Clinical trials: Diseases of the Nervous System
Spinal Cord Injury
Chronic Pain and Brain Activity in Spinal Cord Injury
This study compares five different procedures to see how they affect pain and brain activity. The procedures include neurofeedback, self-hypnosis training, meditation, and two different levels of transcranial direct current…
- Trial name
- NCT01012635
- Testing
- Hypnosis, Meditation, Neurofeedback training
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Washington
Neuropathic Pain, Peripheral Neuropathy
Axon Therapy for Post-Traumatic Peripheral Neuropathic Pain Compared to Conventional Medical Management
Compare Axon Therapy using transcutaneous magnetic stimulation (tMS) against conventional medical management in treating post-traumatic peripheral neuropathic pain (PTPNP).
- Trial name
- NCT04795635
- Testing
- CMM + Axon Therapy
- Where
- 3 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- NeuraLace Medical, Inc.
Dental Anxiety, Inferior Alveolar Nerve
Reducing Pain During Dental Nerve Block Injections in Children
Title of Study: Effect of External Cooling and Vibration, Counterstimulation, and Needle Type on Pain, Physiological, and Behavioral Outcomes During Inferior Alveolar Nerve Block in Pediatric Patients Why was this study done? The…
- Conditions
- Dental Anxiety, Inferior Alveolar Nerve, Pain Management
- Trial name
- IANB (NCT07667725)
- Testing
- Buzzy Device, Counterstimulation, 30-Gauge Needle
- Where
- Iraq
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Al-Mustansiriyah University
Hemifacial Paralysis, Bell Palsy
Electrical Stimulation to Improve Recovery After Peripheral Nerve Injury
After nerve injury and facial palsy, many patients have permanent muscle and sensory dysfunction. Electrical stimulation (ES) of injured nerves may speed up axon growth and improve recovery.
- Trial name
- NCT03996525
- Testing
- Electrical Stimulation
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- The Hospital for Sick Children
Stroke
Perceptual-motor Interaction to Improve Bimanual Coordination After Stroke
Significant difficulty in incorporating the weaker arm in daily activities after stroke is, in part, driven by difficulty in engaging both arms interactively in a coordinated manner.
- Trial name
- Bimanual (NCT03755076)
- Testing
- Perceptual cuing
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Albert Einstein Healthcare Network
Rheumatoid Arthritis, Myositis
Rheumatoid Arthritis and Myositis Cohort
The primary objective of this research is to establish a well characterized clinical and longitudinal cohort for individuals with Rheumatoid Arthritis (RA) and Myositis to create a place to maintain blood, urine, stool specimens…
- Trial name
- NCT05627089
- Sponsor
- Attune Health Research, Inc.
Malignant Melanoma, Brain Metastases
E6201 Plus Dabrafenib for the Treatment of Metastatic Melanoma Central Nervous System Metastases (CNS)
This is a Phase 1 study of E6201 plus dabrafenib for the treatment of CNS metastases in BRAF V600-mutated metastatic melanoma. A total of up to N=28-34 subjects with melanoma metastasized to the CNS will be included.
- Trial name
- NCT03332589
- Testing
- E6201, E6201 plus dabrafenib
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Spirita Oncology, LLC
Delirium, Older Patients
Delirium in Geriatric Hospital Single-bed and Multibed Rooms
To investigate whether single-bed rooms can prevent and reduce incidence and duration of delirium compared to multi-bed rooms in elderly patients admitted to a geriatric department.
