Clinical trials: Disorder of Vein
Venous Leg Ulcer, Diabetic Foot Ulcer
A Study to Evaluate the Clinical Performance, Safety and Pharmacology Effect of EscharEx in Patients With Lower Leg Ulcers
This study will be a multicenter, prospective, open label, one-arm study intended to assess the clinical performance and safety of EX-02 in debridement of lower leg ulcers: Venous Leg Ulcers (VLU) and Diabetic Foot Ulcer (DFU).
- Trial name
- NCT04817228
- Testing
- EscharEx (EX-02 formulation)
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- MediWound Ltd
Cirrhosis, Portal Hypertension Related to Cirrhosis
Effects of Metformin on Hepatic Venous Pressure Gradient in Patients With Cirrhosis and Portal Hypertension
Portal hypertension (PHT) is defined by an elevated pressure gradient between the portal vein and the hepatic veins ≥ 5 mm Hg, and is the main vector of complications in cirrhosis.
- Trial name
- Hyper-Met (NCT06687265)
- Testing
- Metformin
- Where
- France
- Volunteers
- 76 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Adult Primary Hepatocellular Carcinoma, Localized Unresectable Adult Primary Liver Cancer
Bevacizumab in Treating Patients With Unresectable Nonmetastatic Liver Cancer
This phase II trial is to see if bevacizumab works in treating patients who have unresectable nonmetastatic liver cancer that has not spread to the main portal vein.
- Conditions
- Adult Primary Hepatocellular Carcinoma, Localized Unresectable Adult Primary Liver Cancer, Recurrent Adult Primary Liver Cancer
- Trial name
- NCT00055692
- Testing
- bevacizumab
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- National Cancer Institute (NCI)
Atrial Fibrillation, Deep Vein Thrombosis
Weekly Monitoring Strategy of Capillary INR Versus Monthly Monitoring Strategy of Venous INR in Elderly Patients in a Nursing Home.
This primary care study aims to compare the "time in therapeutic range" (TTR) of two strategies for monitoring the international normalized ratio (INR) over 6 months in nursing homes.
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Stroke
- Trial name
- INR-CAP (NCT05561244)
- Testing
- Weekly monitoring using the capillary International Normalised Ratio strategy
- Where
- 33 sites in France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
End Stage Renal Disease, Vascular Access Patency
Determine the Safety/Efficacy of Ticagrelor for Maintaining Patency of Arterio-Venous Fistulae Created for Hemodialysis
This study is a randomized, placebo-controlled, single blind clinical trial. Seventy patients with ESRD on chronic HD and a functioning AVF will be recruited.
- Trial name
- NCT02335099
- Testing
- ticagrelor
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Virginia
Atrial Fibrillation; Paroxysmal Atrial Fibrillation; Persistent Atrial Fibrillation
Pulsed Field Ablation of Atrial Fibrillation: CENTAURI Versus FARAPULSE
The aim of this study is to compare the efficacy of two commercially available pulsed field ablation (PFA) systems for catheter ablation of atrial fibrillation.
- Trial name
- NCT07902739
- Testing
- CENTAURI PEF system, FARAPULSE system
- Where
- Czechia
- Volunteers
- 325 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Alzheimer's Disease
Deep Cervical Lymphovenous Anastomosis for Moderate Alzheimer's Disease
This is a multicenter, prospective, open-label, endpoint-blinded randomized controlled clinical study. We aim to evaluate the safety and efficacy of deep cervical lymphovenous anastomosis (LVA) combined with routine treatment for…
- Trial name
- LYMVA-AD (NCT07658430)
- Testing
- Deep cervical lymphovenous anastomosis (LVA), Routine Treatment
- Where
- China
- Volunteers
- 296 people
- Sponsor
- Southwest Hospital, China
Chronic Venous Disease
Effectiveness of a Nursing Intervention Program for Patients Undergoing Ultrasound-Guided Foam Sclerotherapy
Chronic venous disease can cause pain, swelling, functional limitations, and reduced health-related quality of life. Ultrasound-guided foam sclerotherapy is commonly used to treat venous insufficiency.
- Trial name
- NCT07787065
- Testing
- Structured Nursing Intervention Program
- Where
- Spain
- Volunteers
- 79 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Cirrhosis, Hypertension
Warfarin Prevents Portal Vein Thrombosis in Liver Cirrhotic Patients With Hypersplenism After Laparoscopic Splenectomy
The purpose of this study is to determine whether Warfarin Anticoagulation are effective and safe in Prevention of Portal Vein Thrombosis in Liver Cirrhotic Patients with Hypersplenism after Laparoscopic Splenectomy.
- Conditions
- Cirrhosis, Hypertension, Venous Thrombosis, Status; Splenectomy
- Trial name
- ESWA (NCT02238444)
- Testing
- Warfarin, Dipyridamole, Aspirin
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yangzhou University
Venous Ulcer
Immediate Versus Early Endovenous Ablation In Venous Ulcer
The study is conducted to assess the effects of immediately started foam sclerotherapy in venous ulcer compared to early intervention.
