Clinical trials: Diseases of the Nervous System
Parkinson's Disease
A Study To Evaluate The Safety And Efficacy Of IPX066 In Advanced Parkinson's Disease (ADVANCE-PD).
This is a study to evaluate the safety and efficacy of IPX066 in advanced Parkinson's disease.
- Trial name
- NCT00974974
- Testing
- IPX066, IR CD-LD
- Where
- 73 sites in United States, Canada and 6 more
- Volunteers
- 471 people
- Sponsor
- Impax Laboratories, LLC
Migraine, Transcranial Magnetic Stimulation Repetitive
Individualized Location-based rTMS for Migraine Treatment: A Multicenter Clinical Study
For migraine patients experiencing at least four attack days per month and undergoing transcranial magnetic stimulation (TMS) treatment, a randomized, double-blind controlled trial is conducted, dividing participants into a…
- Trial name
- individua rTMS (NCT07086274)
- Testing
- Individualized location-based Repetitive Transcranial Magnetic Stimulation, Traditional location-based Repetitive Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 152 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Meningococcal Meningitis, Measles
Study of the Safety of Menactra® Vaccine When Administered With Other Pediatric Vaccines to Healthy Toddlers
This clinical trial will evaluate the safety of two injections of Menactra® Vaccine in subjects at 9 months and at 12 months of age when the second dose is given concomitantly with other pediatric vaccines routinely administered…
- Conditions
- Meningococcal Meningitis, Measles, Mumps, Rubella
- Trial name
- NCT00483574
- Testing
- Menactra®: Meningococcal Polysaccharide Diphtheria Toxoid Conjugate, Measles-mumps-rubella-varicella vaccine, Routine paediatric vaccine - Pneumococcal conjugate (PCV)
- Where
- 79 sites in United States, Chile
- Volunteers
- 1,378 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Trisomy 13, Trisomy 18
High Risk Multiple Gestation Study
The objectives of the clinical study are to demonstrate the accuracy of our proprietary algorithm method to determine the genetic health of the developing fetuses in a multiple gestation pregnancy from a maternal blood sample.
- Conditions
- Trisomy 13, Trisomy 18, Trisomy 21, Sex Chromosome Abnormalities
- Trial name
- NCT02278874
- Where
- 4 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
Fibromyalgia
High-intensity Laser Therapy Improves Pain, Health Status and Quality of Life in Women With Fibromyalgia
This study will be conducted to investigate High-intensity laser therapy improves pain, health status and quality of life in women with fibromyalgia
- Trial name
- NCT05904990
- Testing
- traditional exercise therapy only, HILT alongside traditional exercise therapy
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- October 6 University
Brain Injuries, Congenital Heart Disease
Protecting Brains and Saving Futures - the PBSF Protocol
Background: Multiple neonatal disorders are associated with risks of neurological injury. Thus, management of these infants should involve a coordinated approach to permit early diagnosis with improved clinical care.
- Conditions
- Brain Injuries, Congenital Heart Disease, Newborn Morbidity, Intraventricular Hemorrhage
- Trial name
- PBSF (NCT03786497)
- Where
- 2 sites in Brazil
- Volunteers
- 2,268 people
- Sponsor
- Protecting Brains Saving Futures
Depression, Sleep Disorders, Circadian Rhythm
Sleep-Wake Patterns on Illness Trajectories and Treatment Response in MDD
The proposed study will include a longitudinal ecological study (Study 1) and a randomised controlled trial (Study 2). The aims will be to (1) identify the sleep-wake profiles in individuals with MDD through clustering; (2)…
- Trial name
- NCT06181110
- Testing
- Transdiagnostic Intervention for Sleep and Circadian Dysfunction
- Where
- Hong Kong
- Volunteers
- 70 people
- Sponsor
- Chinese University of Hong Kong
Paralysis, Legs
FES-Rowing: Preventing the Secondary Conditions of Paralysis Through Vigorous Exercise
Over the past ten years, the Cardiovascular Research Laboratory at Spaulding has refined a unique form of exercise for those with spinal cord injuries (SCI).
- Trial name
- NCT05144113
- Testing
- Survey subjects to discover their motivations, preferences and challenges pertaining to participation in physical activity in general and FES-rowing.
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Spaulding Rehabilitation Hospital
Multiple Sclerosis, Social Cognition
Evaluation and Neural Basis of Communication in Patients With Multiple Sclerosis
Multiple sclerosis (MS) progressively leads to an increasing level of disability. That's why individuals faced with this chronic disease whose progression is unpredictable have to mobilize all their available resources.
- Conditions
- Multiple Sclerosis, Social Cognition, Neuropsychology, Psychological Therory
- Trial name
- COGNISEP (NCT02652013)
- Testing
- cognitive evaluation
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Pôle Saint Hélier
Neuropathic Pain, Post Operative Pain
Post-Operative Pain After Recovery in Thoracic Surgery
Persistent pain after surgery has significant physical and mental consequences for the patient, as well as a significant economic impact on health systems.
