Clinical trials: Diseases, Metabolic
Obesity, Hypertension
Pathophysiology of Cardiometabolic Risk Factors in African Americans
The overall goal of this proposal is to determine the autonomic and nitric oxide contribution in the pathogenesis of hypertension and insulin resistance in obese African American women.
- Trial name
- NCT01122407
- Testing
- L-NMMA, Trimethaphan
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Obese
Home-Based HIT in Obese Individuals
This study aims to investigate the efficacy of a novel home-based high-intensity interval training (Home-HIT) intervention in obese individuals, with elevated cardiovascular disease (CVD) risk.
- Trial name
- NCT03557736
- Testing
- Training mode
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Liverpool John Moores University
Amyotrophic Lateral Sclerosis
The Efficacy and Safety of Vitamin E Mixed Tocotrienols In Patients With Amyotrophic Lateral Sclerosis (ALS)
There is currently no effective treatment in ALS. Oxidative stress, probably interacting with other neurodegenerative processes, is hypothesized to play a leading role in pathogenesis.
- Trial name
- NCT04140136
- Testing
- Tocotrienols
- Where
- Malaysia
- Volunteers
- 20 people
- Sponsor
- University of Malaya
Osteoarthritis, Post-traumatic Osteoarthritis
Translating Metabolic Responses to Mechanical Insult Into Early Interventions to Prevent PTOA
This is a small-scale proof-of concept clinical trial of amobarbital as a treatment to prevent post-traumatic osteoarthritis in fractured ankle joints.
- Trial name
- NCT04589611
- Testing
- amobarbital/Gel-One (one dose), amobarbital/Gel-One (two doses)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- J L Marsh
Obese Diabetics, Obese Non Diabetic
Comparative Study of Different Weekly GLP-1 Receptor Agonists Among Diabetic and Non-Diabetic Patients: Clinical Trial
titel : Comparative Study of Different Weekly GLP-1 Receptor Agonists Among Diabetic and Non-Diabetic Patients: Clinical Trial Abstract : Background: This study that highlights the different effects of most used three GLP-RA…
- Trial name
- NCT07820111
- Testing
- Dulaglutide 1.5 MG/ML, Semaglutide 2 mg/1.5 ml (1.34 mg/ml), prefilled pen-injector for subcutaneous injection solution, Tirzepatide is administered as part of routine clinical care for obesity management, according to standard prescribing practices. Dosing and treatment duration are determined by the treating physician
- Where
- Saudi Arabia
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Zagazig University
COVID-19, Vitamin D Deficiency
Investigating the Role of Vitamin D in the Morbidity of COVID-19 Patients
The 2019 novel coronavirus disease (COVID-2019) pandemic is an enormous health issue of worldwide scale. Prevention and/or treatment with a widely-available and already-licensed product such as vitamin D (cholecalciferol) could…
- Trial name
- NCT04386044
- Where
- United Kingdom
- Volunteers
- 986 people
- Sponsor
- Tameside General Hospital
Bladder, Lower Urinary Track Symptoms
Low-Energy Shock Wave Therapy for Overactive Bladder in Women With Metabolic Syndrome
Overactive bladder (OAB) is a common condition that causes urinary urgency, frequent urination, and nocturia, which can significantly affect quality of life.
- Conditions
- Bladder, Lower Urinary Track Symptoms, Metabolic Syndrome, Urgency-Frequency
- Trial name
- NCT07563764
- Testing
- Low-Energy Extracorporeal Shock Wave Therapy (LiESWT)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- KMUHIRB-F(I)-20230051
Cirrhosis, Microbiota
Exploring Clinical Characteristics of Liver Disease Patients Based on Digestive Metabolic Exhaled Air
Cirrhosis is a common digestive system disease and represents the final stage of the progression of various chronic liver diseases.
- Conditions
- Cirrhosis, Microbiota, Breath Tests
- Trial name
- NCT06968234
- Where
- 3 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Shanghai Zhongshan Hospital
X-linked Adrenoleukodystrophy
Exercise Study of Function and Pathology for Women With X-linked Adrenoleukodystrophy
The purpose is to see how X-linked adrenoleukodystrophy (X-ALD) is associated with strength and sensation using MRI, in women with X-ALD.
- Trial name
- NCT01594853
- Testing
- exercise training
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Chronic Renal Disease, Cardiovascular Disease
Dyslipidemia-related Risk Factors in Dialysis
In this study, we studied lipoprotein abnormalities-related variables as risk factors for the development of cardiovascular disease in patients on renal replacement therapies.We studied 96 dialyzed patients, 62 males and 34…
- Conditions
- Chronic Renal Disease, Cardiovascular Disease, Dyslipidemia
- Trial name
- NCT02072837
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Pre-diabetes, Breast Cancer
Time Restricted Eating on Cancer Risk
Participants will be randomly assigned to either the time restricted feeding group with a daily eating period of 8 hours or the control group with a daily eating period of greater than or equal to 12 hours.