- Conditions
- Delirium, Older Patients, Admittance to Single-bed Rooms or Multi-bed Rooms
- Trial name
- NCT03199768
- Where
- Denmark
- Volunteers
- 1,014 people
- Sponsor
- Aarhus University Hospital
Hyponatremia, Hyponatremic
Hyponatremia Study (Delayed Hyponatremia After Pituitary Surgery)
Hyponatremia is defined as sodium below the normal range of 135-145. Symptomatically, it can cause patients to experience a wide range of symptoms including lethargy, headache, nausea, vomiting and in severe cases coma and even…
- Conditions
- Hyponatremia, Hyponatremic, Pituitary Tumor, Pituitary
- Trial name
- DHAPS (NCT03636568)
- Testing
- Fluid Restricted Group
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Washington University School of Medicine
Alzheimer's Disease, Pseudobulbar Affect (PBA)
Nuedexta in the Treatment of Pseudobulbar Affect in Patients With Alzheimer's Disease
The primary objective of this study is to test the hypothesis that Nuedexta (20/10) administered orally will reduce Pseudobulbar Affect (PBA) frequency and severity (CNS-Lability Scale and PLACS), with satisfactory safety and…
- Trial name
- NCT01832350
- Testing
- Nuedexta (20/10)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Dementia
Dyadic Personalized Home-Based Activity Program for Mild-to-Moderate Dementia Patients Post-Discharge
This interventional study aims to evaluate the efficacy of a dyadic personalized home-based activity program in managing behavioral and psychological symptoms of dementia (BPSD) among home-dwelling people living with…
- Trial name
- NCT07081750
- Testing
- Dyadic personalized home-based activity program intervention, Routine care
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Fujian Medical University
Multiple Sclerosis Relapsing Remitting, Treatment
Improving the Treatment of Acute Relapses in Multiple Sclerosis Through Intranasal Methylprednisolone Administration
This Clinical Trial evaluates the nasal administration of Methylprednisolone as a treatment strategy for Acute Relapses in Multiple Sclerosis
- Trial name
- IN-DXM-EMRR (NCT06223074)
- Testing
- IV Methylprednisolone administration, Nasal Methylprednisolone (MT)
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- Universidad Nacional Autonoma de Mexico
Amenorrhea, Dysmenorrhea
Ethinyl Estradiol and Cyproterone Acetate in Irregular Menstruation
This is a Phase IV, randomized, double-blind, comparative study of the use of two preparations of ethinyl estradiol and cyproterone acetate in the treatment of menstrual irregularities of hyper-androgenic origin.
- Conditions
- Amenorrhea, Dysmenorrhea, Menstruation Disturbances, Hyperandrogenism
- Trial name
- NCT01103518
- Testing
- Ethinyl Estradiol + Cyproterone acetate
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Fundação Educacional Serra dos Órgãos
Assessment, Chest Pain
External Validation of the SCARE Score
Chest pain is a very common reason for resorting to the call center. The etiologies are very varied, ranging from benign pathologies to some that may involve, in the short term, the vital prognosis such as Acute Coronary Syndrome…
- Conditions
- Assessment, Chest Pain, ACS - Acute Coronary Syndrome
- Trial name
- SCARE (NCT04000490)
- Testing
- SCARE Score
- Where
- 4 sites in France
- Volunteers
- 2,205 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Parkinson Disease
Effects of Home-based Exercise in Parkinson's Disease
Home-based exercise program focusing on axial rigidity could be used as an adjunct rehabilitation program to improve rotational movement, gait and functional movement associated with axial rigidity in individuals with PD.
- Trial name
- NCT04810897
- Testing
- Exercise
- Where
- Thailand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Primary Progressive Aphasia, Nonfluent Progressive Aphasia
Language Treatment for Progressive Aphasia
Progressive aphasia is characterized by a steady and progressive loss of language skills in the presence of relatively preserved memory, attention, and thinking.
- Conditions
- Primary Progressive Aphasia, Nonfluent Progressive Aphasia, Semantic Dementia
- Trial name
- NCT00957710
- Testing
- Errorless learning
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Baycrest
VTE (Venous Thromboembolism), Phantom Limb Pain After Amputation
Venous Thromboembolism and Chronic Pain After Major Limb Trauma
Major limb trauma is associated with a high risk of venous thromboembolism (VTE) due to systemic inflammation, endothelial injury, immobilization, and hypercoagulability.
- Conditions
- VTE (Venous Thromboembolism), Phantom Limb Pain After Amputation, Chronic Pain, Chronic Pain Due to Injury
- Trial name
- THROMBO-PAIN (NCT07475910)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Pain, Postoperative
Posterior Pericapsular Deep-gluteal Block
The goal of this clinical trial is to determine whether adding a posterior pericapsular deep-gluteal (PPD) block to pericapsular nerve group (PENG) and lateral femoral cutaneous nerve (LFCN) blocks improves pain control after…
- Trial name
- NCT07891013
- Testing
- PENG (Pericapsular nerve group) block, LFCN (Lateral femoral cutaneous nerve) block, PPD (Posterior pericapsular deep gluteal) block
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Stroke
Effects of BIONESS in Rehabilitation of Stroke
A four-weeks randomized clinical two-period crossover-design study will be conducted. Each patient will be randomized in a two separate consecutive treatment periods (Parallel Group Design).
- Trial name
- EFES-BIO-SEP (NCT04767360)
- Testing
- Bioness-300
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- LMU Klinikum
Fibromyalgia, Fibromyalgia, Primary
Understanding Health Services Delivery for Fibromyalgia
This research study aims to: i) Explore and understand how health and social care for people with fibromyalgia living in the UK is organised and delivered.
- Conditions
- Fibromyalgia, Fibromyalgia, Primary, Fibromyalgia, Secondary
- Trial name
- NCT04771260
- Where
- United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
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