- Trial name
- NCT03795064
- Testing
- Foam sclerotherapy, Endothermal ablation
- Where
- Finland
- Volunteers
- 23 people
- Sponsor
- Oulu University Hospital
Congestive Heart Failure
Clinical Study of the EASYTRAK 3 Spiral Fixation Coronary Venous Bipolar Pace/Sense Lead
The purpose of this clinical investigation was to assess the safety and effectiveness of the EASYTRAK 3 lead
- Trial name
- NCT00158938
- Testing
- EASYTRAK 3 left ventricular pacing lead
- Volunteers
- 115 people
- Sponsor
- Boston Scientific Corporation
Pulmonary Embolus/Emboli, Thromboembolism, Pulmonary
Venous Phase Dual Energy CT in Patients Suspected for Pulmonary Embolism.
Venous phase spectral or dual energy (DE) chest computed tomography (CT) in patients with suspected pulmonary embolism (PE) compared to standard computed tomography pulmonary angiography (CTPA): sensitivity, evaluation of iodine…
- Trial name
- NCT04859478
- Testing
- Dual energy / spectral portal venous chest computed tomography
- Where
- 2 sites in Denmark
- Volunteers
- 160 people
- Sponsor
- Copenhagen University Hospital at Herlev
Chronic Headache, Nutcracker Phenomenon, Renal
Lumbar Vein Embolization for Chronic Headaches With Nutcracker Physiology
The purpose of this research is to gather information on the safety and feasibility of coiling the lumbar vein for the treatment of chronic headaches in patients with Nutcracker physiology and retrograde lumbar vein flow with…
- Conditions
- Chronic Headache, Nutcracker Phenomenon, Renal, Nutcracker Syndrome, Renal
- Trial name
- NCT06077747
- Testing
- Coil Embolization of the Lumbar Vein
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mayo Clinic
Stroke (CVA) or TIA, Headache, Migraine
Onabotulinum Toxin A (Botox) for the Treatment of Persistent Post-Stroke and Vascular Headache
Post stroke headache occurs in approximately 10-23% of all stroke patients. Its onset is shortly after experiencing a stroke, or stroke like event, and persists for at least three months.
- Conditions
- Stroke (CVA) or TIA, Headache, Migraine, Botulinum Toxins, Type A, Cerebral Venous Sinus Thrombosis
- Trial name
- NCT04580238
- Testing
- Botox 200 UNT Injection, Non Botox based Standard of Care Treatments for Headache/Migraine
- Where
- Canada
- Sponsor
- University of Alberta
Heart Failure, Chronic Obstructive Pulmonary Disease
Primary Care-Hospital Embedding: a Prospective, Multicentric, Observational Study
This is a multicentric, prospective, observational study with two cohorts and adjunctive procedure. It aims at collecting and analyzing data about the function of an innovative hospital-territory integration health service for…
- Conditions
- Heart Failure, Chronic Obstructive Pulmonary Disease, Diabetes Mellitus, Pneumonia
- Trial name
- PRIME (NCT05723185)
- Testing
- Outpatient visit
- Where
- Italy
- Volunteers
- 246 people
- Sponsor
- Rovere Querini Patrizia
Arterio-venous Fistula
Usefulness of Doppler Ultrasound Carried Out by the Vascular Surgeon After Loco-regional Anesthesia for Preferred Access
Preoperative vascular mapping with echo-Doppler is acknowledged as indispensable to create an arteriovenous fistula for haemodialysis (AVF).
- Trial name
- NCT04978155
- Testing
- Duplex ultrasound performed by the surgeon after locoregional anesthesia
- Where
- France
- Volunteers
- 193 people
- Sponsor
- University Paul Sabatier of Toulouse
Emergency Medical Service, Out-of-Hospital Cardiac Arrest
Venous Injection Compared To intraOsseous Injection During Resuscitation of Patients With Out-of-hospital Cardiac Arrest
Overall survival of patients after out-of-hospital cardiac arrest (*OHCA*) is less than 10% worldwide and in Taiwan. Interventions provided by the emergency medical system (*EMS*) before arrival at the hospital are of paramount…
- Conditions
- Emergency Medical Service, Out-of-Hospital Cardiac Arrest, Vascular Access, Intraosseous Access
- Trial name
- VICTOR (NCT04135547)
- Testing
- intra-osseous access vs. intra-venous access
- Where
- Taiwan
- Volunteers
- 1,732 people
- Sponsor
- National Taiwan University Hospital
Venous Leg Ulcer
Feasibility and Tolerance Study for the Treatment of Varicose Ulcers by Cyanoacrylate Glue (ETUVVE)
Ulcers of the lower limbs are a major public health problem whose management needs to be further improved, particularly in terms of healing time, prevalence and recurrence rate.
- Trial name
- ETUVVE (NCT04714749)
- Testing
- Endovenous treatment, Cyanoacrylate glue
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Clinique Pasteur
Long-Functioning Pancreas Allografts, Pancreas Transplant
Assessment of Insulin Production From Native Pancreas in Patients With Pancreas Transplants
This study will examine whether insulin-producing cells in the pancreas (beta cells) can recover in patients with type 1 diabetes who have had a pancreas transplant.
- Trial name
- NCT00246844
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Varicose Veins
Research on the Application of Nursing Intervention Based on ITHBC Theory in Postoperative Self-Management of Patients With Varicose Veins of the Lower Extremities
This study constructed a postoperative self-management nursing intervention program for VVLE patients based on the ITHBC theory, and explored the impact of this program on the patients' postoperative self-management ability…
- Trial name
- NCT07570277
- Testing
- Routine nursing, ITHBC-based self-management intervention for postoperative varicose veins
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
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