Clinical trials: Disease-Free Survival
Long Term Adverse Effects, CAR-T
Long-term Follow-up of Subjects Treated With CAR T Cells
This is a single site, non-randomized, open-label, long-term safety and efficacy follow-up study for Phase 1 studies that evaluate the safety and efficacy of CAR T cells: NCT05660369 (HCC# 22-175), NCT06026319 (HCC# 23-474) and…
- Conditions
- Long Term Adverse Effects, CAR-T, Duty to Follow Up, Adult
- Trial name
- NCT05024175
- Testing
- Disease assessments, Tumor Biopsy, Blood test
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Marcela V. Maus, M.D.,Ph.D.
Esophageal Cancer, Sentinel Lymph Node
A Non-inferiority Study of Indocyanine Green-guided Sentinel Lymph Node Mapping Versus Conventional Lymph Node Dissection in Esophageal Cancer
In the comprehensive treatment system for esophageal cancer, surgical resection combined with regional lymph node dissection remains the core component for achieving cure in patients with resectable esophageal squamous cell…
- Conditions
- Esophageal Cancer, Sentinel Lymph Node, Lymphadenectomy, Indocyanine Green (ICG)
- Trial name
- SIGN (NCT07788001)
- Testing
- ICG-guided sentinel lymph node dissection, ICG-guided systematic lymph node dissection
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fujian Medical University Union Hospital
Esophageal Squamous Cell Cancer (SCC), Overall Survival
A Single-center, Single-arm Clinical Study Evaluating the Short-term Efficacy of Inflatable Mediastinoscopic-assisted Transhiatal Laparoscopic Esophagectomy for the Radical Resection of Thoracic Esophageal Cancer
Abstract Background China has a high incidence of esophageal cancer, with surgery being the primary treatment modality. While the right thoracic approach for radical esophagectomy remains the standard surgical method, it is…
- Conditions
- Esophageal Squamous Cell Cancer (SCC), Overall Survival, Disease Free Survival
- Trial name
- NCT07581236
- Testing
- inflatable video-assisted mediastinoscopic transhiatal esophagectomy (IVMTE) combined with laparoscopy, Minimally invasive McKeown esophagectomy (MIME)
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Sun Yat-sen University
Disease-free Survival
Reduced MBF Regimen for Patients >=55 Years With Myeloid Malignancies
In this multiple-center phase II study, the aim is to evaluate the clinical outcome of reduced intensity conditioning regimen with fludarabine (150mg/m2), busulfan (6.4mg/kg) and melphalan (100mg/m2) in patients with myeloid…
- Trial name
- NCT05436561
- Testing
- MBF-RIC
- Where
- 2 sites in China
- Volunteers
- 61 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Colorectal Cancer, Early Onset Colorectal Cancer
Multi-Center Study Protocol: Impact of Sarcopenia in Early-Onset Colorectal Cancer.
Sarcopenia's role in early-onset colorectal cancer (EOCRC), a subtype increasingly diagnosed in individuals under 50 years, has not yet been investigated according to recent literature.
- Conditions
- Colorectal Cancer, Early Onset Colorectal Cancer, Sarcopenia, Prognostic Factors
- Trial name
- ISoPECC (NCT06868095)
- Testing
- Surgical resection
- Volunteers
- 1,000 people
- Sponsor
- Instituto de Investigación Biomédica de Salamanca
Rectal Cancer, Metformin
DataBase for Analysis of Rectal Cancer Oncological Results
The data will be obtained from 10 tertiary centers located in Poland (Cracow - coordinating center, Warsaw - 3 centers, Sosnowiec, Szczecin, Bydgoszcz, Lublin, Gdansk, Poznan) and 5 foreign centers.
- Conditions
- Rectal Cancer, Metformin, Overall Survival, Lymph Node Metastases
- Trial name
- BARO (NCT04947020)
- Testing
- Metformin
- Where
- Poland
- Volunteers
- 2,443 people
- Sponsor
- Jagiellonian University
Independent Living, Disability Free Survival
A Clinical Trial of STAtin Therapy for Reducing Events in the Elderly (STAREE)
The STAREE study will examine whether treatment with statin (atorvastatin 40mg) compared with placebo will prolong disability free survival and reduce major cardiovascular events amongst healthy elderly people (≥70 years).
