Clinical trials: Disorder of Upper Respiratory System
Cough
C-reactive Protein (CRP)-Guided Management Algorithm for Adults With Acute Cough
We aim to evaluate the impact of a CRP-guided management algorithm for adults with acute cough illness. More specifically, we will examine both process of care and clinical outcomes: 1.
- Trial name
- NCT00221351
- Testing
- CRP point of care testing
- Where
- 2 sites in United States
- Volunteers
- 139 people
- Sponsor
- University of California, San Francisco
Common Cold, Gastroenteritis
Echinacea, Propolis and Vitamin C for URI Prevention in Preschoolers
We hypothesize the herbal preparation will enhance the preschoolers' immune response and when taken prophylactically for 12 weeks will decrease episodes of upper respiratory infections and gastroenteritis in the active versus the…
- Trial name
- NCT00231218
- Testing
- dietary supplement--echinacea, propolis, and vitamin c
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Thyroid Cancer, Mediastinal Diseases
Lateral Approach for Mediastinal Lymph Node Dissection in Thyroid Cancer
Despite the numerous surgical approaches available for superior mediastinal lymph node dissection in thyroid cancer, many of these methods still have significant limitations.
- Conditions
- Thyroid Cancer, Mediastinal Diseases, Lymph Node Metastasis
- Trial name
- NCT06793579
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Chongqing General Hospital
Upper Respiratory Tract Infections
Probiotic Trial for URTI Prevention in Healthy Adults
This randomized, double-blind, placebo-controlled clinical trial in generally healthy adults aged 18-65 years will compare the incidence of upper respiratory tract infections (URTIs) over 16 weeks between probiotic supplement and…
- Trial name
- NCT07908797
- Testing
- Probiotic Formula
- Where
- Greece
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Upper Respiratory Infections
Warming Sensation Intensity and Acceptability of the Flavour, Local Tolerability of Paracetamol 500 mg + Pseudoephedrine 30 mg Syrup in Patients Suffering a URTI
This is an open label, in-use study to assess the warming sensation, acceptability and local tolerability of paracetamol 500 mg + pseudoephedrine 30 mg syrup, given as a single dose in subjects suffering from symptoms of an upper…
- Trial name
- NCT01586962
- Testing
- IFF flavor 316 282, Paracetamol, Pseudoephedrine
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Novartis
Chronic Cough (CC), Upper Airway Cough Syndrome
Inhaled vs Intranasal Corticosteroids for Chronic Cough in Upper Airway Cough Syndrome
Chronic cough - a cough lasting eight weeks or longer - is one of the most common reasons people see a lung specialist. It can disturb sleep, make conversation difficult, and reduce quality of life.
- Conditions
- Chronic Cough (CC), Upper Airway Cough Syndrome, Chronic Rhinitis
- Trial name
- NCT07777796
- Testing
- Budesonide (400μg/d), Mometasone Furoate 50mcg Nasal Spray
- Where
- Poland
- Volunteers
- 56 people
- Sponsor
- Silesian University of Medicine
Obstructive Sleep Apnea
Correlation Between Upper Airway Endoscopy and Physiological Traits of Obstructive Sleep Apnea
OBJECTIVES To train and test a mathematical model to predict complete concentric collapse at the level of the palate (CCCp, primary) and other sites of upper airway collapse (secondary) during drug-induced sleep endoscopy (DISE)…
- Trial name
- NCT04753684
- Where
- Belgium
- Volunteers
- 181 people
- Sponsor
- University Hospital, Antwerp
Superior Sulcus Tumor, Non-small Cell Lung Cancer Stage IIB
Efficacy and Safety of CRT, Durvalumab and Surgery for SST
The safety and efficacy of multimodality treatment of pre- and post-operative durvalumab therapy after pre-operative chemoradiotherapy for resectable superior sulcus tumor (SST) and durvalumab maintenance therapy after…
- Conditions
- Superior Sulcus Tumor, Non-small Cell Lung Cancer Stage IIB, Non Small Cell Lung Cancer Stage III
- Trial name
- DEEP_OCEAN (NCT04465968)
- Testing
- Cisplatin, S1, concurrent radiotherapy
- Volunteers
- 84 people
- Sponsor
- National Cancer Center Hospital East
Upper Extremity Paresis, Stroke, Chronic
Non-invasive Trigeminal and Vagus Nerve Stimulation for Stroke Subjects With Chronic Upper Extremity Deficits
This is a single-center, multiphase pilot study of 16 subjects with residual upper extremity deficits at least six months after a supratentorial ischemic or hemorrhagic stroke.
