Clinical trials: Diseases/Diagnoses
Acute Kidney Injury
Efficacy and Safety of Deferiprone in Patients With Chronic Kidney Disease Undergoing a Cardiac Catheterization and Receiving Contrast Agent
This trial will evaluate whether treatment with CRMD001 (unique formulations of the iron chelator, Deferiprone) will reduce morbidity and mortality in subjects with Chronic Kidney Disease (CKD) and additional risk factors.
- Trial name
- NCT01391520
- Testing
- deferiprone
- Sponsor
- CorMedix Therapeutics
Severe Aplastic Anemia, Refractory Aplastic Anemia
Safety and Efficacy of the JAK1 Inhibitor Combined With Intensive Immunosuppressive Therapy in Severe Aplastic Anemia
This study is designed as a Phase Ib/II trial. The phase Ib cohort will enroll patients with severe aplastic anemia (SAA) who have failed to respond to intensified immunosuppressive therapy.
- Conditions
- Severe Aplastic Anemia, Refractory Aplastic Anemia, Newly Diagnosed Aplastic Anemia
- Trial name
- NCT07297550
- Testing
- Golidocitinib Capsules
- Volunteers
- 42 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
DLBCL - Diffuse Large B Cell Lymphoma, Follicular Lymphoma
Lenalidomide Combined With G-CHOP in the Treatment of Newly Diagnosed DLBCL With FL
To evaluate the efficacy and adverse effects of lenalidomide combined with G-CHOP(LO-CHOP) in the treatment of newly diagnosed diffuse large B-cell lymphoma with follicular lymphoma (CDLBCL-FL).
- Trial name
- NCT06151080
- Testing
- Lenalidomide combined with G-CHOP (LO CHOP)
- Where
- China
- Volunteers
- 38 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Fever, Malaria
Use of Malaria Rapid Diagnostic Tests as a Decision Aid for the Management of Fever by International Travelers
This study is part of a larger prospective cohort study (JOKA), designed to study the incidence and etiological spectrum of febrile illness occurring during a travel to the tropics, as well as clinical course, care, treatment and…
- Trial name
- JOKA-I (NCT02900079)
- Testing
- rapid diagnostic test for malaria antigen
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Cerebral Thrombosis, Venous Thrombosis
TOF-MRV Versus Post-Contrast 3D T1 MRI in Dural Venous Sinus Thrombosis
This cross-sectional study aims to compare the diagnostic performance of time-of-flight MR venography and post-contrast 3D T1-weighted MRI in the detection of dural venous sinus thrombosis.
- Trial name
- NCT07888062
- Volunteers
- 80 people
- Sponsor
- Assiut University
Coronary Artery Disease
Accuracy of Half of the Usual Radiotracer Dose in SPECT
There has been a shortage of nuclear isotopes, not only in Canada but around the world. New, more sensitive SPECT cameras can obtain better images in shorter scan times.
- Trial name
- SPECT-Light (NCT01412827)
- Testing
- 1/2 dose of 99mTc OR 201Tl tracers
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Tafasitamab and Zanubrutinib for the Treatment of Patients With Newly Diagnosed Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma, TaZA CLL Study
This phase II trial tests how well tafasitamab and zanubrutinib works in treating patients with newly diagnosed chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL).
- Trial name
- NCT05718869
- Testing
- Biospecimen Collection, Bone Marrow Biopsy, Computed Tomography
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- City of Hope Medical Center
Non Small Cell Lung Cancer
EBUS-guided TBNA for Molecular Diagnostic of Mediastinal Lymph Nodes (LN)
The purpose of this study is to perform molecular diagnostic in mediastinal lymph nodes of non-small cell lung cancer patients sampled by endobronchial ultrasound guided finde needle aspiration (EBUS-TBNA).
- Trial name
- NCT00982605
- Testing
- EBUS_TBNA
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Heidelberg University
Pancreas Cancer, Diagnosis
Diagnosis of Pancreatic Cancer by Purine Metabolite (Hypoxanthine, Xanthine) in Urine
This study aim to develope a diagnostic method of pancreatic cancer by using a reagent for analyzing purine metabolite (Hypoxanthine, Xanthine) in urine. It is safe and cost effective compare to radiologic or blood test.
- Trial name
- NCT06291779
- Testing
- Purine metabolite (Hypoxanthine, Xanthine) in urine by CubeBio
- Where
- South Korea
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ho-Seong Han
Non-Alcoholic Fatty Liver Disease
NAFLD Study: US vs Liver Biopsy
Evaluate the diagnostic accuracy of the new ultrasound software vs hepatic histology, the current reference standard for the diagnosis of NAFLD and NASH in 20 obese patients (BMI> 30) candidates for laparoscopic bariatric surgery…
- Trial name
- NAFLD (NCT04101162)
- Testing
- shear waves elastography; liver biopsy
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Colorectal Cancer
Point of Care Test to Diagnosed Colorectal Cancer and Polyps in Low Middle Income Countries
This is a-two phase study. Phase 1 will adapt a 3-metabolite biosensor that identifies patients with colorectal cancer (CRC) and precancerous polyps to Nigerian patients.
