Clinical trials: Disorder Heart
Cardiovascular Diseases, Coronary Disease
Framingham Cycle V Offspring-Spouse Nutrition Studies
To examine the associations between diet, nutrition and coronary heart disease (CHD) incidence over seven years using the Cycle V Framingham Offspring/Spouse examination ; to examine the cross-sectional associations between…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Hypertension
- Trial name
- NCT00005347
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertension
Study of Clevidipine Assessing Its Preoperative Antihypertensive Effect in Cardiac Surgery (ESCAPE-1)
The purpose of this study is to determine the efficacy of clevidipine injection versus placebo in treating preoperative hypertension.
- Trial name
- ESCAPE-1 (NCT00093249)
- Testing
- clevidipine
- Where
- 12 sites in United States
- Volunteers
- 105 people
- Sponsor
- The Medicines Company
Heart Failure, Obstructive Sleep Apnea
The Role of Sleep Apnea in the Acute Exacerbation of Heart Failure
This study will evaluate whether treating sleep apnea while in the hospital would help heart failure, and assist recovery from the worsening of the heart function more than the current clinical standard of waiting for treatment…
- Conditions
- Heart Failure, Obstructive Sleep Apnea, Heart Failure, Congestive
- Trial name
- NCT00679549
- Testing
- CPAP Therapy
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Ohio State University
Heart Failure
Improving Goal Directed Medical Therapy for Device Clinic Patients With Reduced EF at UOHI: a QI Initiative (VIGILANT)
This is a quality improvement initiative with the goal of optimizing heart failure (HF) patients seen through the outpatient cardiac implantable electronic device clinic at the University of Ottawa Heart Institute (UOHI).
- Trial name
- VIGILANT (NCT05085249)
- Where
- Canada
- Volunteers
- 2,479 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Acute Coronary Syndrome
Antithrombotic Effects of Ticagrelor Versus Clopidogrel
The purpose of this study is to determine whether treatment with ticagrelor (plus aspirin and bivalirudin) is more effective than treatment with clopidogrel (plus aspirin and bivalirudin).
- Trial name
- NCT01642238
- Testing
- Ticagrelor + ASA + Bivalirudin, Clopidogrel + ASA + Bivalirudin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Juan J Badimon
Coronary Artery Disease
Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation
Narrowing of coronary arteries interferes with blood flow and can cause chest pain. But patients may have more than one narrowing and studies have shown that not all narrowings need to be treated.
- Trial name
- DEFINE-FLAIR (NCT02053038)
- Testing
- iFR, FFR
- Where
- 50 sites in United States, Australia and 15 more
- Volunteers
- 2,500 people
- Sponsor
- Imperial College London
Cardiovascular Diseases, Defect, Congenital Heart
Family Study of Congenital Cardiovascular Malformations
To determine genetic mechanisms responsible for congenital cardiovascular malformations.
- Conditions
- Cardiovascular Diseases, Defect, Congenital Heart, Heart Diseases
- Trial name
- NCT00005258
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Total Anomalous Pulmonary Venous Connection
Sutureless Technique and Conventional Repairs for Total Anomalous Pulmonary Venous Connection
The purpose of this study is to evaluate the efficacy of conventional repair and sutureless surgical repair of total anomalous pulmonary venous connection.
- Trial name
- NCT04234711
- Testing
- Surgical strategy
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Guangdong Provincial People's Hospital
Severe Aortic Stenosis
CLEAR-AS: CT-FFR-Guided Revascularization in Patients With Severe Aortic Stenosis
Severe aortic stenosis (AS) is often accompanied by coronary artery disease (CAD). While coronary computed tomography angiography (CCTA) is routinely used before aortic valve replacement (AVR) to evaluate coronary anatomy, it…
- Trial name
- CLEAR-AS (NCT07469371)
- Testing
- CCTA plus CT-FFR-informed preoperative decision strategy, CCTA-guided preoperative decision strategy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Yan'an Affiliated Hospital of Kunming Medical University
Coronary Artery Disease
Comparison of One-stop Hybrid Revascularization Versus Percutaneous Coronary Intervention for the Treatment of Multi-vessel Disease
The "one-stop" hybrid coronary revascularization combines minimally invasive direct coronary artery bypass (MIDCAB) and PCI to be performed in the hybrid operating suite, an enhanced operating room equipped with radiographic…
- Trial name
- NCT01035034
- Testing
- Hybrid MIDCAB/PCI, PCI with DES
- Where
- 2 sites in China
- Volunteers
- 480 people
- Sponsor
- China National Center for Cardiovascular Diseases
Myocardial Infarction
Post-Myocardial Infarction Patients in Santa Catarina, Brazil - Catarina Heart Study
Prospective cohort evaluating patients in the State of Santa Catarina (Brazil) with the diagnosis of the first acute myocardial infarction from July 2016 until December 2020.
