Clinical trials: Disseminated Intravascular Coagulation
Sepsis, Venous Thromboembolism
An Observational Study in the United States to Learn How Venous Thromboembolism, Disseminated Intravascular Coagulation, and Sepsis Are Related
This is an observational study in which data already collected from people with venous thromboembolism (VTE) due to sepsis (blood poisoning) are studied.
- Conditions
- Sepsis, Venous Thromboembolism, Disseminated Intravascular Coagulation
- Trial name
- NCT06765681
- Testing
- Diagnosis of both VTE and sepsis
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Bayer
Fibrinogen, Spine Deformity
Effect of Prophylactic Fibrinogen Concentrate In Scoliosis Surgery
EFISS is a prospective, randomized, placebo-controlled trial testing the feasibility, safety and efficacy of prophylactic administration of fibrinogen in paediatric spinal surgery.
- Conditions
- Fibrinogen, Spine Deformity, Coagulopathy, Consumption, Bleeding
- Trial name
- EFISS (NCT05391412)
- Testing
- Fibrinogen Concentrate Human
- Where
- Czechia
- Volunteers
- 32 people
- Sponsor
- Brno University Hospital
Sepsis, Coagulopathy
A Study to Learn About How Safe BAY 3389934 is, Its Suitable Dose, and How it Affects the Participants With Sepsis Induced Coagulopathy
Researchers are looking for a better way to treat people who have sepsis induced coagulopathy. Sepsis happens when bacteria and their toxins spread in the blood, causing an infection.
- Trial name
- NCT06854640
- Testing
- BAY3389934
- Where
- 21 sites in United States, Belgium and 3 more
- Volunteers
- 36 people
- Sponsor
- Bayer
Septic Shock, Disseminated Intravascular Coagulation
Disseminated Intravascular Coagulation (DIC) Score and Organ Dysfunction in Septic Shock Patients
Septic shock is common complication in patients with critical illnesses, with higher incidence in low and medium income countries like ours.
- Trial name
- NCT06363149
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Sepsis Associated Disseminated Intravascular Coagulation (DIC)
A Study to Assess the Safety and Effects of Different Doses of an Investigational Drug, BAY 3389934, in Healthy Japanese Volunteers.
This study is designed to evaluate a new investigational drug, BAY 3389934, in healthy Japanese volunteers. The primary purpose is to see how safe the drug is and how well it is tolerated by the body when given at different…
- Trial name
- NCT07176728
- Testing
- BAY 3389934
- Where
- 2 sites in Japan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Bayer
Disseminated Intravascular Coagulation (DIC), Reanimation
EARLY DIAGNOSIS OF SEPTIC DIC
Disseminated Intravascular Coagulation is a severe complication of septic shock, associated with high mortality, whose diagnosis relies on complex scores that are rarely used in practice.
- Conditions
- Disseminated Intravascular Coagulation (DIC), Reanimation, Septic Shock
- Trial name
- EASY-DIC (NCT07630415)
- Where
- France
- Volunteers
- 492 people
- Sponsor
- University Hospital, Strasbourg, France
Sepsis, Disseminated Intravascular Coagulation (DIC)
Fluorescent Leukocytes as a Marker of Early Sepsis/Severity
Sepsis is a medical emergency whose prognosis depends on the early identification of patients at risk of septic shock, but the tools available in the Emergency Department remain insufficient.
- Conditions
- Sepsis, Disseminated Intravascular Coagulation (DIC), Septic Shock
- Trial name
- FLAMES (NCT07585942)
- Where
- France
- Volunteers
- 492 people
- Sponsor
- University Hospital, Strasbourg, France
Septic Shock, Coagulopathy
Study Assessing Efficacy of Plasmatherapy in Septic Shock-induced Coagulopathy: Feasibility Study
No randomized controlled trial (RCT) has investigated the effect of prophylactic fresh frozen plasma (FFP) transfusion in septic or critically ill patients with coagulation abnormalities.
- Conditions
- Septic Shock, Coagulopathy, Disseminated Intravascular Coagulation
- Trial name
- PlasmaFaisa (NCT04580563)
- Testing
- OctaplasLG®, 0.9% NaCl
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Sepsis, Disseminated Intravascular Coagulation
An Observational Study to Learn About the Occurrence of Disseminated Intravascular Coagulation Among Adults With Sepsis in Japan
This is an observational study in which data already collected from people with sepsis (blood poisoning) and/or disseminated intravascular coagulation (DIC) are studied.
- Trial name
- NCT06373159
- Testing
- No study intervention
- Where
- Japan
- Volunteers
- 5,740 people
- Sponsor
- Bayer
Hematologic Neoplasms, Solid Tumor Metastatic Cancer Advanced Cancer
Role of Fibrinolytic Activity in Neoplastic Pathologies Complicated by Coagulopathy
The aim of this research is to measure fibrinolytic activity in neoplastic pathologies in order to provide preliminary data on which to base a future, larger-scale study to determine predictive markers of complication in order to…
- Conditions
- Hematologic Neoplasms, Solid Tumor Metastatic Cancer Advanced Cancer, Disseminated Intravascular Coagulation
- Trial name
- NEO-COAG (NCT07234630)
- Testing
- An additional volume of blood will be drawn as part of routine follow-up care
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Strasbourg, France
Sepsis, Blood Coagulation Disorders
Analysis of the Coagulopathy Developed by COVID-19 Infected Patients
Increased D-dimers at admission of COVID-19 infected patients entering hospital due to a severe disease is a risk factor for death.
- Conditions
- Sepsis, Blood Coagulation Disorders, Thrombin, Disseminated Intravascular Coagulation
- Trial name
- COVID-TGT (NCT04356950)
- Testing
- Thrombin generation test assay, Fibrin generation markers assays
- Where
- 4 sites in France
- Volunteers
- 175 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
DISSEMINATED INTRAVASCULAR COAGULATION ASSOCIATED WITH SEPTIC SHOCK
EVALUATION OF NEUTROPHIL FLUORESCENCE IN PATIENTS WITH DISSEMINATED INTRAVASCULAR COAGULATION ASSOCIATED WITH SEPTIC SHOCK
Neutrophil fluorescence could be a reliable and early diagnostic marker of disseminated intravascular coagulation septic DIC, which can be used routinely.
- Trial name
- HEMATOCLOT (NCT07039487)
- Testing
- Blood sampling collection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Septic Shock, Platelet Signal Processing Defect
PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock
Knowing the dramatic increase in thrombin generation during sepsis, our research hypothesis is that AMPK-induced ACC phosphorylation in platelets is increased and that this might modulate platelets metabolism and more…
- Conditions
- Septic Shock, Platelet Signal Processing Defect, Inflammatory Response, Disseminated Intravascular Coagulation
- Trial name
- PLACCSEPS (NCT04107402)
- Testing
- Assessment of coagulopathy, Platelets activation and Platelets-Neutrophils interplay
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Disseminated Intravascular Coagulation
Recombinant Human Antithrombin (ATryn®) in the Treatment of Patients With DIC Associated With Severe Sepsis
The primary objective of the study is to explore the efficacy and safety of ATryn® (antithrombin alfa) for the treatment of disseminated intravascular coagulation (DIC) associated with severe sepsis, when administered by…
- Trial name
- NCT00506519
- Testing
- Antithrombin alfa (INN name), Control (Standard treatment)
- Volunteers
- 25 people
- Sponsor
- LEO Pharma
Pit Viper Bite, Coagulopathy
Thrombelastography for Coagulopathy in Chinese Snakebites
This study aims to evaluate the coagulation disorders caused by pit viper bites in patients from Zhanjiang and surrounding areas.
- Conditions
- Pit Viper Bite, Coagulopathy, Thromboelastography (TEG), Venom-induced Consumptive Coagulopathy
- Trial name
- NCT06860503
- Where
- China
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hansung University
Sepsis, Septic Shock
Rotational Thromboelastometry Versus DIC Score in Sepsis
Sepsis results in activation of the coagulation system, which is commonly described as disseminated intravascular coagulation (DIC).
- Trial name
- RODSS (NCT04610853)
- Testing
- rotational thromboelastometry
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Leipzig
Immune Thrombocytopenia, Thrombotic Thrombocytopenic Purpura
Longitudinal Cohort of Thrombosis and Hemostasis Diseases
This is a multicenter, prospective, longitudinal, observational cohort study to investigate thrombosis and hemostasis diseases in Chinese patients.
- Conditions
- Immune Thrombocytopenia, Thrombotic Thrombocytopenic Purpura, Hemophilia A, Acquired, Disseminated Intravascular Coagulation
- Trial name
- NCT06727669
- Where
- 5 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Disseminated Intravascular Coagulation, Neonates
Predictive Value of Scoring System in Neonates with Disseminated Intravascular Coagulation
The aims of this study were to investigate underlying diseases associated with neonatal DIC diagnosed on the first 28 days of life, and whether DIC score could predict mortality in neonates.
- Trial name
- NCT06626880
- Volunteers
- 43 people
- Sponsor
- Assiut University
Gastric Cancer, Bone Marrow Metastasis
Infusional Fluorouracil and Weekly Docetaxel for Gastric Cancer With Bone Marrow Involvement and DIC
A distinctive subtype of gastric adenocarcinoma with extensive bone marrow metastasis and DIC has been described. Few patients have been treated properly due to the lack of standard care.
- Conditions
- Gastric Cancer, Bone Marrow Metastasis, Disseminated Intravascular Coagulation
- Trial name
- NCT04547153
- Testing
- 5-fluorouracil, Docetaxel
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Snake Bites, Coagulopathy, Consumption
Hemostatic Variables In Snakebite Study
Background Novelty The global assays of coagulation, namely the viscoelastometric tests and clot waveform has never been studied in detail before in snakebite victims.
- Trial name
- HISS (NCT04520282)
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Jubilee Mission Medical College and Research Institute