Clinical trials: Disorder, Mood
Bipolar Disorders
Escitalopram as a Mood Stabilizer for Bipolar II Disorder
This study will investigate the efficacy of Escitalopram, a Selective Serotonin Reuptake Inhibitor (SSRI) antidepressant, in the treatment of Bipolar II Disorder.
- Trial name
- NCT00156325
- Testing
- Escitalopram (Lexapro)
- Where
- Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The University of New South Wales
Epilepsy, Depressive Disorder
Group Cognitive Behavioral Therapy to Treat Depression in an Epilepsy Clinic Setting
This study involves a form of group therapy called Cognitive Behavioral Therapy or CBT for depressed patients with Epilepsy. The CBT groups will be tailored for an epilepsy clinic population.
- Trial name
- NCT00285740
- Testing
- Cognitive Behavioral Therapy (CBT) in a Group Format
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Stanford University
Depression
Treatments for Depression: Drug Versus Psychotherapy
This 4-8 month study, with a 2-year follow up period, will compare sertraline (Zoloft®), venlafaxine (Effexor®), supportive-expressive psychotherapy, and placebo to determine which is more effective in treating major depression.
- Trial name
- NCT00043550
- Testing
- Supportive Expressive Therapy, Sertraline, Venlafaxine
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- University of Pennsylvania
Dandruff
Neurophysiological and Sleep-Related Effects of a Cosmetic Shampoo and Conditioner in Adults With Scalp Discomfort
The goal of this clinical trial is to learn whether regular use of Nizoral® Daily Prevent shampoo and conditioner can improve scalp comfort, sleep experiences, mood, and overall well-being in adults who have scalp discomfort and…
- Trial name
- NCT07680608
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Zentrela Inc.
Postpartum Depression, Pregnancy Related
Nurtured in Nature
The investigators pilot test a Nature Coach Intervention in a population of postpartum women, to increase the amount of time people spend outside in local nature, with the goal of preventing postpartum depression.
- Conditions
- Postpartum Depression, Pregnancy Related, Environmental Exposure
- Trial name
- NCT04146025
- Testing
- Nature Coach Intervention
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Pennsylvania
Bipolar Disorder
Study Evaluating Cariprazine (RGH-188) in the Treatment of Patients With Acute Mania
This is a study designed to evaluate the efficacy, safety, and tolerability of RGH-188 monotherapy in the treatment of acute mania.
- Trial name
- NCT00488618
- Testing
- Cariprazine (RGH-188)
- Where
- United States
- Volunteers
- 238 people
- Sponsor
- Forest Laboratories
Major Depressive Disorder
A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
This is a randomized, double-blind, active-controlled, multi-center study to evaluate the efficacy of AXS-05, compared to bupropion, in preventing the relapse of depressive symptoms in subjects with major depressive disorder…
- Trial name
- NCT06223880
- Testing
- AXS-05, Bupropion
- Where
- 40 sites in United States
- Volunteers
- 350 people
- Sponsor
- Axsome Therapeutics, Inc.
Bipolar Disorder
Effectiveness RCT of Customized Adherence Enhancement
Approximately one in two individuals with bipolar disorder (BD) are non-adherent with medication, often leading to severe and negative consequences.
- Trial name
- CAE-E (NCT04622150)
- Testing
- Customized Adherence Enhancement (CAE), Enhanced Treatment as Usual (eTAU)
- Where
- 3 sites in United States
- Volunteers
- 190 people
- Sponsor
- Case Western Reserve University
Depression, Depressive Disorder
Electroacupuncture for Major Depression
This study will compare the safety, efficacy, and tolerability of electroacupuncture (EA) and sham electroacupuncture (SA) for the treatment of major depression.
- Trial name
- NCT00071110
- Testing
- Electroacupuncture
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Bipolar I Disorder
Mood Stabilizer (MS)+ Antidepressant vs MS + Placebo in Maintenance of Bipolar Disorder.
Patients with bipolar I disorder (BD) experience depression 3 times more frequently than mania, and antidepressants are prescribed as adjuncts to mood stabilizers in up to 70% of patients.
- Trial name
- NCT00958633
- Testing
- Escitalopram, Bupropion XL
- Where
- Canada
- Volunteers
- 237 people
- Sponsor
- University of British Columbia
Major Depressive Disorder
Electrophysiological Correlates of Cognition in Depression
Biogenetic messages about the etiology of mental illness (e.g., the "chemical imbalance theory" of depression) are increasing but the impact that these have on decision-making and motivation is not yet clear.
- Trial name
- NCT03998748
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mclean Hospital
Major Depression, Dysthymia
Implementation of Harmonized Depression Outcome Measures in a Primary Care Registry and a Mental Health Registry
The purpose of this pilot project is to demonstrate feasibility and value of collecting harmonized outcomes measures for major depressive disorder (MDD) in two registries and combining the data to support patient-centered…
- Trial name
- NCT04235725
- Testing
- Harmonized Depression Outcome Measures
- Where
- 2 sites in United States
- Volunteers
- 953 people
- Sponsor
- OM1, Inc.
Depressive Disorder, Depression in Adolescence
Evaluation of a Website to Improve Depression Literacy in Adolescents With Depression
The aim of this study is to evaluate the efficacy and acceptability of the website "ich bin alles" (https://www.ich-bin-alles.de/) to improve depression literacy (knowledge about depression, which aid the recognition, treatment…
- Trial name
- NCT05300204
- Testing
- Self-help strategies for depression, General information about depression
- Where
- Germany
- Volunteers
- 86 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Depressive Disorder, Major
Efficacy Study of Transcranial Direct Current Stimulation to Treat Major Depressive Disorder
The purpose of this study is to determine whether transcranial direct current stimulation is an effective treatment for major depression, when compared (and combined) to sertraline and placebo.
- Trial name
- SELECT-TDCS (NCT01033084)
- Testing
- transcranial direct current stimulation, Sertraline
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Sao Paulo
Depressive Disorder, Major, Generalized Anxiety Disorder
Student Precarity and Psychiatry
Since the COVID-19 pandemic, mental health disorders have increased significantly, particularly among young people. In France, the proportion of young people aged 18 to 25 suffering from depression almost doubled between 2017 and…
- Conditions
- Depressive Disorder, Major, Generalized Anxiety Disorder, Suicidal Ideation, Loneliness
- Trial name
- PEPSY (NCT07618208)
- Testing
- Questionnaires
- Volunteers
- 45,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bipolar Disorder
Tryptophan Depletion in Acute Mania
Serotonin (5-HT) is important in mood regulation and is believed to play a major role in the pathophysiology of major depression (MD).
- Trial name
- NCT00192725
- Testing
- rapid tryptophan depletion
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Rambam Health Care Campus
Major Depressive Disorder
Pentoxifylline as an Adjunct to Citalopram in Adult Patients With Major Depressive Disorder
The aim of this study is to test if combining the antidepressant Citalopram with Pentoxifylline (PTX), a medicine with anti-inflammatory and phosphodiesterase inhibitory properties, enhanced antidepressant efficacy in adult…
- Trial name
- NCT05271084
- Testing
- Citalopram (tablet) 20 mg + Pentoxifylline (tablet) 400Mg
- Where
- Iraq
- Volunteers
- 100 people
- Sponsor
- Hawler Medical University
Major Depressive Disorder (MDD)
The Study of Ammoxetine Hydrochloride Enteric-coated Tablets in Subjects With Depression
The purpose of this study is to evaluate the efficacy and safety of Ammoxetine hydrochloride enteric-coated tablets in subjects with depression.
- Trial name
- Ammoxetine (NCT05762458)
- Testing
- Ammoxetine
- Volunteers
- 240 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Postpartum Period
Effect of Baby Massage on Postnatal Maternal Attachment and Depression
This study aims to examine the effects of providing infant massage training to mothers in the early postpartum period with the goal of preventing postpartum depression and enhancing maternal bonding.
- Trial name
- NCT06475885
- Testing
- Infant Massage Program
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Gazi University
Suicidal Ideation, Social Behavior
Massive Mental Health Screening Using Smartphones in 24 Pre-graduate Education Centers in Mexico City: TEDUCA Survey Protocol
The objective of this study is to make a massive suicide risk and social behavior assessment in 24 pre-graduate education centers in Mexico City (approximately 30,000 students aged between 15 and 22 years), taking also into…
- Conditions
- Suicidal Ideation, Social Behavior, Depression, Depressive Disorder
- Trial name
- TEDUCA (NCT04067076)
- Testing
- Self-administered evaluation questionnaire
- Where
- Mexico
- Volunteers
- 30,000 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
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