- Trial name
- NCT06288217
- Testing
- NeuraStasis Stimulator System (Non-Invasive Trigeminal and Vagus Nerve Stimulation), Upper Limb Rehabilitation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- NeuraStasis, Inc
Infectious Diseases, Healthy Subjects
Effect of the Consumption of a Fermented Milk on Common Infections in Shift-workers
This single-center, randomized, double-blind and controlled study aims to examine the effect of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel® = tested product) on the incidence of…
- Conditions
- Infectious Diseases, Healthy Subjects, Respiratory Tract Infections, Sore Throat
- Trial name
- NCT01033799
- Testing
- Fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel®), Non fermented dairy product (control)
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Influenza
Immunogenicity and Safety Study to Evaluate Different Formulations of GSK Biologicals' Influenza Vaccine GSK576389A
In order to find the formulation leading to a maximal increase of the immune response while maintaining an acceptable safety profile, this study is designed to evaluate the immunogenicity, safety and reactogenicity of the…
- Trial name
- NCT00540592
- Testing
- GlaxoSmithKline Biologicals' influenza vaccine GSK576389A, Fluarix
- Where
- 30 sites in Germany, Netherlands and 2 more
- Volunteers
- 2,007 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obesity, Bariatric Surgery
Obesity: Prospective Evaluation of Upper Airway Obstruction and Compliance in Obese Patients in Pre and Post Bariatric Surgery
This clinical trial is a monocentric, prospective, observational and controlled trial (historical cohort control group of healthy non-obese subjects who had Nasal functional exploration for Snoring) as part of current care.
- Trial name
- OBANEZ (NCT03360565)
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lymphedema of Upper Limb
Evaluation of Respiratory Parameters in Patients With Upper Limb Lymphedema
The aim of our study is to assess disease severity, respiratory muscle strength, respiratory functions, pectoralis minor muscle shortening, functionality, and quality of life (QoL) in patients with upper limb lymphedema (ULL)…
- Trial name
- NCT06568978
- Testing
- Assessments of respiratory parameters
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Respiratory Syncytial Virus Infections
A Study of 3 Lots of an Investigational Vaccine Against Respiratory Syncytial Virus (RSV) in Adults Aged 60 Years and Above
The purpose of this study is to assess the lot-to-lot consistency in terms of immunogenicity and evaluate the safety and reactogenicity of 3 lots of the RSVPreF3 OA investigational vaccine administered as a single dose in adults…
- Trial name
- NCT05059301
- Testing
- RSVPreF3 OA investigational vaccine
- Where
- 19 sites in United States, Canada and 1 more
- Volunteers
- 770 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Upper Aerodigestive Tract Cancer
Interventional Study Collecting Quantitative and Qualitative Data About Patient With Non Treated Cancer
This study aims to determine the impact of sociocognitive and emotional factors on the time of the initial consult
- Trial name
- DEREDIA (NCT01647477)
- Testing
- interview, questionnaires
- Where
- 6 sites in France
- Volunteers
- 90 people
- Sponsor
- Centre Oscar Lambret
Human Influenza
Safety and Immunogenicity of a Cell Derived Subunit Trivalent Nonadjuvanted Influenza Study Vaccine in Adults Aged 18 Years and Above
The present study is designed to confirm the safety and immunogenicity of cell-derived, trivalent, surface antigen, inactivated influenza vaccine in 2 age cohorts: 18 to ≤60 years and ≥61 years and the antibody response to each…
- Trial name
- NCT01880697
- Testing
- TIVc
- Where
- Germany
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Bronchial Asthma, Adherence, Medication
Efficacy of a Phone Application on Treatment Adherence in Asthmatic Patients in Upper Egypt
asthma adherence is mandatory for disease control
- Trial name
- NCT06233123
- Testing
- the Medisafe android application (https://www.medisafe.com).
- Volunteers
- 180 people
- Sponsor
- Assiut University
Healthy Subjects, Chronic Obstructive Pulmonary Disease
Multicenter Study of Impulse Oscillometry in Chinese
The purpose of this study is to establish the reference values of impulse oscillometry (IOS) in healthy Chinese, and compare the indices of IOS in patients with lung disease, such as chronic obstructive pulmonary disease (COPD)…
- Conditions
- Healthy Subjects, Chronic Obstructive Pulmonary Disease, Asthma, Interstitial Lung Disease
- Trial name
- NCT03467880
- Testing
- Clinical Observation
- Where
- 2 sites in China
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
COVID-19
A Study to Evaluate Safety and Immunogenicity of Inactivated SARS-CoV-2 Vaccine (Vero Cells) in Healthy Population Aged 18 Years and Above(COVID-19)
This study is a randomized, double-blinded, and placebo controlled phase Ⅱ clinical trial of the SARS-CoV-2 inactivated vaccine to evaluate the safety and immunogenicity of the experimental vaccine in healthy adults ⩾18 years.
- Trial name
- NCT04756323
- Testing
- medium dosage inactivated SARS-CoV-2 vaccine, high dosage inactivated SARS-CoV-2 vaccine
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Minhai Biotechnology Co., Ltd
Obstructive Sleep Apnea
Effect of Upper Airway Stimulation on Vascular Function in Obstructive Sleep Apnea
This study will evaluate the effect of hypoglossal nerve stimulation (HGNS) on different measures of cardiovascular function in patients with obstructive sleep apnea (OSA).
- Trial name
- NCT03051165
- Testing
- Hypoglossal Nerve Stimulation Treatment Withdrawal
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Emory University