Clinical trials: Diseases, Metabolic
Obesity
Lorcaserin and Behavioral Modification for Overweight and Obesity Management in Chinese Obese Patients
The purpose of this study is to assess the safety and weight loss effect of lorcaserin at the end of the first year of treatment (Week 48) in overweight and Chinese adult obese patients compared to placebo.
- Trial name
- NCT03720574
- Testing
- Lorcaserin 10 mg BID
- Where
- 9 sites in China
- Volunteers
- 100 people
- Sponsor
- Kanion & Huawe Medicine Co.,Ltd
Diabetes Type 1
Food Collection From Type 1 Diabetic Patients Practicing Insulin Functional Therapy
a food collection will be performed in this study with type 1 diabetic patients trained to carbohydrate counting, to collect data on the meals consumed daily and their quantities for a period of 1 month.
- Trial name
- GLUCAL2 (NCT04587297)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Montpellier
Pancreatic Cancer, Periampullary Cancer
Prehabilitation in Pancreatic Surgery
In patients with pancreatic cancer, older age, multiple comorbidities, frailty, malnutrition and poor functional status are common, especially in individuals receiving neoadjuvant chemotherapy.
- Conditions
- Pancreatic Cancer, Periampullary Cancer, Frailty Syndrome, Malnutrition
- Trial name
- PIPS (NCT06069297)
- Testing
- Multimodal Prehabilitation
- Where
- Italy
- Volunteers
- 238 people
- Sponsor
- IRCCS San Raffaele
Diabetes
N2-(1-carboxyethyl)-2'Deoxyguanosine (CEdG) a Potential Biomarker for Diabetes
The purpose of this study is to see if the CEdG assay can produce internally consistent results and initiate its validation as a biomarker for diabetes in humans.
- Trial name
- NCT02065310
- Testing
- N2-(1-carboxyethyl)-2'deoxyguanosine (CEdG)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Pompe Disease
Development of an Assessment Tool for Health-related Quality of Life in Children and Adolescents With Pompe Disease
Health related quality of life (HrQoL), is "the patient's subjective perception of the impact of his disease and its treatment on his daily life, physical, psychological and social functioning and well-being" and thus constitutes…
- Trial name
- Pompe_HrQol (NCT04724213)
- Testing
- Testing of reliability / validity of new questionnaire
- Where
- Switzerland
- Volunteers
- 101 people
- Sponsor
- University Children's Hospital, Zurich
Diabetes Mellitus, Diabetic Foot Ulcer
Contribution of Psychological Factors in the Healing of the Diabetic Foot Ulcer
Diabetic foot ulcers (DFU) are one of the most serious complications of diabetes and can lead to amputations in 85% of cases, resulting in physical, psychological, family, social and economic consequences.
- Trial name
- NCT04698720
- Testing
- Muscle Relaxation with Guided Imagery, Hypnosis with Guided Imagery, Neutral Guided Imagery
- Where
- 3 sites in Portugal
- Volunteers
- 69 people
- Sponsor
- University of Minho
Prediabetic State, PreDiabetes
Feasibility of a Nutrition Intervention for Patients With Prediabetes at a Federally Qualified Health Center
The purpose of the study is to assess the feasibility and acceptability of incorporating hands-on nutritional demonstrations to enhance the Diabetes Prevention Program (DPP) curriculum among patients who are at-risk for…
- Conditions
- Prediabetic State, PreDiabetes, Health Knowledge, Attitudes, Practice, Nutrition, Healthy
- Trial name
- NCT06897982
- Testing
- One-arm feasibility pilot of a nutrition intervention to recruit, engage, and retain DPP participants in the safety-net setting in Los Angeles
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Congenital Hyperinsulinism
Effect of Exendin-(9-39) on Glycemic Control in Subjects With Congenital Hyperinsulinism
The purpose of this study is to determine if Exendin-(9-39), an antagonist of the glucagon-like peptide-1 (GLP-1) receptor with effects on the pancreatic beta cell, increases fasting blood glucose levels in subjects with…
- Trial name
- NCT00571324
- Testing
- Exendin-(9-39), Vehicle
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Diva De Leon
Multiple Sclerosis, Optic Neuritis, Demyelinating Disease
Visual (Path)Ways in Multiple Sclerosis - Part II
Multiple sclerosis (MS) is an inflammatory demyelinating and degenerative disease of the central nervous system. The mechanisms of neuro-axonal loss remain incompletely elucidated.
- Trial name
- VWIMS - II (NCT06776224)
- Testing
- Measurement of retinal vascular density and visual cognition
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Lille
Hyponatremia
Bioimpedance Spectroscopy for the Differential Diagnosis of Hyponatremia
We aimed to investigate the role of bioimpedance spectroscopy for the diagnosis of hyponatremia
- Trial name
- NCT01838759
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Zonguldak Bulent Ecevit University
Insulin Resistance, Hyperglycemia
A Cold Physical Treatment to Manage Insulin Resistance
Insulin resistant volunteers will choose to undergo an 8-week cold treatment, 2 hours per day, to selective regions of the body enriched with brown fat including neck, supraclavicular and interscapular regions) in combination…
- Conditions
- Insulin Resistance, Hyperglycemia, Hyperinsulinemia, Diabetes
- Trial name
- CTPMIR (NCT02852759)
- Testing
- Selective Cold, Electroacupuncture
- Where
- China
- Volunteers
- 33 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Sarcopenia, Osteopenia or Osteoporosis
Pilot Study On Pulsed Electromagnetic Field Therapy For Osteosarcopenia
This prospective, single-site, single arm pilot study aims to assess the efficacy of Pulsed Electromagnetic Field (PEMF) exposure in the reduction of the decline in muscle strength, function and bone mineral density (BMD) in…
- Trial name
- NCT05043480
- Testing
- PEMF
- Where
- Singapore
- Volunteers
- 80 people
- Sponsor
- Louis Tee
Pregnancy Complications, Diabetes Mellitus
Correlation of CGM Metrics With OGTT and Pregnancy Outcomes in Pregnant Women With or Without a High Risk for GDM
the aim of the study is to obtain CGM data concomitant with OGTT and to determine what CGM metrics obtained in pregnant women with and without a high risk of GDM correlate best with the diagnostic OGTT (obtained via the 2-step…
- Conditions
- Pregnancy Complications, Diabetes Mellitus, Hyperglycemic Disorder
- Trial name
- NCT05537480
- Testing
- Continuous glucose monitoring device
- Where
- Israel
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Non-celiac Gluten Sensitivity
Extraintestinal Non Celiac Wheat Sensitivity
Non Celiac Gluten Sensitivity (NCGS), or, better, Non Celiac Wheat Sensitivity (NCWS), since it is not known the real pathogenetic component(s) of grain, is a syndrome characterized by a cohort of symptoms, both gastrointestinal…
- Trial name
- NCT04769180
- Testing
- Evaluation of extraintestinal manifestations
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- University of Palermo
Obesity, Morbid
Preoperative Carbohydrate Loading in Bariatric Surgery
The aim of this study is to perform a randomized non-blinded clinical trial to assess influence of preoperative carbohydrates loading in patients undergoing bariatric surgery measured by changes in the course of the postoperative…
- Trial name
- NCT04486079
- Testing
- Nutricia PreOp
- Where
- Poland
- Volunteers
- 400 people
- Sponsor
- Medical University of Gdansk
Amyloidosis
A PILOT Study on LSGB vs EMB in the Diagnosis of Cardiac Transthyretin Amyloidosis
Transthyretin (TTR) is a plasma protein mainly synthesized in the liver, recognized as a transporter of thyroxine and retinol-binding protein.
- Trial name
- NCT05375279
- Testing
- Lip Salivary Gland Biopsy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Type 2 Diabetes
Glimepiride Induced Insulin Secretion Will be Inhibited by Hypoglycemia
This study will look at two FDA approved medications that improve how the pancreas works in patients with Type 2 Diabetes. In order to understand how these medications work in patients with diabetes we must first measure the…
- Trial name
- NCT00608179
- Testing
- Glimepiride, glyburide, glucose clamp
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Pediatric Obesity
Evaluation of Body Composition in Pediatric Patients With Overweight or Obesity
In recent decades, the prevalence of obesity and overweight has dramatically increased globally, representing a serious problem for society and for the health system of many countries, estimating an impact of 2-8% on global…
- Trial name
- OBIASITY (NCT06312280)
- Testing
- Mediterranean diet
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Iron Deficiency Anemia of Pregnancy
Adiposity and Iron Requirements in Pregnancy
This study aims to explore how body fat influences the response to either 25 or 50 mg of daily iron supplements during pregnancy.
- Trial name
- ADIPREG (NCT06425796)
- Testing
- Adiposity and Iron Requirements in Pregnancy (ADIPREG)
- Where
- 3 sites in United Kingdom
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Gaucher Disease, Thrombocytopathy
Thrombocytopathy in Gaucher Disease Patients
In Gaucher disease type I bleeding is a common presenting symptom, that may manifest itself as frequent nose bleeds, easy bruising but can also cause substantial bleeding after surgical or dental procedures and may occur in…
- Trial name
- NCT01344096
- Where
- 2 sites in Israel
- Volunteers
- 70 people
- Sponsor
- Rabin Medical Center
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