Clinical trials: Distress Respiratory Syndrome
COVID-19, Acute Respiratory Distress Syndrome
Efficacy and Safety of aerosolizedDornase Alfa Administration in Patients With COVID19 Induced ARDS (COVIDORNASE)
This study plans to learn more about the effects of Dornase Alfa in COVID19 (coronavirus disease of 2019) patients, the medical condition caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
- Trial name
- COVIDORNASE (NCT04355364)
- Testing
- Dornase Alfa Inhalation Solution [Pulmozyme], standard procedure
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Respiratory Distress Syndrome, Newborn, Respiratory Tract Diseases
Nasal HFOV Versus Nasal CPAP to Reduce Post-extubation pCO2
To investigate whether nasal high frequency oscillation ventilation (nHFOV) immediately after extubation reduces the arterial partial pressure of carbon dioxide (paCO2) at 72 hours after extubation in comparison with nasal…
- Trial name
- NCT02340299
- Testing
- nHFOV, nCPAP
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- Charite University, Berlin, Germany
Respiratory Distress Syndrome, Newborn
Infant Respiratory Interface and Accessories Evaluation Study
Determine the usability of an interface and its accessories to provide non-invasive respiratory therapy to neonates and infants.
- Trial name
- NCT05719298
- Testing
- Respiratory interface
- Where
- Australia
- Volunteers
- 150 people
- Sponsor
- Fisher and Paykel Healthcare
ARDS
Extracorporeal Membrane Oxygenation (ECMO) in Non-intubated Patients With Acute Respiratory Distress Syndrome (ARDS)
Proof-of-concept study addressing the feasibility of awake ECMO (v/v) in patients with acute respiratory failure
- Trial name
- NCT01669863
- Testing
- ECMO, ECMO in non-intubated patients
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- Hannover Medical School
COVID-19 Pneumonia, Sepsis
Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia
The research will be retrospective, and will include all patients who were admitted during 2020 and 2021 in the COVID-19 ICU of University Hospital Center Osijek due to pneumonia caused by the Severe acute respiratory syndrome…
- Conditions
- COVID-19 Pneumonia, Sepsis, SARS-CoV-2 Acute Respiratory Disease, Pneumonia
- Trial name
- RANCH-COVID (NCT05181696)
- Testing
- Chest X-ray
- Where
- Croatia
- Volunteers
- 200 people
- Sponsor
- Osijek University Hospital
Medical Condition Requiring Extracorporeal Organ Support
The University of Freiburg Medical Center Extracorporeal Organ Support Device Registry
A prospective registry collecting pseudonymized clinical and treatment data from all patients treated with extracorporeal organ support (i.e., VV ECMO, VA ECMO, ECPR, Impella, IABP, and others) on the wards of the Department of…
- Trial name
- NCT05811780
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- University Hospital Freiburg
Acute Severe Respiratory Failure, Acute Respiratory Distress Syndrome
Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE
We wish to prospectively assess the burden of, management and therapeutic approaches to, and outcomes from acute hypoxaemic respiratory failure requiring ventilatory support, during the winter months in both the northern and…
- Trial name
- LUNG-SAFE (NCT02010073)
- Where
- Belgium
- Volunteers
- 14,000 people
- Sponsor
- European Society of Intensive Care Medicine
Physiological Stress, Psychological Distress
A Health Apps for Post-Pandemic Years for People With Physiological and Psychosocial Distress
The negative impacts on physical and psychological health brought by COVID-19 seem to perpetuate in the post-pandemic era. It is estimated that there will be an impending mental health crisis in the general population in the…
- Conditions
- Physiological Stress, Psychological Distress, COVID-19 Stress Syndrome
- Trial name
- NCT05459896
- Testing
- Physical Activity Training, Mindfulness-based Intervention, Energy Conservation Techniques
- Where
- Hong Kong
- Volunteers
- 814 people
- Sponsor
- The Hong Kong Polytechnic University
COVID-19 Acute Respiratory Distress Syndrome
Prone Positioning and R/I Ratio in COVID-19 Patients With ARDS (SyDRAC-DV)
The purpose of this study is to determine the efects of prone positioning on the recruitment- to-inflation ratio in COVID-19 patients with acute respiratory distress syndrome.
- Trial name
- SyDRAC-DV (NCT05360862)
- Testing
- Prone positioning session
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
ARDS
NMR Based Metabolomics Kinetics in ARDS Patients
Acute respiratory distress syndrome (ARDS) is a life-threatening condition requiring respiratory support to maintain oxygenation.
- Trial name
- NCT06036056
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Sepsis, Acute Respiratory Distress Syndrome (ARDS)
Evaluating Artificial Intelligence-Based Clinical Decision Support for Sepsis and ARDS
Sepsis and acute respiratory distress syndrome (ARDS) are common in intensive care units. Managing sepsis and ARDS is inherently complex and requires making numerous decisions under uncertainty.
