Clinical trials: Disorder, Mood
Major Depressive Disorder
Beat the Blues in Pregnancy Study - Transcranial Magnetic Stimulation
The purpose of this study is to determine if repetitive transcranial magnetic stimulation (TMS) will alleviate symptoms of major depressive disorder (MDD) in pregnant women.
- Trial name
- TMS (NCT01492309)
- Testing
- Active Transcranial Magnetic Simulation
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Pennsylvania
Delta-9-Tetrahydroncannabinol, Bipolar Disorder
Cognitive and Psychophysiological Effects of Delta-9-Tetrahydrocannabinol in Bipolar Disorder
The overarching goal of this study is to characterize the acute cognitive and psychophysiological effects of the main psychoactive constituent of cannabis, 9-delta-tetrahydrocannabinol (THC) in individuals with euthymic bipolar…
- Conditions
- Delta-9-Tetrahydroncannabinol, Bipolar Disorder, Healthy Controls
- Trial name
- THC-BD (NCT03206463)
- Testing
- 4 mg Delta-9-THC, 2 mg Delta-9-THC
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Yale University
Major Depressive Disorder
A Closed-loop Assessment and Treatment Platform for Unipolar Depression and Anxiety
Specific Aim 1: Finalize development of the closed-loop strategy in the MMT application. Specific Aim 2: Evaluate the acceptability and feasibility of the MMT application with the target population to prepare for a large-scale…
- Trial name
- NCT02948036
- Testing
- Mobile-device, plasticity-based adaptive cognitive treatment
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Posit Science Corporation
Aggression, Attention Deficit-Hyperactivity
Metabolic Effects of Antipsychotics in Children
The project aims to describe and compare the outcome of 12 weeks of prospective, randomized treatment with olanzapine, risperidone or aripiprazole on insulin action in skeletal muscle, liver and adipose tissue, abdominal fat…
- Conditions
- Aggression, Attention Deficit-Hyperactivity, Oppositional Defiant Disorder, Pervasive Development Disorders
- Trial name
- MEAC (NCT00205699)
- Testing
- risperidone, olanzapine, aripiprazole
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Washington University School of Medicine
Depression, Depressive Disorder
A Single Group Study of Empower@Home-an Internet Cognitive Behavioral Therapy Intervention
This is a single group study of a novel internet-based cognitive behavioral therapy program for older adults with elevated depressive symptoms.
- Conditions
- Depression, Depressive Disorder, Behavioral Symptoms, Mood Disorders
- Trial name
- NCT05384704
- Testing
- Empower@Home
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Michigan
Overweight, Obesity
Food, Adolescence, Mood, and Exercise
The overall objective of FAME is to examine the metabolic and behavioral links between dietary intake and its subsequent effects on circulating appetite regulating hormones and physical activity levels in Hispanic and African…
- Trial name
- FAME (NCT02015377)
- Testing
- High sugar versus low sugar meals
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Depression, Postpartum, Postpartum Depression (PPD)
Brexanolone Lifting Outcomes Of Moms
The purpose of this research study is to test the study drug, LPCN 1154A, as a possible treatment for postpartum depression (PPD).
- Conditions
- Depression, Postpartum, Postpartum Depression (PPD), Post-partum Depression, Postnatal Depression
- Trial name
- BLOOM (NCT07822321)
- Testing
- LPCN 1154A
- Where
- 16 sites in United States
- Volunteers
- 120 people
- Sponsor
- Lipocine Inc.
Major Depressive Disorder
Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD)
The investigators are testing the efficacy of Smartphone-delivered cognitive behavioral therapy (CBT) treatment for major depressive disorder (MDD).
- Trial name
- NCT04594616
- Testing
- Smartphone-delivered CBT for MDD
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Memory Dysfunction, Mood Disorders
To Access the Effect of Brain Pill™ on Working Memory Capacity and Mood Behaviour.
Brain Pill™ is a mental health enhancing and successfully marketed dietary supplement.
- Trial name
- NCT03198936
- Testing
- Cognizin® SynapsaTM
- Where
- India
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Bipolar Disorder
Effectiveness of Family-Focused Treatment Plus Pharmacotherapy for Bipolar Disorder in Adolescents
This study will evaluate the effectiveness of family-focused treatment (FFT) plus pharmacotherapy in treating adolescents with bipolar disorder.
