Clinical trials: Disk Degeneration
Intervertebral Disc Replacement, Degenerative Disc Disease
Activ C European Multicenter Study
Patients are candidates for single-level Artificial Disc Replacement between C3 and C7 who suffer from cervical symptomatic degenerative disc disease. A maximum of 200 cases will be enrolled into the study.
- Trial name
- NCT02492724
- Where
- 10 sites in Czechia, Finland and 3 more
- Volunteers
- 210 people
- Sponsor
- Aesculap AG
Recurrent Low Back Pain, Degenerative Disc Disease (DDD)
Efficacy of Intradiscal Injection of BM-MSC in Subjects With Chronic Low Back Pain (LBP) Due to Lumbar Degenerative Disc Disease (DDD) Unresponsive
This will be a multicenter, prospective, double blind, randomized phase 2/3 trial comparing culture-expanded allogeneic adult BM-MSCs with sham-treated controls.
- Trial name
- RESPINE (NCT03737461)
- Testing
- Allogenic BM-MSCs Injection
- Where
- 9 sites in France, Germany and 2 more
- Volunteers
- 113 people
- Sponsor
- University Hospital, Montpellier
Cervical Degenerative Disc Disease
Comparison of DISCOVER™ Artificial Cervical Disc and ACDF for Treatment of Cervical DDD (IDE Study)
This study is intended to treat patients with symptomatic degenerative disc disease at one level of the cervical spine. The patients will be randomized to the DISCOVER Artificial Cervical Disc (total disc replacement) or…
- Trial name
- NCT00432159
- Testing
- Cervical TDR, ACDF with plate
- Where
- 32 sites in United States, Australia and 1 more
- Volunteers
- 500 people
- Sponsor
- DePuy Spine
no Obvious Abnormalities, Diabetic Retinopathy (DR)
Retinal Clinical Assessment With AI-derived Quantitative Information
This randomized controlled trial evaluates whether providing clinicians with AI-derived quantitative retinal information improves the quality and efficiency of retinal clinical assessment.
- Conditions
- no Obvious Abnormalities, Diabetic Retinopathy (DR), AMD, Cup-to-disc Ratio Bigger Than 0.5
- Trial name
- NCT07291960
- Testing
- AI-derived retinal quantitative information-assisted reporting
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Degenerative Disc Disease, Low Back Pain
Lumbar Transforaminal Anterior Epidural Steroid Injections in Discogenic Low Back Pain
Modic changes have been associated with low back pain in many clinical studies and are often considered a part of the disc degeneration process. Modic type 1 change is considered an inflammatory process.
- Trial name
- NCT04930211
- Testing
- Dexamethasone-Lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Marmara University
Degenerative Disc Disease
Osteocel® Plus in Transforaminal Lumbar Interbody Fusion (TLIF)
This study is being conducted to determine the percentage of patients with solid spinal fusions after being treated with Osteocel Plus in a TLIF procedure.
- Trial name
- NCT00947583
- Testing
- Osteocel Plus
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- NuVasive
Spinal Disease
ROMEO®2 PAD. 2 YEARS PROSPECTIVE FOLLOW-UP
This study is designed as a post-marketing observational, controlled, prospective, non-inferiority study where the efficacy and safety of the Degenerative Disc Disease treatment by arthrodesis using…
- Trial name
- ROMEO 2 PAD FR (NCT04174534)
- Where
- 3 sites in France
- Volunteers
- 3 people
- Sponsor
- Spineart SA
Spondylolisthesis, Spinal Stenosis
Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis
This study tests the effectiveness of different treatments for the three most commonly diagnosed conditions of the lower backbone (lumbar spine).
- Conditions
- Spondylolisthesis, Spinal Stenosis, Low Back Pain
- Trial name
- SPORT (NCT00000409)
- Testing
- Decompressive laminectomy, Non-surgical treatments, Fusion--Instrumented
- Where
- 13 sites in United States
- Volunteers
- 304 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Lumbar Spine Disc Degeneration
Study to Evaluate Safety and Effectiveness of Dynamic Stabilization Versus Lumbar Fusion in Treatment of Multilevel Lumbar Disc Degeneration Disease
The purpose of this study is to compare outcomes of (i) surgical treatment with posterior dynamic stabilization and (ii) surgical treatment with internal fixation and fusion in patients with multilevel lumbar degenerative disk…
- Trial name
- MLIDH (NCT02385695)
- Testing
- Posterior Dynamic Stabilization, Internal Fixation and Fusion
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Qiang Zhou, MD. PhD.
Degenerative Disc Disease, Low Back Pain
Effectiveness and Safety of Mesenchymal Stem Cell (MSC) Implantation on Degenerative Discus Disease Patients
This study evaluates the effectivity and safety of MSC implantation on Degenerative Disc Disease Patients by assessing visual analog scale, ROM improvement and MRI examination.
- Conditions
- Degenerative Disc Disease, Low Back Pain, Disc Degeneration
- Trial name
- MSC (NCT04499105)
- Testing
- Mesenchymal Stem Cell + NaCl 0,9% 2ml
- Where
- Indonesia
- Volunteers
- 10 people
- Sponsor
- Ahmad Jabir Rahyussalim
Lumbar Disc Degeneration, Lumbar Disc Herniation
Human Umbilical Cord Mesenchymal Stem Cells For the Treatment of Lumbar Disc Degeneration Disease
This study aims to investigate the safety and efficiency of Human Umbilical Cord Mesenchymal Stem Cells (hUCMSC) for treating lumbar disc degeneration diseases.
