Clinical trials: Distal Femur Fractures
Distal Femur Fracture
Distal Femur Fx: ORIF(Open Reduction and Internal Fixation) vs DFR (Distal Femur Replacement Total Knee Arthroplasty)
Supracondylar femur periprosthetic fractures about a total knee arthroplasty (TKA) are a catastrophic and challenging complication of TKA and unfortunately are increasing in incidence.
- Trial name
- NCT05792189
- Testing
- Timed Up and Go Test on subjects with ORIF of distal femur fractures, Koos Jr assesment on subjects with ORIF of distal femur fractures, Timed Up and Go Test on subjects with DFR of distal femur fracture
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Hip Fracture
Influence of Static Distal Locking of a Short Proximal Femoral Nail
Prospective, comparative, randomized, double-blind study to evaluate the outcomes of trochanteric nailing in unstable hip fractures with and without a distal interlocking screw.
- Trial name
- NCT06357312
- Testing
- hip trochanteric nail
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Elda University Hospital
Distal Femur Fracture
Carbo-fix Lateral Plate Devices and Standard Plate-Nail Constructs in Distal Femur Fractures
The purpose of this randomized clinical trial is to decrease non-union rates in distal femur fracture fixation. Carbo-fix lateral femur plate and standard intramedullary nail-plate constructs have been shown to have lower…
- Trial name
- NCT07280169
- Testing
- Carbo-fix Lateral Plate Device, Standard Plate-Nail Construct
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Missouri-Columbia
Femoral Fracture
Retrograde Femoral Nail-Advanced Outcomes for Fixation of Distal Femur and Femoral Shaft Fractures
This project consists of a prospective and retrospective case series design. Study candidates will include all patients 18 years or older, who were evaluated at UCSD and found to have a distal femur or femoral shaft fracture…
- Trial name
- NCT05680987
- Testing
- RFN-Advanced Retrograde Femoral Nailing System
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Proximal (Subtrochanteric)Femoral Fractures, Distal Femoral Fractures
Evaluation of the Safety and Efficacy of a Guided Bone Regeneration Membrane for the Treatment of Femoral Fractures
Certain types of fractures require surgical intervention that may involve the use of bone grafts or bone graft substitutes. Many of the materials used as bone graft substitutes suffer from disadvantages such as soft tissue…
- Trial name
- NCT01687530
- Testing
- AMCA Bone Membrane.
- Where
- 2 sites in Israel
- Volunteers
- 48 people
- Sponsor
- RegeneCure, Ltd.
Distal Femur Fractures
Dynamic Locking Screws 5.0 vs. Standard Locking Screws in Fracture of Distal Femur Treated With Locked Plate Fixation
The purpose of this study is to evaluate the performance of Dynamic Locking Screws (DLS) used to stabilize the shaft component of distal femur fractures in comparison to standard locking screws (SLS).
- Trial name
- NCT01693367
- Testing
- DLS 5.0 (Dynamic locking screws), SLS (Standard locking screw)
- Where
- 12 sites in United States, Austria and 2 more
- Volunteers
- 5 people
- Sponsor
- AO Innovation Translation Center
Intertrochanteric Femur Fracture
Dynamic Versus Static Distal Interlocking In AO/OTA 31A2 Intertrochanteric Femur Fractures: A Prospective Randomized Controlled Trial
AO/OTA 31A2 intertrochanteric femur fractures are unstable injuries commonly treated with cephalomedullary nailing. However, the optimal distal locking configuration for short proximal femoral nails remains uncertain.
- Trial name
- Distal Locking (NCT07772271)
- Testing
- Dynamic Distal Interlocking Intramedullary Nailing, Static Distal Interlocking Intramedullary Nailing
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people
- Sponsor
- Bozyaka Training and Research Hospital
Femoral Fractures
Supracondylar Distal Femur Fractures and Abaloparatide
Supracondylar femur fractures in the geriatric population present a unique challenge to the orthopaedic surgeon both in terms of fixation, healing, and final extremity axial alignment.
- Trial name
- NCT04626141
- Testing
- Abaloparatide
- Where
- United States
- Sponsor
- Daniel Horwitz
Distal Femur Fractures
Single vs. Dual Implant Fixation for Distal Femur Fractures in Older or Compromised Adults
The goal of this clinical trial is to assess the feasibility of conducting a larger study comparing single implant fixation (SIF) and dual implant fixation (DIF) for treating distal femur fractures (DFF) in older or compromised…
- Trial name
- NCT06944964
- Testing
- Single Implant Fixation (SIF), Dual Implant Fixation (DIF)
- Where
- 2 sites in Canada
- Volunteers
- 44 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Articular Fractures
Single Versus Dual Implant Fixation of Distal Femur Fractures
The goal of this clinical trial is to compare two types of surgical fixation in patients with specific kinds of distal femur fractures.
- Trial name
- PRORP (NCT06286670)
- Testing
- Single Implant Fixation, Dual Implant Fixation
- Where
- 16 sites in United States
- Volunteers
- 144 people
- Sponsor
- Wake Forest University Health Sciences
Hip Fractures, Tibial Fractures
Go Fit Fast, Recovery Trajectory Using PROMIS®, Linking PROMIS®
Prospective data will be collected in approximately 3500 patients (700 per 5 injury groups). Patients will be followed up according to the standard (routine) for up to 1 year after the treatment.
- Conditions
- Hip Fractures, Tibial Fractures, Ankle Fractures, Humeral Fracture, Proximal
- Trial name
- NCT04113044
- Testing
- All treatments will remain the standard (routine) care procedures based on individual clinician's judgment and the patient characteristics.
- Where
- 15 sites in United States, Austria and 4 more
- Volunteers
- 1,500 people
- Sponsor
- AO Innovation Translation Center
Distal Radius Fracture, Osteoporosis
Utility of Cortical Bone Tissue Properties in the Assessment of Fracture Risk
The objective of this study is to determine whether a new minimally invasive method for in vivo measurement of cortical bone tissue properties can identify those who are at risk for fragility fractures of the hip and radius.
- Conditions
- Distal Radius Fracture, Osteoporosis, Hip Fractures
- Trial name
- NCT03076034
- Testing
- Reference Point Indentation
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Orthopedic Disorder, Trauma Injury
X-BS Ortho Bone Graft Study
Randomised investigation of the osteoconductive performance and safety of CE-marked FDBS bone graft (GraftR3®), with contextual reference to CE-marked IBS (MBCP® Putty), in the filling of orthopaedic bone defects.
- Conditions
- Orthopedic Disorder, Trauma Injury, Extremity Injury
- Trial name
- NCT06326827
- Testing
- FDBS (GraftR3®), IBS (MBCP® Putty)
- Volunteers
- 200 people
- Sponsor
- Advanced Medical Solutions Ltd.
Single Lateral Plate, Double Plating
Single Lateral Plate Versus Double Plating for the Fixation of Distal Femoral Fractures
This trial aimed to provide Level I evidence on the comparative effectiveness, safety, and functional outcomes of single versus double plating for distal femoral fractures.
- Conditions
- Single Lateral Plate, Double Plating, Fixation, Distal Femoral Fractures
- Trial name
- NCT07381725
- Testing
- Single lateral distal femoral locking compression plate, Double Plating
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Beni-Suef University
Distal Femur Fracture
Early Weight Bearing in Distal Femur Fractures
Assessment of the effect of double plating and single lateral plating on early weight bearing as a primary outcome and improving union and decreasing complications as secondary outcomes.
- Trial name
- NCT06806839
- Testing
- dual plating, single plating
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Assiut University
Distal Femur Fractures
Early Weight Bearing on Supracondylar Distal Femur Fractures in Elderly Patients
The investigators will be looking at geriatric distal femur fractures. The investigators will prospectively enroll these patients and allow patients to either weight bear as tolerated or limit their weight bearing post…
- Trial name
- NCT02475941
- Testing
- Non Weight bearing, Early Weight Bearing
- Where
- 6 sites in United States
- Volunteers
- 50 people
- Sponsor
- St. Louis University
Distal Femur Fracture
Far Cortical Locking Versus Standard Constructs for Distal Femur Fractures
To determine if Far Cortical Locking screws increase fracture healing rates at 3 months in Closed Distal Femur Fractures in adults when compared to Standard screw constructs.
- Trial name
- FCL (NCT01766648)
- Testing
- Far Cortical locking screw fixation, Standard screw fixation
- Where
- Canada
- Volunteers
- 167 people
- Sponsor
- University of British Columbia
Distal Femur Fracture
DIFFIR - Geriatric Distal Femur Fixation Versus Replacement
The current standard of care for most intra-articular distal femur fractures (above the knee joint) in geriatric patients is a surgical fixation using plates and screws to hold the fracture pieces in the correct position, until…
- Trial name
- DIFFIR (NCT04076735)
- Testing
- Distal femoral replacement, Surgical Fixation (ORIF)
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Unity Health Toronto
Proximal or Diaphyseal Humerus Fracture, Diaphyseal or Distal Femur Fracture
Observational Patient Registry of the Dynamic Locking Screws
The purpose of this multi-center patient registry is to obtain first clinical results and to assess short and mid-term clinical outcome data of patients treated with DLS.
- Conditions
- Proximal or Diaphyseal Humerus Fracture, Diaphyseal or Distal Femur Fracture, Diaphyseal, Distal or Proximal Tibia Fracture
- Trial name
- DLS (NCT02656628)
- Testing
- Dynamic Locking Screw 3.7mm and 5.0mm
- Where
- Australia
- Sponsor
- Synthes GmbH
Closed Supracondylar Fracture of Femur
Immediate Weight Bearing Versus Protected Weight Bearing in Supracondylar Distal Femur Fractures
This study is designed to examine if immediate weight bearing on a distal femur fracture fixed with a primary locking plate, either a distal condylar locking plate or a LISS (less invasive stabilization system), is safe and…
- Trial name
- WtBrFemFx (NCT03167099)
- Testing
- Full Weight Bearing
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- West Virginia University