Clinical trials: Disorder of Vein
Venous Thrombosis
Comparison of Arixtra vs. Lovenox to Prevent Blood Clots in Medically Ill Patients
A total of 50 patients >40 yrs of age with an expected hospital stay in the Medical Intensive Care or Regional Heart Unit at LVH Muhlenberg of 6 days or longer will be enrolled.
- Trial name
- BRiEF (NCT00521885)
- Testing
- Arixtra (Fondaparinox) 2.5 mg SC Daily, Lovenox 40mg SC Daily
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Lehigh Valley Hospital
Venous Thromboembolism, Venous Thrombosis
Intermittent Pneumatic Compression in Surgical Patients at Extremely-high Risk for Venous Thromboembolism
The aim of the study is to evaluate efficacy and safety of venous thromboembolism prophylaxis by the combination of graduated compression stockings (GCS), standard doses of low-molecular-weight heparins (LMWH) and sequential…
- Trial name
- IPCSUPER (NCT03044574)
- Testing
- SCD, GCS, LMWH
- Where
- 2 sites in Russia
- Volunteers
- 407 people
- Sponsor
- Pirogov Russian National Research Medical University
Varicose Ulcer
Negative Pressure Vs. Compression in Venous Ulcers
This study randomises patients with venous leg ulcers, to be managed either using conventional compression bandages or a bridged vacuum assisted closure system under compression.
- Trial name
- NCT03688841
- Testing
- Bridged V.A.C.® with compression therapy, Conventional Compression Therapy
- Where
- Ireland
- Volunteers
- 50 people
- Sponsor
- Western Vascular Institute, Ireland
Multiple Sclerosis
DECISIve - DiagnosE Using the Central veIn SIgn v1.0
DECISIve - DiagnosE using the Central veIn SIgn. A prospective diagnostic superiority study comparing T2* MRI and lumbar puncture in patients presenting with possible Multiple Sclerosis
- Trial name
- DECISiVE (NCT05533905)
- Testing
- Lumbar puncture, MRI
- Where
- United Kingdom
- Volunteers
- 113 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Congestion, Heart Failure
Portal Vein Flow Variability to Quantify Right-Sided Hemodynamic Congestion (PORTAL)
This study evaluates the accuracy of a comprehensive venous Doppler echography including the portal vein pulsatility index (PVPI) to quantify invasively measured right-sided venous pressures.
- Conditions
- Congestion, Heart Failure, Right Heart Catheterisation, Central Venous Pressure
- Trial name
- PORTAL (NCT05411263)
- Testing
- Comprehensive transthoracic echocardiography, Doppler echography & Kino-cardiograph (Kino)
- Where
- Belgium
- Volunteers
- 61 people
- Sponsor
- Vrije Universiteit Brussel
Peripheral Arterial Disease, Venous Thormboembolism
VTE Incidence After Rivaroxaban + Aspirin or SAPT After Lower-limb Revascularization
Venous thromboembolism (VTE) has a high prevalence in patients with multiple comorbidities undergoing complex surgical procedures.
- Conditions
- Peripheral Arterial Disease, Venous Thormboembolism, Cardiovascular Diseases, Vascular Surgery Patient with PAD / Carotid Stenosis
- Trial name
- RESOLUTION (NCT06873321)
- Testing
- rivaroxaban 2.5 mg bid + aspirin 100 mg, clopidogrel 75 mg od for 3 months followed by aspirin 100 mg od for endovascular procedures or aspirin for open procedures
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Science Valley Research Institute
Hepatocellular Carcinoma
A Study to Evaluate Sintilimab Plus Lenvatinib as Adjuvant Therapy in Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis (PVTT) After Surgical Resection
To compare the impact on recurrence risk of adjuvant Sintilimab (a recombinant fully human anti-PD-1 monoclonal antibody) plus Lenvatinib for patients with hepatocellular carcinoma and portal vein tumor thrombus (PVTT ) after…
- Trial name
- NCT06089382
- Testing
- Sintilimab, Lenvatinib, Transarterial Chemoembolization (TACE)
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Tongji Hospital
Venous Disease Classification (CEAP): C2 or C3
EXPLORATORY ASSESSMENT OF THE EFFECTS OF CYCLO 3 ® FORT (Ruscus Extract, Hesperidin Methyl Chalcone, Ascorbic Acid) OR MICRONISED PURIFIED FLAVONOID FRACTION ON VASCULAR PARAMETERS AND BIOMARKERS IN WOMEN SUFFERING FROM CHRONIC VENOUS DISEASE (CEAP C2 OR C3), OVER 8 WEEKS
Chronic Venous Disorder is the most prevalent vascular disease. It is multifactorial pathology that has an important impact on quality of life and represents a significant public health concern, due to its very high frequency in…
- Trial name
- NCT02907320
- Testing
- CYCLO 3 ® FORT, MPFF
- Sponsor
- Pierre Fabre Medicament
Venous Leg Ulcer
A Study in Patients With Venous Leg Ulcers and Measuring the Effects of Using Geko™ Device
This is a single centre open label study measuring lower limb physiology in patients with venous leg ulcers at the University Hospital of South Manchester.