- Trial name
- Catarina (NCT03015064)
- Testing
- Myocardial Infarction
- Where
- Brazil
- Volunteers
- 1,426 people
- Sponsor
- Instituto de Cardiologia de Santa Catarina
Heart Failure
Finerenone Plus SGLT2 Inhibitors in Heart Failure
The goal of this clinical study is to evaluate whether adding finerenone to standard treatment with a sodium-glucose cotransporter-2 (SGLT2) inhibitor provides additional benefits in patients with heart failure.
- Trial name
- FIN-SGLT2-HF (NCT07351864)
- Testing
- Finerenone, dapagliflozine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
STEMI
Impact of Cardio-Selective Beta-Blockers on Infarct Size After Acute Myocardial Infarction
Introduction: The effect of intravenous beta-blockers on the extent of the necrotic area, after primary percutaneous transluminal coronary angioplasty (PTCA), for acute myocardial infarction is not well established.
- Trial name
- BLOCK-AMI (NCT07293832)
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aristotle University Of Thessaloniki
Noonan Syndrome
Research Study Using Recombinant Human Insulin-Like Growth Factor-1/Recombinant Human Insulin-Like Growth Factor Binding Protein-3 for Children With Noonan Syndrome
The trial will investigate the treatment of growth failure in children with Noonan syndrome. Abnormalities in the growth hormone (GH) - insulin-like growth factor-I (IGF-I) axis resulting in low IGF-I levels have been suggested…
- Trial name
- NCT00351221
- Testing
- rhIGF-1/rhIGFBP-3
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Insmed Incorporated
Heart Failure
The Validity and Reliability of the Turkish Version of the Heart Failure Somatic Perception Scale
The aim of this study is to evaluate The Validity and Reliability of the Turkish Version of the Heart Failure Somatic Perception Scale in patients with heart failure.
- Trial name
- NCT06681714
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Hacettepe University
Post-cardiac Surgery
Clinical Pilates (CP) Exercises and Kinesiophobia in CABG
To determine Effect of Clinical Pilates (CP) exercises on kinesiophobia and post-operative cardiopulmonary parameters in CABG patients.
- Trial name
- NCT06426914
- Testing
- Clinical Pilates, Cardiac Rehabilitation
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Aortic Stenosis, Conduction Disturbances
Systematic Ambulatory ECG Monitoring Following TAVI
This multicenter, prospective, randomized superiority trial will evaluate whether systematic 14-day ambulatory ECG monitoring following hospital discharge after transcatheter aortic valve implantation (TAVI) reduces the risk of…
- Trial name
- RECORDII (NCT07739316)
- Testing
- Ambulatory ECG monitoring
- Where
- Canada
- Volunteers
- 754 people
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Ekg Change Ischemia Lateral
Diagnostic Value of Electrocardiographic St-t Wave Changes in Patients With Chronic Stable Angina
The electrocardiogram (ECG) is a simple and non-invasive bedside diagnostic tool with a well-established role in the diagnosis of (CAD).
- Trial name
- ECG (NCT02027506)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Alexandria University
Targeted Temperature Management, Nursing Education
Serious Game for Improving Targeted Temperature Management Knowledge and Situational Awareness in Critical Care Nurses
This randomized controlled trial aims to evaluate the effectiveness of a serious game in improving targeted temperature management (TTM) knowledge and situational awareness among critical care nurses.
- Conditions
- Targeted Temperature Management, Nursing Education, Serious Game, Cardiac Arrest
- Trial name
- NCT07239206
- Testing
- Serious Game Intervention, Lecture-based Education
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Clinical Trial Center
Hypoxemic Respiratory Failure
High Flow Oxygen Therapy Versus Conventional Oxygen Therapy in Cardiac Surgery Patients
High flow oxygen therapy has been applied after extubation in cardiac surgery patients with uncertain efficacy. The current authors plan to conduct a prospective, randomized, controlled study of nasal high flow therapy (NHF)…
- Trial name
- NCT03282552
- Testing
- Nasal Cannula High Flow Oxygen
- Where
- Greece
- Volunteers
- 99 people
- Sponsor
- National and Kapodistrian University of Athens
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