Clinical trials: Disorder, Mood
Respiratory Tract Infection, Smell Disorder
Longitudinal Deep Phenotyping of Central Mechanisms in Dysosmia: A Pilot Study Using Electrobulbogram (EBG), Functional MRI (fMRI), and Diffusion-Weighted Imaging (DWI)
Background: Loss of the sense of smell can seriously affect a person's quality of life. The ability to smell can be damaged by many factors, including illnesses, injuries, and exposure to toxic chemicals.
- Conditions
- Respiratory Tract Infection, Smell Disorder, Influenza, Rhinosinusitis
- Trial name
- NCT07149428
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Bipolar Disorder, Schizophrenia
fMRI of Theory of Mind in Schizophrenia and Bipolar Disorder
Theory of mind (TOM), a main component of social cognition processes, refers to the capacity to infer one's own and other person's mental states.
- Trial name
- TOM-i (NCT02834182)
- Testing
- IRMf, Mini International Neuropsychiatric Interview, Positive And Negative Syndrom Scale
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Attention-Deficit/Hyperactivity Disorder
Open-label Safety and Efficacy of SPN-812 (Viloxazine Extended-release Capsule) in Adults With ADHD and Mood Symptoms
Open label, flexible dose, decentralized clinical trial evaluating the efficacy and safety of SPN-812 in adults with ADHD and mood symptoms.
- Trial name
- NCT06185985
- Testing
- SPN-812
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Supernus Pharmaceuticals, Inc.
Exhaustion; Syndrome
Effects of Acute Physical Activity in Patients With Exhaustion Disorder
A new stress-related diagnosis, Exhaustion disorder (ED), was introduced in the Swedish version of ICD-10 in 2005 and has since then increased rapidly.
- Trial name
- NCT06429423
- Testing
- Acute exercise low intensity, Acute exercise moderate intensity
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Victoria Blom
Major Depressive Disorder
Brain Regulation of Emotions in People With Depression and Anhedonia
This study will use magnetic resonance imaging (MRI) to examine how the brain regulates emotions in healthy people and in patients who have major depression and anhedonia (loss of feeling of pleasure in things that normally give…
- Trial name
- NCT00059579
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Postpartum Depression, Psychoeducation
Psychoeducatıon Interventıon Postpartum Depressıon Breastfeedıng
This study was planned to evaluate the effects of psychoeducation intervention for postpartum care on postpartum depression and breastfeeding.
- Conditions
- Postpartum Depression, Psychoeducation, Breastfeeding, Postpartum Care
- Trial name
- NCT06779903
- Testing
- the psychoeducation intervention program booklet, routine care
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Bipolar Disorder
Depakote-ER for Depressive and Bipolar Depression
Obtain information using a randomized treatment to assess the antidepressant and anxiolytic efficacy of divalproex vs. placebo for nonrefractory bipolar patients with major depressive episodes.
- Trial name
- NCT00226343
- Testing
- Depakote-ER
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Healthy, Bipolar Disorder
Brain Ion Homeostasis, Lithium and Bipolar Disorder
In this project, investigators intend to carry out the first simultaneous, in vivo, imaging study of lithium content and sodium ion homeostasis in the brain of Bipolar Disorder (BPD) patients under Lithium therapy.
- Trial name
- NCT02727127
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Depressive Disorder, Treatment-Resistant, Stress Disorders, Post-Traumatic
Ketamine Infusions for PTSD and Treatment-Resistant Depression
The relationship between depression and trauma is well established. Co-occuring depression and post-traumatic stress disorder (PTSD) are associated with more severe symptoms and lower levels of functioning.
- Trial name
- NCT02577250
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Major Depression
Blood Biomarkers in Suicidal Behaviour
Suicidal behavior (SB) is a major public health problem in France, with more than 10,000 suicides and 220,000 suicide attempts per year.
- Trial name
- 2BSB (NCT02855918)
- Testing
- Blood sample for genetic purpose
- Where
- France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Major Depressive Disorder
Family Psychoeducation for Major Depressive Disorder
The aim of the present study is to compare an intervention consisting of Family Psychoeducation (FPE) to an active control intervention of social support for relatives of patients with a diagnosis of major depression.