- Trial name
- NCT07025096
- Testing
- Artifical Intelligence-Generated Treatment Recommendations
- Where
- United States
- Volunteers
- 355 people
- Sponsor
- University of Pennsylvania
Acute Respiratory Distress Syndrome
Prono Position and Mechanical Power
The primary objective of the study is to compare the mechanical power applied to the respiratory system in patient with acute respiratory distress syndrome in supine positioning and after the implementation of prone positioning…
- Trial name
- PROMP (NCT04369105)
- Testing
- Prone position
- Where
- Argentina
- Volunteers
- 45 people
- Sponsor
- Sanatorio Anchorena San Martin
Respiratory Distress Syndrome, Adult
Trial of Therapeutic Hypothermia in Patients With ARDS
Acute Respiratory Distress Syndrome (ARDS) is a serious condition that occurs as a complication of medical and surgical diseases, has a mortality of ~40%, and has no known treatment other than optimization of support.
- Trial name
- CHILL (NCT04545424)
- Testing
- Hypothermia, Neuromuscular Blocking Agents, Standard of care
- Where
- 19 sites in United States
- Volunteers
- 340 people
- Sponsor
- University of Maryland, Baltimore
Pre-Term, Respiratory Distress Syndrome, Newborn
NeO2Matic-Pilot Trial
The main goal of this trial is to test if: automated adjustment of supplemental oxygen to preterm infants in noninvasive respiratory support based on feedback from a measurement of blood-oxygen saturation results in more stable…
- Conditions
- Pre-Term, Respiratory Distress Syndrome, Newborn, Retinopathy of Prematurity, Bronchopulmonary Dysplasia
- Trial name
- NEO2MATIC (NCT05629910)
- Testing
- O2Matic
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Respiratory Insufficiency of Prematurity
Level of Continuous Positive Airway Pressure (CPAP) in Preterm Infants After Extubation (L-CPAP Study)
Despite widely used of nasal CPAP in preterm infants, uncertainties regarding aspects of its application remain. Clinical indications vary greatly between institutions, especially when combined with varieties of systems, devices…
- Trial name
- L-CPAP (NCT00636324)
- Testing
- Nasal CPAP, level 7 to 9 cmH2O, Nasal CPAP, level 4 to 6 cmH2O
- Volunteers
- 23 people
- Sponsor
- Hamilton Health Sciences Corporation
Respiratory Distress Syndrome
Prone Positioning vs. Prone Positioning and NO Inhalation in COVID-19 ARDS.
The investigators aim to investigate the effects of prone positioning and prone positioning with NO inhalation for COVID-19 patients with ARDS.
- Trial name
- NCT05715788
- Testing
- Nitric oxide, prone positioning
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
Enteral Nutrition, COVID-19 Acute Respiratory Distress Syndrome
Early Versus Delayed Enteral Nutrition in Critically Ill Adults With COVID-19
The goal of this observational study is to determine the relationship between the nutritional profile of critically ill patients diagnosed with COVID-19 and disease severity, prognosis, and survival, to assess the ability to meet…
- Trial name
- NCT06134674
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Ankara City Hospital Bilkent
Red Blood Cells(RBC), Acute Respiratory Distress Syndrome (ARDS)
Transfusion of Red Blood Cells for Acute Respiratory Distress Syndrome(ARDS) in Neonates
Acute respiratory distress syndrome (ARDS) in neonates has been defined in 2017. The death rate is over 50%.There are no special treatments for acute respiratory distress syndrome.
- Trial name
- NCT03296059
- Testing
- conventional treatment with RBC transfusion, conventional treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Respiratory Distress Syndrome, Adult, Sars-CoV2
Pilot RCT of Therapeutic Hypothermia Plus Neuromuscular Blockade in COVID-19 Patients With ARDS
Acute Respiratory Distress Syndrome (ARDS) is a serious condition that occurs as a complication of medical and surgical diseases, has a mortality of ~40%, and has no known treatment other than optimization of support.
- Trial name
- CHILL-pilot (NCT03376854)
- Testing
- Hypothermia, Neuromuscular Blocking Agents, Standard of Care
- Where
- United States
- Sponsor
- University of Maryland, Baltimore
Respiratory Distress Syndrome, Pneumonia
Telemedicine in the Generals Practitioners Office
Pediatrician does physical examination through telemedicine and in real life to see whether the telemedicine consultation corresponds with the real life examination. Goal is to determine: 1. Check practical feasability 2.
- Conditions
- Respiratory Distress Syndrome, Pneumonia, Bronchiolitis, Croup
- Trial name
- NCT04168554
- Testing
- Telemedicine
- Volunteers
- 40 people
- Sponsor
- Rijnstate Hospital