Clinical trials: Disorder Related to Renal Transplantation
Disorder Related to Renal Transplantation, Exercise, Aerobic
Effect of the Inhibition of the Mammalian Target of Rapamycin on Metabolism and Exercise
This is an exploratory study based on the hypothesis that kidney transplant patients treated with an immunosuppressive therapy based on an inhibitor of the mammalian target of rapamycin (m-TOR) may increase resistance to physical…
- Conditions
- Disorder Related to Renal Transplantation, Exercise, Aerobic, Muscle Strength
- Trial name
- EXETOR (NCT01561404)
- Testing
- Everolimus
- Where
- Spain
- Volunteers
- 3 people
- Sponsor
- Josep M Cruzado
Unspecified Complication of Kidney Transplant, Disorder Related to Renal Transplantation
Sun Protection of Kidney Transplant Recipients
This study is being done to evaluate the effectiveness of a Sun Protection Strategies internet-based program for kidney transplant recipients.
- Trial name
- NCT01646099
- Testing
- Internet-based sun protection education
- Where
- United States
- Volunteers
- 335 people
- Sponsor
- Northwestern University
Disorder Related to Renal Transplantation, Diabetes
Prevention of Diabetes After Transplantation by Vildagliptin in the Early Post-transplant Period
Post-transplant diabetes affects 15 to 20% of renal transplant patients and contributes to increased morbidity and reduced survival of transplants and patients.
- Trial name
- PRODIG (NCT02849899)
- Testing
- Vildagliptin
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
End Stage Renal Disease, Renal Transplant Rejection
MRI in Renal Transplantation
Renal transplantation is the optimal method of treatment for end stage kidney disease however median lifespan of a kidney transplant is around 15 years.
- Conditions
- End Stage Renal Disease, Renal Transplant Rejection, Kidney Transplant Failure and Rejection, Chronic Kidney Diseases
- Trial name
- TransRASL (NCT03705091)
- Testing
- Magnetic resonance imaging
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- NHS Greater Glasgow and Clyde
Disorder Related to Renal Transplantation
Efficacy of Certican® in Combination With Myfortic® in Renal
The primary objective is to demonstrate the superiority of everolimus plus Myfortic® plus corticosteroids following CNI withdrawal at week 16 compared to tacrolimus plus Myfortic® plus corticosteroids as measured by the change in…
- Trial name
- HUSJ1 (NCT01399242)
- Testing
- Certican
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital Universitário São José
Disorder Related to Renal Transplantation, Chronic Kidney Disease
Contribution of Renal Function to Endothelial Dysfunction in Living Kidney Donors and Transplant Recipients
Endothelial dysfunction one-year after transplantation mainly depends on transplant-associated factors and only marginally on reduced renal function.
- Conditions
- Disorder Related to Renal Transplantation, Chronic Kidney Disease, Endothelial Dysfunction
- Trial name
- CONFUCIUS (NCT02515643)
- Testing
- Endothelial dysfunction
- Where
- 4 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
End-stage Renal Disease (ESRD), Kidney Transplantation
Microbiota Changes Related to Outcomes in Kidney Transplantation
Chronic kidney disease affects approximately 10% of the world population. End-stage renal disease (ESRD) is associated with immune dysregulation, chronic inflammation, and alteration of the gut and urinary microbiota.
- Trial name
- MICRO-KT (NCT07893691)
- Testing
- Fecal samples, Urinary sample, Blood samples
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Pre-kidney Transplant, Living Donor Kidney Transplantation
Proteinuria and Renal Perfusion in Renal Transplant Recipients
Cardiovascular disease remains one of the major cause of mortality in renal transplant recipients, with the rate of cardiac death 10-times higher than that of the general population.
- Conditions
- Pre-kidney Transplant, Living Donor Kidney Transplantation, Renal Perfusion, End Stage Renal Disease
- Trial name
- NCT06051812
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Disorder Related to Renal Transplantation
Study of the Effect of N-acetyl Cysteine on the Renal Graft Function Biomarkers (IL18, NGAL)
The purpose of this study is to investigate the effect of (NAC) N-Acetyl Cysteine on biomarkers of Delayed Graft Function (DGF), including Neutrophil Gelatinase Associated Lipocalin (NGAL) and Intereleukin 18 (IL18).
- Trial name
- NCT01403506
- Testing
- N-acetyl Cysteine
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Polyomavirus Infections
Impact of Immunosuppressive Regimens on Polyomavirus-related Transplant Nephropathy
The aim of this study is to characterize and evaluate risk factors of polyomavirus nephropathy (PVN) including the impact of three immunosuppressive regimens.
- Trial name
- NCT00160966
- Testing
- Ciclosporin and Mycophenolate-mofetil, Tacrolimus and Mycophenolate-mofetil, Tacrolimus and Mycophenolate-mofetil with change from Mycophenolate-mofetil to Everolimus
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- University of Giessen
Disorder Related to Renal Transplantation, Effects of Immunosuppressant Therapy
Prospective Donor Specific T Response Measurment for IS Minimization in de Novo Renal Transplantation
The main objective of the study is to demonstrate the utility and safety of the IFN-γ (Interferon Gamma) ELISPOT (Enzyme-linked immunosorbent spot) marker for the stratification of kidney transplant recipients into low and high…
- Trial name
- NCT02540395
- Testing
- Tacrolimus (for Group B), MMF (mycophenolate mofetil) (for Group B), 6-methyl prednisolone (Steroids) (for Group B)
- Where
- 8 sites in Czechia, France and 4 more
- Volunteers
- 184 people
- Sponsor
- Prof. Dr. Petra Reinke
Liver Transplant
A Multicentre, Randomised, Open-label, Controlled, 12-month Follow-up Study to Assess Impact on Renal Function of an Immunosuppression Regimen Based on Tacrolimus Minimisation in Association With Everolimus in de Novo Liver Transplant Recipients.
Assuming greater efficacy in the prevention of acute rejection in the EVR arm with minimisation of TAC levels, the hypothesis of the present trial was that the introduction of EVR in combination with the minimisation of TAC…
- Trial name
- REDUCE (NCT02040584)
- Testing
- Minimisation of TAC, TAC + MMF + corticosteroids
- Where
- 20 sites in Spain
- Volunteers
- 217 people
- Sponsor
- Novartis Pharmaceuticals
Disorder Related to Renal Transplantation, Cytomegalovirus Infections
Sirolimus Associated With Tacrolimus at Low Doses in Elderly Kidney Transplant Patients
There is no consensus on the best immunosuppressive regimen in elderly people. The aim of this study will be to evaluate the efficacy of sirolimus associated with tacrolimus in elderly kidney transplant recipients.
- Trial name
- NCT02683291
- Testing
- sirolimus, tacrolimus, mycophenolate
- Volunteers
- 48 people
- Sponsor
- Associação Médico Espírita de Botucatu
Unspecified Complications of Kidney Transplant, Disorder Related to Renal Transplantation
Evaluation of Sun Protection Education for Kidney Transplant Recipients
This study is being done to evaluate the effectiveness of a Sun Protection Strategies workbook for kidney transplant recipients.
- Trial name
- NCT01844713
- Testing
- Workbook
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Northwestern University
Disorder Related to Renal Transplantation, Hypercholesterolemia
The Rosuvastatin In TrAnsplant Recipients Study
Renal transplant recipients need life long immunosuppression and one of the new drugs is everolimus. Everolimus is a potent immunosuppressive drug and one of the main side-effects are increased blood cholesterol levels.
- Trial name
- RITA (NCT01524601)
- Testing
- Rosuvastatin
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- University of Oslo School of Pharmacy
Disorder Related to Renal Transplantation
Orientation of the Lymphocyte Response to the Occurrence of Atherosclerotic Complications After Kidney Transplantation
The incidence of atherosclerotic complications is increased after kidney transplantation. Traditional risk factors do not fully explain this increased risk.
- Trial name
- ORLY-Est (NCT02843867)
- Testing
- blood sample
- Where
- 7 sites in France
- Volunteers
- 1,150 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Kidney Transplant Patients
Observational Single-center Study of the Relationship Between Arterial Hypertension and Hypervolemia Defined by Self-measurement of Impedancemetry in Kidney Transplant Patients With Transplantation Less Than 6 Months Old
The working hypothesis is that hypertension during the first post-transplant trimester is partly explained by the patient's hypervolemia.
- Trial name
- HTAôConnect (NCT05039788)
- Testing
- Measurement of systolic and diastolic blood pressure, impedancemetry, weight, creatinemia and Pro-BNP measurements
- Where
- France
- Volunteers
- 57 people
- Sponsor
- Nantes University Hospital
Disorder Related to Renal Transplantation
Anti-thymocyte Globulin-induced Immune Senescence
The aim of the study is to investigate the impact of Anti-Thymocyte Globulin (ATG) on immune senescence. Markers of immune senescence expression is assessed in a prospective cohort of renal transplant recipients the day of…
- Trial name
- SIGAL (NCT02857907)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 97 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Disorder Related to Renal Transplantation, Cancer
Study of Specific CD4 Tumors Th1 Responses in Renal Transplant After Occurrence of Cancer
As early complications of transplantation (acute rejection and infections) were better controlled and that the survival of kidney transplants has increased, chronic complications of immunosuppression became increasing challenges.
- Trial name
- TRAK (NCT02843763)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Disorder Related to Renal Transplantation
Phase IV Study to Evaluate Calcineurin Inhibitor Reduced, Steroid Free Immunosuppression After Renal Transplantation
Current practice of immune suppressive standard therapy after renal transplantation in non-risk patients is a triple therapy consisting of steroids, a calcineurin inhibitor and MMF.
- Trial name
- Harmony (NCT00724022)
- Testing
- Basiliximab, Tacrolimus, MMF, Prednisolon, Basiliximab, Tacrolimus, MMF, Tacrolimus, MMF, rATG
- Where
- 25 sites in Germany
- Volunteers
- 600 people
- Sponsor
- University Hospital Freiburg