- Trial name
- NCT00332098
- Testing
- Family-Focused Treatment Plus Pharmacotherapy, Enhanced Care Plus Pharmacotherapy
- Where
- 3 sites in United States
- Volunteers
- 145 people
- Sponsor
- University of California, Los Angeles
Major Depression
Selenium as Augmentation Treatment for Sertraline Resistant Major Depression
The main goals of antidepressant treatments are to achieve remission of depressive episodes and prevent recurrences. However, clinical trials designed to approve antidepressants targets a response rate of at least 50%, which is…
- Trial name
- NCT02890212
- Testing
- selenium supplementation
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Psychotic Disorders, Mood Disorders
Convergent and Concurrent Validity Between Clinical Recovery and Personal-civic Recovery in Mental Health
Several instruments have been developed by clinicians and academics specialized in mental health and psychiatry to assess clinical recovery in terms of symptom reduction.
- Trial name
- NCT04125030
- Testing
- Validation of questionnaires
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal
Anxiety, Depression
CALM for Pregnant and Post-Partum Women
Anxiety and depression is common along pregnant mothers and has been found to increase risk for negative outcomes in both mothers and infants.
- Conditions
- Anxiety, Depression, Depression, Postpartum, Pregnancy Related
- Trial name
- NCT03351465
- Testing
- Coordinated Anxiety Learning and Management
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Schizophrenia, Bipolar Disorder
Targeting a Genetic Mutation in Glycine Metabolism With D-cycloserine
The purpose of this study is to assess the efficacy of d-cycloserine (DCS) as an augmentation strategy in two psychotic patients with a triplication (4 copies) of the glycine decarboxylase (GLDC) gene.
- Trial name
- DCS (NCT02304432)
- Testing
- D-cycloserine
- Volunteers
- 2 people
- Sponsor
- Mclean Hospital
Depression, Involutional, Healthy
Serotonin Function During Depression
Serotonin is a chemical involved in regulation of emotions, anxiety, sleep, stress hormones, and other body functions. The purpose of this study is to use a procedure called tryptophan depletion to study the function of serotonin…
- Trial name
- NCT00033787
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Major Depressive Disorder
Predictors of Depression Treatment Response to Exercise
50 subjects with Major Depressive Disorder who are not currently receiving treatment will be enrolled in a 12-week exercise program, supervised by a trained exercise interventionist.
- Trial name
- NCT02583867
- Testing
- Exercise
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Texas Southwestern Medical Center
Major Depressive Disorder
PSIL201 Long-term Follow-up Study: Psilocybin or Niacin / Major Depressive Disorder
This is a Phase 2 double-blind, long-term observational follow-up study of participants from Study PSIL201. Participants providing informed consent were enrolled into this study and completed web surveys and telephone interviews…
- Trial name
- NCT04353921
- Testing
- No intervention will be administered as part of this study.
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Usona Institute
Major Depressive Disorder
Safety and Efficacy of Cariprazine as an Adjunctive to Antidepressant Therapy in Major Depressive Disorder
An outpatient study to evaluate the safety and efficacy of cariprazine as adjunct to antidepressant therapy (ADT) in participants with major depressive disorder (MDD) who have an inadequate response to ADT alone.
- Trial name
- NCT01469377
- Testing
- Cariprazine
- Where
- 72 sites in United States, Estonia and 4 more
- Volunteers
- 819 people
- Sponsor
- Forest Laboratories
Major Depressive Disorder
Treatment for Cognitive Impairment in Depression
The proposed study seeks to investigate the effects of modafinil on cognitive function in depression, which holds promise for better treating cognitive impairment in depression, as well as better understand cognitive dysfunction…
- Trial name
- T-CID (NCT04317001)
- Testing
- Modafinil
- Sponsor
- Stanford University
Major Depression, Post-Traumatic Stress Disorder
Expanding and Testing VA Collaborative Care Models for Depression
Based on the published evidence, collaborative care for depression is both necessary and sufficient for improving care and outcomes for depressed patients in primary care settings.
- Trial name
- ReTIDES (NCT00119028)
- Testing
- Depression Care Quality Improvement Implementation
- Where
- 6 sites in United States
- Sponsor
- US Department of Veterans Affairs
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