- Trial name
- NCT02348827
- Testing
- Family psychoeducation, Social support group
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Postpartum Depression (PPD), Self-Efficacy
NICU Utilization of Remote Voice Technology to Improve mateRnal Experience (NURTURE)
The study's objective is to conduct a Phase II randomized controlled trial examining the preliminary efficacy of the VoiceLove app compared to usual care on maternal postpartum depression in mothers with infants admitted to the…
- Conditions
- Postpartum Depression (PPD), Self-Efficacy, Parental Anxiety, Engagement, Patient
- Trial name
- NURTURE (NCT07214597)
- Testing
- VoiceLove mobile phone application
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Post Partum Depression
Relationship-Based Intervention for Post-Partum Depression
A short term dyadic psychotherapy intervention for mothers with Post-Partum depression and their babies in the first year of life was developed.
- Trial name
- NCT04193462
- Testing
- Post-partum depression- Dyadic psychotherapy-, Post-partum depression- Psycho-educational therapy
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Interdisciplinary Center Herzliya
Obesity, Women
Probiotics' Effects on Hormones, Body and Mood in Obese Women
To evaluate the regulatory effect of probiotics formula on visceral fat metabolism and sex hormone balance in obese women.
- Trial name
- NCT07013409
- Testing
- Probiotic, Maltodextrin
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Major Depressive Disorder
Neuroimaging Studies of Reward Processing in Depression
This study investigates stress-related signaling of glutamate and dopamine within the reward-processing circuit in Major Depressive Disorder (MDD), and whether they can be used to predict depressive symptoms in the future.
- Trial name
- NCT03026036
- Testing
- PET Scan with Raclopride
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Covid19, Post Traumatic Stress Disorder
Post-traumatic Stress, Signs of Depression and Burnout Syndrome Among Nursing Home Staff in Occitanie During the COVID-19 Pandemic
Nursing home staff face multiple stresses during the Covid-19 pandemic including personal risk of infection, risk of transmission of the virus to residents and relatives, and risk of witnessing end-of-life scenarios under…
- Conditions
- Covid19, Post Traumatic Stress Disorder, Anxiety, Depressive Disorder
- Trial name
- PSY-COEHPAD-OC (NCT04916275)
- Testing
- Cognitive tests
- Where
- 3 sites in France
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Healthy Participants, Anxiety Disorders (With High Anxiety Symptoms)
tVNS and Approach-Avoidance Behavior in Anhedonia and Anxiety
This study investigates if anhedonia and anxiety symptoms are associated with alterations in reinforcement learning, effort trade-offs for wins vs. punishments, and foraging behavior under threat.
- Conditions
- Healthy Participants, Anxiety Disorders (With High Anxiety Symptoms), Depressive Disorders (With High Anhedonia Symptoms), Comorbid Depression and Anxiety Disorder (With High Anhedonia and High Anxiety Symptoms)
- Trial name
- NCT07476469
- Testing
- tVNS
- Where
- Germany
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Dr. Nils B. Kroemer
Cognitive Therapy, Depression, Postpartum
RCT of Automated Conversational Agent vs. Treatment as Usual for the Management of Perinatal Mood
The purpose of this study is to investigate the efficacy of an evidence-based smartphone application (app) for the management of mood compared to treatment as usual alone among 135 women who have been discharged post-delivery…
- Conditions
- Cognitive Therapy, Depression, Postpartum, Mental Health, Depression
- Trial name
- NCT03646539
- Testing
- Use of smartphone application (app), Treatment as usual
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Stanford University
Postpartum Depression
Peer Administered CBT for PPD
Postpartum depression (PPD) affects up to 20% of women and has profound effects on mothers and their infants. Unfortunately, fewer than 15% of women with PPD receive evidence-based care.
- Trial name
- PL-CBT (NCT03285139)
- Testing
- Cognitive Behavioural Therapy
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- McMaster University
Delayed Sleep Phase Syndrome
Are Patients Suffering From DSPS Show Compromising in Everyday Functions and Abilities Before Handling the Disorder?
The purpose of this study is to determine whether the known treatment for DSPS also improve the cognitive ability and mood of the patients.
- Trial name
- NCT02962037
- Testing
- Melatonin and light therapy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lilach Kemer
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