Clinical trials: Disease-Free Survival
Breast Cancer, Radiotherapy
Impact of Radiotherapy on Survival in Breast Cancer Patients
In this study, using a large retrospective cohort, the investigators evaluate the impact of RT on disease-free survival and overall survival of patients with BC.
- Trial name
- NCT07631962
- Testing
- radiotherapy
- Volunteers
- 1,030 people
- Sponsor
- Motamed Cancer Institute
Breast Cancer
A Study to Evaluate the Efficacy and Safety of Herceptin® (Trastuzumab) in Combination With Arimidex® (Anastrozole) an Aromatase Inhibitor Compared to Arimidex® Alone in Patients With Metastatic Breast Cancer
This 2 arm study assessed the safety and efficacy of adding intravenous trastuzumab (Herceptin®) to daily oral anastrozole (Arimidex®) tablets as first- and second-line treatment in postmenopausal patients with human epidermal…
- Trial name
- NCT00022672
- Testing
- trastuzumab (Herceptin®), anastrazole (Arimidex®)
- Where
- 132 sites in United States, Australia and 24 more
- Volunteers
- 208 people
- Sponsor
- Hoffmann-La Roche
Kidney Cancer
International REgistry of COnservative or Radical Treatment of Localized Kidney Tumors
Partial nephrectomy (PN) is the standard treatment for localized renal masses and should be preferred in clinical T1 (<7 cm tumor diameter) renal tumors over radical nephrectomy (RN) whenever technically feasible.
- Trial name
- i-RECORd (NCT05363657)
- Testing
- Partial Nephrectomy (PN), Radical Nephrectomy (RN), Ablation therapy (AT)
- Where
- 37 sites in United States, Austria and 11 more
- Volunteers
- 10,000 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Colorectal Cancer Metastatic, Liver Metastases
Efficacy of FOLFOX Versus FOLFOX Plus Aflibercept in K-ras Mutant Patients With Resectable Liver Metastases
Patients presenting with multiple innumerable liver metastases will probably never come to resection, however, for all others, including patients with numerous multiple metastases or large metastases, resection should be…
- Conditions
- Colorectal Cancer Metastatic, Liver Metastases, KRAS Mutated Colorectal Cancer
- Trial name
- BOS3 (NCT01646554)
- Testing
- Modified FOLFOX6, Aflibercept, Surgery
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Amyloidosis; Systemic
BCD With or Without Doxycycline in Mayo Stage II-III Light Chain Amyloidosis Patients
Survival of intermediate and high-risk primary light chain amyloidosis (pAL) remains poor due to high mortality within 3-6 months of diagnosis.
- Trial name
- NCT03401372
- Testing
- Doxycycline, Bortezomib, Cyclophosphamide
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Jian Li
Pancreatic Adenocarcinoma
Study to Evaluate if Neoadjuvant Radiotherapy Improves Recurrence Free Survival in Pancreatic Head Cancer
Net-Pac investigates if radiation prior to surgical resection improves survival in patients with pancreatic head cancer without metastases.
- Trial name
- Net-Pac (NCT01419002)
- Testing
- neoadjuvant RTx, Surgery
- Where
- Germany
- Volunteers
- 5 people
- Sponsor
- CHIR-Net
Tonsil Cancer
Photon Therapy Versus Proton Therapy in Early Tonsil Cancer.
In this trial, patients with early squamous cell carcinoma of the tonsil with clinical stage T1-2 (p16-positive or p16-negative) N0-1 (p16-positive)/N0-N2b (p16-negative) according to American Joint Committee on Cancer (AJCC) 8th…
- Trial name
- ARTSCAN V (NCT03829033)
- Testing
- Radiotherapy
- Where
- 12 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Lund University Hospital
Colon Cancer, Pancreatic Cancer
Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal Cancers
Background: Gastrointestinal tumors have a molecule called carbohydrate antigen 19-9 (CA19-9) in the tumors and blood. The agent MVT-5873 was designed to block this molecule.
- Conditions
- Colon Cancer, Pancreatic Cancer, Cholangiocarcinoma, Metastatic Colon Carcinoma
- Trial name
- NCT03801915
- Testing
- MVT-5873, pancreatectomy or hepatectomy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Cancer Institute (NCI)
Ovarian Cancer
Studying DNA in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian Epithelial Cancer
RATIONALE: Studying tissue and blood samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00900289
- Testing
- DNA methylation analysis, microarray analysis, polymerase chain reaction
- Where
- 26 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Liz-Anne Lewsley
Diffuse Large B-cell Lymphoma
R-CDOP Combined With Intrathecal Methotrexate for DLBCL Patients With High-risk of CNS Relapse
This is a double-center, single-arm, phase 2 study to evaluate the efficacy and safety of R-CDOP regimen combined with intrathecal methotrexate in chemo-naive diffuse large B-cell lymphoma patients with high-risk of CNS relapse.
