Clinical trials: Disorder, Pediatric
Diabetic Ketoacidosis
Double Blinded Randomized Control Trial of Types of IVF in Children With DKA
Objectives: Intravenous (IV) fluid administration is a fundamental component of diabetic ketoacidosis (DKA) treatment. Normal saline (NS), the most common IV fluid used in DKA management, contains more chloride than human blood.
- Trial name
- NCT03066440
- Testing
- Normal saline, Lactated Ringers
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- State University of New York at Buffalo
Heart Failure
CentriMag Ventricular Assist System in Treating Failure-to-Wean From Cardiopulmonary Bypass for Pediatric Patients
The purpose of the study is to evaluate the safety and effectiveness of the CentriMag ventricular assist system to help pediatric patients who have experienced heart failure during surgery and cannot be removed from cardiac…
- Trial name
- NCT01171950
- Testing
- CentriMag Ventricular Assist System
- Sponsor
- Abbott Medical Devices
Congenital Disorders
Automated Cardioverter Defibrillator in Children
Automated implantable cardioverter defibrillators ,AICD, and Biventricular,BiV, Pacemakers have been shown in randomized trials to offer an advantage in adults with decreased ventricular ejection fraction, heart failure…
- Trial name
- NCT00268021
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Children's Healthcare of Atlanta
Gastroenteritis
A Study to Evaluate the Safety and Efficacy of Domperidone in Pediatric Participants With Nausea and Vomiting Due to Acute Gastroenteritis
The purpose of this study is to demonstrate that domperidone suspension plus oral rehydration therapy (ORT) is more effective than placebo plus ORT at reducing the symptoms of vomiting associated with acute gastroenteritis (AG)…
- Trial name
- NCT02699385
- Testing
- Oral Rehydration Therapy, Domperidone
- Where
- 29 sites in Austria, Belgium and 4 more
- Volunteers
- 10 people
- Sponsor
- Janssen-Cilag International NV
Pediatric Multiple Sclerosis
Environmental and Genetic Risk Factors for Pediatric Multiple Sclerosis
The purpose of this study is to better understand multiple sclerosis (MS) in children and adolescents, to learn if it differs from adult MS and to investigate if genes or environmental exposures or a combination of both put…
- Trial name
- NCT01396343
- Where
- 17 sites in United States
- Volunteers
- 1,276 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Childhood Oncology, Mucositis Oral
Oral Mucositis Management in Pediatric Oncology Patients
This study evaluated the impact of an oral mucositis care protocol on the severity of mucositis. The main questions it aims to answer are: -What is the severity of mucositis in parents and children who receive oral mucositis…
- Trial name
- NCT06711315
- Testing
- Oral Mucosit Care Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Zubeyde Ezgi Ercelik
Acute Lymphoblastic Leukemia
A Study of Venetoclax in Combination With Chemotherapy to Treat Newly Diagnosed Acute Lymphoblastic Leukemia (ALL)
The researchers are doing this study to find out whether combining venetoclax with several different standard chemotherapy drugs used to treat acute lymphoblastic leukemia (ALL) in children is safe and effective in adults with…
- Trial name
- NCT05386576
- Testing
- Venetoclax
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pulmonary Arterial Hypertension
Safety and Efficacy of Inhaled Iloprost in Pediatric Patients With Pulmonary Arterial Hypertension
The purpose of this study is to evaluate the safety and effectiveness of iloprost for PAH in children who are between the ages of 3 and 18 years old.
- Trial name
- NCT00453414
- Testing
- Iloprost Inhalation Solution (Ventavis)
- Where
- 2 sites in United States
- Sponsor
- Actelion
Solid Tumor, Leukemia
Illness Management and Parental Adjustment to Cancer Treatment
The purpose of this study is to test the efficacy of a clinic-based intervention designed to reduce illness uncertainty for parents of children who have been recently diagnosed with cancer.
- Conditions
- Solid Tumor, Leukemia, Lymphoma, Brain Tumor
- Trial name
- IMPACT (NCT02505165)
- Testing
- IMPACT, ESO
- Where
- 3 sites in United States
- Volunteers
- 279 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Inflammatory Bowel Diseases, Crohn Disease
Pilot and Feasibility Study of 2'-FL as a Dietary Supplement in IBD Patients Receiving Stable Maintenance Anti-TNF Therapy
Randomized, placebo-controlled dose-ranging study of 2'-FL in IBD, Crohn's Disease (CD) and ulcerative colitis (UC). The overarching hypothesis is that 2'-FL supplementation in IBD will be safe and well tolerated, while…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- PRIME (NCT03847467)
- Testing
- 2'-Fucosyllactose
- Where
- 3 sites in United States
- Volunteers
- 128 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Mini Percutaneous Nephrolithotomy, Retrograde Intrarenal Surgery
Mini Percutaneous Nephrolithotomy and Retrograde Intrarenal Surgery for Pediatric Renal Stones (10-30 mm)
This work aimed to compare the safety and efficacy of retrograde intrarenal surgery using single-use flexible ureteroscopy (FURS) with mini-percutaneous nephrolithotomy (PCNL) in children with renal stones measuring 10-30 mm.
