Clinical trials: Distress Respiratory Syndrome
Severe Acute Respiratory Syndrome
The Interaction Between Severe Acute Respiratory Distress Syndrome Viral Proteins and Monocytes
Severe acute respiratory syndrome (SARS) is a new threat to public health since November, 2002. The SARS is highly contagious and is believed to be transmitted by person-to-person through droplet and direct contact.
- Trial name
- NCT00172263
- Testing
- blood sampling
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
COVID-19
Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine
This is a double blind, placebo controlled study in approximately 2,000 health care workers at risk for being exposed to COVID-19.
- Trial name
- HERO-HCQ (NCT04334148)
- Testing
- Hydroxychloroquine
- Where
- 34 sites in United States
- Volunteers
- 1,360 people, healthy volunteers welcome
- Sponsor
- Adrian Hernandez
Fetal Lung Volume of Preterm Fetuses Measured by VOCAL, PA-RI Measured by Pulsed Doppler
Prediction of Neonatal Respiratory Distress Syndrome in Preterm Fetuses by Assessment of Fetal Lung Volume by Vocal and Pulmonary Artery Resistance Index a Pilot Study
The investigators will measure fetal lung volume by VOCAL and pulmonary artery resistance index in preterm fetuses and correlating the results with postnatal respiratory distress of the preterm neonates.
- Trial name
- NCT02283138
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Neonatal Respiratory Distress
Effect of Antenatal Steroid on Pulmonary Artery Blood Flow
The aim of this study is to determine the effect of administering antenatal steroids in term fetuses on the blood flow in the fetal pulmonary artery, and to correlate these findings with clinical data obtained after birth…
- Trial name
- NCT02978976
- Testing
- Betamethasone, saline
- Where
- Egypt
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Coronavirus, Covid19
Impact of Aerosol Box Use on Healthcare Provider Contamination
Aerosol Generating Medical Procedures (AGMP) are procedures that have the potential to create tiny particles suspended in the air. These particles can contain germs such as viruses.
- Conditions
- Coronavirus, Covid19, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT04880668
- Testing
- Aerosol Box (Splashguard)
- Where
- 4 sites in United States, Canada
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- KidSIM Simulation Program
Respiratory Distress Syndrome, Transient Tachypnea of Newborn
The Predictive Value of Amniotic Fluid pH and Electrolytes on Neonatal Respiratory Disorders
Amniotic fluid (AF) is a complex structure with a changing content by gestational time. AF pH can be affected by both maternal and fetal conditions such as preterm ruptures of membranes, prematurity and fetal distress.
- Trial name
- NCT02813954
- Testing
- Blood Gas Sampling
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Prematurity, Low Birth Weight
Paternal Involvement in Nursing Guidance and Breastfeeding Self-Efficacy in Mothers of High-Risk Newborns
This study aims to evaluate whether a structured nursing guidance program that increases fathers' participation in the care of hospitalized high-risk newborns improves maternal outcomes compared with routine nursing care.
- Conditions
- Prematurity, Low Birth Weight, Respiratory Distress Syndrome, Newborn, Neonatal Hyperbilirubinemia
- Trial name
- NCT07834008
- Testing
- step-by-step parent education, active father participation in breastfeeding support
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Acute Respiratory Distress Syndrome
Ultrasonic Weaning Criteria in Prolonged Ventilation
compare and evaluate the effect of use of ultrasonic criteria of weaning versus the conventional ways of weaning in post-traumatic acute respiratory distress syndrome (ARDS) patients who were ventilated for a long time.
- Trial name
- NCT05794867
- Testing
- clinical weaning criteria
- Where
- Saudi Arabia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- King Abdul Aziz Specialist Hospital
COVID-19 Acute Respiratory Distress Syndrome
The Effectiveness of RPSG Intervention for Nurses During the COVID-19
The cases of COVID-19 are continuing to be confirmed around the world. In the clinical settings, the nurses in evacuation acute wards are main responsibility to undertake the care of emergency patient follow-up and suspected or…
- Trial name
- NCT05178199
- Testing
- RPSG, AVMBM
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Neonatal Respiratory Distress
In-person Versus Online Debriefing in HBB
The objective of this study is to assess the effectiveness of online formative feedback and debriefing on nursing and medical students enrolled in the HBB course in comparison to traditional face-to-face feedback.
- Trial name
- NCT05257499
- Testing
- On line debriefing
- Where
- 2 sites in Lebanon
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
ARDS (Acute Respiratory Distress Syndrome)
BALance: ARDS Deconvolution by Bronchoalveolar Lavage Multiomics and Radiomics
Acute respiratory distress syndrome (ARDS) is a major contributor to ICU mortality and is characterised by hypoxaemia and pulmonary oedema.
- Trial name
- BALance (NCT07633366)
- Testing
- sampling blood, Lavage with physiologic saline solution
- Where
- Austria
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Respiratory Infection
Netosis in Determination of Respiratory Infection Severity
The study aims to evaluate the prognostic value of alveolar and blood NETosis in patients under mechanical ventilation and treated for an acute low-respiratory tract infection.
- Trial name
- NETMINDERS (NCT04318691)
- Testing
- Blood sampling, Bronchoalveolar lavage
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19 Acute Respiratory Distress Syndrome, Pregnancy Related
Melatonin Levels on COVID-19 Positive Pregnant Women
This study aimed to investigate the prognostic value of serum melatonin as a biomarker for the determination of severe COVID-19 infection in pregnant women.
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Pregnancy Related, Pregnancy Complications
- Trial name
- NCT05318144
- Where
- Turkey (Türkiye)
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Nazan Yurtcu MD
Covid19, Influenza
Wide Scale Monitoring for Acute Respiratory Infection Using a Mobile-Based Study Platform
This is a prospective observational study using a mobile study platform (app) that is designed for use on Android phones. Study participants will provide baseline demographic and medical information and report symptoms of…
- Conditions
- Covid19, Influenza, Respiratory Tract Infections, Acute Respiratory Tract Infection
- Trial name
- NCT04663776
- Where
- United States
- Volunteers
- 16,000 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Transfusion-Related Acute Lung Injury, ARDS, Human
Comparison of the Proteome in ICU Patients in Search for TRALI Biomarkers: A Case-control Study Using Both Retrospective and Prospective Samples
Transfusion-related acute lung injury (TRALI) is a severe complication of blood transfusions. After a transfusion, TRALI develops in 0.08-15% of cases depending on the characteristics of the studied population.
- Trial name
- CURIE (NCT06444750)
- Testing
- Blood sample collection
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Trauma, Rib Fractures
Percutaneous Cryoablation of Intercostal Nerves for the Treatment of Rib Fractures
The goal of this double blinded randomized control trial is to learn if percutaneous cryoablation of traumatic rib fractures improves outcomes.
- Conditions
- Trauma, Rib Fractures, Chest Wall Disorder, Respiratory Insufficiency
- Trial name
- NCT06533904
- Testing
- Percutaneous Cryoablation of Intercostal Nerves, Multi-modal pain regimen
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
ARDS, Human
First-In-Human Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ALT-100
ALT-100 is a monoclonal antibody developed by Aqualung Therapeutics Corp. as a treatment for Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- NCT05426746
- Testing
- ALT-100, Normal Saline
- Where
- Australia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Aqualung Therapeutics Corp.
Microaspiration, Acute Respiratory Distress Syndrome (ARDS)
Does Cricoid Pressure Reduce the Risk of Aspiration?
In modern anesthesia practice, the application of cricoid pressure during intubation is not infrequently used with the goal of preventing gastric-to-pulmonary aspiration.
- Conditions
- Microaspiration, Acute Respiratory Distress Syndrome (ARDS), Hospital Acquired Pneumonia
- Trial name
- NCT02058004
- Testing
- Cricoid pressure
- Where
- 2 sites in United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
ARDS (Acute Respiratory Distress Syndrome)
Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HT31-1 for Treating ARDS
This Phase 1/2A, randomized, double-blind study will evaluate the safety, tolerability, and pharmacokinetics (PK) of HT31-1 (hCitH3-mAb) in healthy adult volunteers and in patients with mild-to-moderate acute respiratory distress…
- Trial name
- NCT07449572
- Testing
- HT31-1, Saline (0.9%, sterile, for infusion)
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- HTIC, Inc
COVID-19 Acute Respiratory Distress Syndrome
Effects of Exercise on the Renin-angiotensin System
Angiotensin converting enzyme-2 (ACE2) is part of the renin-angiotensin system (RAS), which is involved in maintaining blood flow and electrolyte balance.
- Trial name
- NCT05115383
- Testing
- VO2 Max test
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Western University, Canada