Clinical trials: Disease Spread
Traumatic Brain Injury
Spreading Depolarizations in Traumatic Brain Injury
This research aims to extend the application of spreading depolarization monitoring to non-surgical TBI patients, using intraparenchymal electrode arrays and scalp electroencephalography to detect depolarizations and develop less…
- Trial name
- NCT03379220
- Where
- 7 sites in United States
- Volunteers
- 147 people
- Sponsor
- University of Cincinnati
Pulmonary Tuberculosis, Other Specified Pulmonary Tuberculosis
PanACEA Sutezolid Dose-finding and Combination Evaluation
This study is an open-label, randomized, controlled, multi-center Phase IIB dose-finding trial to evaluate the safety, tolerability, pharmacokinetics and exposure-response-relationship of different doses of sutezolid (STZ) in…
- Trial name
- SUDOCU (NCT03959566)
- Testing
- Sutezolid, Bedaquiline, Delamanid, Moxifloxacin, Midazolam oral solution
- Where
- 4 sites in South Africa, Tanzania
- Volunteers
- 75 people
- Sponsor
- Michael Hoelscher
Gynecologic
Stress Balls in Gynecologic Exams: A Patient Comfort Trial
Women's anxiety about gynecological examinations causes them to skip examinations during this process. Research shows that women with high levels of anxiety are more likely to feel pain.
- Trial name
- NCT06679231
- Testing
- Stress Ball
- Where
- Turkey (Türkiye)
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Probiotic, Human Papillomavirus Infection, Pap Smear, Microbiome
The Influence of Oral Probiotic on the Vaginal Flora and Microenvironment Alteration in the Vaginosis Infection Women
A single-blind, randomized, and probiotic-treatment including adult women with vaginitis and/or HPV positive. After oral probiotics, all participants will be followd-up cervical swabs and vaginal microbiome alteration till the…
- Trial name
- NCT06001190
- Testing
- probiotic:Lactobacillus crispatus
- Where
- Taiwan
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Bladder Urothelial Carcinoma, Stage III Bladder Cancer AJCC v8
A Study of Chemotherapy and Radiation Therapy Compared to Chemotherapy and Radiation Therapy Plus MEDI4736 (Durvalumab) Immunotherapy for Bladder Cancer Which Has Spread to the Lymph Nodes, INSPIRE Trial
This phase II trial studies the benefit of adding an immunotherapy drug called MEDI4736 (durvalumab) to standard chemotherapy and radiation therapy in treating bladder cancer which has spread to the lymph nodes.
- Trial name
- NCT04216290
- Testing
- Biopsy of Bladder, Biospecimen Collection, Cisplatin
- Where
- 216 sites in United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
Squamous Cell Carcinoma of Oropharynx, Squamous Cell Carcinoma of Hypopharynx
Interest of Narrow Band Imaging in Detection of Upper Aerodigestive Cancers
The aim of this study is to prospectively determine if the use of NBI endoscopy modifies the superficial extension of these tumors.
- Conditions
- Squamous Cell Carcinoma of Oropharynx, Squamous Cell Carcinoma of Hypopharynx, Squamous Cell Carcinoma of Larynx
- Trial name
- NCT02035735
- Testing
- WL and NBI
- Where
- France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Toulouse
Cervical Cancer, Human Papillomavirus Infection
Self-sampling and Human Papillomavirus (HPV)-Testing for Unscreened Women in Cervical Cancer Prevention
Scientific Context: High-risk types of human papillomavirus (HPV) are the causative agents for cervical cancer. Cervical cancer screening strategies rely on periodic Papanicolaou (Pap) testing.
- Trial name
- APACHE-2 (NCT01588301)
- Testing
- Attending for cervical cytology, Kit for Self-collected vaginal sample
- Volunteers
- 5,998 people
- Sponsor
- University Hospital, Tours
Cervical Cancer, Precancerous Condition
Study of Pap Smears From Patients Enrolled on Clinical Trial GOG-171
RATIONALE: Studying Pap smears in the laboratory from women with atypical glandular cells of unspecified significance may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00898144
- Testing
- Papanicolaou test, laboratory biomarker analysis
- Volunteers
- 55 people
- Sponsor
- Gynecologic Oncology Group
Tuberculosis, Pulmonary
A New Treatment for Primary Smear-positive Pulmonary Tuberculosis With Interleukin-2
The purpose of the study is to compare the efficacy and safety of standard chemotherapy regimen 2HRZE/4HR plus IL-2 and standard regimen 2HRZE/4HR for newly diagnosed smear positive pulmonary tuberculosis.
- Trial name
- NCT04766307
- Testing
- Interleukin-2
- Where
- 16 sites in China
- Volunteers
- 1,100 people
- Sponsor
- Beijing Chest Hospital
Melanoma
An Investigational Immuno-therapy Study to Evaluate Safety and Effectiveness in Patients With Melanoma That Has Spread to the Brain, Treated With Nivolumab in Combination With Ipilimumab, Followed by Nivolumab by Itself
This is a study of Nivolumab combined with Ipilimumab followed by Nivolumab by itself for the treatment of patients with Melanoma that has spread to the brain.