- Conditions
- Independent Living, Disability Free Survival, Elderly, Healthy
- Trial name
- STAREE (NCT02099123)
- Testing
- Atorvastatin
- Where
- 6 sites in Australia
- Volunteers
- 9,971 people, healthy volunteers welcome
- Sponsor
- Monash University
3-year Disease-free Survival
Befotertinib Adjuvant Therapy in Stage IA2-IB NSCLC Patients
To evaluate 3-year disease-free survival after complete resection in patients with MRD-positive EGFR-sensitive mutations in Stage IA2-IB NSCLC treated with adjuvant befortinib and under routine observation (3y-DFS).
- Trial name
- NCT06561620
- Testing
- Befotertinib
- Where
- China
- Volunteers
- 592 people
- Sponsor
- Fudan University
Overall Survival, Disease-free Survival
Microwave Ablation Versus Liver Resection for Intrahepatic Cholangiocarcinoma
Thermal ablation has been recommended by worldwide guidelines as first-line treatment for hepatocellular carcinoma (HCC), while evidence regarding its efficacy for primary intrahepatic cholangiocarcinoma (iCCA) is lacking.
- Trial name
- MALRIC (NCT06462742)
- Testing
- Microwave ablation (MWA) versus Liver Resection (LR)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Chinese PLA General Hospital
Progression-free Survival Was Defined From Date of Surgery to Disease Progression Post-surgery or Death or Last Follow-up, Overall Survival Was Defined as Time From Surgery to Death From Any Cause or Last Follow-up
Observational, Bivariate Analysis of Clinical Big Data in Patients With Cervical Cancer
This is a large non-interventional observational bidirectional study planned to collect clinically relevant data and prognostic follow-up information of patients with cervical cancer who were seen at our center from 2010.01.01 to…
- Trial name
- NCT06480617
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Anhui Provincial Hospital
Pulmonary Function Assessment, Disease Free Survival
Pulmonary Watershed Topographic Map Navigation for Lung Nodule Resection
A method of ICG counterstaining localization under target artery occlusion without cutting，It's a new method of localization of small pulmonary nodules.
- Conditions
- Pulmonary Function Assessment, Disease Free Survival, NSCLC, Stage I
- Trial name
- NCT06404164
- Testing
- Wedge resection under watershed analysis method
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Guangdong Provincial People's Hospital
Disease Free Survival, Overall Survival
Efficacy of Chemopreventive Agents on Disease-free and Overall Survival in Patients With Pancreatic Ductal Adenocarcinoma: The CAOS Study
The evidence on the value of aspirin, statins, metformin, beta-blocking ACE inhibitors agents as chemopreventive agents in patients with pancreatic ductal adenocarcinoma is limited.
- Conditions
- Disease Free Survival, Overall Survival, Pancreatic Cancer
- Trial name
- CAOS (NCT04245644)
- Testing
- use of targeted drugs such as aspirin, B-Blockers, Metformin, ACE-inhibitors, Statins
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- Massimo Falconi
Papillary Thyroid Carcinoma; Molecular Heterogeneity; Multi-model Analysis; Artificial Intelligence; Lymph Node Metastases; Disease-free Survival
AI-Based Multimodal Multi-tasks Analysis Reveals Tumor Molecular Heterogeneity, Predicts Preoperative Lymph Node Metastasis and Prognosis in Papillary Thyroid Carcinoma
This study involved a comprehensive analysis of 256 PTC patients from Sun Yat-sen Memorial Hospital of Sun Yat-sen University (SYSMH) and 499 patients from The Cancer Genome Atlas.
- Trial name
- NCT06241092
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
to Explore Whether the Adjuvant Therapy of Metronomic Capecitabine Could Improve the Disease-free Survival of Locoregionally Advanced Hypopharyngeal Carcinoma
A Prospective Exploratory Clinical Study of Metronomic Capecitabine as Adjuvant Therapy in Locoregionally Advanced Hypopharyngeal Carcinoma
To explore whether the adjuvant therapy of metronomic capecitabine could improve the disease-free survival of locoregionally advanced hypopharyngeal carcinoma (stage IV：T4N0-1M0，anyTN2-3M0).
