Clinical trials: Disease Severity
Adult Respiratory Distress Syndrome
PaO2/FiO2*PEEP (P/FP) Ratio and Mortality in Acute Respiratory Distress Syndrome.
The PaO2/FiO2 (P/F) ratio is same for all the Positive End Expiratory Pressure (PEEP) ≥ to 5. This P/F ratio misleads the severity of disease without the knowledge of set PEEP.
- Trial name
- NCT03946150
- Testing
- P/FP Ratio
- Where
- Singapore
- Volunteers
- 4,361 people
- Sponsor
- National University Health System, Singapore
Facioscapulohumeral Muscular Dystrophy
Rasch-analysis of Clinical Severity in FSHD
The purpose of this study is to make a standardized and scalable Rasch-built clinical severity scale to help in finding genetic and environmental modifiers of disease in Facioscapulohumeral muscular dystrophy (FSHD).
- Trial name
- ROC-FSHD (NCT02766985)
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- University of Kansas Medical Center
Dietary Habits, Coronary Artery Disease
Relationship Between Diet, Lifestyle, and the Severity of Coronary Artery Disease
This study is a prospective study of patients referred for coronary angiography at Bellevue Hospital Center and NYU Langone Medical Center.
- Conditions
- Dietary Habits, Coronary Artery Disease, Lifestyle
- Trial name
- NCT02382250
- Testing
- Survey
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Acute Kidney Injury (Nontraumatic), Dialysis; Complications
WISDOM UK: Low Dose-intensity Versus Standard Dose-intensity CRRT in Critically Ill Patients
Acute kidney injury is a potentially life threatening condition which affects 1 in 2 patients in the Intensive Care Unit (ICU). Patients often need dialysis treatment, also called renal replacement therapy.
- Trial name
- WISDOM UK (NCT07447791)
- Testing
- low intensity of CRRT, usual intensity of CRRT
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Breast Cancer, Proton Therapy
Safety and Efficacy of IMPT or IMRT for Breast Cancer
The purpose of this trial is to compare the toxicities and efficacy of intensity-modulated proton therapy (IMPT) and intensity-modulated radiation therapy (IMRT) for breast cancer patients indicated for radiotherapy including…
- Conditions
- Breast Cancer, Proton Therapy, Intensity Modulated Radiation Therapy, Efficacy and Safety
- Trial name
- SEPPT-BC (NCT06826885)
- Testing
- Postoperative radiotherapy, Preoperative Radiotherapy, Definitive Radiotherapy
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ruijin Hospital
Chronic Low-back Pain, Back Disorder
Movement Performance in Persons With Chronic Back Pain
The goal of this laboratory-based cross-over randomized controlled study is to study the immediate effects Spinal manipulative therapy (SMT) and exercise therapy (ET) compared to open-label placebo (OLP) on movement performance…
- Trial name
- NCT06891625
- Testing
- SMT, ET, OLP
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Non-small Cell Lung Cancer
High Dose Radiation Therapy With Concurrent Chemotherapy in Locally Advanced Non-small Cell Lung Cancer
To assess the efficacy and feasibility of high-dose intensity-modulated radiotherapy with concurrent weekly paclitaxel and cisplatin for patients with locoregionally advanced non-small lung cancer.
- Trial name
- NCT03598517
- Testing
- high dose chemoradiotherapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Pectus Excavatum
Multicenter Trial of Magnetic Mini-Mover for Pectus Excavatum
This study is a Phase 3, multicenter, non-randomized study to evaluate the safety and efficacy of the next-generation outpatient Magnetic Mini-Mover Procedure (3MP) in 15 patients aged 8-14 years for the correction of pectus…
- Trial name
- 3MP (NCT01327274)
- Testing
- Magnetic Mini-Mover Procedure (Magnimplant)
- Where
- 3 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Michael Harrison
Ureteral Calculi, Hyperalgic, Not Complicated
Nefopam and Morphine Consumption in the Treatment of Ureteral Calculi
The administration of néfopam after initial treatment by kétoproféne, could obtain, in patients remaining pain and classically need morphine, analgesia at least the same as morphine alone.
- Trial name
- NCT00639574
- Testing
- Néfopam
- Where
- France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hydroxymethylglutaryl-CoA Reductase Inhibitors, Diabetes Mellitus
Statins in Patients With Type 2 Diabetes Mellitus and Previous History of Acute Coronary Syndrome
The purpose of this study was to compare the efficacy and safety of high dose atorvastatin (40 mg) versus high dose rosuvastatin (20 mg) in Egyptian type II diabetic patients with previous acute coronary syndrome history.
- Trial name
- NCT05306990
- Testing
- Atorvastatin 40 Mg Oral Tablet, Rosuvastatin 20 Mg Oral Tablet
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Helwan University
Obesity
For the Health of Our Children--Clinic Based Treatment of Childhood Obesity
Childhood obesity is a major public health problem in the U.S. Currently approximately one in three children is considered overweight or obese. Most overweight children grow to become overweight adults.
