Clinical trials: Disorder
Respiration Disorders
Epidural Analgesia and Postoperative Respiratory Functions (EPAPRES)
Patients operated with posterolateral thoracotomy were enrolled. Post-operative analgesia was provided either by TEA with 0.1% bupivacaine or pethidine based intravenous analgesia (IVA) in our sample population.
- Trial name
- EPAPRES (NCT03643757)
- Testing
- Thoracic epidural analgesia, Bupivacaine
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Yedikule Training and Research Hospital
Metabolic Syndrome, Obesity
Body Weight and Vascular Function
An increased body mass impairs vascular function (VF), an important characteristic of subjects suffering from type 2 diabetes and a risk marker for cardiovascular diseases.
- Trial name
- NCT01675401
- Testing
- Weight-loss treatment, No-weight loss treatment
- Where
- Netherlands
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive
The Effect of Education Based on the Chronic Care Model in COPD Patients
Individuals who have COPD need a nursing service, which provides qualified and effective professional care, self-care, and supportive care to perform their daily life activities, and improve their quality of life.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive, Self-Management, Nursing Care
- Trial name
- NCT05029557
- Testing
- Education and telephone follow ups based on the Chronic Care Model
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Ankylosing Spondylitis
Evaluation of Physical Performance in Ankylosing Spondylitis Patients
Ankylosing spondylitis (AS) can cause serious limitations in individuals' physical performance, as it involves the musculoskeletal system and can cause ankylosis and arthritis in both axial and peripheral joints.
- Trial name
- NCT04451681
- Testing
- Cardiopulmonary exercise test
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Cardiovascular Diseases
Clinical Study to Investigate the PK Profiles and Safety of CKD-385 in Healthy Volunteers Under Fed Conditions
Clinical Study to Investigate the Pharmacokinetic Profiles and Safety of High-dose CKD-385 in Healthy Volunteers under fed conditions
- Trial name
- NCT04651881
- Testing
- Reference drug, Test drug 1, Test drug 2
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Anesthesia, Pain, Postoperative
Ultrasound Guided Repositioning of a New Suture-Method Catheter for Adductor Canal Block
This is a randomized clinical trial in healthy volunteers. 12 volunteers will have suture-method catheters placed in the adductor canal of each leg using the long-axis plane and short-axis plane technique.
- Conditions
- Anesthesia, Pain, Postoperative, Pain, Pain, Joint
- Trial name
- NCT03315481
- Testing
- SAX catheter insertion, LAX catheter insertion
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital
Liver Fibrosis, Liver Cirrhosis
Acoustic Radiation Force Impulse Imaging (ARFI) : a New Technique to Assess Liver Elasticity
Liver stiffness measurement (LSM) by non invasive methods is increasingly used to estimate liver fibrosis in patients with chronic liver diseases.
- Conditions
- Liver Fibrosis, Liver Cirrhosis, Viral Hepatitis, Liver Tumour
- Trial name
- NARFI (NCT01082419)
- Testing
- ARFI measurement
- Where
- France
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
HIV Infections
Safety of and Immune Response to a DNA HIV Vaccine Followed By Boosting With One of Two Serotypes of Adenoviral Vector HIV Vaccine in Healthy Adults
The purpose of this study is to determine the safety of and immune response to an experimental DNA HIV vaccine followed by boosting with either an experimental adenoviral vector HIV vaccine of serotype 5 or 35 in HIV uninfected…
- Trial name
- NCT00472719
- Testing
- VRC-HIVADV027-00-VP, VRC-HIVADV038-00-VP, VRC-HIVDNA044-00-VP
- Where
- 7 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Parodontosis
Immunoregulation of Periodontal Diseases
Periodontal diseases are a group of diseases that affect 15% of the population and in the absence of treatment causes tooth loss. Periodontal lesions are characterized mainly by strong inflammation and hyper-vascularization.
- Trial name
- NCT02567019
- Testing
- blood samples
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
HIV Infections, HIV Seronegativity
Carotid Artery Thickness in HIV Infected and Uninfected Adults
The intima-media thickness (IMT) test is a low cost, non-invasive way to measure the thickness of the carotid artery (the large artery in the neck).
