Clinical trials: Disorder of Upper Respiratory System
Myalgia, Apnea, Obstructive Sleep
Temporomandibular Disorder (TMD) Pain in Response to Jaw Advancement in People With TMD and Obstructive Sleep Apnea
The purpose of this study is to characterize the course of temporomandibular disorder (TMD) pain in adults with TMD and obstructive sleep apnea (OSA), all of whom are being treated with mandibular advancement splint (MAS)…
- Trial name
- NCT02685202
- Testing
- Mandibular advancement splint
- Volunteers
- 9 people
- Sponsor
- University of North Carolina, Chapel Hill
Acute Upper Respiratory Infection, Signs and Symptoms
Comparison of Supportive Therapies for Symptom Relief From Pediatric Upper Respiratory Infections (URIs)
This is a nonblinded randomized controlled trial which is a survey-based comparison between supportive treatments for symptom relief from pediatric upper respiratory infection (URI).
- Trial name
- NCT01814293
- Testing
- Handheld humidifier
- Where
- United States
- Sponsor
- University of California, San Francisco
Influenza, Pneumonia
Oseltamivir Randomised Controlled Efficacy Trial
Background In preparation for a global influenza pandemic, there is an urgent need for representative data from populations and settings where the pandemic is most likely to arise.
- Conditions
- Influenza, Pneumonia, Lower Respiratory Tract Infection, Upper Respiratory Tract Infection
- Trial name
- NCT00707941
- Testing
- Oseltamivir
- Where
- Bangladesh
- Volunteers
- 1,190 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Upper Respiratory Tract Infections, Gastrointestinal Infection
Preventive Effect of Cow's Milk Fermented With Lactobacillus Paracasei CBA L74 on Common Infectious Diseases in Children
this is a double-blind randomized placebo controlled clinical trial. 200 healthy children aged 12-48 months, attending day care or preschool for at least 5 days a week, regularly checked by the family pediatrician (FP) involved…
- Conditions
- Upper Respiratory Tract Infections, Gastrointestinal Infection, Children, Only
- Trial name
- FERCT19 (NCT05484102)
- Testing
- milk fermented with lactobacillus paracasei CBA L74
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Bari
Obstructive Sleep Apnea
Effects of Lung Volume on Upper Airway Patency During Drug Induced Sleep Endoscopy
Obstructive sleep apnea (OSA) is a disorder where a person has recurrent choking episodes during sleep. Surgery can treat OSA and drug induced sleep endoscopy (DISE) is a procedure that surgeons use to evaluate the throat while a…
- Trial name
- DISE-Pulm (NCT05350332)
- Testing
- Negative Pressure Ventilator, Pulmonary Function Testing (PFT), Transcutaneous Phrenic Nerve Stimulation
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Emory University
Critically Ill, Obstructive Sleep Apnea
Predictors of Upper Airway Function and Sleep-disordered Breathing in the Critically Ill
This is part 2 of the #NCT01618240 under the same IRB protocol #2010P001919. The primary objective of this study is to examine factors that are related to sleep-disordered breathing and upper airway patency in critically ill…
- Trial name
- NCT02112604
- Testing
- Ventilator, Alice PDx, Pulmonary function test
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Undernutrition, Surgery
Respiratory Muscle Training in Malnourished Patients Undergoing Abdominal Surgery
Malnutrition affects 50% of hospitalized patients around the world and causes changes in respiratory muscles predisposing the development of pulmonary complications probable, because of the ineffectiveness of cough.
- Trial name
- NCT02200198
- Testing
- Expiratory muscle training, Inspiratory muscle training
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- University of Sao Paulo General Hospital
Post-infectious Cough
Oral Corticosteroids for Post-infectious Cough in Adults
The purpose of this study is to assess whether a 5-day treatment with orally administered prednisone provides patient-relevant benefits by improving the cough-related QoL of patients with post-infectious cough triggered by an…
- Trial name
- OSPIC (NCT04232449)
- Testing
- PREDNISON Galepharm Tabl. 20 mg
- Where
- 2 sites in Switzerland
- Volunteers
- 32 people
- Sponsor
- University Hospital, Basel, Switzerland
Multiple Sclerosis
Proprioceptive Neuromuscular Facilitation in Multiple Sclerosis
Multiple Sclerosis (MS) is an autoimmune central nervous system disease characterized by inflammation, demyelination, and axonal degeneration.
- Trial name
- NCT05342025
- Testing
- PNF, Breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Biruni University
Cystic Fibrosis, Muscle Strength
Muscle Strength, Functional Capacity, Respiratory Function and Quality Of Life In Cystic Fibrosis Patients
This study was designed to investigate the relationship between upper extremity muscle strength and endurance, functional capacity, and quality of life child and adolescent with cystic fibrosis
- Conditions
- Cystic Fibrosis, Muscle Strength, Pulmonary Function, Functional Capacity
- Trial name
- NCT04734743
- Testing
- cystic fibrosis
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Cagtay Maden
Influenza
Study to Evaluate Immunogenicity and Safety of an Investigational Influenza Vaccine (H1N1) in Adults
The objective of the study is to evaluate the immunogenicity and safety of GSK Biologicals' investigational vaccine GSK2340272A.
- Trial name
- NCT00968526
- Testing
- GSK investigational vaccine GSK2340272A
- Where
- Belgium
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Asthma
Safety and Tolerability of Omalizumab in Patients With Mild to Moderate Asthma
This study will evaluate the safety and efficacy of omalizumab against asthma attacks in mild to moderate allergic asthma
- Trial name
- NCT00546143
- Testing
- Omalizumab
- Where
- 5 sites in Germany, South Africa
- Volunteers
- 32 people
- Sponsor
- Novartis
COVID-19, Vaccine-Preventable Diseases
The Efficacy of the 2023-2024 Updated COVID-19 Vaccines Against COVID-19 Infection
The purpose of this research study is to find out how well two different 2023-2024 updated COVID-19 vaccines protect people from COVID-19 (the disease caused by the SARS-CoV-2 virus), and to determine if getting a 2023-2024…
- Conditions
- COVID-19, Vaccine-Preventable Diseases, SARS CoV 2 Infection, Upper Respiratory Tract Infection
- Trial name
- BEEHIVE (NCT06065176)
- Testing
- Novavax COVID-19 vaccine (2023-2024 formula XBB containing), Pfizer COVID-19 mRNA vaccine (2023-2024 formula XBB containing)
- Where
- United States
- Volunteers
- 1,188 people, healthy volunteers welcome
- Sponsor
- Sarang K. Yoon, DO, MOH
Recurrent Upper Respiratory Tract Infections, Iron Deficiency Anemia
Iron Supplementation Outcome on Recurrent Upper Respiratory Tract Infections in 6-15 Years Old Egyptian School Children
Recurrent upper respiratory infections ( RURTIs) are common in school aged children. An adequate iron status might reduce their prevalence.
- Trial name
- NCT02398968
- Testing
- iron fumerate
- Where
- Egypt
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
SCLC, Extensive Stage
Utidelone in Third-line and Above Treatment of Small Cell Lung Cancer
SCLC has a very high degree of malignancy, and 60% to 70% of patients are diagnosed as extensive stage. The median survival of patients with limited-stage disease is about 15-20 months, and the median OS of patients with…
- Trial name
- NCT05299255
- Testing
- Utidelone
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Henan Cancer Hospital
Common Cold
Evaluation of the Efficacy and Safety of Two Ibuprofen Combination Products for the Treatment of the Common Cold and Flu in Latin America
This is a multicenter, prospective, randomized, double-blind, triple-dummy, parallel group, comparative, study designed to evaluate the efficacy of Ibuprofen (IBU) 200 mg/ Phenylephrine (PE) 10 mg and IBU 200 mg/ PE 10 mg/…
- Trial name
- NCT01938144
- Testing
- Advil Congestion Relief, Advil Allergy and Congestion Relief, Paracetamol
- Sponsor
- Pfizer
Sepsis, Viral Pneumonia
Discover the Immune Signature of Sepsis Caused by Acute Pulmonary Infection: A Cohort Study
The goal of this observational study is to describe the immune signature of acute pulmonary infection.The main questions it aims to answer are: 1. Nasal mucosal immune response in patients with influenza infection 2.
- Conditions
- Sepsis, Viral Pneumonia, Influenza, Upper Respiratory Tract Infection
- Trial name
- DISPLAY (NCT05612893)
- Testing
- pathogen
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
COVID-19
Safety and Immunogenicity Study of COVID-19 Protein Subunit Recombinant Vaccine Adjuvanted With Alum+CpG 1018
The study is an observer-blind, randomized, controlled prospective intervention study of Phase I. The primary objective is to evaluate the safety and immunogenicity of the SARS-CoV-2 protein subunit recombinant vaccine adjuvanted…
- Trial name
- NCT05228613
- Testing
- SARS-CoV-2 protein subunit recombinant vaccine, SARS-CoV-2 inactivated vaccine
- Where
- 2 sites in Indonesia
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- PT Bio Farma
Upper Respiratory Tract Infection
To Compare the Efficacy and Tolerability of A. Paniculata/A. Chilensis in Individuals With URTI
Conventional therapy of upper respiratory tract infection (URTI) is not always effective and sometimes leads to side effects and also to inappropriate use of antibiotic.
- Trial name
- A Paniculata (NCT04955327)
- Testing
- A. Paniculata, A. Chilensis, A. Paniculata and A. Chilensis
- Where
- 5 sites in India
- Volunteers
- 225 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Obstructive Sleep Apnea Syndrome
Upper Airway Physical Therapy for the Treatment of Obstructive Sleep Apnea
The purpose of this study is to determine the effectiveness and feasibility of upper airway muscle physical therapy utilizing negative airway pressure (NAP) breathing training in patients with Obstructive Sleep Apnea Syndrome…
- Trial name
- NCT02109731
- Testing
- Negative airway pressure delivery
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Rochester