Clinical trials: Distension, active
Intracranial Vasospasm
Mechanical Intracranial Artery DilAtation Using Stent-retriever for Cerebral Vasospasm
Solitaire-x is a stent-retriever that is currently world-widely used, but is currently FDA-approved only as a revascularization device indicated for use to restore blood flow in the neurovasculature by removing thrombus for the…
- Trial name
- NCT06615882
- Testing
- stent-angioplasty & nimodipine infusion (During the stent (Solitaire-X) -angioplasty, IA nimodipine was also infused)
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Yonsei University
Urinary Tract Dilatation
Retrospective Evaluation of a Cohort of Patients Diagnosed With Pre- and Postnatal Urinary Dilatation: Outcome and Long-term Follow-up
Retrospective evaluation of a cohort of patients diagnosed with pre- and postnatal urinary dilatation: outcome and long-term follow-up
- Trial name
- NCT06764472
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Coronary Artery Disease
Optimization of Percutaenous Coronary Intervention With Liberal Use of Post-dilatation
To achieve optimal long-term clinical results after percutaneous coronary intervention (PCI), adequate deployment of stents is essential.
- Trial name
- OPTIMIZE-PCI (NCT06558474)
- Testing
- Liberal post-dilatation strategy during PCI
- Where
- Netherlands
- Volunteers
- 12,000 people
- Sponsor
- Cathreine BV
Delayed Gastric Conduit Emtpying (DGCE), Minimally-invasive Esophagectomy
Balloon Dilation in Patients Undergoing Minimally Invasive Ivor Lewis Esophagectomy and Its Effect on Reducing DGCE
Background: Esophageal carcinoma ranks among the most common and lethal cancers worldwide. Minimally invasive esophagectomy is the standard curative treatment, but postoperative delayed gastric conduit emptying (DGCE) remains a…
- Trial name
- WIDE (NCT07355374)
- Testing
- endoscopic plyoric balloon dilatation performed by experienced gastroenterologists
- Where
- Switzerland
- Volunteers
- 116 people
- Sponsor
- University Hospital, Basel, Switzerland
Coronary Microvascular Dysfunction
A Plant-Based Diet in the Treatment of Coronary Microvascular Dysfunction
This study will evaluate whether a fully provided, unrefined, polyphenol-rich plant-based diet can improve blood vessel function in adults with coronary microvascular dysfunction (CMD), a condition that causes reduced blood flow…
- Trial name
- NCT07821372
- Testing
- Polyphenol-Rich Plant-Based Diet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Coronary Artery Disease, Drug Eluting Stents
Impact of Stepwise Pressure-Increasing NC Balloon Post-Dilation on Stent Expansion
This is a prospective, single-center, single-arm exploratory observational study aiming to evaluate the impact of stepwise pressure-increasing non-compliant (NC) balloon post-dilation on stent expansion rate in patients…
- Trial name
- SPND (NCT07853261)
- Testing
- Coronary stent + non-compliant post-dilation balloon
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Jilin University
Coronary Artery Disease
Treatment of Primary Coronary Artery Vascular Lesions With Biolimus Coated Coronary Balloon Dilation Catheter
The purpose of the study was to further evaluate the long-term safety and efficacy of the Biolimus Coated Coronary Artery Balloon Dilation Catheter in the real world.
- Trial name
- NCT06385067
- Testing
- Biolimus Coated Coronary Artery Balloon Dilation Catheter
- Where
- 2 sites in China
- Volunteers
- 400 people
- Sponsor
- JW Medical Systems Ltd
Choledochal Cyst
Efficacy and Safety of Surgical Treatment for Type IVa CBD
This study is a multicenter, bidirectional cohort study aimed at continuously enrolling patients with biliary dilatation from 25 medical centers in China.
- Trial name
- NCT07036848
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Keratoconus, Ectasia of Cornea
Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure vs. a 24-Minute UVA Exposure on Eyes With Ectatic Corneal Diseases
The goal of this clinical trial is to study the effects of an experimental (not Food and Drug Administration (FDA)-approved) treatment called corneal crosslinking (CXL) for conditions in which the cornea becomes progressively…
- Conditions
- Keratoconus, Ectasia of Cornea, Pellucid Marginal Corneal Degeneration, Forme Fruste Keratoconus (FFK)
- Trial name
- NCT07124910
- Testing
- Epi-ON corneal cross-linking
- Where
- 12 sites in United States
- Volunteers
- 485 people
- Sponsor
- Woolfson Eye Institute
Cervical Preparation Prior to Dilation and Evacuation
RCT of Cervical Ripening Double Ballon Catheter Prior to Dilation and Evacuation.
