Clinical trials: Distal Pancreatectomy
Distal Pancreatectomy, Postoperative Pancreatic Fistula
Intrapapillary Botulinum Toxin Injection for PREvention of Post-surgical PAncREactic Fistula
Surgery is required for the treatment of many pancreatic conditions, either malignant or benign. Mortality of pancreatic surgery can be up to 3% even in expert centers.
- Trial name
- PREPARE (NCT04220931)
- Testing
- botulinum toxin injection
- Where
- France
- Volunteers
- 460 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pancreatic Fistula, Distal Pancreatectomy Complications
An Evaluation of a New Technique Utilizing a Biologic Glue and Tissue Patch to Seal the Cut Edge of the Pancreas Following Removal of the Tail of the Pancreas
The purpose of this trial is to determine whether the use of an autologous falciform ligament patch combined with fibrin glue will reduce the rate of pancreatic fistula in patients completing distal pancreatectomy.
- Conditions
- Pancreatic Fistula, Distal Pancreatectomy Complications, Falciform Patch Pancreatic Closure, Fibrin Glue Pancreatic Closure
- Trial name
- NCT00889213
- Testing
- Falciform patch and fibrin glue application, standard pancreatic closure
- Where
- 2 sites in United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Pancreas Neoplasm Malignant Resectable
Laparoscopic Versus Open Distal Pancreatectomy for Pancreatic Cancer: a Multicenter Randomized Controlled Trial
When pancreatic cancer of the body and tail is diagnosed, a distal pancreatectomy is planned. This operation can be performed with open surgery, or with laparoscopic surgery.
- Trial name
- NCT03957135
- Testing
- Laparoscopic distal pancreatectomy, open distal pancreatectomy
- Where
- South Korea
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Pancreatic Cancer, Pancreatic Cystic Lesions
Trial Assessing Roux-en-Y Anastomosis of the Pancreatic Stump to Prevent Pancreatic Fistula Following Distal Pancreatectomy
The objective is to clarify Roux-en-Y anastomosis of the pancreatic stump decreases pancreatic fistula following distal pancreatectomy, compared with stapling closure of the pancreatic stump.
- Conditions
- Pancreatic Cancer, Pancreatic Cystic Lesions, Chronic Pancreatitis, Pancreatic Neuroendocrine Tumors
- Trial name
- NCT01384617
- Testing
- Stapling closure of the pancreatic stump, Roux-en-Y anastomosis of the pancreatic stump
- Where
- Japan
- Volunteers
- 136 people
- Sponsor
- Wakayama Medical University
Pancreatectomy
Attachable Coolingbis® for Distal Pancreatectomy
This pilot study evaluates the safety and technical feasibility of a new radiofrequency-assisted device, the Attachable Coolingbis® (ACB), when used during robotic distal pancreatectomy.
- Trial name
- NCT07687901
- Testing
- Internally-cooled bipolar radiofrequency device
- Volunteers
- 20 people
- Sponsor
- Hospital del Mar
Pancreaticoduodenectomy, Distal Pancreatectomy
Randomized Controlled Trial Comparing Closed-suction Drain Versus Passive Gravity Drain Following Pancreatic Resection
Pancreatic resection is the only potentially curative modality of treatment for pancreatic neoplasm. The mortality associated with this procedure decreased rapidly in the past decades.
- Trial name
- DRAPA (NCT01988519)
- Testing
- Closed gravity drain, closed suction drain
- Where
- 2 sites in Czechia
- Volunteers
- 223 people
- Sponsor
- University Hospital Hradec Kralove
Pancreatic Cancer
Randomized Trial of Restrictive Versus Liberal Perioperative Fluid Management for Patients Undergoing Pancreatic Resection
The purpose of this study is to help us learn what the best amount of fluid is that patients should receive during pancreas surgery.
- Trial name
- NCT01058746
- Testing
- restrictive perioperative fluid management, Liberal perioperative fluid management
- Where
- United States
- Volunteers
- 331 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Chronic Pancreatitis, Distal Pancreatectomy
A Phase IIa Study With Escalating Dose of MS1819-SD
This is a Phase IIa study sponsored by AzurRx SAS and Syneos Health is a local representative sponsor and involves testing of a new medication for the compensation of exocrine pancreatic insufficiency (EPI) caused by chronic…
- Trial name
- NCT03481803
- Testing
- MS1819-SD
- Where
- 6 sites in Australia, France and 1 more
- Volunteers
- 11 people
- Sponsor
- AzurRx SAS
Pancreatic Tumor, Benign, Pancreatic Neoplasms
Laser Tissue Welding - Distal Pancreatectomy Sealing Study
The laser tissue welding device is intended for use in patients requiring sealing of the pancreas after partial pancreatectomy, and including those patients who are fully heparinized or have hemodilutional coagulation failure.
- Conditions
- Pancreatic Tumor, Benign, Pancreatic Neoplasms, Pancreatic Adenocarcinoma, Pancreatic Pseudocyst
- Trial name
- LTW (NCT03147768)
- Testing
- Distal Pancreatectomy Sealing Using LTW
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Laser Tissue Welding, Inc.
Surgery
Learning Curves in Laparoscopic Distal Pancreatectomy: A Different Experience for Each Generation
This study compared the learning curves and outcome of Laparoscopic Distal Pancreatectomy between 'pioneers' and early adopters in terms of feasibility and proficiency using short term outcomes.
