Clinical trials: Diseases of the Nervous System
Cerebral Palsy (CP)
Effects of an Intensive Rhythmic Dance Program on Learning Skills in Children With Cerebral Palsy
Cerebral palsy is a neurological disorder that affects 1 in 1,000 children and causes motor disability , with sometimes sensorymotor disability which have consequences on daily life.
- Trial name
- DANS-SCED (NCT07500896)
- Testing
- Repeated assessments
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Toulouse
Systemic Lupus Erythematosus, Depression
LUPUS Brain: tACS to Target the Neurophysiology of Depression, Cognitive Deficits, and Pain in Patients With SLE
The purpose of this study is to investigate the effects of a type of non-invasive transcranial alternating current stimulation (tACS) on patients diagnosed with systemic lupus erythematosus (SLE) who are experiencing depression.
- Trial name
- NCT04141046
- Testing
- XCSITE100 Stimulator - Individualized theta-tACS, XCSITE100 Stimulator - Individualized alpha-tACS
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of North Carolina, Chapel Hill
Alzheimer Disease
Multiregional rtfMRI Neurofeedback for the Prevention of Alzheimer's Disease (NPAD)
This study aims to predict cognitive decline using a performance endophenotype of neuro-feedback based on functional magnetic resonance imaging in real time in a population at risk for Alzheimer's disease (AD).
- Trial name
- NPAD (NCT03173846)
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Cardiac Disease
Role of Cerebral Oximetry In Reducing Delirium After Complex Cardiac Surgery
Delirium after cardiac surgery is reported in a range of 3-47% of patients. Delirium is a serious complication that results in prolonged length of stay, increased health care costs and is associated with higher death rates.
- Trial name
- NCT01707446
- Testing
- Cerebral oximetry monitor (The INVOS® Cerebral/Somatic Oximeter), An alarm threshold at 75% of the baseline rSO2 value
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- University Health Network, Toronto
Cerebral Small Vessel Diseases
Effect of Hyperbaric Oxygen on Functional Connectivity in Patients With Cerebral Small Vessel Disease
Patients will have a Functional MRI before and after 10 hyperbaric Oxygen treatments.
- Trial name
- NCT02890888
- Testing
- hyperbaric oxygen treatment
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- St. Luke's Hospital, Chesterfield, Missouri
Fibromyalgia
Serious Game for Fibromyalgia Patients
Aim: To check the applicability of LitEmotion© in people with Fibromyalgia. Design: randomized clinical trial, with pre, post and follow-up evaluation. Researchers and outcome evaluator blinded.
- Trial name
- NCT03906188
- Testing
- LitEmotion
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidad de Burgos
Stroke
Interaction Between the Brain Hemispheres - Key to Motor Recovery After Stroke
Rationale: Acute stroke leaves many patients with functional deficits, of which upper extremity motor impairment is one of the most disabling.
- Trial name
- InterAct (NCT06381388)
- Testing
- cTBS
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jord Vink
Piriformis Syndrome
Effects of MET and MFR on Piriformis Syndrome
The aim of this study is to comparatively evaluate the effects of two different manual therapy approaches, Muscle Energy Technique (MET) and Myofascial Release Technique (MFR), on pain threshold, muscle activation patterns, and…
- Trial name
- NCT07769203
- Testing
- Muscle Energy Technique, Myofascial Release Technique, Conventional Physical Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Igdir University
Parkinson's Disease
ADX48621 for the Treatment of Levodopa Induced Dyskinesia in Patients With Parkinson's Disease
The primary objective of the study is to evaluate the safety and tolerability of ADX48621 in Parkinson's disease patients following four weeks of dosing.
- Trial name
- NCT01336088
- Testing
- ADX48621
- Where
- 25 sites in United States, Austria and 2 more
- Volunteers
- 83 people
- Sponsor
- Addex Pharma S.A.
Inflammatory Myositis, Idiopathic Inflammatory Myositis
Follow-up of Patients With Inflammatory Myopathies Associated With a Biobank
Myositis are rare diseases for which the development of a cohort associated with a bank of biological samples (biobank) will allow for the conduct of researches to better delineate the underlying pathophysiology and find cures.
- Conditions
- Inflammatory Myositis, Idiopathic Inflammatory Myositis, Drug-induced Inflammatory Myositis
- Trial name
- MASC2 (NCT05454527)
- Where
- 2 sites in France
- Volunteers
- 4,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aneurysmal Subarachnoid Hemorrhage (aSAH), Delayed Cerebral Ischemia
Early Prophylactic Aspirin for Aneurysmal Subarachnoid Hemorrhage
This study is a multicenter, prospective, double-blind, randomized controlled trial designed to evaluate whether early prophylactic use of aspirin improves functional outcomes in patients with aneurysmal subarachnoid hemorrhage…
- Trial name
- aSAH-ASA (NCT07642427)
- Testing
- Aspirin
- Where
- China
- Volunteers
- 388 people
- Sponsor
- Ganzhou City People's Hospital
Alzheimer Disease, Mild Cognitive Impairment
Dementia Signal Development Study of Nautilus NeuroWave TM for the Detection of Dementia
This study is being performed to generate data regarding brain vibration /oscillation differences between individuals with dementia and normal controls.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Frontotemporal Lobar Degeneration, Memory Disorders
- Trial name
- NCT02333942
- Testing
- Nautilus NeuroWaveTM System
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Jan Medical, Inc.
Acute Stroke
Intra-arterial Magnesium Administration for Acute Stroke
Stroke is the second leading cause of death and the leading cause of adult disability worldwide. This investigation will address the safety and feasibility of directed, intra-arterial Magnesium measurement and therapy, through…
- Trial name
- NCT01502761
- Testing
- Magnesium Sulfate
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- University of Southern California
Fibromyalgia
Virtual Reality for Fibromyalgia
Fibromyalgia is a frequent chronic pain syndrome almost often affecting women and associating diffuse chronic musculoskeletal pain (for more than 3 months), fatigue and sleep disturbances.
- Trial name
- VR_Fibro (NCT05567861)
- Where
- Monaco
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Princesse Grace
Statin Adverse Reaction, Statin-induced Myopathy
Metabolic and Mitochondrial Changes in Statin-Induced Myopathy
The goal of this observational study is to learn whether statin-related muscle symptoms are linked to problems in fat metabolism in muscle cells, specifically involving acylcarnitines, in adults taking or not taking statins.
- Trial name
- NCT07511686
- Testing
- Blood sampling and laboratory assessment, Muscle biopsy
- Where
- Latvia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Riga Stradins University
Memory Impairment, Amnesia
Sedation and Memory Consolidation
The study of plasticity processes, in particular, memory, is one of the fundamental directions in anesthesiology. To date, there are different views on the impact of sedation and anesthesia on memory.
- Conditions
- Memory Impairment, Amnesia, Recall, Recognition
- Trial name
- NCT05045170
- Testing
- Influence of propofol sedation on memory consolidation and 'working memory', Influence of dexmedetomidine sedation on memory consolidation and 'working memory', Influence of spinal anesthesia on memory consolidation and 'working memory'
- Where
- Russia
- Volunteers
- 81 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Metastatic Olfactory Neuroblastoma
A Phase 2 Study Of Zanzalintinib For Patients With Recurrent Or Metastatic Olfactory Neuroblastoma
The goal of this clinical research study is to learn if zanzalintinib can help to control recurrent/metastatic ONB. The safety of zanzalintinib will also be studied.
- Trial name
- NCT07527169
- Testing
- Zanzalintinib
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- M.D. Anderson Cancer Center
Functional Movement Disorder, Functional Neurological Disorder
Tremor Retrainer Software Application for Functional Tremor
The purpose of this clinical trial is to learn about the Tremor Retrainer smartphone application and Simplified Functional Movement Disorder Rating Scale in patients with functional tremor.
- Conditions
- Functional Movement Disorder, Functional Neurological Disorder, Functional Neurological Symptom Disorder
- Trial name
- NCT06257069
- Testing
- Tremor Retrainer Smartphone Application
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Muscle Weakness, Muscle Loss
Physical Activity as Intervention Against Age-related Loss of Muscle Mass and Function
A minimum of 450 healthy individuals (62-70 years old) will be recruited. Each individual will be randomized into one of three groups stratified according to gender (M/F), BMI (≤28/>28), and 30 sec chair stand (≤11/>11).
- Conditions
- Muscle Weakness, Muscle Loss, Sarcopenia, Physical Activity
- Trial name
- LISA (NCT02123641)
- Testing
- Heavy resistance training, Moderate intensity training, Control
- Where
- Denmark
- Volunteers
- 451 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Sleep Apnea
The Role of Oxidative Stress in the Cardiovascular Consequences of Sleep Apnea
Obstructive Sleep Apnea (OSA) is the most common sleep disorder affecting up to 9-24 percent of middle aged adults, and is becoming increasingly implicated in the pathogenesis of hypertension, and other cardiovascular disorders.
- Trial name
- NCT00701441
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Rami Khayat
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