- Trial name
- NCT04414592
- Testing
- human umbilical cord mesenchymal stem cells
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Chronic Low-back Pain, Disc Degeneration
Evaluation of Safety, Tolerability, and Efficacy of CordSTEM-DD in Patients With Chronic Low Back Pain
The purpose of this clinical study is to evaluate the safety, tolerability, and efficacy of CordSTEM-DD, an allogeneic umbilical cord-derived mesenchymal stem cell, as a cell-therapeutic drug in patients with chronic low back…
- Trial name
- NCT04530071
- Testing
- CordSTEM-DD (0.7 x 10^7 cells), CordSTEM-DD (2.1 x 10^7 cells)
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- CHABiotech CO., Ltd
Degenerative Disc Disease, Craniocervical Injuries
Posterior Cervical Fixation Study
The objective of this study is to evaluate the safety and performance of occipito-cervico-thoracic spine surgery using posterior fixation as measured by reported complications, radiographic outcomes, and patients reported…
- Conditions
- Degenerative Disc Disease, Craniocervical Injuries, Cervical Radiculopathy, Cervical Disc Disease
- Trial name
- NCT04770571
- Testing
- observational study
- Where
- 7 sites in United States
- Volunteers
- 150 people
- Sponsor
- NuVasive
Degenerative Disc Disease
Enhanced Metal Reduction Techniques for Definitive CT Scanning to Assess Spinal Fusion With TM-Ardis
To determine if the subject metal reduction software helps to better visualize bone interphase and fusion reliability. Assess whether the appropriate procedural modification facilitates clearer images when implanted with a…
- Trial name
- NCT02170558
- Testing
- TM- Ardis implant and Metal Reduction CT software
- Where
- United States
- Sponsor
- Zimmer Biomet
Low Back Pain, Mechanical, Degenerative Disc Disease Lumbar
Fusion or Not - a Study on Low Back Pain
Problems from the musculoskeletal system are one of the most common reasons for disability and sick leave. These problems include low back pain. Low back pain affects as many as 8 out of 10 individuals at some point in life.
- Trial name
- NCT06709391
- Testing
- Fusion surgery, Non-fusion surgery
- Where
- 4 sites in Sweden
- Volunteers
- 90 people
- Sponsor
- Uppsala University
Degenerative Disc Disease
A Pivotal Study of rhBMP-2/ACS/LT-CAGE® Device for Anterior Lumbar Interbody Fusion in Patients With Degenerative Disc Disease
This study is designed to assess the safety and effectiveness of the rhBMP-2/ACS/LT-CAGE® Device using laparoscopic surgical technique as compared to an historical control group treated with Autogenous Bone/LT-CAGE® Device using…
- Trial name
- NCT01491425
- Testing
- rhBMP-2/ACS//LT-CAGE® Device, Autogenous Bone//LT-CAGE® Device
- Volunteers
- 134 people
- Sponsor
- Medtronic Spinal and Biologics
Degenerative Disc Disease in Cervical Spine, Stenosis Cervical Spine
PMCF Study Fortilink-SC
This study is setup to be able to gather information on the safety and performance of the Fortilink-SC Ti cage of Paradigm Spine GmbH, up to one year after the surgery.
- Trial name
- NCT07834749
- Testing
- Cervical interbody fusion surgery (standalone)
- Where
- 2 sites in Spain
- Volunteers
- 50 people
- Sponsor
- BAAT Medical Products B.V.
Spondylolisthesis, Degenerative Lumbar Disc Disease
Spine Research With Roentgen Stereophotogrammetric Analysis
The purpose of this study is to gather information on the effectiveness of a new spine implant for patients who require spinal fusion surgery.
- Conditions
- Spondylolisthesis, Degenerative Lumbar Disc Disease, Spinal Stenosis
- Trial name
- SpineRSA (NCT00493558)
- Testing
- Trabecular Metal Intervertebral Cage with RSA beads
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- Nova Scotia Health Authority
Degenerative Disc Disease, Herniated Nucleus Pulposus
The Course of Hip Flexion Weakness Following LLIF or ALIF
The purpose of this study is to assess the course of hip weakness after LLIF or ALIF procedures. These outcomes include measures of hip strength using a dynamometer, which is a device used to measure muscle strength.
- Conditions
- Degenerative Disc Disease, Herniated Nucleus Pulposus, Spondylolisthesis
- Trial name
- NCT04204135
- Testing
- LLIF or ALIF procedures
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Rush University Medical Center
Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy
Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
This prospective, observational, non-randomized clinical study aims to evaluate the intraoperative and postoperative effects of opioid-free multimodal anesthesia compared with opioid-containing anesthesia methods in adult…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy, Lumbar Degenerative Spondylolisthesis, Lumbar Disc Degeneration
- Trial name
- NCT07489001
- Testing
- Opioid-free Anesthesia, Erector Spinae Plane Block, Opioid based Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Marmara University