- Trial name
- NCT05595343
- Testing
- Laparoscopic distal pancreatectomy
- Volunteers
- 600 people
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
Pancreaticoduodenectomy, Distal Pancreatectomy
Randomized Trial of Early Versus Standard Drainage Removal After Pancreatic Resections
Despite a substantial decrease in postoperative mortality, morbidity after pancreatic resections is still high, even at high-volume centers.
- Conditions
- Pancreaticoduodenectomy, Distal Pancreatectomy, Pancreatic Fistula, Abdominal Abscess
- Trial name
- NCT00931554
- Testing
- Postoperative drain removal
- Where
- Italy
- Volunteers
- 114 people
- Sponsor
- Universita di Verona
Pancreatic Ductal Adenocarcinoma
Distal Pancreatectomy, Minimally Invasive or Open, for Malignancy (DIPLOMA)
Objective: To compare MIDP with ODP regarding radical resection rate for pancreatic ductal adenocarcinoma (PDAC) in the pancreatic body or tail.
- Trial name
- DIPLOMA (NCT04483726)
- Testing
- minimally invasive distal pancreatectomy, open distal pancreatectomy
- Where
- 5 sites in France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Montpellier
Pancreatic Surgery, Pancreatic Duct Stenting
Pancreatic Stent to Prevent Leak After Distal Pancreatectomy
The purpose of this study is to investigate an intervention to prevent complications after pancreas surgery. The goal is to determine if placing a stent into the pancreatic duct before surgery will decrease or prevent leaking…
- Conditions
- Pancreatic Surgery, Pancreatic Duct Stenting, Pancreatic Cancer, Distal Pancreatectomy
- Trial name
- LEAPS (NCT00671463)
- Testing
- Pancreatic duct stenting
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Pancreatic Neoplasms
A Prospective, Multi-center Trial for Reinforced Staple During Distal Pancreatectomy
The aim of this study is to evaluate if the Endo GIA Reinforced Reload with Tri-Staple Technology reduce incidence of pancreatic fistula (ISGPF grade B and C) after distal pancreatectomy by a prospective, multi-center trial.
- Trial name
- NCT02270554
- Testing
- Endo GIA Reinforced Reload with Tri-Staple technology
- Where
- 11 sites in Japan
- Volunteers
- 120 people
- Sponsor
- Wakayama Medical University
Pancreas Cancer, Pancreas Disease
Intra-operative Application of HEMOPATCH to the Pancreatic Stump to Prevent Post-operative Pancreatic Fistula Following Distal Pancreatectomy
Despite improvements and advances in pancreas surgery, about 30-35% of patients who have pancreas surgery develop a type of complication called a pancreatic fistula.
- Conditions
- Pancreas Cancer, Pancreas Disease, Pancreas Adenocarcinoma, Pancreas; Fistula
- Trial name
- PATCH-DP (NCT03410914)
- Testing
- Hemopatch
- Where
- 7 sites in Canada
- Volunteers
- 52 people
- Sponsor
- Sunnybrook Health Sciences Centre
Pancreatic Fistula
Prospective Trial Evaluating the Effect of Closed Suction Drainage Versus Straight Drainage After Distal Pancreatectomy
A very common complication following distal pancreatectomy is leakage from the pancreas, or what is called a pancreatic fistula.
- Trial name
- NCT02343302
- Testing
- Jackson-Pratt Drain, Non-suctioning drainage
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Johns Hopkins University
Pancreatic Neoplasms
Combined Resection vs. Separated Resection After Mobilization of Splenic Vein During Distal Pancreatectomy
Eligible patients will be centrally randomized to either Arm A (resection of the splenic vein after isolation from the pancreatic parenchyma) or Arm B (co-resection of the vein together with the pancreas).
- Trial name
- COSMOS-DP (NCT02871804)
- Testing
- combined resection of the splenic vein, separated resection of the splenic vein
- Where
- Japan
- Volunteers
- 304 people
- Sponsor
- Wakayama Medical University
Pancreatectomy, Pancreatic Fistula
Preoperative Endoscopic Pancreatic Stent for Distal Pancreatectomy
Distal pancreatectomy (DP) with or without splenectomy is commonly indicated for pancreatic body or tail lesions. Postoperative pancreatic fistula (POPF) remains the commonest complication after DP.
- Trial name
- NCT05297136
- Testing
- Pancreatic Stenting, No Stent
- Where
- Hong Kong
- Volunteers
- 56 people
- Sponsor
- Chinese University of Hong Kong
Pancreas Neoplasms, Liver Metastasis
Surgical Approach for Adenocarcinoma of the Pancreas With Synchronous Liver Metastases
The study focuses on patients with synchronous liver metastasis from pancreatic adenocarcinoma that underwent both pancreatic and liver resection.
- Conditions
- Pancreas Neoplasms, Liver Metastasis, Pancreas Ductal Adenocarcinoma, Surgery of the Pancreatic Head
- Trial name
- NCT06980792
- Testing
- Pancreatectomy and liver resection, Chemotherapy
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Benign Pancreas Tumor, Malignant Pancreatic Neoplasm
Patients Undergoing Pancreatic Surgery at the Antwerp University Hospital.
There is a need for a structured registry to collect real-world data on patient characteristics, surgical strategies, perioperative outcomes, and long-term results.
- Trial name
- PANREG (NCT07443761)
- Where
- Belgium
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Antwerp