pulmonary rehabilitation (EPR)
- Where
- 3 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College Hospital NHS Trust
COPD
Effect of Home-Based Pulmonary Rehabilitation
This clinical trial aims to assess the effectiveness of home-based pulmonary rehabilitation in improving the clinical outcomes of patients with COPD.
- Trial name
- PR (NCT06954948)
- Testing
- pulmonary rehabilitation (PR)
- Where
- Iraq
- Volunteers
- 128 people
- Sponsor
- Hawler Medical University
Lung Diseases, Bronchitis, Chronic
Intermittent Moxifloxacin Therapy For The Prevention Of Acute Exacerbations In Patients With Chronic Bronchitis
Moxifloxacin, is being tested at approximately 60 study centres in 15 countries to determine if this drug, when taken periodically in addition to the patients normal treatment, is effective at reducing the number of flare-ups of…
- Trial name
- NCT00473460
- Testing
- Avelox (Moxifloxacin, BAY12-8039)
- Where
- 78 sites in United States, Andorra and 13 more
- Volunteers
- 1,404 people
- Sponsor
- Bayer
COPD, COPD Exacerbation
Markers of COPD Exacerbations
Acute exacerbations of COPD (AECOPD) are episodes of acute worsening of respiratory symptoms that require additional therapy. Exacerbations play a pivotal role in the burden and progressive course of COPD (1).
- Trial name
- MARKED (NCT05315674)
- Testing
- Frequent assessment of biomarker panel
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Center of Expertise for Chronic Organ Failure
Schizophrenia
Study to Assess Adverse Events and Change in Disease Activity of Oral Cariprazine Capsules in Adult Participants With Schizophrenia
Schizophrenia is a common and severe psychiatric illness characterized by extreme disturbances of cognition and thought, affecting language, perception and sense of self.
- Trial name
- 509 JPN Schz (NCT05368558)
- Testing
- Cariprazine
- Where
- 52 sites in Japan, Taiwan
- Volunteers
- 34 people
- Sponsor
- AbbVie
Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) and Advance Directives
The aim of this study is to evaluate if the participation of COPD patients to a workshop on advance directives increases the number of patients who write them.
- Trial name
- DIABPCO (NCT04459143)
- Testing
- Advance directives
- Where
- France
- Volunteers
- 525 people
- Sponsor
- Hôpital NOVO
Pulmonary Disease, Chronic Obstructive, Airway Disease
Innate Immunity in Ozone-induced Airway Inflammation in COPD
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States. Patients with COPD are routinely exposed to indoor and outdoor air pollution, which appears to cause escalation of their…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Airway Disease, COPD Exacerbation, Pollution; Exposure
- Trial name
- CO3PD (NCT04669743)
- Testing
- Ozone exposure
- Where
- 3 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Schizophrenia
A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Inpatient Adults With Schizophrenia
ML-007C-MA-211 is a Phase 2, randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety, and tolerability of orally administered ML-007C-MA in inpatient adult participants aged 18 to 64 years with…
- Trial name
- NCT07038876
- Testing
- ML-007C-MA BID, ML-007C-MA QD
- Where
- 24 sites in United States
- Volunteers
- 307 people
- Sponsor
- MapLight Therapeutics
Cystic Fibrosis
Outpatient Antibiotic Treatment for a Cystic Fibrosis Pulmonary Exacerbation
This study plans to learn more about the effect of oral antibiotics for an outpatient pulmonary exacerbation (respiratory illness) on sputum (mucus) bacterial infections, lung function, airway inflammation and quality of life.
- Trial name
- NCT02480270
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Colorado, Denver
Asthma
Long Term Special Drug Use Investigation of Mepolizumab
This study is a special drug use investigation program of NUCALA (a brand name for Mepolizumab) administered subcutaneously (SC).
- Trial name
- NCT03028480
- Testing
- NUCALA Injection
- Volunteers
- 1,061 people
- Sponsor
- GlaxoSmithKline
Asthma
Efficacy of Oral AB1010 in Adult Patients With Severe Persistent Corticosteroid Dependent Asthma
The aim of the study is to evaluate, comparatively to a placebo, the activity of oral AB1010, administered at three dose levels during 4 months to patients with severe persistent corticosteroid dependent asthma, assessed on : the…
- Trial name
- NCT00842270
- Testing
- AB1010
- Volunteers
- 44 people
- Sponsor
- AB Science
Pulmonary Disease, Chronic Obstructive
Magnesium Sulfate to Prevent Hospitalisation of Acute Exacerbations of Chronic Obstructive Pulmonary Disease
The purpose of this study is to assess whether administration of a bolus dose of MgSO4 (magnesium sulfate) plus standard therapy is superior to standard therapy alone for the management of Acute Exacerbations of Chronic Pulmonary…
- Trial name
- NCT02498496
- Testing
- Magnesium Sulfate
- Sponsor
- Hôpital de Verdun
Myasthaenia Gravis, Myasthenia
Myasthenia Gravis Foundation of America Global MG Patient Registry
The goal of this observational study is to learn about the experiences of people living with Myasthenia Gravis (MG) in the United States.