- Trial name
- NCT02884323
- Testing
- geko™ device
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Firstkind Ltd
Stroke, Acute, Venous Thromboembolism
GEKO Venous Thromboembolism Prevention Study
This multicentre, randomised geko™ venous thromboembolism (VTE) prevention study will prospectively collect clinical data on VTE occurrences in immobile patients after stroke, who will be randomised, on a 1:1 allocation, to…
- Conditions
- Stroke, Acute, Venous Thromboembolism, Deep Vein Thrombosis, Pulmonary Embolism
- Trial name
- NCT05476913
- Testing
- geko™ device
- Where
- 18 sites in United Kingdom
- Volunteers
- 1,200 people
- Sponsor
- Firstkind Ltd
Osteoarthritis, Deep Venous Thrombosis
Exercise and Cycle Ergometry Post TKA - A Randomized Controlled Trial
The purpose of this investigation is to examine the effect of, and improve patient compliance and motivation following total knee arthroplasty; to determine the efficacy of two post-surgical exercise programs on knee pain…
- Trial name
- NCT02265523
- Testing
- Cycle ergometer
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- Lakehead University
Catheters, Indwelling, Thrombosis
A Randomized Evaluation of the Effect of Routine Normal Saline Flush Versus Heparinized Saline Solution in Groshong and Groshong PICC Catheters
The Groshong and Groshong PICC catheters are popular venous access devices because they are maintained with only weekly saline flushes.
- Trial name
- NCT00001518
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Central Retinal Vein Occlusion
Assessing the Efficacy and Safety of Brolucizumab Versus Aflibercept in Patients With Visual Impairment Due to Macular Edema Secondary to Central Retinal Vein Occlusion
The purpose of this study was to evaluate the efficacy and safety of brolucizumab in treatment of patients with macular edema (ME) secondary to central retinal vein occlusion (CRVO).
- Trial name
- RAVEN (NCT03810313)
- Testing
- Brolucizumab 6 mg, Aflibercept 2 mg
- Where
- 120 sites in United States, Australia and 18 more
- Volunteers
- 493 people
- Sponsor
- Novartis Pharmaceuticals
Venous Thromboembolism
A Trial to Learn How Well REGN7508 Works for Preventing Blood Clots After a Knee Replacement in Adult Participants
This study is researching an experimental drug called REGN7508 (called "study drug"). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement (TKR) surgery.
- Trial name
- ROXI-VTE II (NCT06454630)
- Testing
- REGN7508, Enoxaparin
- Where
- 14 sites in Bulgaria, Hungary and 3 more
- Volunteers
- 179 people
- Sponsor
- Regeneron Pharmaceuticals
Deep Vein Thrombosis
New Clinical Score for Deep Vein Thrombosis
A new Clinical Score (CS) to rule out Deep Vein Thrombosis (DVT) has to be derived and internally validated (with bootstrap method), from patients suspected of DVT in Italy.
- Trial name
- NCT05680636
- Testing
- temperature measurement
- Where
- Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Accademia Italiana Medicina Osteopatica
Acute Kidney Injury, Continuous Renal Replacement Therapy
Continuous Veno-venous Hemodialysis and Continuous Veno-venous Hemodiafiltration on Urea Reduction Rate in Intensive Care Patient
In patients requiring renal replacement therapy (RRT) in the intensive care unit (ICU), continuous techniques are predominantly using due to better hemodynamic tolerance.
- Conditions
- Acute Kidney Injury, Continuous Renal Replacement Therapy, Intensive Care Unit
- Trial name
- CompEER (NCT06369064)
- Testing
- CVVHD Dialysis parameters, CVVHDF Dialysis parameters
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Idiopathic Intracranial Hypertension
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension
Idiopathic intracranial hypertension (IIH) is a condition characterized by an increase in intracranial pressure (ICP), papilledema with a risk of permanent visual loss, and severe headaches that profoundly affect quality of life.
- Trial name
- BEHIND (NCT06059703)
- Testing
- Blood punction, Central blood sampling, Intracranial pressure measurement
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Adenocarcinoma, Rectal Diseases
Molecular, Pathologic and MRI Investigation of the Prognostic and Redictive Importance of Extramural Venous Invasion in Rectal Cancer (MARVEL) Trial
Extramural venous invasion (EMVI) is the spread of microscopic tumour cells into the veins around the tumour. Rectal cancer treatment has improved greatly over recent years.
- Conditions
- Adenocarcinoma, Rectal Diseases, Colorectal Neoplasms, Adenocarcinoma, Mucinous
- Trial name
- MARVEL (NCT01995942)
- Where
- 19 sites in United Kingdom
- Volunteers
- 246 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Coronary Artery Disease, Hemodynamic Monitoring
Single Transpulmonary Thermodilution and Continuous Monitoring of Central Venous Oxygen Saturation During Off-pump Coronary Surgery
The aim of the present study was to evaluate the usefulness of an algorithm based on hemodynamic parameters obtained by single transpulmonary thermodilution (STD) combined with continuous monitoring of central venous oxygen…
- Conditions
- Coronary Artery Disease, Hemodynamic Monitoring, Goal Directed Therapy
- Trial name
- OPCAB (NCT00624494)
- Testing
- Conventional monitoring, Advanced monitoring
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Northern State Medical University
Chronic Kidney Disease Requiring Hemodialysis, End Stage Renal Disease (ESRD)
Early Feasibility Study of the Velocity™ Percutaneous Arterio-Venous Fistula System for Creating Hemodialysis Vascular Access
The Velocity Percutaneous Arterio-Venous System is a minimally invasive method of creating hemodialysis vascular access. The study aims to understand clinical efficacy and initial clinical safety data of the device.
- Trial name
- VENOS-2 (NCT06712251)
- Testing
- Velocity pAVF System
- Where
- 5 sites in United States
- Volunteers
- 20 people
- Sponsor
- Venova Medical
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