Clinical trials: Disorder, Mood
Bipolar Disorder
Double-blind, Placebo-Controlled Divalproex Sodium ER in Bipolar I or Bipolar II Depression
Double-Blind, Placebo-Controlled Divalproex Sodium ER in Bipolar I or Bipolar II Depression Previously Diagnosed and Treated as Recurrent Major Depression: This study recruits males and females aged 18 - 70 who currently meet…
- Trial name
- NCT00194116
- Testing
- Divalproex Sodium ER
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Postpartum Depression
Serotonin, Leptin and Adiponectin Level in Patients With Postpartum Depression: Controlled Study
After vaginal delivery, all of the participants will evaluate by using Edinburg depression scale and venous blood sample will obtain.
- Trial name
- NCT02682004
- Testing
- leptin, serotonin and adiponectin level, leptin,serotonin, adiponectin level
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Psychotic Disorders, Depressive Disorder, Major
Adolescent Mental Health: Canadian Psychiatric Risk and Outcome Study
The primary study aims are to determine the clinical, behavioural and social predictors of SMI development in youth, and to investigate whether neuroimaging can distinguish youth who will develop SMI from those who will not.
- Conditions
- Psychotic Disorders, Depressive Disorder, Major, Bipolar Disorder
- Trial name
- PROCAN (NCT02739932)
- Where
- 2 sites in Canada
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Major Depressive Disorder
Metabolic Profiling of Esketamine Treatment in Depressive Disorder
Major depressive disorder (MDD) is one of the most common psychiatric disorders, characterized by extremely high prevalence, relapse rate and therapeutic resistance.
- Trial name
- NCT07002684
- Testing
- Esketamine
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Postoperative Pain, Postpartum Depression
Dose Low Dose Ketamine in Casesarian
The results of ketamine, ketamine and midazolom can be copied after birth in cesareans subjected to spinal anesthesia.
- Trial name
- ketamine (NCT06237569)
- Testing
- Application of ketamine and midazolam or ketamine alone to patients undergoing cesarean section under spinal anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Inonu University
Suicidal Ideation, Suicide Attempt
Neural Correlates of Suicidal Behavior in Youth
This study, titled "Neural Correlates of Suicidal Behavior in Youth: a Pre and Post CAMS Therapy Neuroimaging Study," aims to better understand the brain mechanisms underlying suicidal thoughts and behaviors in adolescents and…
- Conditions
- Suicidal Ideation, Suicide Attempt, Suicidal Behavior, Depression / Major Depressive Disorder
- Trial name
- NCT07568054
- Testing
- CAMS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Depressive Disorder
28-day Repeat Dose and Drug Interaction Study With Orvepitant (GW823296)
This study is being conducted to obtain information on the safety and tolerability of repeated doses of GW823296 for 28 days in healthy male and female subjects.
- Trial name
- NCT00511654
- Testing
- GW823296 tablet, Midazolam
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Schizophrenia, Bipolar Disorder
CSP #572 - Genetics of Functional Disability in Schizophrenia and Bipolar Illness
The purpose of this study is to detect genetic associations for the development of schizophrenia (SZ) and bipolar illness (BP) by comparing Veterans with these diseases to "psychiatrically healthy" Veterans from Veterans Health…
- Trial name
- NCT01149551
- Where
- 25 sites in United States
- Volunteers
- 9,356 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder
Prevalence of smoking among individuals with opioid use disorder (OUD) is six-fold that of the general US adult population. The mortality rate of opioid-dependent smokers is four times that of opioid-dependent nonsmokers, and…
- Trial name
- NCT04092101
- Testing
- Cigarettes with varying nicotine content, E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Mood Disorder, Substance-Related Disorders
Interaction Between Duloxetine and 3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy)
The purpose of this study is to determinate the effect of a pre-treatment with the combined serotonin (5-HT) and norepinephrine (NE) transport blocker duloxetine on the pharmacodynamics and pharmacokinetics of…
- Conditions
- Mood Disorder, Substance-Related Disorders, Amphetamine-Related Disorders
- Trial name
- NCT00990067
- Testing
- 3,4-Methylenedioxymethamphetamine, Duloxetine
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Depressive; Episode, Major, Depression, Postpartum
Diagnostic Accuracy of the Stepped Screening Protocol and Its Screening Tools in the Perinatal Period.