- Conditions
- HIV Infections, HIV Seronegativity, Atherosclerosis
- Trial name
- NCT00007319
- Where
- 10 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hallux Rigidus, Hallux Valgus
Return to Cross Country Skiing and Other Physical Activities After Arthrodesis of the First Metatarsophalangeal Joint
Patients who have undergone arthrodesis of the first metatarsophalangeal joint due to hallux valgus or hallux rigidus are invited to participate in this study, which aims to investigate how the foot functions after this…
- Trial name
- NCT07610330
- Testing
- Arthrodesis
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Pain, Hypoxemia
Effects of Walking Apnea At High Lung Volume on Hypoalgesia
The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent walking apneas training session at high lung volume in healthy subjects; also, as secondary objectives, to analyze…
- Conditions
- Pain, Hypoxemia, Hypercapnia, Apnea
- Trial name
- NCT06638528
- Testing
- Walking apnea at High Lung Volume, Walking normal breathing
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Osteoarthritis
The Role of Intra-Operative Intracapsular Blocks in Post-Operative Pain Management Following Total Knee Arthroplasty
The purpose of this study is to use a new combination of anesthesia techniques in an attempt to minimize early pain after surgery and improve the patient's ability to participate more fully with physical therapy.
- Trial name
- NCT00620828
- Testing
- Ropivicaine 0.5%
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Duke University
Human Immunodeficiency Virus, Treatment
First in Human Study of TLC-ART 101 (ACTU 2001)
This study is a prospective, open-label, single-site, first-in-human study of a long-acting, injectable combination antiretroviral therapy platform, with a pharmacologically-guided adaptive design for dose escalation…
- Conditions
- Human Immunodeficiency Virus, Treatment, Antiretroviral Therapy
- Trial name
- NCT05850728
- Testing
- TLC-ART
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Washington
Influenza Infection
Effect of the Interferon Alpha Citizen by Sub-Lingual Way on the Humoral Immunizing Answer
Influenza vaccination reduces the morbidity and mortality associated with influenza infection in at risk groups including the elderly and individuals with an impaired immune response, but is not totally protective in all…
- Trial name
- GP-INFA (NCT00647465)
- Testing
- vaccine
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hepatic Insufficiency
Nintedanib in Volunteers With Hepatic Impairment Compared With Healthy Volunteers
The primary objective of this study is to investigate the effect of mild (Child-Pugh A, score 5-6) and moderate (Child-Pugh B, score 7-9) hepatic impairment on the pharmacokinetics, safety and tolerability of nintedanib, in…
- Trial name
- NCT02191865
- Testing
- Nintedanib
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Atherosclerosis
Study to Determine the Effect of Repeated Administration of Diltiazem on the Pharmacokinetics of Darapladib (Sb-480848).
Darapladib (SB-480848) is a novel, selective, orally active inhibitor of lipoprotein associated phospholipase A2 (Lp-PLA2) currently under clinical development by GlaxoSmithKline as a potential anti-atherosclerosis agent for…
- Trial name
- NCT01852565
- Testing
- Darapladib, Diltiazem
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy, Diabetes Mellitus Type 1
The Effect of Light Therapy on Cellular Energy and Oxidative Stress in Healthy Adults and Type 1 Diabetic Patients
The goal of this clinical trial is to evaluate the effects of low-level light therapy on cellular energy and oxidative stress in healthy adults and patients with Type 1 diabetes.
- Trial name
- PBM-T1D (NCT07833865)
- Testing
- Red and Near-Infrared Light Therapy Pad
- Where
- Iraq
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Thi-Qar
COVID-19, SARS-CoV2
Previfenon® as Chemoprophylaxis of COVID-19 in Health Workers
The purpose of this clinical trial is to determine the efficacy of Previfenon® (EGCG) to prevent COVID-19, enhance systemic immunity, and decrease the frequency and intensity of selected symptoms when used as pre-exposure…
- Trial name
- HERD (NCT04446065)
- Testing
- Previfenon®
- Volunteers
- healthy volunteers welcome
- Sponsor
- MELISA Institute Genomics & Proteomics Research SpA
Influenza
A Comparison of One Versus Two Doses of Influenza Vaccine in Children 5-8 Years of Age
The purpose of the study was to find out if children 5 through 8 years of age who are getting influenza vaccine for the first time should get one or two doses.
- Trial name
- NCT00158665
- Testing
- 2 0.5 ml doses of '04-05 Trivalent Influenza Vaccine
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
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