Clinical trials: Diseases of the Nervous System
Stroke
Potential for Recovery of Voluntary Finger Extension After Stroke
Stroke patients with absent voluntary finger extension (VFE) 6-months after stroke are not expected to recover hand function. However, experience from the Queen Square Upper Limb neurorehabilitation service contradicts this view.
- Trial name
- PROVES (NCT07592247)
- Testing
- Neuromuscular Electrical Stimulation and Home Exercise Programme
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London
Hypoxic Encephalopathy
The Neurological Pupil Index (NPi) on Intensive Care Unit (ICU) Trial
The trial will evaluate the use of the "Neurological Pupil index" NPi, measured with the digital pupillometer (NeurOptics) compared to clinical examination for better reliability.
- Trial name
- NPI-ON-ICU (NCT01920347)
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Parkinson's Disease and Parkinsonism
Aim 3 Particle Swarm Optimization PIGD
In Parkinson's disease (PD) patients undergoing standard-of-care Deep Brain Stimulation (DBS) therapy, to compare the effect on Parkinson's symptoms of two different neurostimulator settings designed to differ from each other as…
- Trial name
- NCT05934747
- Testing
- DBS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Neuromuscular Diseases, Sarcopenia
Soft-robotic Glove Support of High-demand Tasks
The hand is important to perform activities of daily living (ADL). However, many people experience a loss of hand function as result of a traumatic brain injury, spinal cord injury, stroke or orthopedic problems, or due to…
- Trial name
- NCT05318638
- Testing
- Soft robotic glove
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Roessingh Research and Development
Neuropathy, Diabetic, Small Nerve Fiber Neuropathy
Characterization and Prediction of Early Onset Diabetic Peripheral Neuropathy
Predicting early onset neuropathy in people with type 1 diabetes
- Conditions
- Neuropathy, Diabetic, Small Nerve Fiber Neuropathy, Type 1 Diabetes
- Trial name
- NeuroPredict (NCT05546138)
- Testing
- Skin biopsies with quantification of intra-epidermal nerve fibre density, Perception Threshold Tracking, Thermal perception thresholds
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Aalborg University Hospital
Tinnitus
Randomized Trial Of Tinnitus Retraining Therapy
Millions of Americans suffer from tinnitus. However, there is no widely accepted treatment that has been shown to be effective in controlled investigations.
- Trial name
- NCT00578058
- Testing
- Counseling and Sound Therapy
- Where
- 4 sites in United States
- Volunteers
- 180 people
- Sponsor
- University of Iowa
Auditory Hallucination, Psychotic Disorders
Avatar-mediated Therapy Versus Cognitive Behavioural Therapy for Persisting Experiences of Hearing Voices
The aim of this study is to compare the effects of a new psychological therapy, Avatar Therapy, to the current standard therapy, Cognitive Behavioural Therapy (CBT), in improving outcomes in people living with psychotic disorders…
- Conditions
- Auditory Hallucination, Psychotic Disorders, Schizophrenia and Related Disorders
- Trial name
- AMETHYST (NCT05982158)
- Testing
- Avatar therapy, Cognitive behavioural therapy (CBT)
- Where
- Australia
- Volunteers
- 212 people
- Sponsor
- Swinburne University of Technology
Healthy, Multiple Sclerosis
Normal Chinese Lifespan Brain Charts Initiative (NCLBCI)
Major brain diseases (including neuroimmune diseases, neurodegenerative diseases, and cerebrovascular diseases) are leading causes of death and disability in humans.
- Conditions
- Healthy, Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Neurodegenerative Diseases
- Trial name
- NCT06643858
- Testing
- No intervention
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Sensorineural Hearing Loss, Low-Frequency Residual Hearing
Hearing Implant Performance in Adults With Low-Frequency Residual Hearing
The purpose of the feasibility study is to investigate hearing performance (audiometry and speech perception) using the CI624 in a group of adults (n=15) with low-frequency residual hearing who meet inclusion criteria.
- Trial name
- NCT04741048
- Testing
- CI624 Slim 20 Electrode
- Where
- United States
- Sponsor
- Cochlear
Facioscapulohumeral Muscular Dystrophy
Electrostimulation of Shoulder Girdle and Quadriceps Muscles in Facioscapulohumeral Muscular Dystrophy Patients
The investigators evaluated clinical tolerance, biological tolerance, feasibility and efficacy of daily electrostimulation training of shoulder girdle and quadriceps muscles in 10 patients with facioscapulohumeral muscular…
- Trial name
- NCT00821548
- Testing
- electrostimulation
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Neuropathic Pain
Ziconotide as First-Line IDT
The primary objective of this study is to prospectively examine outcomes in 12 patients using ziconotide Intrathecal Drug Therapy(IDT) as first-line monotherapy with the use of an algorithm of slow titration for dosing.
