Clinical trials: Distension
Prehypertension
Study of Amiloride on Vascular Phenotypes in Young Adults With Prehypertension
Primary Specific Aim: To test the hypothesis that amiloride will improve vascular health of young adults with prehypertension.
- Trial name
- SAPHA (NCT01308983)
- Testing
- Amiloride
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Augusta University
Bile Duct Diseases
The Role of Endoscopic Ultrasound in Evaluation of Patients With Indefinite Cause of Bile Duct Dilatation
In the era of diagnostic imaging advances, Bile Duct Dilatation becomes a common incidental finding in patients present with either gastrointestinal symptoms or undergone the imaging study for any other complaints.
- Trial name
- NCT05475964
- Testing
- Endoscopic ultrasound
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- HMHamed
Preterm Birth, Preterm Premature Rupture of Membrane
Cerclage After Full Dilatation Caesarean Section
CRAFT-OBS: Observational Study; To evaluate subsequent pregnancy risk of preterm birth in women with a history of previous caesarean in established labour.
- Conditions
- Preterm Birth, Preterm Premature Rupture of Membrane, Preterm Spontaneous Labor With Preterm Delivery
- Trial name
- CRAFT (NCT04110704)
- Testing
- Insertion of transvaginal cerclage
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Cardiovascular Diseases, Vascular Dilation
Chardonnay Marc and Vascular Response
This study aims to obtain data on the potential influence of Vine to Bar product(s) containing Chardonnay marc on cardiometabolic health.
- Conditions
- Cardiovascular Diseases, Vascular Dilation, Oxidative Stress
- Trial name
- NCT05545865
- Testing
- Low Flavanol Cocoa Powder, High Flavanol Cocoa Powder, Vine to Bar Chocolate - 2 servings
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Pregnancy, No Pregnancy Complications
Effect of Maryam Plant and Surah on Birth Pain, Anxiety and Satisfaction
This randomized controlled trial was conducted to determine the effects of spiritual support provided by Virgin Mary's hand plant and Surah Maryam on labor anxiety, labor pain, and satisfaction.
- Conditions
- Pregnancy, No Pregnancy Complications, Cervical Dilatation of 4-6 cm (Early Active Phase), Muslim
- Trial name
- NCT07175337
- Testing
- Surah Maryam group, Virgin Mary's Hand Plant Group
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Abdominal Aortic Aneurysm, AAA
First In Human Study for Small to Medium-sized Abdominal Aortic Aneurysm (AAA)
This is a first in human study to evaluate the safety and clinical utility of an investigational medical device called the Nectero EAST System to treat Abdominal Aortic Aneurysms or AAA.
- Conditions
- Abdominal Aortic Aneurysm, AAA, Dilation Aorta
- Trial name
- AAA (NCT05133492)
- Testing
- Endovascular Aneurysm Stabilization Treatment (EAST)
- Where
- 5 sites in Australia, China and 3 more
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Nectero Medical, Inc.
Chronic Renal Failure
Evaluation of Endothelial Dysfunction Using the "Flow Mediated Dilation" Test in a Population of Chronic Renal Failure Patients at Different Stages, and Evaluation of the Role of Antiphospholipid Antibodies
The vascular endothelium is an organ in its own right, playing, among other things, a primordial role in the control of vascular tone.
- Trial name
- NCT06347029
- Testing
- Urine sampling, Blood sampling, Flow mediated dilatation test
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Brugmann University Hospital
Healthy
Efficacy of Brooke Bond Black Tea Extract on Flow Mediated Dilation in Indian Males
This study examines the effect of 1800 mg/day standardized Brooke Bond black tea extract, equivalent to 400 mg flavonoids, on Flow Mediated Dilation in healthy Indian males.
- Trial name
- NCT01561300
- Testing
- Nutrition intervention study with a black tea extract, Nutrition intervention study with a control
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Congenital Heart Disease, Aortic Root Dilatation
Predictors of Aortic Root Dilatation in Tetralogy of Fallot Patients
To predict vulnerable patients for aortic root dilatation in TOF patients using CT as a reliable imaging modality, thus aiding early intervention, and identifying those who will require strict follow-up.
