Clinical trials: Disorder, Mood
Treatment Resistant Depression (TRD)
Algorithm Guided Treatment Versus Treatment as Usual (TAU) for Patients With Treatment Resistant Depression
The trial utilizes a pragmatic, randomized, open label design with two parallel arms. Participants aged 18-65 with a diagnosis of unipolar depressive disorder and without stable remission in the past 12 months are randomized 1:1…
- Trial name
- NCT07080723
- Testing
- Algorithm guided treatment (AGT), Treatment as usual (TAU)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Aalborg University Hospital
Bipolar I Disorder
A Comparison of Olanzapine in Combination With a Mood Stabilizer vs Mood Stabilizer Alone, in Mixed Bipolar Patients
Whether treatment with olanzapine in combination with mood stabilizer reduces symptoms of both mania and depression more than treatment with mood stabilizer alone, in patients with a mixed episode of bipolar I disorder.
- Trial name
- NCT00402324
- Testing
- olanzapine, divalproex
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Eli Lilly and Company
Depressed Mood, Young Adults
Heat and Mental Health - PART 2
The goal of this clinical trial is to learn how hot indoor temperatures affect mood in young adults with depression, with or without anxiety.
- Conditions
- Depressed Mood, Young Adults, Heat Stress, Sleep
- Trial name
- NCT07903896
- Testing
- Heat/Humidity Exposure Condition, Thermoneutral Condition
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Hartford Hospital
Major Depressive Disorder
Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive Disorder
Primary Objective: To compare the antidepressant efficacy and safety of subjects receiving DVS-233 SR versus subjects receiving placebo.
- Trial name
- NCT00073762
- Testing
- DVS-233 SR
- Volunteers
- 375 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Depressive Disorder
Single Dose Pharmacokinetic (PK) Study Of Paroxetine CR(12.5-37.5mg) In Healthy Chinese Subjects
The study was designed to describe the relationship between dose and pharmacokinetic parameters of paroxetine over the range of proposed dosage strengths of the paroxetine CR tablet (12.5 to 37.5 mg) as well as safety profile
- Trial name
- NCT00406003
- Testing
- Paroxetine controlled release tablet
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Depressive Disorder, Treatment-Resistant
Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine
The overarching aim of this research is to determine the acute effects of ketamine on brain glutamate, functional connectivity and cerebral blood flow in treatment-resistant depression, explore whether the effects are attenuated…
- Trial name
- GO-MARK (NCT04977674)
- Testing
- Naltrexone, Ketamine
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- King's College London
Major Depressive Disorder, MDD
Extended Reality Behavioral Activation: An Intervention for Major Depressive Disorder
The primary aims of this study are to assess the feasibility, acceptability, and tolerability of using an immersive extended reality (XR) headset to engage in behavioral activation (BA) for individuals diagnosed with major…
- Conditions
- Major Depressive Disorder, MDD, Depression
- Trial name
- NCT05525390
- Testing
- Extended Reality-Enhanced Behavioral Activation, Traditional Behavioral Activation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Stanford University
Bipolar Affective Disorder
rTMS in the Treatment of Bipolar Depression
Bipolar affective disorder (BPAD) is: A serious mental illness Estimated to be present in as high as 6.4% of the population in Western populations Associated with considerable disability and high morbidity.
- Trial name
- NCT00436020
- Testing
- TMS
- Where
- Australia
- Volunteers
- 51 people
- Sponsor
- Bayside Health
Stress, Physiological, Stress, Psychological
Wise Interventions and Responses to Stress
This study compares the effects of two wise interventions (implicit theory of personality intervention and implicit theory of personality intervention plus self-affirmation) with a control condition in the stress responses of…
- Conditions
- Stress, Physiological, Stress, Psychological, Social Stress, Depression
- Trial name
- ITP-RSA (NCT04786496)
- Testing
- ITP+SA Wise intervention, ITP Wise intervention, Control condition
- Where
- Spain
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Deusto
Major Depressive Disorder
Ultrabrief Pulsewidth Electroconvulsive Therapy (ECT)
Electroconvulsive Therapy (ECT) remains essential to contemporary psychiatric practice and is one of the safest and most effective treatments available for depression.
- Trial name
- UB ECT (NCT00870805)
- Testing
- bilateral ultrabrief ECT, bilateral standard ECT, right-unilateral ultrabrief ECT
- Where
- 3 sites in Australia
- Volunteers
- 150 people
- Sponsor
- The University of New South Wales
Depression, Depression, Bipolar
Dallas 2K: A Natural History Study of Depression
The primary objective of this initiative is to implement a prospective study that will allow us to identify and validate biosignatures of response to treatments for depression and depression outcome (using an integrated array of…
- Trial name
- D2K (NCT02919280)
- Testing
- Observational Study
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Sleep Disorder (Disorder), Mood Disorders
Exploring the Efficacy of a Breathing Training Intervention in Patients With Emotionally Regulated Sleep Disorders
In recent years, the incidence of sleep disorders, especially insomnia, has been rising. Insomnia can directly lead to damage to patients' daytime functions, such as daytime sleepiness, inattention, etc., affecting people's…
- Trial name
- NCT07495423
- Testing
- respiratory training intervention
- Where
- China
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Anxiety Disorders, Psychotic Disorders
Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness
This research study aims to develop a brief group-based treatment called Resilience Training for Teens, then to test how well it protects high school students with mild symptoms of depression, anxiety, or having unusual feelings…
- Conditions
- Anxiety Disorders, Psychotic Disorders, Depressive Disorder, Psychosocial Functioning
- Trial name
- NCT05962879
- Testing
- Resilience Training for Teens
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Insomnia, Traumatic Brain Injury
Effects of Nurse-Guided BBTi for Improving Insomnia : in Patients at the Recovery Following Traumatic Brain Injury
nsomnia is a frequent complaint reported by patients with TBI, and exacerbates their ability to return to productive activity, which subsequently elevate related healthcare costs and burden.
- Trial name
- NCT05402761
- Testing
- Nurse-guided BBTi group, Mobile-delivered BBTi group
- Where
- 2 sites in Taiwan
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Psychotic Disorders, Mood Disorders
A Preventive Behavioral Intervention for Young Adults With Psychotic Experiences
This is a randomized controlled trial testing the efficacy of Resilience Training in college students with elevated transdiagnostic risk for developing a serious mental illness.
- Conditions
- Psychotic Disorders, Mood Disorders, Anxiety Disorders
- Trial name
- NCT06929442
- Testing
- Resilience Training (RT), Life Skills Training (LST)
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder
Neurocognitive Enhancement in Major Depressive Disorder
The purpose of this study is to examine the effects of neurocognitive enhancement on cognitive abilities and related social and adaptive behaviours in individuals diagnosed with major depressive disorder.
- Trial name
- MDDNET (NCT00998569)
- Testing
- Neurocognitive Enhancement, Wait List
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Queen's University
Major Depressive Disorder (MDD)
A Duloxetine Dosing Strategy Study in Korean Patients With Major Depressive Disorder
The purpose of this study is to assess nausea severity in response to four different drug dosing strategies of Duloxetine (30 mg with food, 60 mg with food, 30 mg without food, and 60 mg without food) in Korean patients with…
- Trial name
- NCT00960986
- Testing
- Duloxetine hydrochloride
- Where
- 7 sites in South Korea
- Volunteers
- 249 people
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder
Physical EXercise as an Adjunct Treatment for Depression
35 participants diagnosed with major depressive disorder were randomized in 3 intervention groups: (1) aerobic exercise (AE) ; (2) placebo (stretching) exercise (ST); and (3) no intervention (control group; NI).
- Trial name
- PEXAT (NCT02612142)
- Testing
- physical exercise
- Volunteers
- 48 people
- Sponsor
- Université de Reims Champagne-Ardenne
Bipolar Disorder, Schizophrenia
Antipsychotics and Blood Vessel Function
Over the last decade, second generation antipsychotics have been increasingly utilized. Since their introduction, however, atypical antipsychotics have been increasingly associated with significant metabolic complications…
- Trial name
- NCT00585273
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Jess G. Fiedorowicz
Major Depressive Disorder, Bipolar Disorder
Wake Therapy in the Treatment of Depression
This pilot study seeks to replicate previous findings that sleep deprivation results in marked improvement in depression symptoms, as well as to test whether concurrent treatment with Light Therapy and Lithium are successful in…
- Trial name
- NCT01431573
- Testing
- Wake Therapy, light box, Lithium
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- New York State Psychiatric Institute
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