- Trial name
- NCT05940441
- Testing
- Capecitabine 500Mg Oral Tablet
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Objective Response Rate, Progression-free Survival
Real-world Study for Patients With Advanced Hepatobiliary Tumors
The investigators design a large sample size study in the real-world to explore whether targeted therapy and immunotherapy can improve the survival, quality of life and drug safety of patients with advanced hepatobiliary tumors…
- Conditions
- Objective Response Rate, Progression-free Survival, Overall Survival, Disease Control Rate
- Trial name
- NCT03892577
- Testing
- Precision oncology including targeted therapy and immunotherapy
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Peking Union Medical College Hospital
Rectal Cancer, Pathological Complete Response
Effect of Concurrent Capecitabine-based Long-term Radiotherapy Followed by XELOX Plus TME in Patients With High Risk Rectal Cancer: a Multi-centers, Randomized Controlled, Open-Label Trial
The purpose of this study was to evaluate the effect of concurrent capecitabine-based long-term radiotherapy followed by 4 cycles XELOX pre- a delayed TME compared with 6 cycles XELOX post- a Regular Timing TME in patients with…
- Conditions
- Rectal Cancer, Pathological Complete Response, Disease Free Survival
- Trial name
- EXPLORE (NCT03038256)
- Testing
- concurrent capecitabine-based long-term radiotherapy followed by 4 cycles XELOX and a delayed TME, concurrent capecitabine-based long-term radiotherapy followed by a Regular TME and 6 Cycles XELOX
- Where
- 2 sites in China
- Volunteers
- 244 people
- Sponsor
- Peking University People's Hospital
Disease-free Survival Rate
Phase Ⅱ Trial of Camrelizumab in Patients Without Distant Metastasis Nasopharyngeal Carcinoma
To see the effect if a combination of neoadjuvant chemotherapy combined with Camrelizumab followed by chemoradiotherapy in treating patients without distant metastasis nasopharyngeal carcinoma
- Trial name
- NCT04782765
- Testing
- Camrelizumab+Chemotherapy+Chemoradiotherapy
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Circumferential Resection Margin, Intraoperative Perforation of Rectum
Surgery Without Neoadjuvant Chemoradiotherapy Compared With Neoadjuvant Chemoradiotherapy for Rectal Cancer With Negative Circumferential Resection Margin Based on MRI Assessment, a Perspective Multicenter Randomized Controlled Trial
For now, neoadjuvant chemoradiotherapy is routinely performed for T3N1-2M0 rectal cancer. However, there are lots of complications following neoadjuvant chemoradiotherapy, such as Wound-related complications, anastomotic leakage…
- Conditions
- Circumferential Resection Margin, Intraoperative Perforation of Rectum, Local Recurrence of Malignant Tumor of Rectum, Disease-free Survival
- Trial name
- SCRM-01 (NCT03504449)
- Testing
- neoadjuvant chemoradiotherapy
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Beijing Chao Yang Hospital
Surgical Procedure, Disease Free Survival
Surgical Treatment of Pancreatic Metastases From Renal Cell Carcinoma
Pancreatic metastases are a rare entity. In cases of metastatic renal carcinoma (RCC) it can present as isolated pancreatic metastasis, considering the possibility of surgical resection.
- Conditions
- Surgical Procedure, Disease Free Survival, Overall Survival
- Trial name
- PANMEKID (NCT04245410)
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Universidad de Extremadura
Disease Free Survival
A Study on the Efficacy and Safety of Bevacizumab in Untreated Patients With Locally Advanced Cervical Cancer
To verify the clinical efficacy and safety of bevacizumab in treating local advanced cervical cancer, present study was designed to investigate the clinical results of bevacizumab combined with concurrent chemoradiotherapy (CCRT)…
- Trial name
- NCT04138992
- Testing
- bevacizumab, DDP, Docetaxel
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Air Force Military Medical University, China