- Trial name
- NCT03173729
- Testing
- Biosensor Point of Care Device
- Where
- 5 sites in Nigeria
- Volunteers
- 926 people, healthy volunteers welcome
- Sponsor
- Obafemi Awolowo University Teaching Hospital
Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL)
Pharmacokinetic and Pharmacodynamic Assessment of Treatment With CPX-351 (Cytarabine: Daunorubicin) Liposome for Injection in Acute Leukemias and MDS Patients With Moderate Hepatic Impairment
To assess the impact of moderate hepatic impairment on cytarabine and daunorubicin pharmacokinetics and their metabolites following administration of CPX-351.
- Conditions
- Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Myelodysplastic Syndrome (MDS)
- Trial name
- NCT02269579
- Testing
- CPX-351
- Where
- 5 sites in United States
- Sponsor
- Jazz Pharmaceuticals
Hypertension
Clinical Response of EXTOR (Amlodipine/Valsartan) in Newly Diagnosed Hypertensive Patients.
The American College of Cardiology/American Heart Association hypertension guidelines recommend treatment initiation with dual antihypertensive therapy in adults with stage 2 hypertension (corresponding to grade 1 and 2 in the…
- Trial name
- HELP (NCT06625346)
- Testing
- Fixed-Dose Combination of Amlodipine/Valsartan
- Where
- 2 sites in Pakistan
- Volunteers
- 420 people
- Sponsor
- The Searle Company Limited Pakistan
Gaucher Disease, Acid SphingoMyelinase Deficiency
PREDIGA 2: Spanish Acronym of "Educational and Diagnostic Project for Gaucher and ASMD"
The study of splenomegaly, and the follow-up of splenectomized patients, is one of the causes of referral of these patients to pediatric gastroenterology and oncohematology clinics, and adult internal medicine and hematology.
- Conditions
- Gaucher Disease, Acid SphingoMyelinase Deficiency, ASMD, Niemann-Pick Diseases
- Trial name
- PREDIGA-2 (NCT05641103)
- Testing
- Patient with splenomegaly or splenectomy
- Where
- 14 sites in Spain
- Volunteers
- 122 people
- Sponsor
- Fundación Española de Hematología y Hemoterapía
Glioma, Malignant, Surgery
Effect of Perampanel on Peritumoral Hyperexcitability in HGG
The purpose of this research study is to learn more about seizures in people with primary brain tumors. It will evaluate whether an antiseizure medication decreases hyperexcitability activity around tumors and prevents seizures.
- Conditions
- Glioma, Malignant, Surgery, Seizures
- Trial name
- NCT04497142
- Testing
- Perampanel, Standard of Care
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Dana-Farber Cancer Institute
High Grade B-Cell Lymphoma, Not Otherwise Specified, High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements
Study of Zanubrutinib, Rituximab and Combination Chemotherapy in Newly-diagnosed Aggressive B-cell Non-Hodgkin Lymphoma
Non-Hodgkin lymphoma (NHL), with high aggressiveness and mortality, is one of the top ten high-incidence tumors in the world and is among the ten most prevalent cancers worldwide with the fastest growing incidence.
- Conditions
- High Grade B-Cell Lymphoma, Not Otherwise Specified, High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements, Diffuse Large B Cell Lymphoma, B-cell Non Hodgkin Lymphoma
- Trial name
- NCT05164770
- Testing
- Zanubrutinib+R-CHOP; Zanubrutinib+R-DA-EPOCH; Zanubrutinib+R-HD MTX, R-CHOP; R-DA-EPOCH; R-HD MTX
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shandong Provincial Hospital
Thyroid Neoplasms
Pyrosequencing of the BRAFV600E Mutation
To investigate the diagnostic efficiency of pyrosequencing for the mutant BRAF allele in ultrasound (US)-guided fine needle aspiration biopsies (FNAB) of thyroid incidentalomas.
- Trial name
- NCT00551486
- Testing
- ultrasound-guided fine needle aspiration biopsy
- Where
- South Korea
- Volunteers
- 101 people
- Sponsor
- Chungnam National University
Lipedema
Efficacy of Complex Decongestive Therapy, Exercise and Diet in Women With Lipedema
The purpose of this study is to compare the effectiveness of standard physical therapy methods (Complex Decongestive Therapy, Pneumatic Compression, and Exercise) combined with two different nutritional approaches (personalized…
- Trial name
- NCT07667270
- Testing
- Anti-inflammatory Diet and Physical Therapy, Standard Diet and Physical Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Balikesir University
Basal Cell Carcinoma
Clinical Diagnosis of Basal Cell Carcinoma Subtype
Skin cancer is the most common cancer in Caucasians. Basal cell carcinoma (BCC) is the most frequent skin cancer with around 44.000 new tumours per year in the Netherlands, and its incidence is still rising.
- Trial name
- NCT01370824
- Testing
- Punch biopsy, Surgical excision
- Where
- 2 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- Maastricht University Medical Center
Benign Paroxysmal Positional Vertigo, Multiple Sclerosis
Epley Manoeuvre in Participants With Multiple Sclerosis Diagnosed From Benign Paroxysmal Positional Vertigo
Vertigo, dizziness and control postural disturbance are one of the most disabling symptoms in Multiple Sclerosis. These could be caused by a peripheral or central vestibular disorder.
- Trial name
- NCT04578262
- Testing
- Epley Manoeuvre
- Volunteers
- 80 people
- Sponsor
- University of Seville
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