It is known that 1 in 5 women experience psychological difficulties during their pregnancy or in the first year after giving birth.
- Conditions
- Depressive; Episode, Major, Depression, Postpartum, Anxiety Disorders, Obsessive-Compulsive Disorder
- Trial name
- DAS (NCT05961306)
- Testing
- SCID 5
- Where
- 2 sites in Belgium
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Healthy, Mood Disorders
Effects of Drugs on Cerebral Blood Flow in Patients With Mood Disorders
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal biochemical and metabolic processes of the central nervous system of…
- Trial name
- NCT00001478
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder, Anhedonia
Dopamine Neurotransmission in Major Depression
The overall aim of this study is to utilize an integrative research model in order to dynamically assess reward-related dopamine (DA) transmission in major depressive disorder (MDD) and test the role of dysfunctional DA release…
- Trial name
- NCT01659814
- Where
- 2 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Major Depression
Serum Markers as a Bioassay for Unipolar Depression
The goal of the study is to validate a biomarker assay for unipolar depression based on serum proteins involved in inflammation, metabolism, and stress response.
- Trial name
- NCT00825799
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
CBD, Cannabidiol
Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms
The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response.
- Conditions
- CBD, Cannabidiol, Stress, Acute Stress Reaction
- Trial name
- NCT07069478
- Testing
- Stress Intervention
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Delta-9-Tetrahydroncannabinol, Bipolar Disorder
Cognitive and Psychophysiological Effects of Delta-9-Tetrahydrocannabinol in Bipolar Disorder
The overarching goal of this study is to characterize the acute cognitive and psychophysiological effects of the main psychoactive constituent of cannabis, 9-delta-tetrahydrocannabinol (THC) in individuals with euthymic bipolar…
- Conditions
- Delta-9-Tetrahydroncannabinol, Bipolar Disorder, Healthy Controls
- Trial name
- THC-BD (NCT03206463)
- Testing
- 4 mg Delta-9-THC, 2 mg Delta-9-THC
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Yale University
Psychiatric/Mood Disorder | Patient, Estrogen Receptor Levels
Validation of [18F]FES for Imaging of Brain Estrogen Receptors
Validation of [18F]-FES for imaging of estrogen receptors in the brain The primary objective of the study is to determine if [18F]-FES Positron Emission Tomography (PET) can be used to quantify the estrogen receptor expression in…
- Conditions
- Psychiatric/Mood Disorder | Patient, Estrogen Receptor Levels, Premenopausal, Postmenopausal
- Trial name
- NCT01842217
- Testing
- FES-PET
- Where
- Netherlands
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Bipolar Disorder
Culturally Adapted Psychoeducation (CaPE) for Bipolar Disorders in Nigeria
Bipolar disorders are chronic mental health disorders that often result in functional impairment, constituting a significant disease burden.
- Trial name
- NCT05721196
- Testing
- Culturally adapted Psychoeducation (CaPE), Treatment as Usual (TaU)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Adult ADHD, Adult-onset ADHD With Mood Disorder
EEG-MRI Imaging of Methylphenidate Effects in Adult ADHD and Attentional Symptoms in Mood Disorders
Attention Deficit Hyperactivity Disorder (ADHD) in adults is a common psychiatric disorder, with important consequences in terms of quality of life, mental health (associated disorders and poorer response to treatment), family…
- Trial name
- ImAteM-TDA (NCT05832489)
- Testing
- Methylphenidate immediate release 25mg
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Major Depressive Disorder
Regulation of Affect and Physiology in Depression
Although treatments for depression are effective for many people, not everyone responds to treatment. This lack of treatment response could be due, in part, to the presence of multiple underlying causes of people's depression.
- Trial name
- RAPID (NCT06345859)
- Testing
- Heart rate variability biofeedback
- Where
- United States
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- University of Southern California
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