Clinical trials: Disorder Heart
Mixed Aortic Valve Disease
Outcomes in Moderate Mixed Aortic Valve Disease
Mixed aortic valve disease (MAVD) is defined as the combination of aortic valve stenosis (AS) and regurgitation (AR) and is relatively frequent, with a reported prevalence up to 20-30% of patients with aortic valve disease.
- Trial name
- NCT06789211
- Where
- Netherlands
- Volunteers
- 1,900 people
- Sponsor
- Leiden University Medical Center
Heart Failure
HeartLogic™ in Patients With Heart Failure.
This randomized, multicenter clinical trial will evaluate whether remote management guided by the HeartLogic™ algorithm improves outcomes compared with traditional face-to-face follow-up in adult patients with heart failure…
- Trial name
- HERO (NCT07544771)
- Testing
- Alert-guided remote follow-up, Traditional follow up
- Where
- 15 sites in France
- Volunteers
- 578 people
- Sponsor
- Poitiers University Hospital
Coronary Artery Disease
Effect of PADMA 28 on Endothelial Function, Autonomic Nervous System and Biomarkers in Patients With Coronary Artery Disease
This randomized, placebo-controlled, double-blinded trial investigates the effect of a 6 week intake of PADMA 28 on the endothelial function, biomarkers and the autonomic nervous systems in patients with coronary artery disease.
- Trial name
- PADMA 28 (NCT01581034)
- Testing
- PADMA 28
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Congenital Heart Disease in Pregnancy, Prenatal Diagnosis
The National Program for the Improvement of Management of Fetal Congenital Heart Disease in China
To investigate and evaluate the capacity of prenatal screening, diagnosis and counseling of congenital heart disease in medical institutions in China, in order to understand the current status and existing problems of prenatal…
- Conditions
- Congenital Heart Disease in Pregnancy, Prenatal Diagnosis, Fetal Echocardiography
- Trial name
- NCT05940363
- Testing
- Improvement on Prenatal Screening and Treatment Capabilities for Congenital Heart Disease with a Comprehensive Diagnosis and Treatment Program Incorporating New Technologies
- Volunteers
- 9,000 people
- Sponsor
- Beijing Anzhen Hospital
Cardiac Arrest
CODE Registry - Cardiac Arrest Outcomes Data Evaluation
The purpose of this study is based on method Utstein, registering all recommended items of that model, in addition to adding more information, characterizing this way using a template Utstein modified for the epidemiology of…
- Trial name
- CODE (NCT01327833)
- Where
- Brazil
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Cardiomyopathy, Dilated
Early Treatment With Candesartan vs Placebo in Genetic Carriers of Dilated Cardiomyopathy (EARLY-GENE Trial)
Prospective, multicenter, randomized, placebo-controlled, double-blind clinical trial to evaluate safety and efficacy of candesartan in the prevention of the development of Dilated Cardiomyopathy (DCM) in genetic carriers of a…
- Trial name
- EARLY-GENE (NCT05321875)
- Testing
- Candesartan
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- Cristina Avendaño Solá
Atherosclerosis
A Study of Atherosclerosis in Patients After Radiation Treatment for Breast Cancer
The purpose of this study is to compare plaque burden in the coronary and carotid arteries 5 years after adjuvant radiotherapy in women with right sided breast cancer vs left sided breast cancer.
- Trial name
- ABCART (NCT00960401)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Winthrop University Hospital
Cardiovascular Disease, Diabetes
Care China-Diabetes
This multicenter, prospective, observational registry will assess efficacy and safety outcomes associated with percutaneous coronary intervention (PCI) with implantation of the CYPHER Select™+ Sirolimus-eluting Coronary Stents in…
- Trial name
- NCT00938119
- Where
- 46 sites in China
- Volunteers
- 1,603 people
- Sponsor
- Johnson & Johnson Medical, China
Coronary Artery Disease
Italian Diffuse/Multivessel Disease ABSORB Prospective Registry: IT-Disappears
The purpose of this study is to determine whether patients with diffuse or multivessel coronary artery disease may benefit from the percutaneous implantation of the device ABSORB in larger extent with respect to the general…
- Trial name
- NCT02004730
- Testing
- ABSORB implantation
- Where
- 2 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Infective Endocarditis
Effect of Dexmedetomidine on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery
Acute kidney injury is major complication after open heart surgery. The cause of acute kidney injury following open heart surgery is related to activation of sympathetic nervous system, decrease of renal blood flow…
- Trial name
- NCT02698930
- Testing
- dexmedetomidine, Normal saline
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Yonsei University
Acute Myocardial Infarction
Stem Cells in Myocardial Infarction
The purpose of this trial is to investigate the effect of treatment with granulocyte-colony stimulating factor (G-CSF) bone marrow stimulation on circulating stem cells' ability to develop new blood vessels in the myocardium…
- Trial name
- NCT00135928
- Testing
- Granulocyte Colony Stimulating Factor G-CSF (Neupogen®)
- Where
- Denmark
- Volunteers
- 78 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Heart Failure
A Pilot Study of Interventricular Septal Puncture for Cardiac Resynchronization Therapy to Treat Heart Failure
Cardiac resynchronization therapy (CRT) is known to result in significant improvement in the symptoms of selected patients with heart failure, and to reduce hospital admission and death rates in these patients.