- Conditions
- Congenital Heart Disease, Aortic Root Dilatation, Tetralogy of Fallot
- Trial name
- NCT06081855
- Testing
- CT
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Assiut University
Aging, Vascular Stiffness
Acetate and Age-associated Arterial Dysfunction
Cardiovascular diseases are the leading cause of morbidity and mortality and contribute most to healthcare costs in the U.S. Age is the strongest cardiovascular disease risk factor, with >90% of all deaths from cardiovascular…
- Conditions
- Aging, Vascular Stiffness, Vascular Dilation
- Trial name
- NCT05424263
- Testing
- Calcium Acetate Oral Solution, Calcium Carbonate Oral Suspension
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pregnancy
Pregnancy, Nitrate, Endothelial Function and Tissue Oxygen Saturation
Adequate macro and microvascular endothelial function during pregnancy is essential for the normal placental development and growing fetus.
- Trial name
- NCT03315806
- Testing
- Beetroot juice
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Healthy
Effects of Non-invasive Ventilation on Function Diaphragmatic and Caval Distension
Introduction: Understanding how the applicability of non-invasive ventilation can directly affect the anatomy and diaphragmatic function, as well as the opening diameter of the inferior vena cava in healthy individuals is…
- Trial name
- NCT06384027
- Testing
- Non-invasive ventilation
- Where
- Brazil
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
Cardiovascular Diseases
Cardiovascular Benefits of Acai Polyphenols in Volunteers at Risk of Metabolic Syndrome
The purpose of this study is to carry out a randomized double blind controlled trial in 30 male subjects to investigate the effect of acai consumption on acute changes in vascular function, and to other cardiovascular markers.
- Trial name
- AF1 (NCT02292329)
- Testing
- Acai puree, frozen blended it with banana, Control Macronutrient matched
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Reading
Postprandial Abdominal Distension, Bloating
A Study to Evaluate Acute and Short-term Efficacy of Digest Gold on Postprandial Abdominal Distension and Subjective Bloating in Healthy Adults
The goal of this clinical trial is to investigate the acute and short-term efficacy of Digest Gold on postprandial abdominal distension and subjective bloating in healthy adults.
- Trial name
- NCT07830992
- Testing
- Digest Gold
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Enzymedica
Insulin Sensitivity, Flow-mediated Dilation
Vascular Function, Insulin Sensitivity, and Vitamin D
The overall objectives of this study are to examine the relationships between circulating vitamin D, insulin sensitivity, and multiple indices of vascular function and to examine whether vitamin D deficiency in African Americans…
- Conditions
- Insulin Sensitivity, Flow-mediated Dilation, Arterial Stiffness
- Trial name
- VIVID (NCT01041547)
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy
Effect of Abdominal Wall Activity on the Responses to Meal Ingestion
Meal ingestion induces sensations that are influenced by a series of conditioning factors. Aim: to determine the effect of abdominal wall activity on the responses to a standard probe meal.
- Trial name
- NCT04691882
- Testing
- Diaphragmatic contraction, Diaphagmatic relaxation
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Pain, Cancer
Study on Analgesia of GIC-1001 & GIC-1002 on Visceral Pain, Rectal Sensory Threshold Using the Barostat Method
This study evaluates colonic analgesia by comparing two novel formulations, GIC-1001 and GIC-1002 with placebo using a barostat distender.
- Conditions
- Pain, Cancer, Colonic Disease
- Trial name
- NCT02276768
- Testing
- GIC-1001 375 mg TID, GIC-1001 500 mg TID, GIC-1002 345 mg TID (equimolar to GIC-1001 375 mg TID)
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- gicare Pharma Inc.
Health Subjects With Cardiovascular Risk Factors
Sublingual L-GSH Supplementation in Male Subjects With Smoking Habit and/or Hypertension
Background. The antioxidant systems are the main endogenous defense against free radicals, and glutathione seems to play an important role in this mechanism.
- Trial name
- NCT02125045
- Testing
- L-GSH
- Where
- Italy
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Niguarda Hospital
Asthma, Inflammation
Vascular Implications of a Naturally Occurring Asthma Exacerbation
Although asthma is a disease of the airways, research is now showing that asthmatics are more likely to develop cardiovascular disease (CVD) compared to non-asthmatics.
- Conditions
- Asthma, Inflammation, Cardiovascular Risk Factor
- Trial name
- NCT03679299
- Testing
- Observational - No intervention
- Where
- 2 sites in Canada
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Sedentary Lifestyle
Polarized Aerobic Training and Vascular Adaptations in Apparently Healthy Individuals
This randomized controlled trial will investigate the effects of a 6-week polarized aerobic training intervention on vascular and cardiorespiratory function in apparently healthy sedentary adults aged 30-50 years.
- Trial name
- ACT-ON-CHRONIC (NCT07665632)
- Testing
- Polarized Aerobic Training
- Where
- Slovenia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana