Clinical trials: Distension
Recurrent Clostridium Difficile Infection, Laboratory Confirmed Clostridium Difficile Infection
Oral Vancomycin Followed by Fecal Transplant Versus Tapering Oral Vancomycin
Recurrent CDI is a growing problem with few treatment options that provide lasting effect. Fecal transplantation has been shown in several case series to be successful in controlling recurrent CDI.
- Trial name
- NCT01226992
- Testing
- Vancomycin, Fecal Transplant
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Chronic Sinusitis
In-office Placement of the Propel Mini Sinus Implant in the Frontal Sinus Ostia
A randomized controlled trial
- Trial name
- FRONTIER (NCT02880514)
- Testing
- PROPEL Mini Sinus Implant, Balloon Sinus Dilation Alone
- Where
- 9 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Intersect ENT
Menopause
Vascular Effect of Tibolone in the Brachial Artery
The interruption of the secretion of sex steroids occurring during menopause, causes a change in vascular pattern at various levels. As a result, several agencies have side effects that interfere with women's health.
- Trial name
- TDILA (NCT01543399)
- Testing
- Tibolone
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Selmo Geber
SLE, Cardiovascular Diseases
Flow Mediated Dilation in Association With Hyperuricemia
Assess cardiovascular affection and subclinical atherosclerosis in patients with systemic lupus using the non invasive flow mediated dilation.
- Conditions
- SLE, Cardiovascular Diseases, Atherosclerosis
- Trial name
- NCT05342285
- Testing
- Flow mediated dilation
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Rheumatoid Arthritis, Lymph Node Mass
Relationship Between the Activity of Rheumatoid Arthritis and Lymph Node Morphology and Lymphatics Drainage
To observe the relationship between the activity of rheumatoid arthritis and popliteal/epitrochlear lymph node morphology and the drainage of hand/foot superficial lymphatic vessels
- Conditions
- Rheumatoid Arthritis, Lymph Node Mass, Lymphatic Vessel; Dilatation
- Trial name
- NCT02876874
- Testing
- indocyanine green(ICG)
- Where
- 2 sites in China
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Pain During Outpatient Hysteroscopy, Pain Reduction in Outpatient Hysteroscopy
Warm Versus Room Temperature Saline as a Uterine Distension Medium for Pain Reduction in Women Undergoing Outpatient Hysteroscopy: Protocol for a Randomized Controlled Trial
The goal of this randomized clinical trial is to determine whether using warmed saline at 37°C during outpatient diagnostic hysteroscopy can reduce pain compared with room-temperature saline.
- Trial name
- NCT07773376
- Testing
- Warmed Saline at 37 degrees celsius, Room-Temperature Normal Saline
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Reem Mohamed
Pupillary Dilation Effect During Cycloplegic Refraction
Comparing Efficacy and Safety of CTO0303 in Pediatric Subjects
This is a prospective randomized study compared with active control arm.
- Trial name
- NCT06609525
- Testing
- CTO0303-A, CTO0303-B, CTO0303-C
- Where
- South Korea
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Taejoon Pharmaceutical Co., Ltd.
Thrombosis, Menopause
Exercise Training and Thrombotic Risk in Post-menopausal Women
At menopausal transition, the risk of cardiovascular diseases increases. This is partly due to aging, but largely also the loss of estrogen, which has many positive effects on the circulation and protects against cardiovascular…
- Conditions
- Thrombosis, Menopause, Exercise Training, Vascular Dilation
- Trial name
- TIME (NCT04596501)
- Testing
- Early and late postmenopausal women
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy Participants
Pupillary Dilation Reflex in Healthy Volunteers
This a single site, observational study that will examine how the pupil responds to neurostimulation under different conditions in healthy adults.
- Trial name
- NCT07746167
- Testing
- No intervention (observational study)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Healthy
The Vascular and Cognitive Effects of Chronic High-flavanol Intake in Healthy Males
A randomised, placebo-controlled, parallel human dietary intervention trial conducted in 33 healthy males to investigate the vascular and cognitive effects of bi-daily consumption of high-flavanol (epicatechin-rich) milk…
- Trial name
- NCT02789761
- Testing
- High-flavanol milk choocolate, Low-flavanol milk chocolate
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Reading
Keratoconus, Ectasia
A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia
We have developed novel Brillouin microscopy and we are testing its potential for keratoconus and ectasia diagnostics. We plan to perform axial scans of the cornea in human volunteers in order to compare biomechanical properties…
- Conditions
- Keratoconus, Ectasia, Crosslinking, Fuchs' Endothelial Dystrophy
- Trial name
- NCT02118922
- Testing
- Brillouin imaging
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Choledochal Cyst
Host-Microbe Interactions in Biliary Dilatation
This study is an observational cohort study aimed at continuously enrolling patients with biliary dilatation and healthy controls.
- Trial name
- NCT07152496
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Stomach Distended, Bloating
Examining the Effectiveness of Digestive Enzymes at Reducing Bloating and Stomach Distension
Flatter Me is a product that includes digestive enzymes in a way to support digestion of macronutrients and their constituents and provides herbs traditionally used for digestive health support.
- Trial name
- NCT05520411
- Testing
- HUM Flatter Me
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- HUM Nutrition, Inc.
Endothelial Dysfunction
Effect of Different Methodologies on Variability of Brachial Artery Flow Mediated Dilation
Flow mediated dilation (FMD) of the brachial artery has been widely used as a non-invasive measure of endothelial function. FMD independently predicts future cardiovascular events and can be readily influenced by pharmacological…
- Trial name
- NCT01899937
- Where
- 4 sites in Italy, Netherlands
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Gastric Distention
High-Flow Heated and Humidified Oxygen Therapy and Gastric Distension
High Flow Heated and Humidified Nasal Oxygen therapy (HFHHNO) has been increasingly used in emergency medicine to assist patients with short term respiratory failure and to provide adequate oxygen to the body prior to intubation.
- Trial name
- HFHHNOGastric (NCT03134937)
- Testing
- High-Flow Heated and Humidified Oxygen Therapy (HFHHNO)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Venous Distension Reflex, Blood Pressure
Autonomic Control of the Circulation and VDR
The study objective of this project is to examine the mechanisms of the venous distension reflex (VDR) in humans. We hypothesize that COX blockade with ketorolac tromethamine, an intravenous NSAID, will attenuate the muscle…
- Trial name
- VDR (NCT03513770)
- Testing
- Wrist-to-elbow (W-E) occlusion, ketorolac tromethamine, saline control
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Labor; Poor, Primary
Mixed Reality Training for Teaching Cervical Effacement and Dilation
The aim of this educational research is to determine whether a mixed reality-based training program is effective in teaching midwifery students how to assess cervical effacement and dilation.
- Trial name
- NCT07238205
- Testing
- mixed reality education, Standard Education Group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mardin Artuklu University
Abortion, Dilation and Evacuation
Effect of Prophylactic Tranexamic Acid on Bleeding Outcomes for Dilation and Evacuation
Prophylactic tranexamic acid has shown been shown to reduce maternal mortality from postpartum hemorrhage with no adverse effects, but has not been studied to reduce bleeding complications with dilation and evacuation (D\&E).
- Conditions
- Abortion, Dilation and Evacuation, Hemorrhage, Blood Loss
- Trial name
- NCT04651166
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Smoking Cessation, Brachial Flow Mediated Dilatation
Smoking Cessation in a Cohort HIV+ Rio de Janeiro, Brazil.
The study was carried out within a large, urban prospective cohort of PLHIV at the Instituto Nacional de Infectologia Evandro Chagas (INI).
- Conditions
- Smoking Cessation, Brachial Flow Mediated Dilatation, Nicotine Replacement Therapy
- Trial name
- NCT05873738
- Testing
- Nicotine replacement
- Where
- Brazil
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Instituto Fernandes Figueira
Insulin Sensitivity, Flow-mediated Dilation
Vascular Function, Insulin Sensitivity, and Vitamin D
The overall objectives of this study are to examine the relationships between circulating vitamin D, insulin sensitivity, and multiple indices of vascular function and to examine whether vitamin D deficiency in African Americans…
- Conditions
- Insulin Sensitivity, Flow-mediated Dilation, Arterial Stiffness
- Trial name
- VIVID (NCT01041547)
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham