Clinical trials: Disease Spread
Metastatic Breast Cancer
A Study of Tucatinib Given Before Surgery to People With HER2+ Cancers That Have Spread to the Brain
The purpose of this study to see how the brain absorbs, distributes, and gets rid of tucatinib in people who have HER2+ cancers (breast cancer, NSCLC, CRC, or GEC) that have spread to the brain, and to learn more about how cancer…
- Trial name
- NCT05892068
- Testing
- Tucatinib
- Where
- 7 sites in United States
- Volunteers
- 9 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Liver Metastases, Mucinous Adenocarcinoma of the Colon
Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal Cancer That Has Spread to the Liver
This phase I trial studies the side effects and best dose of irinotecan-eluting beads in treating patients with colon or rectal cancer that has spread to the liver and does not respond to treatment with standard therapy.
- Conditions
- Liver Metastases, Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum, Recurrent Colon Cancer
- Trial name
- NCT02110953
- Testing
- irinotecan-eluting beads, hepatic artery embolization
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Fox Chase Cancer Center
Tuberculosis
SMF to Improve Performance of Microscopy for the Diagnosis of PTB in a High HIV Prevalence Setting
This study is investigating a better method to see if someone has tuberculosis (TB) as compared to the method that is being used now.
- Trial name
- PTB (NCT02701439)
- Testing
- Small membrane filtration
- Where
- Uganda
- Volunteers
- 1,050 people
- Sponsor
- Epicentre
Uterine Cervical Neoplasms
Improving Access to Cervical Cancer Screening
Every year, in France, 3 000 women are diagnosed with cervical cancer, and 1 000 die each year. Recent studies highlighted regional, social and economical inequalities with respect to cervical cancer incidence.
- Trial name
- NCT03118258
- Testing
- 'Pap smear' arm, 'Self-collected vaginal swab for HPV testing + pap smear triage' arm
- Where
- France
- Volunteers
- 1,258 people, healthy volunteers welcome
- Sponsor
- Médecins du Monde
Apical Periodontitis
Effect of Smear Layer on Endodontic Outcome
This study evaluated the effect of removal of smear layer on the success of primary root canal treatment.Patients requiring primary root canal treatment in mature mandibular first and second molars were allocated to either smear…
- Trial name
- NCT03277404
- Testing
- Root canal treatment with smear layer removal, Root canal treatment without smear layer removal
- Volunteers
- 86 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Pulmonary Tuberculosis
Phase 2 Trial to Evaluate the Early Bactericidal Activity, Safety and Tolerability of Meropenem Plus Amoxycillin/CA and Faropenem Plus Amoxycillin/CA in Adult Patients With Newly Diagnosed Pulmonary Tuberculosis
To evaluate the early bactericidal activity (EBA), safety, tolerability and pharmacokinetics of meropenem administered intravenously three times a day, plus amoxycillin/CA administered orally three times a day; and of faropenem…
- Trial name
- NCT02349841
- Testing
- Meropenem, Faropenem, Amoxycillin/clavulanic acid
- Where
- South Africa
- Volunteers
- 46 people
- Sponsor
- TASK Applied Science
Cervical Cancer, CIN
Non-invasive Biomarker Discovery for Pre-cervical or/and Cervical Cancer--ACTN4 and Other Biomarkers in Menstrual Blood
The goal of this clinical trial is 1. To test the sensitivity and specificity of using ACTN4 from menstrual blood for the detection of pre-cervical or/and cervical cancer. 2.
- Trial name
- NCT06261879
- Testing
- Special sanitary pad
- Where
- Hong Kong
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- WomenX Biotech Limited
Malnutrition
Effectiveness Trial on Alleviation of Infant Malnutrition With Fortified Spread or Maize-Soy Flour Food Supplements
This study tests the hypothesis that moderately underweight but not severely wasted 6-17-month old infants receiving fortified spread or maize-spy flour as a food supplement for 12 weeks grow better during the supplementation…
- Trial name
- NCT00420758
- Testing
- Food supplement: fortified spread, Food supplement: maize-soy flour
- Where
- Malawi
- Volunteers
- 299 people
- Sponsor
- Tampere University
Pseudomyxoma Peritonei, Appendiceal Neoplasm
Gastrointestinal Microbiome Study of Appendiceal Cancer
This study analyzes the gastrointestinal microbiome of appendiceal cancer patients with peritoneal spread scheduled to undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC).
- Conditions
- Pseudomyxoma Peritonei, Appendiceal Neoplasm, Cancer, Appendiceal
- Trial name
- NCT02599116
- Testing
- Bio-specimen collection, Questionnaire
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mercy Medical Center
Leprosy, Leprosy Neuropathy
Accuracy of the Polymerase Chain Reaction of Ulnar Perineural Subcutaneous Aspirate Guided by Ultrasound for the Diagnosis and Monitoring of Leprosy Cure
Brief Summary Leprosy is a chronic granulomatous infectious disease caused by *Mycobacterium leprae* or *Mycobacterium lepromatosis*, characterized by peripheral nerve involvement that may lead to progressive neurological damage…
- Conditions
- Leprosy, Leprosy Neuropathy, Leprosy, Multibacillary, Leprosy--Patients
- Trial name
- Does not exist (NCT07515989)
- Testing
- Ultrasound-Guided Ulnar Perineural Subcutaneous Aspirate
- Where
- Brazil
- Volunteers
- 108 people
- Sponsor
- University of Brasilia
Blood Disease, Cytomegalovirus Infections
Cytomegalovirus Spread and Reactivation in Blood Cells
To investigate the relationship between HCMV and bone marrow progenitor cells to understand whether HCMV is latent in CD34 + bone marrow progenitors and the mechanism by which the virus remains in a latent state.
- Trial name
- NCT00006314
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cerebral Palsy and Botulinum Toxin
Spread And Effectiveness Of Botulinum Neurotoxin A In Spastic Equinus In Cerebral Palsy
Objectives. To study the short-term neurophysiological and clinical outcome of botulinum toxin type A(BoNT-A), injected at standard doses, and assess toxin spread to neighboring uninjected muscles in children with cerebral palsy.
- Trial name
- NCT01276015
- Testing
- Botulinum Toxin Type A
- Volunteers
- 18 people
- Sponsor
- Universita di Verona
COVID-19
Non Invasive Positive Pressure Ventilation to Minimize Aerosolization for COVID 19
Patients presenting to the emergency department, or needing hospitalization, for a variety of medical conditions often require non-invasive ventilation (breathing support).
- Trial name
- NCT04344925
- Testing
- Aerosol-reducing Mask, Standard Mask
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Non-Small Cell Lung Cancer
A Study Comparing the Combination of the Best Supportive Care Plus E7080 Versus Best Supportive Care Alone, in Patients With Advanced Lung Cancer or Lung Cancer That Has Spread, Who Have Been Previously Treated, Unsuccessfully, With at Least 2 Different Treatments
The purpose of this study is to compare the overall survival of patients receiving E7080 + Best Supportive Care (BSC) with those receiving placebo + Best Supportive Care.
- Trial name
- NCT01529112
- Testing
- Lenvatinib, BSC
- Where
- 50 sites in United States, Belgium and 5 more
- Volunteers
- 135 people
- Sponsor
- Eisai Inc.
Melanoma
Cost of Adverse Events Related to How Often Follow-Up Occurs Among Patients With Cancer That Has Spread
This study is a real-world retrospective claims analysis to assess and compare AE-related HCRU and medical costs among patients with different follow-up frequency after initiating a melanoma therapy.
- Trial name
- NCT03165409
- Testing
- Nivolumab, Ipilimumab
- Where
- United States
- Volunteers
- 1,828 people
- Sponsor
- Bristol-Myers Squibb
Cervix Neoplasms
The IMAP Study Improving Management of Mildly Abnormal Pap Smears
The study compares the psychosocial outcomes of different management strategies for women with minor atypia (including 'HPV effect') detected on Pap smears: conventional management (a repeat Pap smear at 6 months) versus Human…
- Trial name
- NCT00119509
- Testing
- HPV DNA testing, Conventional management (repeat Pap smear at 6 months), Decision aid with choice of management
- Where
- 7 sites in Australia
- Volunteers
- 300 people
- Sponsor
- University of Sydney
Neoplasms, Colorectal
Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for Colorectal Laterally Spreading Lesions.
EMR and ESD are both effective and safe and are associated with a very low risk of procedure related mortality when performed for colorectal laterally spreading lesions (LSL).
- Trial name
- intERsection (NCT04593407)
- Testing
- Endoscopic mucosal resection (EMR), Endoscopic submucosal dissection (ESD)
- Where
- Spain
- Volunteers
- 236 people
- Sponsor
- José Carlos Marín Gabriel
Malaria
Malaria Prevalence Around Maferinyah, Guinea
Background: Many women in Sub-Saharan Africa get malaria while they are pregnant. Plasmodium falciparum is a parasite that can cause malaria. Placental malaria (PM) caused by P.
- Trial name
- NCT04105855
- Where
- Guinea
- Volunteers
- 3,392 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Onychomycosis, Tinea Pedis
Spread of Dermatophytes Among Families
The objective is to demonstrate person-to-person spread of dermatophytes of the skin and nails among family members, as measured by fungal culture and DNA typing of the dermatophytes isolated.
- Trial name
- NCT00233493
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Obesity
Protein Nutrition During Weight Loss
The purpose of this study is to minimize the loss of lean body mass that occurs during a weight-loss program in obese people by changing the nature of ingested protein and the pattern of protein feeding
- Trial name
- SURPROL-CF-H (NCT00690781)
- Testing
- Pulse casein feeding during energy restriction, Spread casein feeding during energy restriction, Pulse milk soluble protein feeding during energy restriction
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement