Clinical trials: Disseminated Fungal Infection
Invasive Pulmonary Aspergillosis, COPD
Voriconazole for IPA in Chinese Patients With COPD
voriconazole is recommended as first-line therapy for invasive pulmonary aspergillosis, however the efficacy and safety of voriconazole for treating invasive pulmonary aspergillosis secondary to COPD is not clear.
- Trial name
- VIA-COPD (NCT02234739)
- Testing
- Voriconazole
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Red Cross Hospital, Hangzhou, China
Fungal Disease
A Real-world Prospective Observational Study on the Efficacy and Safety of L-AmB(Liposomal Amphotericin B) for br- IFD(Breakthrough Invasive Fungal Disease) in Children and Adolescent Patients With Hematological Malignancies Receiving Triazoles or Echinocandins Prophylaxis
The goal of this observational study is to evaluate the efficacy the favorable response rate and safety of L-AmB(liposomal amphotericin B) for the treatment of br-IFD(breakthrough invasive fungal disease) in Chinese children and…
- Trial name
- NCT07357038
- Testing
- Patients received the Drug: liposomal amphotericin B（AmBisome） for treatment
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Sepsis, Bacteremia
Clinical Evaluation of Novel Biomarkers in Patients With Septicemia
The protein ST2 is a member of the interleukin-1 receptor family. Blood concentrations of the soluble isoform of ST2 (sST2) are increased in inflammatory and heart diseases and are considered a prognostic marker in both.
- Conditions
- Sepsis, Bacteremia, Fungemia
- Trial name
- NOBIS (NCT01359891)
- Where
- Austria
- Volunteers
- 750 people
- Sponsor
- Medical University of Graz
Lyme Disease
Direct Diagnosis of Disseminated Lyme Borreliosis.
Lyme borreliosis is a bacterial multisystemic infection transmitted by an Ixodes tick. It affects the skin, the joint and the brain.
- Trial name
- DIALYD (NCT04719962)
- Testing
- Targeted proteomics in skin +/- cerebrospinal or synovial fluid to diagnose disseminated Lyme disease
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Strasbourg, France
Invasive Candidiases
ECMM Candida Registry - CandiReg
The objective of the European Confederation of Medical Mycology - ECMM Candida Registry (CandiReg) is to overcome the lack of knowledge on epidemiology, clinical course, and molecular characteristics of invasive infections due to…
- Trial name
- CandiReg (NCT03450005)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- University of Cologne
Mycobacterium Avium-Intracellulare Infection, HIV Infections
A Study of Viracept in AIDS Patients With Mycobacterium Avium Complex Disease (MAC)
The purpose of this study is to see if it is safe and effective to give Viracept to AIDS patients who are being treated for MAC.
- Trial name
- NCT00002170
- Testing
- Nelfinavir mesylate
- Where
- 5 sites in United States
- Sponsor
- Agouron Pharmaceuticals
Candidiasis, Invasive
Safety, Tolerability, and Efficacy of Caspofungin Versus Amphotericin B Deoxycholate in the Treatment of Invasive Candidiasis in Neonates and Infants (MK-0991-064)
The study will evaluate the safety, tolerability, and efficacy of caspofungin as compared with amphotericin B deoxycholate in the treatment of invasive candidiasis in neonates and infants.
- Trial name
- NCT01945281
- Testing
- Caspofungin, Amphotericin B Deoxycholate
- Volunteers
- 51 people
- Sponsor
- Merck Sharp & Dohme LLC
Invasive Fungal Infections
Usefulness of PET-CT for Invasive Fungal Infection
The goal of this national multicenter prospective cohort study is to learn about the added value of 18F-FDG (18F-2-fluoro-2-deoxy-D-glucose) PET-CT in invasive fungal disease management.
- Trial name
- PETIFI (NCT05688592)
- Testing
- PET-CT
- Where
- 14 sites in Spain
- Volunteers
- 224 people
- Sponsor
- Puerta de Hierro University Hospital
Candidiasis
Early Clinical Experience With Anidulafungin In Patients With Liver Disease In The United Kingdom
The purpose of this study is to describe the real world effectiveness of anidulafungin in clinical practice in a large Liver Unit in the United Kingdom.
- Trial name
- NCT01202253
- Testing
- anidulafungin
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Pfizer
Aspergillosis, Invasive Fungal Infection
Isavuconazole (BAL8557) for Primary Treatment of Invasive Aspergillosis
The purpose of this study is to compare the efficacy and safety of isavuconazole versus voriconazole in the treatment of patients with invasive aspergillosis.
- Trial name
- NCT00412893
- Testing
- Isavuconazole, Voriconazole
- Where
- 107 sites in United States, Argentina and 24 more
- Volunteers
- 527 people
- Sponsor
- Astellas Pharma Inc
Breast Cancer, Chronic Myeloproliferative Disorders
Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer
RATIONALE: Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing. Combining chemotherapy and peripheral stem cell transplantation with biological therapy may kill more cancer…
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Kidney Cancer
- Trial name
- NCT00003408
- Testing
- aldesleukin, recombinant interferon alfa, sargramostim
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cancer Treatment Centers of America
Invasive Candidiasis
Pharmacokinetics of Micafungin in Patients of Intensive Care Units
Invasive fungal infections (IFIs) are a frequent cause of morbidity and mortality in high-risk patients, such as immunocompromised patients.
- Trial name
- MI-K (NCT02164890)
- Testing
- micafungin
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Limoges
Candidiasis
Caspofungin to Prevent Candidiasis in Adults in Hospital Intensive Care Units
This study will examine whether the anti-fungal drug caspofungin can prevent Candida infections in adult patients in intensive care units (ICUs).
- Trial name
- NCT00099775
- Testing
- Caspofungin
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- National Cancer Institute (NCI)
Pulmonary Invasive Fungal Infections, Pulmonary Invasive Aspergillosis
Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
This study will establish a non-invasive diagnostic approach and evaluate clinical outcomes for children at high-risk for pulmonary invasive fungal infection (PIFI).
- Trial name
- DOMINIC (NCT03827694)
- Testing
- Non-Invasive Testing for PIFI
- Where
- 33 sites in United States, Canada
- Volunteers
- 400 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Aspergillosis, Invasive Pulmonary Aspergillosis
Voriconazole And Anidulafungin Combination For Invasive Aspergillosis In Pediatric Subjects
This study aims to compare the safety, tolerability, and efficacy of voriconazole and anidulafungin in combination versus voriconazole alone in pediatric subjects aged 2 to 17 years with invasive aspergillosis.
- Conditions
- Aspergillosis, Invasive Pulmonary Aspergillosis, Neuroaspergillosis
- Trial name
- NCT01188759
- Testing
- Voriconazole, Anidulafungin
- Sponsor
- Pfizer
Plasma Administration, Invasive Fungal Infection
Association of Plasma Transfusions and Invasive Fungal Infection
Although lacking strong evidences, plasma transfusions are commonly used in critically ill neonates. To date, the relationships between plasma transfusions and nosocomial infection remain controversial and no study has reported…
- Conditions
- Plasma Administration, Invasive Fungal Infection, Neonatal Infection
- Trial name
- PT (NCT03149562)
- Testing
- plasma transfusions, non-plasma transfusions
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Candidemia, Invasive Candidiasis
Non-Conventional Microbiological Methods in the Diagnosis of Candidemia
This study evaluates the diagnostic value of non-conventional microbiological methods for early detection of candidemia and invasive candidiasis in adult hospitalized patients with suspected invasive fungal infection.
- Trial name
- NCT07422155
- Testing
- Candida Diagnostic Testing Panel
- Where
- Slovenia
- Volunteers
- 2 people
- Sponsor
- Institute of Oncology Ljubljana