- Trial name
- LV-CONSEPT (NCT01818765)
- Testing
- Trans-ventricular-septal placement of LV pacing lead, Pre-procedure speckle-tracking echocardiography, Acute response assessment
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Oxford University Hospitals NHS Trust
Aortic Valve Stenosis
ExCEED: CENTERA THV System in Intermediate Risk Patients Who Have Symptomatic, Severe, Calcific, Aortic Stenosis
This study will monitor the safety and valve performance of the Edwards CENTERA Transcatheter Heart Valve (THV) System in patients with symptomatic, severe, calcific aortic stenosis who are at intermediate operative risk for…
- Trial name
- NCT03517436
- Testing
- TAVR with CENTERA THV
- Where
- 23 sites in United States
- Volunteers
- 101 people
- Sponsor
- Edwards Lifesciences
Stable Angina Pectoris, Periodontitis
Effect of Periodontal Therapy on Asprosin in Stable Angina
This study aims to evaluate the effect of non-surgical periodontal therapy on serum asprosin levels in patients with stable angina and periodontitis.
- Trial name
- NCT07591844
- Testing
- Non-surgical periodontal therapy (scaling and root planing), Non-surgical periodontal therapy (Professional dental cleaning)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Cardiomyopathy, Dilated
Registry of Cell Therapy in Non-Ischemic Dilated Cardiomyopathy
Although several studies have demonstrated beneficial effects of stem cell therapy in patients with non-ischemic dilated cardiomyopathy, the long term benefits and predictors of response to therapy remain undefined.
- Trial name
- RECORD (NCT02445534)
- Testing
- Autologous stem cell therapy
- Where
- Slovenia
- Volunteers
- 250 people
- Sponsor
- University Medical Centre Ljubljana
Coronary Artery Disease
S-FLEX Netherlands Registry: Prospective Evaluation of the Supraflex Family Sirolimus-eluting Coronary Stent System
The primary objective of this registry is to evaluate the safety and efficacy of the Supraflex Family sirolimus-eluting coronary stent system in a 'real-world' patient population requiring stent implantation.
- Trial name
- NCT03443999
- Testing
- Supraflex Family Sirolimus-eluting Coronary Stent System
- Where
- 7 sites in Netherlands
- Volunteers
- 10,000 people
- Sponsor
- Sahajanand Medical Technologies Limited
Heart Failure
Jarvik 2000 Heart as a Bridge to Cardiac Transplantation - Pivotal Trial
The purpose of the study is to determine the safety and effectiveness of the Jarvik 2000 Heart as a bridge to heart transplantation in end-stage heart failure patients who are approved heart transplant candidates.
- Trial name
- NCT00591799
- Testing
- The Jarvik 2000 Ventricular Assist System
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Jarvik Heart, Inc.
Coronary Artery Disease
MDCT of the Coronary Arteries in Heart Transplanted Patients
Heart transplanted patients often develop coronary artery disease and therefore have their coronary arteries examined with coronary angiography once a year.The purpose of the study is to validate computer tomography of the…
- Trial name
- NCT00403299
- Testing
- MDCT of the coronary arteries.
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Oslo University Hospital
Coronary Artery Disease
HELIOS China Registry: Evaluation of the HELIOS Stent in a 'Real-World' Patient Population
The study aims to evaluate the safety and efficacy of biodegradable polymer sirolimus-eluting coronary stent system (HELIOS) in patients with coronary artery disease .
- Trial name
- NCT03916432
- Testing
- HELIOS biodegradable polymer sirolimus-eluting stents
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Xijing Hospital
Stable Coronary Artery Disease CAD
Helium-free Magnetocardiography Guided Therapy for Stable Coronary Artery Disease - A Randomized Controlled Trial
This rigorously designed randomized controlled trial aims to investigate whether Magnetocardiography (MCG) can optimize the clinical pathway, improve quality of life, and reduce healthcare costs in patients with stable coronary…
- Trial name
- NCT07341932
- Testing
- MCG Group, Conventional Management Group
- Where
- 5 sites in China
- Volunteers
- 1,312 people
- Sponsor
- Beijing Anzhen Hospital
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