Clinical trials: Disorder of Consciousness
Fatigue, Low Mood
A Study to Evaluate the Effects of a Beef Liver Supplement on Energy, Mood, and Mental Clarity
This is a randomized, triple-blind, placebo-controlled clinical trial evaluating the effects of the Ancestral Supplements Grass Fed Beef Liver oral supplement on energy, mood, and mental clarity over 12 weeks.
- Conditions
- Fatigue, Low Mood, Mental Clarity, Iron Deficiency
- Trial name
- NCT07892911
- Testing
- Intervention
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ancestral Supplements, LLC
Psychological Distress, Psychological Well-being
Two Sessions of Coach-Delivered Core Transformation for Distress and Well-Being
The goal of this study is to learn if Core Transformation, a guided coaching process, lowers psychological distress in adults. It will also look at well-being, daily functioning, and whether any changes last over time.
- Trial name
- NCT07879196
- Testing
- Core Transformation Process
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Andreas NLP (Legal Entity - Real People Press)
Consciousness, Level Altered
Investigating Near-Threshold Perception During Ultrasonic Deep Brain Stimulation
This research is studying changes in awareness and metabolism in the brain that may take place in various brain regions stimulated with ultrasound (low-intensity focused ultrasound pulsation or LIFUP) while undergoing magnetic…
- Trial name
- NCT07840521
- Testing
- Low-intensity focused ultrasound pulsation (LIFUP), Functional Magnetic Resonance Imaging (fMRI), Magnetic Resonance Spectroscopy
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Metabolic Syndrome, Inactivity/Low Levels of Exercise
Impact of Lifestyle on Health Maintenance: A Randomized Controlled Trial
This study aims to evaluate the impact of public health interventions on changes in healthy lifestyle habits over time and their subsequent effects on health outcomes.
- Conditions
- Metabolic Syndrome, Inactivity/Low Levels of Exercise, Unhealthy Diet, Unhealthy Alcohol Use
- Trial name
- LifeHealth-RCT (NCT07314957)
- Testing
- Intervention of physical activity, Mediterranean Diet Education, Behavioral: Stress-Resilience Training
- Where
- Croatia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Zadar
Disorder of Consciousness, Comatose
Prognostication of Recovery in Early Disorders of Consciousness Study
The goal of this study is to determine the extent to which neuroimaging metrics (e.g., functional MRI) are associated with the current level of consciousness, and future consciousness recovery, in patients with disorders of…
- Conditions
- Disorder of Consciousness, Comatose, Coma; Prolonged, Vegetative State
- Trial name
- PREDICT (NCT07074678)
- Testing
- Functional MRI (fMRI)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Depression
Cognitive Control Training for Depression
Depression is frequently characterized by patterns of inflexible, maladaptive, and ruminative thinking styles; these patterns themselves are thought to result from a combination of decreased attentional control, decreased…
- Trial name
- NCT01454141
- Testing
- Cognitive Control Training, Peripheral Vision Task
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Disorders of Consciousness
Spontaneous Eye Blinking in Disorders of Consciousness
Differential diagnosis between Unresponsive Wakefulness Syndrome (UWS) and Minimally Conscious State (MCS) is complicated due to severe cognitive and/or sensorimotor deficits in these patients.
- Trial name
- Blink-DoC (NCT06323031)
- Where
- 8 sites in Belgium, Germany and 2 more
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Disorders of Consciousness, Acquired Brain Injury
Spontaneous Eye Blinking Evaluation for Cognitive Assessment of Individuals With Severe Acquired Brain Injury
Assessment of consciousness and attention in individuals with severe Acquired Brain Injury (sABI) is crucial for planning rehabilitation, but it is often hindered by coexisting sensory-motor and/or cognitive-behavioural…
- Trial name
- SEE-ABI (NCT06464549)
- Testing
- EEG-EOG recording at rest and during an auditory oddball paradigm
- Where
- 2 sites in Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Alfonso Magliacano
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness
fNIRS for Disorders of Consciousness
The goal of this observational study is to learn whether functional near-infrared spectroscopy (fNIRS) can measure brain activity in healthy adults and in people with disorders of consciousness (DoC) in the neuro-intensive care…
- Conditions
- Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness, Coma, Minimally Conscious State
- Trial name
- NCT07485361
- Testing
- Functional Near-Infrared Spectroscopy Monitoring
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Traumatic Brain Injury (TBI) Patients, Severe Traumatic Brain Injury
SeeMe: Using Automated Facial Tracking to Detect Voluntary Behavior in Brain Injury
Objective: This prospective interventional study introduces "SeeMe," an automated, high-resolution computer vision platform designed to objectively quantify microscopic, auditory command-evoked movements in patients with…
- Trial name
- NCT07560631
- Testing
- SeeMe Multimodal Auditory Command Protocol
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Individuals Aged 60 and Over, Individuals Who Are Physically and Mentally Suitable to Practice Pranayama Breathing Technique
Effects of Pranayama Breathing Technique on Stress Level, Sleep Quality, and Quality of Life Among Older Adults
Aging is associated with progressive tissue deterioration resulting from a continuous decline in the ability to renew homeostatic cell regeneration and replace cells lost during tissue damage.