- Conditions
- Neuropathic Pain, Post Operative Pain, Thoracic Surgery
- Trial name
- POPARTS (NCT04300660)
- Testing
- neuropathic pain after thoracic surgery
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- University of Trieste
Parkinson's Disease
Motor Cortex Stimulation for Parkinson's Disease
Deep Brain Stimulation represents the golden standard for surgical treatment of Parkinson disease (PD), but it is not optimally effective for controlling every motor sign and adverse events are not so infrequent Therefore, other…
- Trial name
- NCT00637260
- Testing
- Motor cortex stimulation on., motor cortex stimulation off
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Catholic University, Italy
Traumatic Brain Injury, Cognitive Symptoms
Cognitive Rehabilitation of Blast Traumatic Brain Injury (TBI)
The purpose of this study is to investigate the efficacy of a structured rehabilitation program on cognitive function and quality of life in individuals with blast-induced traumatic brain injury (bTBI).
- Trial name
- CRbTBI (NCT01138020)
- Testing
- Cognitive Intervention, Educational intervention
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea, Hypertension
Screening Using Portable Electronic Recorders for Sleep Apnea in Hypertensive At-Risk Populations (SUPER-SHARP Trial)
Uncontrolled hypertension is associated with an increased risk of heart disease, stroke, and mortality. Obstructive sleep apnea (OSA) is common in hypertension and treatment using continuous positive airway pressure (CPAP) has…
- Trial name
- SUPER-SHARP (NCT05918120)
- Testing
- Home Sleep Apnea Test, In-laboratory polysomnography
- Where
- 3 sites in Canada
- Volunteers
- 190 people
- Sponsor
- Sunnybrook Health Sciences Centre
Glioma
The Role of Gene Changes in Brain Tumor Formation and Growth
This study will examine tissue from gliomas (a type of brain tumor) removed during surgery for gene mutations, or changes, thought to be involved in tumor formation and growth.
- Trial name
- NCT00059020
- Where
- United States
- Volunteers
- 344 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Concussion, Brain, TBI
Collaborative Care Model for the Treatment of Persistent Symptoms After Concussion Among Youth
SPECIFIC AIMS While post-concussive symptoms following sports-related concussion are typically transient and resolve spontaneously within two weeks of concussive injury, 14% or more of youth who sustain concussion experience…
- Conditions
- Concussion, Brain, TBI, Depression, Anxiety
- Trial name
- NCT03034720
- Testing
- Collaborative Care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Seattle Children's Hospital
Obstructive Sleep Apnea, Treatment Compliance
Impact of Automatic Positive Airway Pressure on Treatment Compliance in OSA Patients Awaiting Bariatric Surgery
Obstructive sleep apnea (OSA) is a syndrome characterized by intermittent dynamic obstruction of the upper airways that causes a fall in oxygen saturation, reflex sympathetic activation and sleep micro-arousals.
- Conditions
- Obstructive Sleep Apnea, Treatment Compliance, Automatic Positive Airway Pressure
- Trial name
- APAP-CPAP (NCT02209220)
- Testing
- Positive airway pressure for the treatment of OSA
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Laval University
Obstructive Sleep Apnea
Stimulation Therapy for Apnea Reduction (Www.theSTARtrial.Com)
The purpose of this clinical trial is to demonstrate long-term safety and efficacy of the Inspire system. The Inspire Upper Airway Stimulation (UAS) therapy is intended to treat moderate-to-severe obstructive sleep apnea by…
- Trial name
- STAR (NCT01161420)
- Testing
- Inspire Upper Airway Stimulation System
- Where
- 22 sites in United States, Belgium and 3 more
- Volunteers
- 929 people
- Sponsor
- Inspire Medical Systems, Inc.
Atrial Septal Aneurysm
Transcatheter Exclusion of Atrial-septal-aneurysm (TEA)
This study aims to investigate the safety and efficacy of transcatheter exclusion of atrial septal aneurysm (ASA) via transseptal perforation in patients with ASA.
- Trial name
- TEA (NCT04561882)
- Testing
- Transcatheter exclusion of atrial septal aneurysm
- Where
- 2 sites in China
- Volunteers
- 70 people
- Sponsor
- China National Center for Cardiovascular Diseases
Multiple Sclerosis
Relationship Between Single- and Dual-Task Obstacle Crossing Performance and Fatigue and Disability in Multiple Sclerosis
This cross-sectional observational study aims to investigate the relationship between obstacle crossing performance under single-task and dual-task conditions and the levels of fatigue and disability in individuals with…
- Trial name
- NCT07736482
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Afyonkarahisar Health Sciences University
Parkinson Disease
Asymmetric Subthalamic Deep Brain Stimulation for Axial Motor Dysfunction in Parkinson's Disease
This single-center, randomized, quadruple-blinded, double-crossover comparative efficacy trial will study the effects of unilateral 50% voltage reduction in axial motor dysfunction for patients with Parkinson's disease that…
- Trial name
- NCT03462082
- Testing
- Asymmetric STN-DBS
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of Toronto
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