Clinical trials: Disease Spread
Colo-rectal Cancer
EMVI as a Determinant of Metastasis in Colorectal Cancer
Bowel cancer is the fourth most commonly occurring cancer and the second highest cause of cancer deaths in the UK. Despite advances in treatment, over 40% of patients will die within 5 years.
- Trial name
- EVIDENCE (NCT06646341)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Imperial College London
Neoplasms, Neoplasm Metastasis
A Trial to Find the Safe Dose for BI 891065 Alone and in Combination With BI 754091 in Patients With Incurable Tumours or Tumours That Have Spread
The main objective of the dose-escalation parts of the trial is to determine the maximum tolerated dose (MTD), based on the frequency of patients experiencing dose-limiting toxicities (DLTs), and/or the recommended dose for…
- Conditions
- Neoplasms, Neoplasm Metastasis, Carcinoma, Non-Small-Cell Lung
- Trial name
- NCT03166631
- Testing
- BI 891065, BI 754091
- Where
- 3 sites in United States
- Volunteers
- 62 people
- Sponsor
- Boehringer Ingelheim
Tuberculosis, Pulmonary
EBA, Safety and Tolerability of Sanfetrinem Cilexetil
To evaluate the 2-week bactericidal activity, pharmacokinetics, safety and tolerability of sanfetrinem cilexetil in participants with rifampicin-susceptible pulmonary tuberculosis.
- Trial name
- NCT05388448
- Testing
- Sanfetrinem Cilexetil, Rifampicin
- Where
- South Africa
- Volunteers
- 54 people
- Sponsor
- TASK Applied Science
Venous Thromboembolism, Delivery of Health Care
Improving Venous Thromboembolism Prophylaxis
Preventing the formation of blood clots in the veins so they do not injure leg veins or travel to the lungs, also called venous thromboembolism prophylaxis (VTE-P) is an essential component of safe in-patient care, yet it is…
- Conditions
- Venous Thromboembolism, Delivery of Health Care, Quality Improvement
- Trial name
- NCT01304108
- Testing
- VTE-P Tollgate, BLAZE Pop up, Usual Care
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Postoperative Pain, Breast Cancer
RISS Versus SPSIP Block in Modified Radical Mastectomy
This prospective randomized double-blind controlled trial aims to compare the postoperative analgesic efficacy and dermatomal spread of rhomboid intercostal-subserratus plane (RISS) block and serratus posterior superior…
- Trial name
- RSMRM (NCT07659990)
- Testing
- Rhomboid Intercostal-Subserratus Plane Block, Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ferit Yetik
Vascular Diseases, Hypercholesterolemia
The Effects of a Spread With Added Plant Sterols and Omega-3 Fatty Acids on Blood Lipids
The main aim of the study is to investigate the effect of daily consumption of a margarine enriched with plant sterol esters and fish oil on fasting triglycerides (TG) concentrations.
- Trial name
- NCT02728583
- Testing
- Margarine enriched with plant sterols and fish oil
- Where
- Germany
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Renal Cell Carcinoma
A Study to Observe the Treatment Patterns and Outcomes of Patients in Japan With Kidney Cancer That is Unable to be Removed by Surgery or That Has Spread
A medical review chart study in Japan to describe the treatment patterns and outcomes of patients with kidney cancer that is unable to be removed by surgery or that has spread.
- Trial name
- NCT03161145
- Where
- Japan
- Volunteers
- 297 people
- Sponsor
- Bristol-Myers Squibb
Traumatic Brain Injury, Aneurysmal Subarachnoid Hemorrhage
Monitoring Brain Activity in Human Brain Injury
The outcome of brain injury (physical or stroke) may be related to a brain electrical phenomenon known as Cortical Spreading Depression (CSD). This is a brief cessation of function in a local region of brain tissue.
- Conditions
- Traumatic Brain Injury, Aneurysmal Subarachnoid Hemorrhage, Cerebral Infarction, Cerebral Hemorrhage
- Trial name
- NCT00258505
- Testing
- Procedure: intracranial monitoring up to 9 days after injury
- Where
- 2 sites in Germany, Israel
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
Advanced Malignant Mesothelioma, Extensive Stage Small Cell Lung Cancer
Cryotherapy in Treating Patients With Lung Cancer That Has Spread to the Other Lung or Parts of the Body
This pilot clinical trial studies the side effects of cryotherapy (cryoablation [CA]) in treating patients with lung cancer. Cryotherapy kills cancer cells by freezing them.
- Conditions
- Advanced Malignant Mesothelioma, Extensive Stage Small Cell Lung Cancer, Lung Metastases, Recurrent Malignant Mesothelioma
- Trial name
- NCT01325753
- Testing
- cryotherapy, quality-of-life assessment
- Sponsor
- Wake Forest University Health Sciences
Cystic Fibrosis
Human Papillomavirus and Cervical Dysplasia in Women With Cystic Fibrosis
Background The main risk factor for cervical cancer is the infection by human papillomavirus (HPV), with several intermediate steps between HPV infection and cervical cancer.
- Trial name
- MUCOHPV (NCT03052556)
- Testing
- Pap smear test and HPV test
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Hospices Civils de Lyon
Metastatic Castration-Resistant Prostate Cancer, mCRPC
REGN21353 Alone or in Combination With Nezastomig for Metastatic Castration-Resistant Prostate Cancer in Adult Participants
This study will test an experimental Regeneron drug called REGN21353 ("study drug") to see if it can help treat previously treated prostate cancer that has spread (also called metastatic castration-resistant prostate cancer or…
- Trial name
- NCT07850921
- Testing
- REGN21353, Nezastomig, Sarilumab Prophylaxis (Contingency)
- Volunteers
- 192 people
- Sponsor
- Regeneron Pharmaceuticals
Hallux Valgus
The Toe-spread-out Exercise in Patients With Hallux Valgus and Without the Deformity
The effectiveness of conservative treatment of hallux valgus deformity has not been sufficiently explored yet. The aim of this study was to assess the effect of the toe-spread-out exercise on the amplitude and frequency pattern…
- Trial name
- NCT03423498
- Testing
- toe-spread-out exercise
- Where
- Poland
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Colorectal Cancer
Risk Factors for Residual Neoplasia After Endoscopic Mucosal Resection
Laterally Spreading Tumors (LST) are important precursosrs of invasive colorectal cancer. Endoscopic treatment has replaced surgery in most of the cases.
- Trial name
- NCT01478919
- Where
- Czechia
- Volunteers
- 127 people
- Sponsor
- Vitkovice Hospital
Spondyloarthritis, Rhumatoid Arthisis
Papillomavirus Load in Rheumatic Inflammatory Diseases
Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are the two most common chronic inflammatory rheumatism, with a prevalence in the French population of 0.3% and 0.4%, according to the criteria European League Against…
- Trial name
- PAPLOR (NCT03713736)
- Testing
- Cervical smear, Pregnancy test, Sexual activity questionnary
- Where
- 3 sites in France
- Volunteers
- 385 people
- Sponsor
- Hospices Civils de Lyon
Cervical Intraepithelial Neoplasia
Randomized Clinical Trial on Clinical Management of ASCUS and LSIL (ALTS)
Approximately 65 million Pap smears are performed each year in the United States. The vast majority of results are negative (no abnormality identified) but about 5 percent to 8 percent are reported as abnormal.
- Trial name
- NCT01131312
- Testing
- Thinprep, Hybrid capture 2, Colposcopy
- Where
- 3 sites in United States
- Volunteers
- 5,060 people
- Sponsor
- National Cancer Institute (NCI)
Falciparum; Malaria
The Transmission of Artemisinin Resistant Parasites Before and After Conventional Artemisinin-combination Therapy
A prospective study will be carried out in an area where parasites with reduced sensitivity to malaria drugs (artemisinins) have recently emerged.
- Trial name
- SPARTAN (NCT06347471)
- Testing
- Artemether-lumefantrine, Dihydroartemisinin-Piperaquine
- Where
- 2 sites in Uganda
- Volunteers
- 160 people
- Sponsor
- Infectious Diseases Research Collaboration, Uganda
Smear Layer, Cervical Cancer
The Effect of Virtual Reality and Distraction Cards on Pain
When the literature is examined, it is seen that virtual reality and distraction cards are used during medical procedures, and they have a reducing effect on pain perception and lowering the level of anxiety .
- Trial name
- Pap-Smear (NCT05662683)
- Testing
- Virtual Reality (VR), Distraction Cards Practice Group, Virtual Reality (VR) Breathing Exercise Group
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Turkish Ministry of Health, Kahramanmaras Provincial Health Directorate
Cervical Cancer
Self-Collection of the Pap Smear as Agency: A Novel Way to Improve Refractory Low Cervical Cancer Screening Rates in Rural Alabama
The purpose of the study is to find out if a self-administered (by the patient) Papanicolaou (Pap) smear is as accurate as a traditional Pap smear administered by a healthcare provider.
- Trial name
- Pap (NCT04093388)
- Testing
- Self-PAP, Traditional Pap smear
- Where
- 3 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of Alabama at Birmingham
Traumatic Brain Injury
Cortical Spreading Depolarization After Severe Traumatic Brain Injury
Preliminary evaluation of electrodes placed on the brain for recording brain activity and novel algorithms to determine cortical spreading depolarization foci of origination following severe traumatic brain injury requiring…
- Trial name
- NCT03321370
- Testing
- Continuous electrocorticography post severe traumatic brain injury requiring neurosurgical intervention
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Samuel Cramer
Carcinoma, Basal Cell, Porokeratosis, Disseminated Superficial Actinic
Cytodiagnosis of Basal Cell Carcinoma and Actinic Keratosis Using Papanicolaou and May-grunwald-giemsa Stained Tissue Smear
The purpose of this study is to compare and evaluate the diagnostic performance of scrape cytology using two different cytological staining techniques, and to evaluate additional touch imprint cytology with that of histopathology…
- Trial name
- NCT00218868
- Testing
- Skin scrape
- Where
- Norway
- Volunteers
- 66 people
- Sponsor
- Norwegian University of Science and Technology