- Trial name
- NCT05257018
- Testing
- R-CDOP+intrathecal MTX
- Where
- 2 sites in China
- Volunteers
- 83 people
- Sponsor
- Fudan University
Carcinoma, Squamous Cell, Skin Cancer
Time to Treatment and Disease-free Survival of Patients With High-risk Head-neck Cutaneous Squamous Cell Carcinoma
The purpose of this study is to investigate the association between time to treatment (defined as date of pathological diagnosis to date of start treatment) and disease free survival in patients with high risk cutaneous squamous…
- Conditions
- Carcinoma, Squamous Cell, Skin Cancer, Carcinoma, Squamous Cell, Skin, Carcinoma, Squamous Cell of Head and Neck
- Trial name
- NCT05845632
- Testing
- Treatment
- Where
- 2 sites in Netherlands
- Volunteers
- 965 people
- Sponsor
- Maastricht University Medical Center
Lung Cancers, Lung Cancer, Non-Small Cell
Quality of Life as a Predictor of OS and PFS in Patients With Lung Cancer
By 2020, lung cancer continues leading the first cause of cancer mortality and the second most common type of cancer in the world.
- Trial name
- FACT-L_Pred (NCT06900283)
- Where
- Colombia
- Volunteers
- 320 people
- Sponsor
- Instituto Nacional de Cancerologia, Columbia
Hepatocellular Carcinoma (HCC)
Efficacy Evaluation of Microwave Ablation Assisted by Diaphragm Hydrodissection for Hepatocellular Carcinoma and Comparative Analysis With Surgical
The goal of this observational study is to evaluate the local efficacy and safety of hydrodissection-assisted microwave ablation for patients with hepatocellular carcinoma, and to compare its therapeutic outcomes with surgical…
- Trial name
- NCT07815054
- Testing
- Microwave Ablation Assisted by Diaphragm Hydrodissection, Surgical Resection
- Volunteers
- 200 people
- Sponsor
- The First Hospital of Jilin University
Colorectal Neoplasms
Prospective Multicenter Cohort Study of Clinical and Molecular Biomarkers in Colorectal Cancer
This prospective, multicenter observational study aims to identify clinical and molecular biomarkers associated with treatment response, disease recurrence, progression, and survival in patients with colorectal cancer (CRC).
- Trial name
- NCT07913802
- Where
- 4 sites in Austria
- Volunteers
- 200 people
- Sponsor
- Vorarlberg Institute for Vascular Investigation and Treatment
Bone Sarcoma, Osteosarcoma
Efficacy of Regorafenib Combined With Best Supportive Care as Maintenance Treatment in High Grade Bone Sarcomas Patients
This is a multicenter phase II study concerning patients with high-grade bone sarcoma (HGBS) without complete remission after standard treatment at diagnosis or at relapse.
- Trial name
- REGOMAIN (NCT04698785)
- Testing
- Treatment by regorafenib and best supportive care
- Where
- 16 sites in France
- Volunteers
- 36 people
- Sponsor
- Centre Leon Berard
Progression-Free-Survival, Recurrence
Clinical Study on Triple Negative Breast Cancer With Chinese Medicine
Breast cancer is one of the most serious threat to women's health of malignant tumors, also the most common causes of cancer death in women.Triple-negative breast cancer (TNBC) refers to the immunohistochemical detection of…
- Conditions
- Progression-Free-Survival, Recurrence, Overall Survival
- Trial name
- NCT03332368
- Testing
- Traditional Chinese medicine
- Where
- 5 sites in China
- Volunteers
- 620 people
- Sponsor
- Sheng Liu
Breast Cancer
Clinico-biological Data Collection Study of Metastatic Breast Cancer
RATIONALE : Currently, the mechanisms associated with the response or resistance to treatment are poorly understood and are multifactorial.
- Trial name
- EPICURE_SEIN (NCT03958136)
- Testing
- Metastasis biopsy, Biomarkers blood, urine and microbiota samples, Patient Reported Outcome (PRO)
- Where
- 2 sites in France
- Volunteers
- 289 people
- Sponsor
- Institut Cancerologie de l'Ouest
Gastric Cancer
Laparoscopic Gastrectomy With D2 Lymphadenectomy Combined With Hyperthermic Intraperitoneal Chemotherapy (HIPEC) or Not
The goal of this clinical trial is to learn about Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Locally Advanced Gastric Cancer after Laparoscopic Gastrectomy with D2 Lymphadenectomy.
- Trial name
- NCT05871099
- Testing
- Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
- Where
- China
- Volunteers
- 616 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Local Recurrence of Malignant Tumor of Breast
Oncoplastic Breast-conserving Surgery in Non-metastatic Breast Cancer Patients
Breast-conserving surgery (BCS) is the traditional surgical treatment for early-stage breast cancer patients. There are evidences indicating that oncoplastic-BCS (displacement technique) could improve cosmetic outcomes and/or…
- Trial name
- NCT02376413
- Testing
- Breast surgery, Chemotherapy or endocrine therapy or Trastuzumab therapy, Radiation therapy
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
HIV Infections
A Multicenter, Double-Blind, Phase III, Adjuvant-Controlled Study of the Effect of 10 Units of HIV-1 Immunogen (Remune) Compared to Incomplete Freund's Adjuvant (IFA) Alone Every 12 Weeks on AIDS-Free Survival in Subjects With HIV Infection and CD4 T-Lymphocytes Between 300 and 549 Cells/microL Rega
To determine the effect of HIV-1 immunogen (Remune) on AIDS-free survival, defined as the time prior to development of an AIDS-defining condition or death.
- Trial name
- NCT00002359
- Testing
- HIV-1 Immunogen
- Where
- 54 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- The Immune Response Corporation