- Trial name
- NCT03321955
- Testing
- Ziconotide 100 MCG(microgram)/ML Intrathecal Solution, Quantitative sensory testing, Serum markers: Interleukin-1, Interleukin-6, and tumor necrosis factor
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Albany Medical College
Demyelinating Disease
Pharmacological Recruitment of Endogenous Neural Precursors to Promote Pediatric White Matter Repair: Establishing Correlations Between Visual Outcomes, Saccadic Function and MEG Oscillations in Children With Demyelinating Disorders in Comparison to Healthy Control Children
The neural circuits in our brains require a layer of insulation in order to transmit signals in a rapid and efficient fashion. This insulation is called White Matter and is comprised of a specific type of brain cell called an…
- Trial name
- NCT03010826
- Where
- 2 sites in Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Multiple Sclerosis, Myasthenia Gravis
Serum Auto-Antibodies in Neurological Diseases
Under normal conditions our immune system protects us against infections and tumors. The immune system does this by recognizing that the infecting organism or the tumor is foreign to the body and attacking it.
- Conditions
- Multiple Sclerosis, Myasthenia Gravis, Transverse Myelitis
- Trial name
- SAA (NCT00704626)
- Testing
- Blood Draw, Cheek swab
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Davis
Parkinson Disease, Mood
The Benefits of Nature for Mood and Cognition in Persons With and Without Parkinson's Disease
This online study aims to explore the benefits of nature for mood and cognition in persons with and without Parkinson's disease.
- Conditions
- Parkinson Disease, Mood, Cognition
- Trial name
- NCT06483126
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
tDCS, Sham tDCS
tdCS Combined With Treadmill Training in Patients With Multiple Sclerosis
This clinical trial aims to evaluate the therapeutic effectiveness of transcranial direct current stimulation (tDCS), a non-invasive technique that modulates cortical excitability, in combination with gait training in patients…
- Trial name
- TDCS (NCT06986278)
- Testing
- tDCS
- Where
- 2 sites in Spain
- Volunteers
- 78 people
- Sponsor
- University of Castilla-La Mancha
Osteoporosis, Multiple Sclerosis
Zoledronic Acid in MS-patients With Osteoporosis
This study is designed to evaluate the efficacy and safety of zoledronic acid 5 mg intravenous (i.v.) relative to placebo in Multiple Sclerosis (MS) patients with osteoporosis and to support the optimal use of zoledronic acid for…
- Trial name
- EXALT (NCT01166178)
- Testing
- Zoledronic Acid, Calcium and Vitamin D combination
- Where
- 15 sites in Germany
- Volunteers
- 29 people
- Sponsor
- Novartis
Ischemic Stroke, Intracranial Hemorrhages
Novel Oral Anticoagulants in Stroke Patients
The present study will monitor and explore acute neurovascular emergencies in patients treated with NOACs compared to those under treatment with VKAs.
- Trial name
- NOACISP (NCT02353585)
- Where
- Switzerland
- Volunteers
- 1,050 people
- Sponsor
- University Hospital, Basel, Switzerland
Chronic Kidney Failure, Chronic Kidney Diseases
Physical Impairments in Children With Chronic Renal Failure
When the literature is examined, it is seen that the extent to which cough strength, grip strength, physical activity level and quality of life levels are affected in children with chronic kidney failure compared to healthy…
- Trial name
- NCT06981585
- Testing
- Physical Evaluations of Patients with Chronic Kidney Failure, Physical Evaluations of Healthy Children
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Izmir Democracy University
Glycogen Storage Disease Type II (GSD-II), Pompe Disease (Late-Onset)
Alglucosidase Alfa Temporary Access Program
Pompe disease (also known as glycogen storage disease Type II) is caused by a deficiency of a critical enzyme in the body called acid alpha-glucosidase (GAA).
- Conditions
- Glycogen Storage Disease Type II (GSD-II), Pompe Disease (Late-Onset), Acid Maltase Deficiency Disease, Glycogenosis 2
- Trial name
- ATAP (NCT00520143)
- Testing
- alglucosidase alfa (recombinant human acid alpha-glucosidase [rhGAA])
- Where
- 74 sites in United States
- Sponsor
- Genzyme, a Sanofi Company
Fibromyalgia
Efficacy of Shiatsu in Individuals With Fibromyalgia: a Randomized Clinical Trial
Fibromyalgia is a syndrome characterized by chronic and generalized musculoskeletal pain and tenderness in tender points. Its etiology and physiopathology are not well known; therefore its treatment is not satisfactory.
- Trial name
- NCT01291043
- Testing
- Shiatsu
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- University of Sao Paulo General Hospital
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