- Conditions
- Individuals Aged 60 and Over, Individuals Who Are Physically and Mentally Suitable to Practice Pranayama Breathing Technique, Individuals Without a Malignant Respiratory System Disease (Such as Bronchial and Lung Cancer), Individuals Without a Pathological Condition Affecting Their Level of Consciousness and Concentration
- Trial name
- NCT07451756
- Testing
- Pranayama group
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Namik Kemal University
Depressed Mood, Toddler Sleep
Sleep Parenting, Maternal Depression, and Toddler Sleep
This study examined the relationship between maternal depression and toddler sleep. The moderating role of sleep parenting practices in the relationship was also explored.
- Trial name
- NCT07426536
- Testing
- Beck Depression Inventory-II, Brief Infant Sleep Questionnaire-Revised, Background data sheet
- Where
- Taiwan
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University
Anesthesia, Healthy
REcovery From DEXmedetomidine-induced Unconsciousness
This pilot study in healthy volunteers aims to determine if biological sex has an impact on recovery from dexmedetomidine-induced unconsciousness, and if transcranial magnetic stimulation combined with electroencephalography…
- Conditions
- Anesthesia, Healthy, Consciousness, Level Altered
- Trial name
- REDEX (NCT06003127)
- Testing
- Transcranial Magnetic Stimulation-Electroencephalography
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Consciousness Disorders
Micro-expressions in Patients With Prolonged Disorders of Consciousness
The goal of this observational study is to learn about the microexpressions in patients with prolonged disorders of consciousness.
- Trial name
- NCT06088628
- Testing
- Facial expression; Electroencephalogram; MRI
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Consciousness Disorders
Micro-movements in Patients With Prolonged Disorders of Consciousness
The goal of this observational study is to learn about the micro-movements in patients with prolonged disorders of consciousness.
- Trial name
- NCT06406413
- Testing
- micro-movement; electroencephalogram; MRI
- Where
- China
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Disorders of Consciousness
Resting State fMRI in Disorders of Consciousness
Disorders of consciousness (DoC) remain a major clinical challenge in which high rates of misdiagnosis and difficult prognostication stem from limitations in the ability to access the disordered physiological processes mechanisms…
- Trial name
- NCT05463029
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Disorders of Consciousness
Diagnosis Value of Interoceptive EEG Indicators by Rectal Stimulation in DoC
Study on the Significance and Value of Interoception-Related Indicators in the Classification of Patients with Disorders of Consciousness (DoC) via Rectal Stimulation
- Trial name
- NCT07208942
- Testing
- Rectal Stimulation
- Where
- 2 sites in China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- YiLin Zhao
Coma
Beneficial Effects of Music on Cognition and Consciousness Level
Exposure to music improves cognitive function in 'healthy' participants and in brain-damaged patients. However, it is still difficult to understand what precisely in music causes a positive effect : are they emotional components…
- Trial name
- MUSICOREVEIL (NCT02742506)
- Testing
- Electroencephalography (EEG)
- Where
- France
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Major Depressive Disorder, Low Mood
Positive Feedback vs. No-Feedback Games for Behavioral Change
We aim to investigate here whether we can develop a reinforcement learning game which provides game-based feedback to encourage positive actions (behaviors) both inside and outside of the game.
- Trial name
- NCT06025838
- Testing
- positive feedback
- Where
- United States
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Bard College
Disorders of Consciousness
What is the Perceived Role of Risk in DOC Healthcare.
Critical ethnography exploring how decisions are made on behalf of people in disorder of consciousness (DOC). Prospective longitudinal case study design including observation, field interview and video reflexive ethnography.
- Trial name
- NCT06647433
- Testing
- Observation
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham