Clinical trials: Diseases/Diagnoses
Brucellosis, Zoonotic Disease
Investigation of Fever Suspected as a Zoonosis Using Advanced Diagnostic Technologies
Zoonosis including brucellosis and rickettsial infections are a major contributor to infectious morbidity in southern Israel. The Bedouins, a nomadic tribal population residing in the Negev area are notably exposed to…
- Trial name
- NCT04717622
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Soroka University Medical Center
Acute Respiratory Distress Syndrome (ARDS)
Accuracy of the Chest Radiograph for the Diagnosis of Acute Respiratory Distress Syndrome
The presence of bilateral lung infiltrates on chest imaging is a mandatory criterion for the diagnosis of acute respiratory distress syndrome (ARDS).
- Trial name
- CT 4 ARDS (NCT07400445)
- Where
- France
- Volunteers
- 277 people
- Sponsor
- Poitiers University Hospital
Refractory Plasma Cell Myeloma
Autologous or Syngeneic Stem Cell Transplant Followed by Donor Stem Cell Transplant and Bortezomib in Treating Patients With Newly Diagnosed High-Risk, Relapsed, or Refractory Multiple Myeloma
This phase II trial studies the side-effects and anti-cancer effects of giving an autologous or syngeneic stem cell transplant followed by an allogeneic donor stem cell transplant and bortezomib.
- Trial name
- NCT00793572
- Testing
- Autologous Hematopoietic Stem Cell Transplantation, Bortezomib, Cyclosporine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Fred Hutchinson Cancer Center
Thyroid Nodular Disease
Thyroid Fine Needle Biopsy and Impact on Pain and Diagnostic Adequacy
This randomized study compares patient pain and comfort during ultrasound-guided thyroid fine needle biopsy using 21-gauge versus 27-gauge needles. Patients with thyroid nodules were randomly assigned to one of two needle sizes.
- Trial name
- THY-BPSY (NCT07683039)
- Testing
- Thyroid fine needle biopsy with 21-gauge needle, Thyroid fine needle biopsy with 27-gauge needle
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people
- Sponsor
- Izmir Ataturk Training and Research Hospital
Dialysis, Covid19
Antibody Response in Hemodialysis and Non-dialysis Patients Diagnosed With COVID-19.
This is prospective cohort study aimed to compare antibody response against SARS-CoV-2 in dialysis patients and non-dialysis-dependent volunteers.
- Trial name
- COV-HD (NCT04633915)
- Where
- Russia
- Volunteers
- 51 people
- Sponsor
- Saint Petersburg State University, Russia
Diabetes Mellitus, Type 2, Obesity
Effect of Acarbose and Vildagliptin on Visceral Fat Distribution in Newly Diagnosed Type 2 Diabetes Patients
Focusing on newly diagnosed type 2 diabetes participants with overweight and obesity (24kg/m2 ≤ body mass index ≤ 30kg/m2). 50 participants per arm (acarbose \& lifestyle combination / vildagliptin \& lifestyle combination)…
- Trial name
- VISA-T2DM (NCT02999841)
- Testing
- Acarbose, Vildagliptin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University
Lung Nodule, Lung Cancer
Biobank for the Identification of Biomarkers in Lung Cancer (BIRD, Biomarkers in Respiratory Disease)
The BIRD biobank aims at collecting clinical and biological data from patients suffering from a chronic respiratory disease. The lung cancer subpopulation will be divided into two cohorts to identify biomarkers of cancer.
- Trial name
- BIRD-NK (NCT06054854)
- Testing
- Extra blood sampling, Non-invasive or leftover samples or medical waste
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- University Hospital, Toulouse
Community-acquired Pneumonia
DiagNostic Study of Low-dose CT and multipleX PCR on Antibiotic Treatment and Outcome of Community-Acquired Pneumonia
Rationale: Uncertainty in the clinical and etiological diagnosis of community-acquired pneumonia (CAP) often leads to incorrect treatment and unnecessary use of broad-spectrum antibiotics.
- Trial name
- CAP-NEXT (NCT03360851)
- Testing
- low-dose CT, PoC-PCR
- Where
- 7 sites in Netherlands
- Volunteers
- 3,555 people
- Sponsor
- MJM Bonten
Cutaneous Leishmaniases
Cutaneous Leishmaniasis Diagnostic Study
The performance of the CL Detect Rapid test will be tested in individuals with suspected cutaneous leishmaniasis in Ethiopia using both skin slit and dental broach samples against a combined reference of microscopy and PCR.
- Trial name
- NCT03837431
- Testing
- Skin slit, Dental broach, Tape disc
- Where
- Ethiopia
- Volunteers
- 351 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Prostate Cancer
Imaging Study to Investigate Safety and Diagnostic Performance of 18F rhPSMA 7.3 PET Ligand in Suspected Prostate Cancer Recurrence
A prospective, Phase 3, multi center, single-arm, imaging study investigating the safety and diagnostic performance of rhPSMA 7.3 (18F) Positron Emission Tomography (PET) ligand in men with suspected prostate cancer recurrence…
- Trial name
- NCT04186845
- Testing
- rhPSMA-7.3 (18F) Injection, Positron emission tomography scan
- Where
- 28 sites in United States, Finland and 1 more
- Volunteers
- 391 people
- Sponsor
- Blue Earth Diagnostics
Sleep Apnea, Obstructive
Evaluating the Diagnostic Efficacy of Smartwatch and Smartphone for Sleep Apnea
The purpose of this study is to evaluate the diagnostic value of smartphones and watches for OSA screening. The study will be conducted in individuals suspected of having OSA.
- Trial name
- NCT06573372
- Where
- China
- Volunteers
- 377 people
- Sponsor
- Peking University First Hospital
COPD
Effectiveness of Education Given to Patients With COPD
This study was conducted to examine the effects of chronic obstructive pulmonary disease management education given to patients diagnosed with chronic obstructive pulmonary disease on self-care agency and rational drug use.
- Trial name
- NCT05577897
- Testing
- Education
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Zeynep Yildirim
Pulmonary Arterial Hypertension
Pilot Study Evaluating the Safety and Performance of the GeNO NITROsyl Delivery System for Inhaled Nitric Oxide
This is an open label phase 2 pilot study designed to evaluate the safety, tolerability and device performance of the GeNO nitrosyl delivery system during right heart catheterization (RHC) in participants with pulmonary arterial…
- Trial name
- PILOT (NCT01092559)
- Testing
- Nitric Oxide generated by the GeNO nitrosyl delivery system
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- Geno LLC
Coronary Artery Disease
Comparison of Digital Electronic Stethoscope to Computed Tomography (CT) Angiography in Detection of Coronary Artery Disease
The study is designed to evaluate the predictive diagnostic accuracy of SonoMedica's CardioSond digital electronic stethoscope in the detection of coronary artery disease (CAD) in patients without known disease who are referred…
- Trial name
- NCT01040923
- Testing
- CardioSond Cardiac Sonospectrographic Analyzer
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- SonoMedica, Inc.
Diagnoses Disease
Quantitative Ultrasound for Diagnosing Hepatic Steatosis in Nonalcoholic Fatty Liver Multicenter Study
To evaluate the diagnostic performance of quantitative ultrasound parameters for assessing hepatic steatosis in non-alcoholic fatty liver disease using histologic results as reference standard
- Trial name
- NCT04985188
- Testing
- Quantitative ultrasound (QUS) technique
- Volunteers
- 112 people
- Sponsor
- Seoul National University Hospital
Breast Cancer
Test of Digital Breast Tomosynthesis vs. Regular Mammography in Detecting Breast Cancer in Women Undergoing Diagnostic Mammography
Comparison of the ability of DBT and FFDM to detect breast cancer.
- Trial name
- NCT00535327
- Volunteers
- 220 people
- Sponsor
- GE Healthcare
Multiple Myeloma, New Diagnosis Tumor
A Trial That Compare Two Treatments in Newly Diagnosed Myeloma Patients Not Eligible for Transplant
The combination of lenalidomide plus low-dose dexamethasone (Rd) is considered the new standard for elderly newly diagnosed multiple myeloma (NDMM) patients.
- Trial name
- KRdvsRd (NCT04096066)
- Testing
- Carfilzomib, Lenalidomide, Dexamethasone
- Where
- 40 sites in Italy
- Volunteers
- 84 people
- Sponsor
- Fondazione EMN Italy Onlus
Breast Cancer, Decision Aid
Decision Aid for Women Newly Diagnosed With Breast Cancer
The goal of this multi-center randomized controlled trial is to determine if the clinical decision aid (BCT Aid) works to help breast cancer patients participate in decision-making and make high-quality decisions, thereby…
- Conditions
- Breast Cancer, Decision Aid, Shared Decision Making, Cost Effectiveness
- Trial name
- BCT Aid (NCT07497256)
- Testing
- BCT Aid, Usual Care
- Where
- 3 sites in China
- Volunteers
- 160 people
- Sponsor
- Xiamen University
Multiple Myeloma
Isa-RVD Study in Patients With Newly Diagnosed Multiple Myeloma
This study aims to evaluate the stringent Complete Response (sCR) rate by the end of two cycles of induction treatment, defined as the proportion of patients who have achieved sCR, according to International Myeloma Working Group…
- Trial name
- Isa-RVD (NCT05123131)
- Testing
- Isatuximab, Bortezomib, Lenalidomide
- Where
- 5 sites in Denmark, Ireland
- Volunteers
- 54 people
- Sponsor
- Cancer Trials Ireland
Stage IV Small Cell Lung Cancer
A Phase 1b/2 Study of OMP-59R5 (Tarextumab) in Combination With Etoposide and Platinum Therapy
The study consists of a Phase1b lead-in portion to determine the maximum tolerated dose (MTD) of OMP-59R5 (tarextumab) in combination with etoposide (EP) for 6 cycles followed a Phase 2, multi center, randomized…
- Trial name
- PINNACLE (NCT01859741)
- Testing
- OMP-59R5, Etoposide, Cisplatin or Carboplatin
- Where
- 35 sites in United States
- Volunteers
- 172 people
- Sponsor
- OncoMed Pharmaceuticals, Inc.
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