The purpose of this study is to determine whether the overnight use of an FDA-cleared CRDB catheter is superior to the use of overnight osmotic dilators as is standard of care cervical preparation for patients presenting for…
- Trial name
- CRDB RCT (NCT07200115)
- Testing
- Cervical Ripening Double Balloon (CRDB) Catheter, Osmotic Dilators
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Pancreatitis, Acute, Bleeding
Quick Large Balloon Dilatation for Removal of Large Bile Duct Stones (SHODBADI)
ESGE guidelines suggests 30-60 seconds endoscopic large balloon papillary dilation from the disappearance of the waist of the papilla.
- Conditions
- Pancreatitis, Acute, Bleeding, Cholangitis
- Trial name
- SHODBADI (NCT05061680)
- Testing
- endoscopic short duration papillary large balloon dilation
- Where
- 2 sites in Finland
- Volunteers
- 600 people
- Sponsor
- Helsinki University Central Hospital
Liver Cirrhosis, Gastric Antral Vascular Ectasia
Thalidomide Versus Argon Plasma Coagulation in Gastric Antral Vascular Ectasia(GAVE)-Related Anaemia in Cirrhosis (TAG Trial)
Gastric Antral Vascular Ectasia (GAVE) is an erosive form of gastritis distinguished by veno-capillary ectasia, which manifests as tortuous columns of dilated vessels.
- Trial name
- NCT06772480
- Testing
- Thalidomide, Argon Plasma Coagulation
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Keratoconus, Unstable, Bacterial Keratitis
Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking
To determine whether the Peschke PXL-330 system is safe and effective in the treatment of corneal thinning conditions.
- Conditions
- Keratoconus, Unstable, Bacterial Keratitis, Ectasia of Cornea
- Trial name
- NCT03918408
- Testing
- PXL-330 Platinum device for crosslinking with Peschke ribofflavin solution
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Pacific Clear Vision Institute
Endothelial Dysfunction
Enhancing Parasympathetic Activity to Improve Endothelial Dysfunction, Vascular Oxidative Stress in African Americans
Specific Aim 1: To test the hypothesis that prolonged (3-month) treatment with galantamine inhibits NADPH IsoLG-protein adducts formation and improves markers of endothelial cell (EC) dysfunction in AAs.
- Trial name
- NCT04769206
- Testing
- Galantamine, TENS 7000
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Blood Pressure
The Venous Distension Reflex and Orthostatic Hypertension
This research is being done to find out whether distension of veins in legs will cause a rise in blood pressure (orthostatic hypertension).
- Trial name
- OH (NCT03496792)
- Testing
- Tilt + external pressure, Tilt + no external pressure., Limb occlusion + negative pressure
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Kawasaki Disease, Coronary Aneurysm
Doxycycline Treatment to Prevent Progressive Coronary Artery Dilation in Children With Kawasaki Disease
Kawasaki disease (KD) affects infants and young children causing inflammation of the skin and blood vessels including the coronary arteries of the heart.
- Trial name
- NCT01917721
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Hawaii Pacific Health
Hypertension
Endothelin Receptor Function and Acute Stress
Our bodies respond differently to stress. Animal studies by the investigators have found that endothelin-1 plays a role in regulating blood pressure in response to stress.
- Trial name
- End-Stress (NCT02116335)
- Testing
- Bosentan
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Augusta University
Sensorineural Hearing Loss
Cochlear Implanted Listening Effort and Hearing Attention
Cochlear implant users perceive mainly sound amplitude modulation cues. Processing of these amplitude modulations can be subject to interferences, so that the perception of a modulation in a target sound can be impaired by a…
- Trial name
- EffICAtt (NCT04733950)
- Testing
- Forced choice psychoacoustic task for the evaluation of modulation detection performance and selective auditory attention. (for both arm), Measurement of the pupil diameter for the evaluation of listening effort during speech perception
- Where
- France
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pain During Outpatient Hysteroscopy, Pain Reduction in Outpatient Hysteroscopy
Warm Versus Room Temperature Saline as a Uterine Distension Medium for Pain Reduction in Women Undergoing Outpatient Hysteroscopy: Protocol for a Randomized Controlled Trial
The goal of this randomized clinical trial is to determine whether using warmed saline at 37°C during outpatient diagnostic hysteroscopy can reduce pain compared with room-temperature saline.
- Trial name
- NCT07773376
- Testing
- Warmed Saline at 37 degrees celsius, Room-Temperature Normal Saline
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Reem Mohamed
Tricuspid Regurgitation Functional
Early Feasibility Study of the Cardiac Implants Percutaneous Ring Annuloplasty System
An early feasibility study to evaluate the safety and performance of 1) the transcatheter delivery and implantation of the Cardiac Implants (CI) annuloplasty ring and 2) the adjustment of the ring approximately 90 days following…
- Trial name
- NCT04890821
- Testing
- CI Percutaneous Ring Annuloplasty System
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Cardiac Implants LLC