- Conditions
- Mini Percutaneous Nephrolithotomy, Retrograde Intrarenal Surgery, Pediatric, Renal Stones
- Trial name
- NCT07836192
- Testing
- Mini percutaneous nephrolithotomy, Flexible ureteroscopy
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Bronchiolitis
Treatment of Pediatric Bronchiolitis
Bronchiolitis (BQ) is the acute viral infection of the tract respiratory syndrome in infants that affects the bronchioles of babies under 24 months of age.
- Trial name
- NCT03835936
- Testing
- High frequency compression of the chest wall group, Manual maneuvers physiotherapy group
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Guadarrama Hospital
Critical Illness, Multiple Organ Dysfunction Syndrome
pSOFA Score in Predicting Mortality in Pediatric Intensive Care
This prospective observational cohort study aims to evaluate the predictive performance of the Pediatric Sequential Organ Failure Assessment (pSOFA) score for mortality and selected clinical outcomes among critically ill children…
- Trial name
- NCT07858487
- Volunteers
- 121 people
- Sponsor
- Assiut University
Pediatric Cancer
Pilot Evaluation of a Healthy Lifestyle Intervention for Adolescent and Young Adult Survivors of Pediatric Cancer
This is a feasibility and acceptability trial to test a newly developed healthy lifestyle intervention for adolescent and young adult survivors of pediatric cancer.
- Trial name
- NCT04839952
- Testing
- Healthy Lifestyles, Education-Only Control
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins All Children's Hospital
Cerebral Palsy Hemiparetic Cerebral Palsy Spasticity Gait Disorders, Neurologic Postural Balance Impairment
Vibration Effects on Gait and Balance in CP
This randomized controlled study aims to investigate the acute effects of local vibration applied to the spastic medial gastrocnemius muscle on balance and spatiotemporal gait parameters in children with hemiparetic cerebral…
- Trial name
- NCT07045519
- Testing
- Local Vibration Therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kırıkkale University
Concussion Post Syndrome, Headaches Posttraumatic
Pediatric Concussion Outcomes
This is a randomized, placebo-controlled, double-blinded trial in which subjects with a post concussive headache meeting inclusion criterion will be assigned to one of two treatment groups: placebo or nortriptyline.
- Conditions
- Concussion Post Syndrome, Headaches Posttraumatic, Mild Traumatic Brain Injury
- Trial name
- PeCon (NCT04226365)
- Testing
- Nortriptyline
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Lancaster General Hospital
Transplant-Related Disorder
Neuropsychological and Biopsychosocial Evolution During Pediatric Transplantation: Pre/Post-stages and at 6 Months
This pioneering prospective observational study aims to examine biopsychosocial and neuropsychological functioning, care needs and predictors of therapeutic adherence in children/adolescents in pre/post-surgical transplant (solid…
- Trial name
- NCT05441436
- Testing
- Allogeneic hematopoietic stem cell transplantation, Solid organ transplantation
- Where
- 2 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario La Paz
Hypothyroidism
Pediatric Risk of Hypothyroidism With Iodinated Contrast Media
This is a Phase 4 multicenter prospective study to estimate the proportion of patients aged birth to 3 years who develop hypothyroidism within 6 months after receiving intravascular iohexol (Omnipaque™), iodixanol (Visipaque™)…
- Trial name
- NCT03631771
- Testing
- Iohexol, Iodixanol, Iopromide
- Sponsor
- GE Healthcare
Anesthesia, Pediatric ALL
Topical Analgesia Before Inhalational Anaesthesia
Peripheral venous cannulation (insertion of a drip line into a vein) is a fundamental component of anaesthesia for both children and adults alike.
- Trial name
- NCT04959409
- Testing
- Topical analgesia (EMLA or AMETOP)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
HIV Infections
Piloting At-birth Point of Care HIV Testing Strategies in Kenya
Innovative strategies to expedite HIV diagnosis among exposed infants, including at-birth testing and two portable point-of-care (POC) diagnostic systems, will be piloted using an implementation framework.
- Trial name
- NCT03435887
- Testing
- Alere q HIV-1/2 Detect for point of care infant testing, GeneXpert HIV-1 Qual for point of care infant testing, HIV DNA PCR testing (Standard of Care)
- Where
- 5 sites in United States, Kenya
- Volunteers
- 1,999 people
- Sponsor
- University of Kansas Medical Center
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