Clinical trials: Disorder, Mood
Bipolar Disorder, Involutional Depression
Omega-3 Fatty Acids in the Treatment of Bipolar Disorder: A Double-Blind, Placebo-Controlled Trial
This study will examine the effectiveness of omega-3 fatty acids, compounds found in plants and fish, in treating bipolar disorder. Some studies have indicated that omega-3 fatty acids may be effective in treating mood disorders.
- Conditions
- Bipolar Disorder, Involutional Depression, Mood Disorder
- Trial name
- NCT00001146
- Testing
- Ethyl Eicosapentaenoic Acid, OmegaBrite
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar Disorder, Involutional Depression
Study of the Psychological Development of Children of Parents With and Without Affective Disorders
This research study is the continuation of a study started more than 20 years ago. The study was designed to explore the effect that depressed parents have on their children and to better understand the factors that contribute to…
- Conditions
- Bipolar Disorder, Involutional Depression, Mood Disorder
- Trial name
- NCT00001170
- Where
- United States
- Volunteers
- 1,045 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Disorder, Healthy
The Effect of GnRH on Pitutitary Hormones in Menstrual-Cycle Mood Related Disorders
The normal menstrual cycle is produced by a series of hormonal signals that starts with the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus.
- Conditions
- Depressive Disorder, Healthy, Mental Disorders, Mood Disorders
- Trial name
- NCT00001232
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy, Mood Disorders
Effects of Drugs on Cerebral Blood Flow in Patients With Mood Disorders
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal biochemical and metabolic processes of the central nervous system of…
- Trial name
- NCT00001478
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Fatigue Syndrome, Chronic, Healthy
Study of the Hypothalmic-Pituitary-Adrenal (HPA) Axis and Its Role in Major Depression
Major depression represents a major public health problem worldwide and in the U.S. Fifteen percent of the U.S. population has depression at some point in life (40 million individuals).
- Conditions
- Fatigue Syndrome, Chronic, Healthy, Mood Disorders
- Trial name
- NCT00001479
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Anxiety Disorder, Mood Disorder
New Drugs in the Treatment of Mood Disorders
This clinical study compares the effectiveness of two anticonvulsants Lamotrigine (Lamictal) Monotherapy and Gabapentin (Neurontin) in patients with treatment resistant affective disorders.
- Conditions
- Anxiety Disorder, Mood Disorder, Psychotic Disorder
- Trial name
- NCT00001482
- Testing
- Lamotrigine (Lamictal® (Registered Trademark), Gabapentin (Neurontin® (Registered Trademark))
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Disorder, Mood Disorder
Treatment of Mid-Life-Related Mood Disorders
Dehydroepiandrosterone (DHEA) is a hormone produced by the adrenal gland. As humans grow older the levels of DHEA naturally decrease.
- Trial name
- NCT00001487
- Testing
- Dehydroepiandrosterone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Mental Health (NIMH)
Mood Disorder
The Role of Emotion in the Development of Psychopathology
The dysregulated experience and expression of emotion is implicated in psychiatric disorders associated both with externalizing problems (aggressive, antisocial behaviors) and internalizing problems (anxiety, depression).
- Trial name
- NCT00001654
- Where
- United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Disorder, Mood Disorder
Progestin (Progesterone-Like Hormones) Induced Dysphoria (Depressed Mood, Irritability, Anxiety)
Often women are prescribed hormone replacement therapy (HRT) during the perimenopause or menopause. Hormone replacement therapy includes both estrogen and progesterone.
- Conditions
- Depressive Disorder, Mood Disorder, Psychomotor Agitation
- Trial name
- NCT00001770
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy, Mood Disorder
Neuroimaging of St. John's Wort-Induced Changes of Serotonin Metabolism in Normal Subjects
St. John's Wort is a popular dietary supplement that many people take to elevate mood or relieve stress. This study will test in normal volunteers whether this preparation may alter mood and if so, by what means.
- Trial name
- NCT00001919
- Testing
- Hypericum (LI-160)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar Disorder
Clozapine for Treatment-Resistant Mania
The purpose of this study is to evaluate the safety and effectiveness of clozapine as a treatment for the manic phase of bipolar disorder.
- Trial name
- NCT00029458
- Testing
- Clozapine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression
Examination of a Soy-Based Supplement for Major Depression
The purpose of this study is to find out if the soy-based dietary supplement Novasoy (Registered Trademark) is effective for the short-term treatment of clinical depression.
- Trial name
- NCT00042380
- Testing
- Novasoy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Disorder
An Investigation of the Antidepressant Efficacy of the 5-HT2A Antagonist, M100907, in Combination With Citalopram in Treatment Resistant Depression
This study will examine whether a highly specific and powerful 5-hydroxytryptamine 2A (5-HT2A) antagonist, M100907, combined with escitalopram, is responsible for an antidepressant effect.
- Trial name
- NCT00070694
- Testing
- MDL100.907
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- National Institute of Mental Health (NIMH)
Mood Disorders, Alzheimer Disease
The Serotonergic Transmitter System in Dementia and Affective Disorders
The aim of this project is to examine the serotonergic transmitter system using functional imaging of the brain (positron emission tomography [PET]) to gain knowledge about early pathophysiological changes in Alzheimer's dementia…
- Trial name
- NCT00192998
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Mood Disorders, Anxiety Disorders
First Experimental Study of Transference-Interpretations (FEST)
Analysis of the ongoing patient-therapist interaction, the transference, is considered a key active ingredient in psychoanalytically oriented psychotherapy and psychoanalysis.However, one century after Sigmund Freuds's famous…
- Conditions
- Mood Disorders, Anxiety Disorders, Personality Disorders
- Trial name
- NCT00423462
- Testing
- Brief dynamic psychotherapy
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- University of Oslo
Bipolar Disorder
Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
A long-term study of current treatments for bipolar disorder, including medications and psychosocial therapies.
- Trial name
- NCT00012558
- Testing
- lithium, valproate, bupropion
- Where
- 11 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- National Institute of Mental Health (NIMH)
Mental Disorders, Mood Disorders
PET Neuroimaging of [11C]Mirtazapine
Recent studies show that 25 - 30% of depressed patients never fully recover, resulting in a treatment-resistant condition. Thus, depression is a major cause of human suffering.
- Conditions
- Mental Disorders, Mood Disorders, Affective Disorders, Depressive Disorders
- Trial name
- NCT00288782
- Testing
- Mirtazapine
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Alcohol Abuse, Anxiety Disorders
The Measurement of Mood Variability and Sustained Attention in Women With Alcohol Dependence.
The purpose of this study is to measure daily mood changes and to find out whether these mood changes are related to the ability to maintain attention on a task.
- Conditions
- Alcohol Abuse, Anxiety Disorders, Mood Disorders
- Trial name
- NCT00230425
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Saskatchewan
Major Depression, Dysthymia
A Study of Omega-3 as a Treatment for Major Depression
The purpose of this study is to determine whether omega-3 polyunsaturated fatty acids are effective as a monotherapy for depression.
- Trial name
- NCT00238758
- Testing
- Omega-3 Polyunsaturated Fatty Acids
- Where
- Australia
- Volunteers
- 128 people
- Sponsor
- The University of New South Wales
Major Depression
A Study of Omega-3 as an Augmentor of Antidepressant Treatment for Major Depression
The purpose of this study is to determine whether augmentation of antidepressant medication with Omega-3 polyunsaturated fatty acids increases the speed and degree of improvement for patients with major depression
- Trial name
- NCT00289484
- Testing
- Omega-3 Polyunsaturated Fatty Acids
- Where
- Australia
- Volunteers
- 52 people
- Sponsor
- The University of New South Wales