Clinical trials: Disorder; Heart, Functional, Postoperative, Cardiac Surgery
Cardiac Defects, Disorder; Heart, Functional, Postoperative, Cardiac Surgery
Chest CT With Iterative Reconstruction as an Alternative to Conventional Chest X-ray Prior to Heart Surgery
To assess if information about aortic calcification obtained from routine preoperative ultra low-dose chest CT lowers the postoperative stroke rate in patients undergoing heart surgery by optimizing surgical strategy compared to…
- Conditions
- Cardiac Defects, Disorder; Heart, Functional, Postoperative, Cardiac Surgery, Stroke
- Trial name
- CRICKET (NCT02173470)
- Testing
- CT scan
- Where
- 3 sites in Hungary, Netherlands
- Volunteers
- 866 people
- Sponsor
- UMC Utrecht
Postoperative Complications, Heart Diseases
Detection of Right Ventricular Dysfunction by Portal Vein Doppler After Cardiac Surgery
Right ventricular (RV) failure after cardiac surgery is associated with morbidity and mortality, but is hard to diagnose with conventional echocardiographic means.
- Conditions
- Postoperative Complications, Heart Diseases, Heart Failure, Heart Valve Diseases
- Trial name
- DVDDP (NCT04890860)
- Testing
- cardiac surgery involving mitral or tricuspid valve repair procedure, with cardiopulmonary bypass
- Where
- France
- Volunteers
- 70 people
- Sponsor
- CMC Ambroise Paré
Cardiac Infarct, Cardiac Valve Disease
Frailty, Physical Capacity and Lung Function in Postoperative Cardiac Surgery Patients
The goal of this observational and prospective study is to investigate changes in physical performance, lung function, and respiratory and peripheral muscle strength in patients during the postoperative period following coronary…
- Conditions
- Cardiac Infarct, Cardiac Valve Disease, Fragility, Physical Disability
- Trial name
- NCT06247358
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo General Hospital
Postoperative Cognitive Dysfunction
Comparison of Postoperative Outcome After Sevoflurane and Propofol Anaesthesia
As the investigators know, postoperative cognitive dysfunction (POCD) is a fairly well-documented clinical phenomenon, which affect patients' short-term and long-term outcome.
- Trial name
- NCT02931877
- Testing
- sevoflurane, propofol
- Where
- 3 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Xinqiao Hospital of Chongqing
Heart; Surgery, Heart, Functional Disturbance as Result
Multifunctional Approach in Cardiac Surgery
Postoperative pain and swallowing disorders are complex, multifactorial phenomenon that frequently occur after cardiac surgery. Preoperative anxiety and the interaction between sex and other sociocultural factors may predict…
- Trial name
- TITANIC (NCT05824598)
- Testing
- Multifunctional rehabilitation treatment
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Postoperative Period, Physical Therapy Modalities
Positive Pressure Therapy to Optimize LUNG Function After Heart Surgery
The most common cardiac surgeries are myocardial revascularization and valve replacement or plastic surgery. In the postoperative period of cardiac surgeries, the incidence of pulmonary complications ranges from 30% to 50% and is…
- Conditions
- Postoperative Period, Physical Therapy Modalities, Continuous Positive Airway Pressure, Respiratory Function Tests
- Trial name
- PRO-LUNGHS (NCT06611527)
- Testing
- PS+PEEP group, CPAP group
- Where
- Brazil
- Volunteers
- 156 people
- Sponsor
- Federal University of São Paulo
Fatigue
Effects of Oral Iron on Postoperative Fatigue Upon Coronary Artery Bypass Graft Patients
The purpose of this research study is to examine how an oral iron supplement (Feramax®) influences fatigue during early postoperative recovery (at three months) among CABG patients and, the effects on recovery outcomes (e.g.
- Trial name
- NCT01912261
- Testing
- Polysaccharide iron complex
- Where
- Canada
- Volunteers
- 121 people
- Sponsor
- Nova Scotia Health Authority
Heart; Dysfunction Postoperative, Cardiac Surgery, Disorder; Heart, Functional, Postoperative, Cardiac Surgery
Influence of Anesthesia on Mechanical Efficiency of Left Ventricle in Patients Undergoing Open Heart Surgery
The aim of the study is to delineate and compare the changes in coupled mechanical properties of left ventricle and arterial vascular bed caused by two popular anesthetic protocols commonly used in cardiac surgery (intravenous…
- Trial name
- NCT01397331
- Testing
- Isoflurane, Propofol
- Where
- Israel
- Volunteers
- 28 people
- Sponsor
- Sheba Medical Center
Postoperative Cognitive Dysfunction
Post Cardiac Surgery Neurocognitive Decline: Correlations Between Neuropsychological Tests and Functional MRI Techniques
Postoperative cognitive decline (POCD) is a frequent complication after cardiac surgery. It is estimated that 40-70% of all cardiac patients show cognitive dysfunction during the first post-surgical week.
- Trial name
- CardChNeuroMRI (NCT01622452)
- Volunteers
- 50 people
- Sponsor
- Fondazione Toscana Gabriele Monasterio
Kidney Failure, Chronic, Coronary Artery Disease
Prophylactic Effect of Nifedipine on Further Decline in Renal Function in Patients Undergoing Open-Heart Surgery
To compare renal function (51Cr-EDTA clearance) 48 hours post open-heart surgery (coronary bypass or valve surgery) in patients with impaired renal function after randomization to either nifedipine infusion at start of surgery…
- Trial name
- NCT00244530
- Testing
- Nifedipine
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- University of Oslo School of Pharmacy
Disorder; Heart, Functional, Postoperative, Cardiac Surgery
Functional Recovery After Cardiac Surgery : Does Delirium and Calorie Intake Matter?
The aims of the cohort study is to describe the rates of 30-day surgical complication, functional decline, frailty and one-year mortality for patients experienced cardiac surgery and to delineate the trajectory of functional…
- Trial name
- NCT02212509
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Postoperative Complications, Heart Failure
Association Between Portal Flow Pulsatility and Right Ventricular Dysfunction in the Postoperative Period of Cardiac Surgery
Right ventricular dysfunction (RVD) after cardiac surgery is associated with ischemia and myocardial injury. While echocardiographic measures like Tricuspid Annular Plane Systolic Excursion (TAPSE) are frequently used to assess…
- Trial name
- LIFESAVE (NCT06777355)
- Testing
- Transthoracic and Transesophageal echography within 24 hours post cardiac surgery
- Where
- France
- Volunteers
- 32 people
- Sponsor
- CMC Ambroise Paré
Colorectal Cancer, Intraoperative Hemodynamic Management
MAP- Versus Cardiac Index-Guided Hemodynamic Management in Colorectal Surgery
This prospective randomized trial aims to compare the effects of two intraoperative hemodynamic management strategies on early postoperative renal function in patients undergoing colorectal surgery.
- Trial name
- NCT07609680
- Testing
- Mean Arterial Pressure-Guided Hemodynamic Management, Cardiac Index-Guided Hemodynamic Management
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Acute Kidney Injury
The Effects of Dexmedetomidine on Postoperative Renal Function in Valvular Heart Surgery
The purpose of study is to compare the incidence of acute kidney injury in patients receiving perioperative dexmedetomidine or placebo undergoing valvular heart surgery.
- Trial name
- NCT01886079
- Testing
- dexmedetomidine, Saline
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Blood Clotting
Thromboelastography (TEG®) and Platelet Function in Patients on Anti-platelet Agents
Can a post-operative analysis using a simple blood test (Thromboelastography(TEG®)) and Platelet Mapping Assay (PMA™) be able to detect the occurence of clotting or bleeding complications in patients on blood thinning…
- Trial name
- NCT00901160
- Testing
- blood test
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- McMaster University
Acute Kidney Injury
Perfusion - Pressure - Creatinine Trial
In Denmark around 3500 procedures are conducted involving a heart-lung-machine per year. An increase in the prevalence of postoperative kidney insufficiency have been observed following these procedures, during the last years.
- Trial name
- PPC (NCT01408420)
- Testing
- MAP > 60 mmHg
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Postoperative Delirium (POD)
The Study of Postoperative Delirium and Glymphatic System Function in Cardiac Surgery
Postoperative delirium after cardiac surgery is an acute cerebral dysfunction characterized by inattention, impaired consciousness, and cognitive and orientation disturbances.
- Trial name
- Delirium (NCT06901479)
- Testing
- Blood was drawn for proteomics testing and Magnetic Resonance Imaging.
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Disorder; Heart, Functional, Postoperative, Cardiac Surgery
Effectiveness of an Enhanced Recovery After Surgery Protocol in Patients Undergoing On-pump Cardiac Surgery
In 2019, the Enhanced Recovery After Surgery (ERAS) Society published recommendations for perioperative care in cardiac surgery.
- Trial name
- ERASCs (NCT05225272)
- Testing
- Enhanced Recovery Program for on-pump cardiac surgery
- Where
- Canada
- Volunteers
- 92 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Acute Myocardial Infarction, Disorder; Heart, Functional, Postoperative, Cardiac Surgery
High-sensitivity Troponin T in Acute Myocardial Infarction After Cardiac Valvular Surgery
A measurable degree of heart muscle tissue injury is expected in patients undergoing heart valvular surgery. The level of this injury can be measured by cardiac biomarkers in blood samples.
- Conditions
- Acute Myocardial Infarction, Disorder; Heart, Functional, Postoperative, Cardiac Surgery, Myocardial Infarction, Heart Valve Diseases
- Trial name
- NCT02518282
- Testing
- Serum levels of high-sensitivity troponin T, Twelve-lead ECGs, Transthoracic echocardiography (TTE)
- Where
- Spain
- Volunteers
- 800 people
- Sponsor
- University of Valladolid
Oxidative Stress, Cognition Disorders
The Effect of Dexmedetomidine Infusion on Post-operative Cognitive Function and Oxidative Stress in Cardiac Surgery
Objective: The aim of this study was to determine the effect of dexmedetomidine in reducing postoperative cognitive dysfunction (POCD) in cardiac surgical patients which use cardiopulmonary bypass machine (CPB).
- Trial name
- NCT03054857
- Testing
- Dexmedetomidine
- Volunteers
- 100 people
- Sponsor
- Chulalongkorn University