- Conditions
- Myasthaenia Gravis, Myasthenia, Myasthenia Gravis Associated with Thymoma, Myasthenia Gravis Crisis
- Trial name
- MGFAPR (NCT06617741)
- Where
- United States
- Volunteers
- 3,800 people
- Sponsor
- Myasthenia Gravis Foundation of America
COPD Exacerbation, COPD
Borg Score Outcomes in Respiratory Compromised Acute Exacerbating Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Treatment Via Vibrating Mesh Nebuliser Versus Jet Nebuliser in the Emergency Department
The purpose of this study is to compare clinical outcomes in patients with acute COPD treated with a vibrating mesh nebuliser (VMN) versus a current standard jet nebuliser (JN), in the Emergency Department (ED).
- Trial name
- BRAVE (NCT04181073)
- Testing
- Jet Nebuliser, Vibrating Mesh Nebuliser
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- NHS Greater Clyde and Glasgow
COPD, Muscle Weakness
Feasibility of Strength Training in Patients Hospitalized Due to COPD
To examine the feasibility of progressive unilateral knee-extension strength training using ankle weight cuffs in patients hospitalized due to acute exacerbation in COPD
- Trial name
- NCT01981200
- Testing
- Resistance training in AECOPD
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Frederikssunds Hospital, Denmark
Colitis, Ulcerative, Colitis Ulcerative Exacerbation
Beneficial and Harmful Effects of Azathioprine and Allopurinol Versus Standard Azathioprine Therapy for Patients With Ulcerative Colitis
Azathioprine is considered first line immunomodulatory therapy for patients with ulcerative colitis. Up to 50% are treatment failures or experience adverse events leading to treatment withdrawal.
- Trial name
- NCT03101800
- Testing
- Azathioprine and Allopurinol, Azathioprine
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- Hvidovre University Hospital
COPD, COPD Exacerbation Acute
The Italian Registry of Patients With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a treatable but debilitating medical condition associated with persistent symptoms and chronic airflow obstruction.
- Conditions
- COPD, COPD Exacerbation Acute, Comorbid Chronic Lung Disease on Heart Failure, Mortality
- Trial name
- ICoRe (NCT06652776)
- Testing
- Pharmacological treatment
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- University of Milan
Chronic Obstructive Pulmonary Disease
Comparative Effects of Different Noninvasive Ventilation Mode on Neural Respiratory Drive in Recovering AECOPD Patients
Background: The efficiency of Neural respiratory drive (NRD)expressed by a ratio of ventilation to the diaphragm electromyogram (EMGdi) decreases in patients with COPD .Improving the neural respiratory drive efficiency of COPD…
- Trial name
- NCT01782768
- Testing
- noninvasive positive pressure ventilation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Frailty, Sarcopenia
The SHAPE Project (Hospital System for Physical Activity and Active Participation) After Hospitalized Decompensation of Respiratory Chronic Diseases
It is widely established that a lack of adapted physical activity (APA) and sedentary behaviors increase the prevalence of frailty, which exacerbates chronic diseases.
- Conditions
- Frailty, Sarcopenia, Hospital Discharge, Physical Activity
- Trial name
- SHAPE (NCT07663955)
- Testing
- Hospital System for Physical Activity and Active Participation
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Hospital Universitari de Bellvitge
Chronic Obstructive Pulmonary Disease, Anxiety
Anxiety and Depression in Patients Hospitalizes for an Acute Exacerbation of COPD
This study will try to elucidate wheter the impact of a psychiatric intervention in patients hospitalized because an acute exacerbation of COPD and anxiety/depression and reconsulting at 1 and 6 month after discharge.
- Conditions
- Chronic Obstructive Pulmonary Disease, Anxiety, Depression
- Trial name
- ADPHA-EPOC (NCT01520376)
- Testing
- Counselling
- Where
- Spain
- Volunteers
- 169 people
- Sponsor
- Nestor Soler Porcar, MD, PhD
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