Clinical trials: Diseases/Diagnoses
Coronary Artery Disease
Stress Echocardiography Versus Exercise ECG (ExECG) in Women With Chest Pain
The overall question the investigators would like to help answer is whether SE with or without MCE data can be widely used as a first line investigation in women with no previous history of Coronary Artery Disease (CAD) who…
- Trial name
- NCT02346565
- Testing
- Exercise ECG, Stress Echocardiography
- Where
- United Kingdom
- Volunteers
- 416 people
- Sponsor
- London North West Healthcare NHS Trust
Lymphedema of Upper Arm, Breast Cancer
Pre-existing Factors, Early Detection and Early Treatment of Breast Cancer Related Lymphedema
Breast-cancer related lymphoedema (BCRL) is a common phenomenon. Early diagnosis and treatment is very important to alter the normal progression of this disease.
- Conditions
- Lymphedema of Upper Arm, Breast Cancer, Diagnoses Disease
- Trial name
- DEARLY (NCT03210311)
- Testing
- compression
- Where
- Belgium
- Volunteers
- 128 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
NASH/MASH, NAFLD/MASLD
A Study Evaluating Efruxifermin in Subjects With Non-invasively Diagnosed Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Nonalcoholic Fatty Liver Disease (NAFLD)/Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
The aim of this study is to assess the safety and tolerability of EFX compared to placebo in subjects with non-invasively diagnosed NASH/MASH and NAFLD/MASLD.
- Trial name
- NCT06161571
- Testing
- Efruxifermin
- Where
- 211 sites in United States, Argentina and 11 more
- Volunteers
- 700 people
- Sponsor
- Akero Therapeutics, Inc
B Acute Lymphoblastic Leukemia, Ph-Like Acute Lymphoblastic Leukemia
Venetoclax and a Pediatric-Inspired Regimen for the Treatment of Newly Diagnosed B Cell Acute Lymphoblastic Leukemia
This phase I trial tests the safety, side effects, and best dose of venetoclax in combination with a pediatric-inspired chemotherapy regimen known as C10403 in treating patients with newly diagnosed B cell acute lymphoblastic…
- Trial name
- NCT05157971
- Testing
- Cyclophosphamide, Cytarabine, Daunorubicin Hydrochloride
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- City of Hope Medical Center
Pancreatic Cancer, Adult, Gastroesophageal Cancer (GC)
BEFAST Study, [68Ga]Ga-FAPI Total Body PET/CT for Better and Faster Imaging in Cancer
The goal of this clinical trial is to learn if [68Ga]Ga-FAPI-46 Total Body PET/CT can diagnose patients suffering from gastroesophageal cancer and pancreatic cancer.
- Trial name
- BEFAST (NCT07629609)
- Testing
- [68Ga]Ga-FAPI-46
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Barbara Malene Fischer
Ischemic Heart Disease
Dose Optimization for Rubidium PET Imaging in Patients With Known or Suspected Ischemic Heart Disease
Selection of the appropriate administered activity for each patient's body habitus is very important to obtain diagnostic image quality.
- Trial name
- RUBY-DOSE (NCT05037799)
- Testing
- Rb-82 Radioisotope
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Neurodevelopmental Disorders, Intellectual Developmental Disorder
High Depth Exome Sequencing on DNA From a Salivary Sample by Mouth Smear.
Despite technological advances, a genetic etiology has been identified in only about 50% to 60% of patients with Neurodevelopmental disorders (NDDs), with a higher diagnostic yield in the syndromic NDD and IDD subgroups.
- Trial name
- SEPASA (NCT07492199)
- Testing
- genetic
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Focal Onset Seizure
Open-label Study of Cenobamate Monotherapy in Adult Subjects With Newly Diagnosed or Recurrent Partial-Onset Epilepsy
Cenobamate (YKP3089) is a small molecule approved in the United States (US), Europe and several other countries around the world for the treatment of Partial-Onset (focal) seizures in adult subjects (≥18 years of age).
- Trial name
- NCT06453213
- Testing
- Cenobamate
- Where
- 19 sites in United States
- Volunteers
- 49 people
- Sponsor
- SK Life Science, Inc.
Obesity
GLP-1 Response and Effect in Individuals With Obesity Causing Genetic Mutations
The obesity epidemic is attributable to dietary and behavioral trends acting on a person's genetic makeup to determine body mass and susceptibility to obesity-related diseases.
- Trial name
- NCT02082496
- Testing
- Liraglutide
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Nosocomial Pneumonia
Use of Microscopy, Cultures and Molecular Biological Methods for Diagnosing Nosocomial Pneumonia
Nosocomial pneumonia in the Intensive Care Unit is often not properly diagnosed mainly due to ongoing antimicrobial therapy. The study investigates the feasibility of more advanced diagnostic technics.
- Trial name
- NCT04279873
- Testing
- Microbiological diagnostics on pulmonary secretion
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- Zealand University Hospital
Leukemia
Interferon Alfa in Treating Patients With Newly Diagnosed Chronic Myelogenous Leukemia
RATIONALE: Interferon alfa may interfere with the growth of cancer cells. Low doses of interferon alfa may be as effective as high doses.
- Trial name
- NCT00002869
- Testing
- recombinant interferon alfa, cytarabine, hydroxyurea
- Where
- United Kingdom
- Volunteers
- 800 people
- Sponsor
- Medical Research Council
Pancreatic Ductal Adenocarcinoma (PDAC)
Diagnostic Accuracy of Circulating Tumor Cells (CTCs) and Onco-exosome Quantification in the Diagnosis of Pancreatic Cancer - PANC-CTC
The proposal aims at determining whether liquid biopsy approaches are valid in the diagnosis of pancreatic cancer. Step1 will test 3 CTC isolation methods and analyse by flow cytometry the presence of onco-exosomes in the culture…
- Trial name
- PANC-CTC (NCT03032913)
- Testing
- Blood samples, Portal vein blood sample
- Where
- France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Bordeaux
Breast Cancer
Breast MRI for Newly Diagnosed Breast Cancer:Impact on Re-excision Lumpectomy
This study is being done to find out the number of surgical procedures required to achieve clear margins in women with newly diagnosed early stage breast carcinoma.
- Trial name
- NCT01568346
- Testing
- MRI
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Dana-Farber Cancer Institute
Multiple Myeloma, AL Amyloidosis
A Phase II Study to Evaluate the Efficacy and Safety of Teclistamab in Combination With Daratumumab (Tec-Dara) in Newly Diagnosed Multiple Myeloma With Concurrent Light Chain Amyloidosis (MM+AL).
The goal of this clinical trial is to learn if teclistamab in combination with daratumumab (Tec-Dara) works to treat newly diagnosed multiple myeloma with concurrent light chain amyloidosis (MM+AL).
- Trial name
- NCT07638683
- Testing
- Teclistamab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
Chronic Pancreatitis
Correlation of Chronic Pancreatitis Pathology Features With Endoscopic Ultrasound (EUS) Criteria
In this research project the investigators intend to find out if Endoscopic Ultrasound (EUS) criteria for diagnosing chronic pancreatitis can be correlated with pathologic characteristics of tissues taken from pancreas of…
- Trial name
- NCT01442441
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Indiana University
CML, Chronic Phase
A Study of the Efficacy and Safety of Flumatinib in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase.
It's a double-blind , randomized ,multi-center study. The purpose of this study is to explore the efficacy and safety of flumatinib 400mg once daily (QD) versus 600mg QD as the first line therapy in patients with chronic myleiod…
- Trial name
- NCT05353205
- Testing
- Flumatinib mesylate tablets (400mg), Flumatinib mesylate tablets (600mg)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Parkinson's Disease, Parkinson-Dementia Syndrome
Predictive and Diagnostic Value of Tau and Beta-amyloid Markers in the Dementia of Parkinson's Disease
The PET tracer Fluoro-ethyl-methyl-amino-naphthyl-ethylidene-malononitrile ([F18]-FDDNP) has a specific affinity for lesions containing tau protein and beta-amyloid The study consists of two phases In a first transversal phase, 8…
- Trial name
- NCT02243982
- Testing
- [F18]-FDDNP
- Where
- Spain
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Congestive Heart Failure
Retrograde Delivery of BMAC (Bone Marrow Aspirate Concentrate) for Congestive Heart Failure
The primary objective of this feasibility study is to provide clinical data to demonstrate the safety and activity of a concentrate of nucleated cells from bone marrow aspirate (BMAC) produced with the Harvest Bone Marrow…
- Trial name
- NCT01299324
- Testing
- BMAC infusion
- Where
- 3 sites in Germany, India and 1 more
- Volunteers
- 30 people
- Sponsor
- Harvest Technologies
Heart Failure
IMAGE-HF Project I-C: Computed Tomographic Coronary Angiography for Heart Failure Patients
Background: The prevalence of heart failure (HF) is rapidly rising in industrialized and developing countries. Though invasive coronary angiography (ICA) remains the gold standard for anatomical assessment of coronary arteries…
- Trial name
- CTA-HF (NCT01283659)
- Testing
- Standard Imaging, Advanced Imaging
- Where
- 15 sites in Canada, Finland
- Volunteers
- 253 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Lymphoma
Concurrent Chemotherapy and Radiation Therapy for Newly Diagnosed Nasal NK Cell Lymphoma
The goal of this clinical research study is to learn if radiation therapy and chemotherapy can help control Stage 1 and/or 2 NK cell lymphoma. The safety of the radiation and chemotherapy combination will also be studied.
- Trial name
- NCT02106988
- Testing
- Radiation Therapy, Dexamethasone, Etoposide phosphate
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- M.D. Anderson Cancer Center
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