- Conditions
- Pre-diabetes, Breast Cancer, Time Restricted Feeding
- Trial name
- TREC (NCT05038137)
- Testing
- Time restricted feeding, Control
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Medical University of South Carolina
Overweight (BMI > 25), Obesity &Amp; Overweight
Effects of Three Dietary Strategies on Body Composition and Metabolic Health in Adults With Overweight or Obesity
This study aims to compare the effects of three dietary interventions-a traditional Mediterranean diet, a Mediterranean low-carbohydrate diet, and a high-protein diet-on body composition, metabolic health markers, and metabolic…
- Conditions
- Overweight (BMI > 25), Obesity &Amp; Overweight, Metabolic Syndrome (MetS), Cardiometabolic Risk Factors
- Trial name
- NCT07314177
- Testing
- Mediterranean Diet, Mediterranean Low-Carbohydrate Diet, High-Protein Diet
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Amyloid, AL Amyloidosis
Daratumumab, Pomalidomide, and Dexamethasone (DPd) in Relapsed/Refractory Light Chain Amyloidosis Patients Previously Exposed to Daratumumab
This study will test the hypothesis that in patients with previous daratumumab exposure, combination therapy of daratumumab, pomalidomide, and dexamethasone (DPd) will yield higher complete remission (CR) rates in…
- Conditions
- Amyloid, AL Amyloidosis, Refractory AL Amyloidosis
- Trial name
- NCT04270175
- Testing
- Daratumumab SC, Pomalidomide, Dexamethasone
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Weill Medical College of Cornell University
Diabetes Mellitus, Type 2
Liquid Meal Study With Insulin Lispro With/Without Recombinant Human Hyaluronidase PH20 (rHuPH20) and Regular Human Insulin With rHuPH20 to Compare Pharmacokinetics, Postprandial Glycemic Response, and Optimal Insulin Dose in Participants With Type 2 Diabetes Mellitus (T2DM)
This is a single-center, Phase 2, randomized, double-blind, 3-way crossover meal study in participants with Type 2 Diabetes Mellitus (T2DM) to determine the optimum dose and compare the pharmacokinetics (PK) and postprandial…
- Trial name
- NCT00916357
- Testing
- Humalog, Humulin-R, Recombinant human hyaluronidase PH20 (rHuPH20)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Halozyme Therapeutics
Gestational Diabetes
Associations of Plasma Vanadium Concentrations With Gestational Diabetes Mellitus
Background: Vanadium compounds have been shown to exert insulin-mimetic effects and thereby control glucose homeostasis. However, studies regarding the levels of vanadium and gestational diabetes mellitus (GDM) are limited and…
- Trial name
- NCT05267457
- Testing
- Plasma vanadium concentration
- Volunteers
- 504 people, healthy volunteers welcome
- Sponsor
- Liegang Liu
Gestational Age, Birth Weight
Resistance Exercise Training During Pregnancy: a Randomized Controlled Trial
The investigators investigated the effects of a supervised maternal exercise training program (performed during the 2nd and 3rd trimesters of pregnancy) on maternal-newborn unit health outcomes in a group of previously sedentary…
- Conditions
- Gestational Age, Birth Weight, Anaemia, Gestational Diabetes Mellitus
- Trial name
- NCT00813657
- Testing
- Exercise
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidad Politecnica de Madrid
Renal Impairment, Gout
Evaluation of Colchicine and Nonsteroidal Anti-inflammatory Drug Combination Therapy and Renal Function in Gout Patients
Our findings are expected to provide real-world evidence of the renal-adverse effects of colchicine and NSAIDs combination therapy in patients with gout, which will guide healthcare professions in optimizing gout treatment…
- Conditions
- Renal Impairment, Gout, Colchicine Adverse Reaction, Nonsteroidals (NSAIDs)Toxicity
- Trial name
- NCT05006001
- Testing
- Colchicine and NSAID
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- En Chu Kong Hospital
Dysmetabolic Syndrome, Hyperferritinemia
Respiratory Variations for Assessing Blood Withdrawal 2
OBJECTIVES: To investigate whether respiratory variations of the inferior vena cava (ΔIVC) and internal jugular vein (ΔIJV) diameters during standardized breathing (ΔIVCST and ΔIJVST) increase after a therapeutic bleeding in…
- Conditions
- Dysmetabolic Syndrome, Hyperferritinemia, Obese
- Trial name
- ReVAs2 (NCT03066401)
- Testing
- echography
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Lille
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, MASH - Metabolic Dysfunction-Associated Steatohepatitis
Exercise for an Aging Liver (EXALIVER)
The goal of this clinical trial is to learn how physical exercise affects liver health in adults with metabolic dysfunction-associated steatotic liver disease (MASLD) or at-risk metabolic dysfunction-associated steatohepatitis…
- Conditions
- MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, MASH - Metabolic Dysfunction-Associated Steatohepatitis, Liver Fibrosis/NASH
- Trial name
- EXALIVER (NCT07467512)
- Testing
- Exercise, Usual Care
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Mild Autonomous Cortisol Secretion, Autonomous Cortisol Secretion (ACS)
Impact of 1 mg Osilodrostat Therapy on Mild Autonomous Cortisol Secretion (MACS)
The purpose of this study is to evaluate the safety and tolerability of 1 mg osilodrostat therapy in patients with mild autonomous cortisol secretion (MACS), and to determine the impact on 24h urine steroid metabolome and…
- Trial name
- NCT07104812
- Testing
- Osilodrostat 1 MG
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
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