Clinical trials: Disorder
Atrial Fibrillation
Atrial Fibrillation Algorithms Clinical Validation Study
The purpose of the study is to evaluate the performances of investigational Irregular Rhythm Notification Feature (version 2.0) and Atrial Fibrillation History Feature algorithms.
- Trial name
- NCT04699812
- Testing
- ELECTROCARDIOGRAM (ECG) PATCH WEAR
- Where
- 4 sites in United States
- Volunteers
- 573 people, healthy volunteers welcome
- Sponsor
- Apple Inc.
Influenza
Immunogenicity and Safety Study to Assess Influenza Vaccine Formulated With Haemagglutinin (HA) Antigen From Two Different Suppliers
The purpose of this study is to assess the humoral immune response and safety of the parenteral formulation of the 2010/2011-season virosomal subunit influenza vaccine Inflexal V using two different HA antigen suppliers (AdImmune…
- Trial name
- NCT01412281
- Testing
- Virosomal influenza vaccine (AdImmune HA Antigen), Virosomal influenza vaccine (CSL HA Antigen)
- Where
- Switzerland
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Crucell Holland BV
Coronary Artery Disease
Customizable Respiratory Exercise Device in Individuals Who Have Undergone Cardiac Surgery
The cardiorespiratory system integrates systemic and pulmonary circulation while ensuring adequate oxygenation of the body at rest and during exercise.
- Trial name
- NCT06258681
- Testing
- Incentive spirometer, Individualized respiratory training group
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Biruni University
Diabetes Mellitus, Type 2
First Research Study of the Possible New Medicine NNC0113-2023 in Healthy Men.
The aim of this study is to assess how safe the study drug is and how well a participant tolerates it after a single oral (taken by mouth) dose.
- Trial name
- NCT03617081
- Testing
- NNC0113-2023
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Evaporative Dry Eye
Comparison of Tear Evaporation Rate With Systane Complete in Dry Eye and Non-Dry Eye
The objective of the study is to compare the rate of tear evaporation, measured with a novel evaporimeter, before and for one hour after an eye drop containing nano-sized oil droplets has been instilled.
- Trial name
- BULLDOG (NCT04091581)
- Testing
- Systane Complete
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Epiphora, Ptosis
Bupivacaine Epiphora Trial
The objective of this study is to investigate quantitative improvement in excessive tearing after administration of Bupivacaine, a local anesthetic, into the affected eyelids.
- Trial name
- NCT03266081
- Testing
- 0.75% bupivacaine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Type 1 Diabetes Mellitus, Quality of Life (QOL)
Societal Burden Associated With Type 1 Diabetes in Canada
The purpose of this observational study is to estimate the burden of T1D on caregivers of patient with T1D in terms of work productivity, healthcare resource utilization and quality of life.
- Conditions
- Type 1 Diabetes Mellitus, Quality of Life (QOL), Work Productivity, Caregiver Subjective Burden
- Trial name
- T1D (NCT06786130)
- Testing
- observational study
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- PeriPharm
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Registry
With the increase in life expectancy of our population due to advancement of medical diagnosis and treatments, the incidence of age dependent neurodegenerative diseases increased, including Alzheimer's disease (AD), parkinsonian…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Multiple System Atrophy, Progressive Supranuclear Palsy
- Trial name
- NDD Registry (NCT04472130)
- Where
- Hong Kong
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Vincent Mok
Hypertension, Endothelial Function
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Adults With Newly Diagnosed Hypertension
Hypertension is associated with endothelial dysfunction, an early event in the development of cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation and…
- Trial name
- HYPER-endoEV-a (NCT07728630)
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Epilepsy, Lamotrigine
Effect of Adding Lamotrigine to Sodium Valproate in Childhood Epilepsy: Clinicolabratory Study
Epilepsy is one of the most common serious chronic brain disorders of childhood. The causes of epilepsy include :acquired brain damage, altered metabolic states, inborn brain malformations, and genetic causes.
- Conditions
- Epilepsy, Lamotrigine, Sodium Valproate Adverse Reaction
- Trial name
- NCT05881928
- Testing
- Sodium Valproate 500 Mg Prolonged-Release Oral Tablet, Lamotrigine, E.E.G
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Influenza
Inactivated Split Virus Seasonal Influenza Vaccine (Vero Cell-Derived)
The purpose of this study is to determine if a Vero cell-derived trivalent seasonal influenza vaccine produced by the modified manufacturing process: 1.
- Trial name
- NCT01773928
- Testing
- Vero cell-derived trivalent influenza vaccine manufactured with the modified manufacturing process (VCIV modified), VCIV manufactured with the current manufacturing process (VCIV current), Fluzone®, licensed trivalent influenza vaccine (TIV)
- Where
- 20 sites in United States
- Volunteers
- 1,928 people, healthy volunteers welcome
- Sponsor
- Alachua Government Services, Inc.
Primary Immune Deficiency Disorder
Identification of New Inborn Errors of Immunity
Analysis of DNA samples of patients with molecularly undetermined PID by whole exome/genome sequencing. Transcriptome analysis of patients with molecularly undetermined PID.
- Trial name
- NCT03414528
- Testing
- Diagnostic Test
- Where
- Switzerland
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Attention Deficit and Hyperactivity Disorder (ADHD), Attention Deficit Hyperactivity Disorder in Adults
The Effect of 5-hydroxytryptophan on ADHD Traits and Eye Movements
The aim of this project is to look at the impact of 5-Hydroxytryptophan (5-HTP) on distractibility. 5-HTP is the precursor to the neurotransmitter serotonin and is a chemical that the body produces naturally.
- Conditions
- Attention Deficit and Hyperactivity Disorder (ADHD), Attention Deficit Hyperactivity Disorder in Adults, Attention Deficits
- Trial name
- NCT07777328
- Testing
- 5-hydroxytryptophan (food supplement) 200mg, 5-hydroxytryptophan (food supplement) 300mg
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Sheffield
Eye Infection, Infection
Effectiveness Study of Zymar Versus Vigamox for Preoperative Sterilization of the Ocular Surface After Loading Dose
The purpose of this study is to analyze the effect of Zymar and Vigamox on ocular surface bacteria. We believe that Zymar will eradicate more ocular surface bacteria than Vigamox.
- Trial name
- NCT00347828
- Testing
- Moxifloxacin ophthalmic solution 0.5%, Gatifloxacin ophthalmic solution 0.3%
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ophthalmic Consultants of Boston
Sepsis, Hyperglycemia
Gluconeogenesis Rates and Its Precursors in Pediatric Sepsis
Critically ill children have abnormal utilization of nutrients such as glucose, lipids and protein. Often sick children have increased glucose concentrations in blood.
- Conditions
- Sepsis, Hyperglycemia, Critical Illness
- Trial name
- NCT01890928
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
COVID-19, Vaccine
Evaluation of Menstrual Irregularities and Abnormal Uterine Bleeding After Covid-19 Vaccine
Covid-19 vaccines offered a good opportunity to counteract the spread of Sars-Cov-2 infection among the general population, reducing significantly both morbidity and mortality.
- Conditions
- COVID-19, Vaccine, Menstrual Irregularity, Menopausal Bleeding
- Trial name
- MECOVAC-1 (NCT05083065)
- Testing
- Covid-19 vaccine
- Where
- Italy
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- Università degli Studi dell'Insubria
Type 2 Diabetes
Evaluation of CYP450 Activities in Diabetic Patients vs. Non-diabetic Subjects
Type 2 diabetes (T2D) could modulate CYP450 activities involved in drug-metabolism and cardiovascular homeostasis. We propose to carry out, for the first time, a comprehensive characterization of the effects of T2D on the…
- Trial name
- NCT02291666
- Testing
- CRCHUM-MT cocktail
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Internet Addiction
Effectiveness of Acceptance and Commitment Therapy in Promoting Mental Health of Emerging Adults With Internet Addiction
Internet addiction, a growing epidemic among young adults, significantly impairs mental health, emotional regulation, and overall well-being.
- Trial name
- NCT07750366
- Testing
- Acceptance and Commitment Therapy (ACT)
- Where
- Pakistan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National University of Modern Languages
Lynch Syndrome
Predictive Factor Study of the Occurrence of Endometrial Cancer in Patients With Lynch Syndrome
Lynch Syndrome increases Endometrial Cancer Occurrence in women due to failure in MisMatch Repair System. Lifetime Cumulative risk of developing endometrial Cancer is approximatively 40% in women with Lynch Syndrome.
- Trial name
- PrediLynch (NCT04452266)
- Testing
- questionnaire assesment
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
ADHD
The Effects of Yoga on Attention, Impulsivity and Hyperactivity in Pre-school Age Children
This pilot project will evaluate yoga as an intervention to improve attention and reduce challenging behaviors such as hyperactivity and impulsivity, rated by parent and teachers, in preschool age children with or "at risk" for…
- Trial name
- NCT02642666
- Testing
- Children's Yoga
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
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