- Trial name
- CheckMate204 (NCT02320058)
- Testing
- Ipilimumab, Nivolumab
- Where
- 36 sites in United States
- Volunteers
- 119 people
- Sponsor
- Bristol-Myers Squibb
Clear Cell Renal Cell Carcinoma
A Study of Subcutaneous Nivolumab Versus Intravenous Nivolumab in Participants With Previously Treated Clear Cell Renal Cell Carcinoma That is Advanced or Has Spread
The purpose of this study is to evaluate the drug levels, efficacy, safety, and tolerability of subcutaneous nivolumab versus intravenous nivolumab in participants with previously treated clear cell renal cell carcinoma that is…
- Trial name
- CheckMate-67T (NCT04810078)
- Testing
- Nivolumab and rHuPH20, Nivolumab
- Where
- 89 sites in United States, Argentina and 15 more
- Volunteers
- 681 people
- Sponsor
- Bristol-Myers Squibb
COVID, Influenza
Innovative Tool to Limit Spread of COVID 19 in Residential Aged Care Facilities
This project is a randomised trial in order to determine if "gamification" can result in behaviour change for healthcare workers in the residential aged care setting.
- Conditions
- COVID, Influenza, Gastroenteritis
- Trial name
- NCT04377165
- Testing
- Gamification, Newsfeed function
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Cervical Cancer, Precancerous Condition
Digital Colposcopy in Finding Cervical Intraepithelial Neoplasia in Patients With An Abnormal Pap Smear
RATIONALE: Diagnostic procedures, such as digital colposcopy, may help doctors find and diagnose cervical intraepithelial neoplasia.
- Trial name
- NCT00610662
- Where
- Canada
- Sponsor
- British Columbia Cancer Agency
Coronary Artery Disease, Postoperative Pain
Five Multimodal AI Configurations Versus Expert Anaesthesiologists for Classifying Pecto-Intercostal Fascial Plane Block Spread in CABG
This prospective observational cohort with a nested archived-image reader study compared the sonographic pecto-intercostal fascial plane block classifications of five general-purpose multimodal artificial-intelligence…
- Trial name
- NCT07581678
- Testing
- Pecto-Intercostal Fascial Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Injection; Complications, Sepsis, Injection Site Disorder
Transgender, Silicone and Blood Smear
This cross-sectional monocentric study will describe transgender men transitioning into women and who had cosmetic silicone injection.
- Conditions
- Injection; Complications, Sepsis, Injection Site Disorder, Injection Site Extravasation, Intentional Poisoning by Silicone
- Trial name
- TSBS (NCT02580760)
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colorectal Neoplasms
Full Thickness Resection or Endoscopic Submucosal Dissection for Difficult Colorectal Lesions.
Compare the efficacy and safety of endoscopic resection a full thickness (EFTR) with Full Thickness Resection Device (FTRD) System versus endoscopic submucosal dissection (ESD) in the treatment of Laterally Spreading Tumor Non…
- Trial name
- NCT05502276
- Testing
- Endoscopic Full-Thickness Resection (EFTR), Endoscopic Submucosal Dissection (ESD)
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- University of Roma La Sapienza
In Need of a Pap Smear (Cervical Cancer Screening), In Need of a Blood Pressure Check (Hypertension Screening)
The Effect of a Coloring Prompt on Health Engagement
The goal of this project is to determine whether prompting the recipient of a health reminder mailing to ask his or her 4-9 year-old child to color on the reminder could increase engagement with the targeted health behavior
- Conditions
- In Need of a Pap Smear (Cervical Cancer Screening), In Need of a Blood Pressure Check (Hypertension Screening), In Need of a Cholesterol Test (Lipid Disorder Screening), In Need of a Fasting Plasma Glucose Test (Diabetes)
- Trial name
- NCT01352390
- Testing
- Planning Prompt, Control Condition
- Where
- United States
- Volunteers
- 8,711 people
- Sponsor
- University of Pennsylvania
Colorectal Cancer, Metastatic Cancer
Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving drugs in different ways may kill more tumor cells.
- Trial name
- NCT00006050
- Testing
- FOLFOX regimen, fluorouracil, isolated perfusion
- Where
- 3 sites in France
- Sponsor
- UNICANCER
Carcinoma in Situ of Uterine Cervix
Follow-up of Abnormal and Inadequate Smear-test Results
Denmark has a higher incidence of cervical cancer than other Nordic countries, although all Danish women (aged 23-65) are screened regularly to identify possible cervical dysplasia or asymptomatic invasive cancer.
- Trial name
- NCT02002468
- Testing
- Test result sent by letter, Test result conveyed by general practitioners
- Where
- Denmark
- Volunteers
- 125,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Lung Non-Small Cell Carcinoma
Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery
This phase III trial compares the effect of adding whole brain radiotherapy with hippocampal avoidance and memantine versus stereotactic radiosurgery alone in treating patients with cancer that has spread to the brain and come…
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Lung Small Cell Carcinoma, Metastatic Malignant Breast Neoplasm
- Trial name
- NCT04588246
- Testing
- Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging
- Where
- 81 sites in United States, Canada and 1 more
- Volunteers
- 19 people
- Sponsor
- NRG Oncology