- Trial name
- NCT01625910
- Testing
- Behavioral counseling
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Non-alcoholic Fatty Liver
High-intensity Interval Training Versus Moderate Intensity Continuous Training on Gut Microbiota in Non-alcoholic Fatty Liver
To compare High-Intensity Interval Training versus moderate intensity continuous training on gut microbiota in Non- Alcoholic Fatty Liver.
- Trial name
- NCT07697313
- Testing
- High intensity interval training, moderate intensity continuous training, Mediterranean diet
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Horus University
Acute Myeloid Leukemia
FLUDARABINE-TREOSULFAN REDUCED INTENSITY CONDITIONING REGIMEN PRIOR HAPLOIDENTICAL STEM CELL TRANSPLANTATION WITH POST TRANSPLANTATION CYCLOPHOSPHAMIDE FOR OLDER AND/OR FRAIL PATIENTS WITH AML
Acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (MDS) predominantly affect older adults, and their incidence continues to rise with advanced age.
- Trial name
- FT-RIC-HAPLO (NCT07598110)
- Testing
- fludarabine and treosulfan
- Volunteers
- 77 people
- Sponsor
- Institut Paoli-Calmettes
Parkinson's Disease
Intensity of Aerobic Training and Neuroprotection in Parkinson's Disease
In phenotypic animal models of Parkinson's Disease (PD), chronic physical exercise has produced nigrostriatal neuroprotection and symptom improvement, provided training was of high-intensity and prolonged duration (>3 months in…
- Trial name
- AEROPROTECT (NCT04046276)
- Testing
- High Intensity Aerobic program, Conventional Physical Therapy, Medium Intensity Aerobic program
- Where
- 3 sites in France
- Volunteers
- 69 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postoperative Pain, Pain Management
The Effect of Intravenous Dexketoprofen on the Severity and Incidence of Rebound Pain
Orthopedic shoulder surgeries are associated with severe postoperative pain, particularly within the first 24-48 hours after surgery.
- Conditions
- Postoperative Pain, Pain Management, Rebound Pain, Interscalene Block
- Trial name
- NCT07642674
- Testing
- ISB + paracetamol IV 3*1, ISB+ paracetamol IV 3*1 +deksketoprofen IV 2*1
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Eskisehir Osmangazi University
Fecal Incontinence
Functional Outcomes in Ulcerative Colitis Patients With Ileal Pouch Anal Anastomosis Treated With High Intensity Focused Electromagnetic Stimulation
The purpose of this research is to evaluate functional outcomes in patients with Ulcerative Colitis and IBDU who have received an ileal pouch anal anastomosis (IPAA), commonly referred to as a J pouch, after treatment with the…
- Trial name
- NCT07034443
- Testing
- High Intensity Focused Electromagnetic Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Shoulder Impingement Syndrome
Effect of High Intensity Exercises in Treatment of Patients With Shoulder Impingement Syndrome
Purposes of the study To investigate the effect of adding High-Intensity Exercises to conventional physical therapy in patients with Shoulder Impingement Syndrome
- Trial name
- NCT05950880
- Testing
- High intensity shoulder exercise, Conventional physical therapy
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Cairo University
Overweight
Comparing HICT and MICT for Health Improvements in Overweight Young Adults
The increasing prevalence of overweight and obesity is becoming a concern worldwide as it is associated with the increased prevalence of non-communicable diseases.
- Trial name
- HiMod Impact (NCT07008326)
- Testing
- High Intensity Circuit Training, Moderate Intensity Continuous Training
- Where
- Indonesia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Esophagus Cancer, Esophagogastric Junction Cancer
Phase II/III Study Comparing Chemoradiotherapy With Radiotherapy in Elderly Patients With Esophageal or Esophagogastric Cancer - 3JECROG P-01
Ratiotherapy alone is the current standard treatment for elderly esophageal or esophagogastric cancer in China. And Little is known about chemoradiotherapy (CRT) in elderly patients.
- Conditions
- Esophagus Cancer, Esophagogastric Junction Cancer, Radiotherapy; Complications, Chemoradiation
- Trial name
- NCT02979691
- Testing
- SIB-IMRT, S-1
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Chinese Academy of Medical Sciences
Actinic Keratoses
Frequency and Intensity of Local Reactions in Patients Treated With 4% 5-FU vs 4% 5-FU Associated With an Emollient Cream: a Randomised, Controlled Clinical Trial
Transient local skin reactions with topical Actinic Keratosis treatments such as 5-FluoroUracil (5-FU) often lead to non-adhesion from patients and thus to treatment failure.
- Trial name
- NCT04875026
- Testing
- 5-fluorouracil 4% (Tolak), Dexeryl
- Where
- 27 sites in France, Germany and 2 more
- Volunteers
- 146 people
- Sponsor
- Pierre Fabre Medicament