Clinical trials: Disorder, Mood
Major Depression
A Family-based Primary Care Intervention to Enhance Older Men's Depression Care
Despite the public health importance of clinical depression, more than 50% of depressed adults receive inadequate or no treatment, with even higher rates of under-treatment in men and minorities.
- Trial name
- NCT02143024
- Testing
- Family-based depression intervention, Usual care plus educational materials
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of California, Davis
Major Depressive Disorder
PKC as Serum Biomarkers for Depression
Inflammation that is mediated by microglia activation plays an important role in the pathogenesis of depression. Microglia activation can lead to an increase in the levels of proinflammatory cytokines, including TNF-α, which…
- Trial name
- NCT04531423
- Testing
- SSRI + golimumab
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Adult Attention Deficit Hyperactivity Disorder (ADHD) With Co-occuring Anxiety and Depressive Disorders
Lisdexamfetamine Dimesylate in the Treatment of Adult ADHD With Anxiety Disorder Comorbidity
1. To evaluate the safety, and efficacy of Lisdexamfetamine dimesylate in the treatment of outpatients with DSM-IV ADHD with anxiety and depressive disorder comorbidity, as well as to evaluate the effects on quality of life . 2.
- Trial name
- NCT01863459
- Testing
- Lisdexamfetamine Dimesylate
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Centre for Anxiety, Attention Deficit and Trauma, Ontario, Canada
Bipolar and Related Disorders
Enhancing Cognitive Reserve of the Offsprings of Bipolar and Schizophrenic Patients
The high hereditary component and the contribution of neurodevelopmental processes in bipolar disorder and schizophrenia means implies the children of these patients are considered a high risk population for both diseases and…
- Trial name
- NCT03722082
- Testing
- Enhancing Cognitive Reserve, Support intervention
- Where
- Spain
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Bipolar Disorder
Safety and Efficacy Study of Ramelteon (TAK-375) Tablets for Sublingual Administration (SL) in Adults With Bipolar 1 Disorder
To evaluate the efficacy of ramelteon for treatment of acute depressive episodes associated with Bipolar 1 Disorder.
- Trial name
- NCT01677182
- Testing
- Ramelteon
- Where
- 104 sites in United States, Bulgaria and 8 more
- Volunteers
- 535 people
- Sponsor
- Takeda
Appetitive Behavior
Weight Stigma Effect on Neural Control of Appetite
The limited data available suggest that exposure to weight-based stigmatization leads to overeating and increased desire for food.
- Trial name
- NCT03934424
- Testing
- Weight stigma, Ethnic stigma
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Depression, Pregnancy
mHealth for Antenatal Mental Health
The aim of this study is to determine the feasibility of using mobile technology for: 1. Implementing the recommendations of the Antenatal and postnatal mental health: clinical management and service guidance NICE guideline for…
- Trial name
- AMHS (NCT02516982)
- Testing
- Whooley Questions, Edinburgh Postnatal Depression Scale, Momentary questions
- Where
- 14 sites in United Kingdom
- Volunteers
- 946 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Major Depressive Disorder
Linking Affective Dynamics in Response to Daily Stress to Peripheral Vascular Function in Working Age Adults
The objective of this proposal is to determine whether heightened negative affective responsivity (NA-R) to daily stressors is related to blunted nitric oxide (NO)-mediated endothelium-dependent dilation (EDD) in working age…
- Trial name
- NCT06860724
- Testing
- NG-nitro-L-arginine methyl ester (L-NAME)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Major Depressive Disorder
SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder
This study will examine SPD489 in subjects aged 18-65 with major depressive disorder (MDD) who are taking certain types of antidepressants but continue to have residual depression symptoms.
- Trial name
- NCT01435759
- Testing
- Antidepressant + SPD489 (Lisdexamfetamine dimesylate) 10 mg, Antidepressant + SPD489 (Lisdexamfetamine dimesylate) 30 mg, Antidepressant + SPD489 (Lisdexamfetamine dimesylate) 50 mg
- Where
- 82 sites in United States, Argentina and 3 more
- Volunteers
- 1,197 people
- Sponsor
- Shire
Bipolar Disorder, Pediatric Bipolar Disorder
Retrain Your Brain in Children/Adolescents With Bipolar Disorder: A Pilot Study
The main aim of this study is to test a new, non-medication computer-based potential treatment for bipolar disorder in children and adolescents.
- Conditions
- Bipolar Disorder, Pediatric Bipolar Disorder, Childhood-onset Bipolar Disorder
- Trial name
- COGFLEX (NCT01954680)
- Testing
- COGFLEX-skill building levels, COGFLEX-control condition
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Bradley Hospital
Clinical Depression, Clinical Anxiety
Efficacy of Psychological Intervention for Children With Cancer
The study will be conductued at the Pediatric Oncology Department of the Children's Hospital, PIMS Islamabad, over the peroid of six months.
- Conditions
- Clinical Depression, Clinical Anxiety, Quality of Life
- Trial name
- NCT06620445
- Testing
- Interventiion or CBT Group
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Pakistan Institute of Medical Sciences
Bipolar Disorder
Identifying Predictors of Bipolar Disorder Relapse During Pregnancy and the Postpartum Period
This study will evaluate pregnant women who have bipolar disorder to gain a better understanding of risk factors for bipolar disorder relapse during pregnancy and the postpartum period.
- Trial name
- NCT00720395
- Where
- United States
- Sponsor
- National Institute of Mental Health (NIMH)
Amphetamine Dependence
Dose Response of Mirtazapine to Methamphetamine Induced Interest, Mood Elevation and Reward
The primary purpose of this study is to determine if Mirtazapine will produce a decrease in interest in the drug, a decrease in mood elevation, and/or a decrease in reward when given before methamphetamine compared to placebo.
- Trial name
- NCT00600145
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Virginia
Bipolar Disorder, Depressive Episode
BezafibrateTreatment for Bipolar Depression: A Proof of Concept Study
We propose to test the hypothesis that bezafibrate, a pan-PPAR agonist, may be effective and safe for bipolar depression with the following specific aims: Aim #1.
- Trial name
- NCT02481245
- Testing
- Bezafibrate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Bipolar Depression Depressed Phase, Obesity & Overweight
The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar Depression
This research study examines how a medication called lumateperone may affect mood symptoms, and inflammation in adults with bipolar disorder over approximately 6 weeks.
- Trial name
- NCT07699445
- Testing
- Lumateperone 42 mg
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Mild Cognitive Impairment
Cognitive and Aerobic Resilience for the Brain
This is a randomized controlled trial (RCT) of the effectiveness of cognitive and exercise training versus control condition on cognitive function in older adults with mild cognitive impairment (MCI).
- Trial name
- CARB (NCT02390453)
- Testing
- Combined Cognitive and Physical, Cognitive, Physical
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Indiana University
Depression, Premenstrual Dysphoric Disorder (PMDD)
Neurofeedback Treatment of Affective Instability in Premenstrual Dysphoric Disorder(PMDD)
Premenstrual Dysphoric Disorder (PMDD) is characterized by affective instability and irritability, diagnosed in 5% of reproductive-age women.
- Trial name
- NCT01945372
- Testing
- EEG NeuroFeedback
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Depression, Postpartum, Social Adjustment
Perinatal Interpersonal Psychotherapy Group for Distressed Women
This is the first perinatal interpersonal psychotherapy group (P-IPTG) implemented for distressed women from pregnancy to postpartum. The feasibility and effects of P-IPTG are explored.
- Trial name
- NCT06431672
- Testing
- interpersonal group psychotherapy
- Where
- Taiwan
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University
Social Determinants of Health, Major Depressive Disorder
The Role of Social Determinants in Cardiovascular Health and Vascular Function
This study aims to identify the influence of social determinants of health domains on vascular function in a low income, racial, and ethnic minority population at risk for disparities.
- Conditions
- Social Determinants of Health, Major Depressive Disorder, Cardiovascular Diseases
- Trial name
- CVRRC (NCT05772221)
- Testing
- Screening
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Postpartum Depression (PPD), Ecological Momentary Assessment
EMA and mHealth in Preventing Postpartum Depression
This proposed study aims to develop and examine the feasibility, acceptability, and preliminary effectiveness of a proactive intervention model that combines brief psychological counselling, Ecological Momentary Assessment (EMA)…
- Conditions
- Postpartum Depression (PPD), Ecological Momentary Assessment, mHealth Intervention
- Trial name
- NCT06777563
- Testing
- Brief psychological counselling and health education, 2 Weeks of Ecological Momentary Assessment (EMA), 10 weeks of mobile health psychological support
- Where
- 2 sites in Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
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