Clinical trials: Distress Respiratory Syndrome
Respiratory Distress Syndrome, Adult
A Validation/Interventional Study on Stress Index in Predicting Mechanical Stress in ARDS Patients
30% of ARDS patients ventilated according to NIH protocol presents CT scan evidence of hyperinflation. Functional analysis of pressure-time curve (Stress Index=SI) has been shown to identify this condition in experimental…
- Trial name
- NCT00465374
- Testing
- Change ventilatory parameters with stress index monitoring
- Where
- Italy
- Sponsor
- University of Turin, Italy
Acute Respiratory Distress Syndrome
Lung Open Ventilation to Decrease Mortality in the Acute Respiratory Distress Syndrome
A multinational, randomized trial comparing two lung protecting strategies of respiratory life support among critically ill patients with severe lung injury.
- Trial name
- LOVS (NCT00182195)
- Testing
- Control Ventilation Strategy
- Where
- Canada
- Volunteers
- 980 people
- Sponsor
- Hamilton Health Sciences Corporation
Fetal Membranes, Premature Rupture, Premature Birth
The Use of Cranberries in Women With Preterm Premature Rupture of Membranes
Cranberries have been proved to reduce the rate of urinary tract infections in a population of women with recurrent urinary tract infections in previous studies.
- Trial name
- NCT00247104
- Testing
- Cranberries - Vaccinium macrocarpon
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Acute Lung Injury, Acute Respiratory Distress Syndrome
Noninvasive Positive Pressure Ventilation for ALI/ARDS:a Multicentre Randomized Controlled Trial
with appropriate inspired oxygen concentrations, NPPV would prevent intubation and hence avert the poor outcome associated with the need of invasive ventilation in patients with ALI/ARDS.
- Trial name
- NCT00343993
- Testing
- noninvasive positive pressure ventilation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Chao Yang Hospital
Respiratory Distress Syndrome, Adult
Effect of Positive Expiratory Pressure on Right Ventricular Function in Patients With Respiratory Distress Syndrome
The objective of this study is to analyze by trans-oesophageal echocardiography the effect on the right ventricle of positive expiratory pressure (PEP) level variations with constant plate pressure among patients with syndrome of…
- Trial name
- NCT00236262
- Testing
- ventilatory strategies with pressure
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Distress Syndrome, Acute Lung Injury
Early Low Dose Steroid Therapy of Acute Respiratory Distress Syndrome
The purpose of this study is to determine whether the 2mg/kg administration of corticosteroids, in the form of methylprednisolone sodium succinate, in early phase acute respiratory distress syndrome after thoracic surgery, will…
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, Postoperative Complications
- Trial name
- NCT00290602
- Testing
- Methylprednisolone sodium succinate
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- National Cancer Center, Korea
Respiratory Distress Syndrome, Intraventricular Hemorrhage
Antenatal Betamethasone Compared to Dexamethasone - "BETACODE TRIAL"
Antenatal corticosteroids result in substantial decrease in neonatal morbidity and mortality by specifically reducing the risk of respiratory distress syndrome, intraventricular hemorrhage and neonatal death among premature…
- Conditions
- Respiratory Distress Syndrome, Intraventricular Hemorrhage, Neonatal Mortality
- Trial name
- NCT00418353
- Testing
- Betamethasone(Celestone soluspan) and Dexamethasone
- Where
- United States
- Sponsor
- University of Oklahoma
Respiratory Distress Syndrome
Remifentanil Versus Morphine for Sedation of Premature Neonates With Respiratory Distress Syndrome
In this randomised controlled study we intended to compared intubation conditions and the continuous infusion of remifentanil (n=10) and morphine (n=10) in mechanically ventilated premature neonates (28-34wk) regarding the time…
- Trial name
- NCT00391105
- Testing
- Remifentanil
- Sponsor
- Federal University of Minas Gerais
Respiratory Distress Syndrome
Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams
The purpose of this study is to compare two different treatment strategies for RDS in preterm infants > 1500 grams and evaluate whether a selective surfactant administration would reduce the need of intubation, mechanical…
- Trial name
- NCT00277030
- Testing
- Surfactant, Nasal CPAP
- Where
- 3 sites in Chile
- Volunteers
- 110 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Respiratory Distress Syndrome, Adult, Acute Lung Injury
A Phase II Study to Determine the Efficacy and Safety of Sivelestat in Subjects With Acute Lung Injury
The purpose of this study is to determine whether sivelestat will reduce the amount of time a patient must spend on a ventilator and/or increase the chance of survival of patients with acute lung injury.
- Trial name
- NCT00036062
- Testing
- Sivelestat
- Where
- 110 sites in United States, Australia and 4 more
- Volunteers
- 600 people
- Sponsor
- Eli Lilly and Company
Premature Infants, Respiratory Distress Syndrome
Cytokine Change in Bronchoalveolar Lavage Fluid After Early Budesonide-Surfactant Treatment in Premature Infants
Pulmonary inflammation plays an important role in the development of chronic lung disease (CLD) in preterm infants. This inflammation occurs very early in postnatal life.
- Conditions
- Premature Infants, Respiratory Distress Syndrome, Chronic Lung Disease, Bronchoalveolar Lavage Fluid
- Trial name
- NCT00146497
- Testing
- Budesonide-Surfactant
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- China Medical University Hospital
Acute Respiratory Distress Syndrome, Lung Diseases
Corticosteroids as Rescue Therapy for the Late Phase of Acute Respiratory Distress Syndrome
The purpose of this study is to assess innovative treatment methods in patients with adult respiratory distress syndrome (ARDS) as well as those at risk of developing ARDS.
- Trial name
- NCT00295269
- Testing
- Mythylprednisolone
- Volunteers
- 200 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Respiratory Distress Syndrome, Intraventricular Haemorrhage
Antenatal Rescue Course of Glucocorticoids in Threatened Premature Birth
Administration of steroid to the mother in imminent preterm delivery is a known effective practice to decrease the risk of respiratory distress syndrome and intraventricular haemorrhage in preterm infants if given with a week of…
- Trial name
- NCT00295464
- Testing
- Betamethasone sodium phos (drug)
- Where
- 10 sites in Finland
- Volunteers
- 440 people
- Sponsor
- University of Oulu
Adult Respiratory Distress Syndrome
ACE Gene Polymorphism and ARDS Outcome
The acute respiratory distress syndrome (ARDS) is an important cause of acute respiratory failure with a high mortality rate. The mechanism of resolution of the late organizing phase remains uncertain.
- Trial name
- NCT00155779
- Where
- Taiwan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Acute Respiratory Distress Syndrome
Short Term Outcomes of Children With Acute Respiratory Distress Syndrome
The study is a chart review of all children admitted over a two year period with the diagnosis of acute respiratory distress syndrome.
- Trial name
- NCT00142376
- Where
- United States
- Sponsor
- Nationwide Children's Hospital
Respiratory Distress Syndrome
Phase III Randomized, Double-Blind, Placebo-Controlled Study of Antenatal Thyrotropin-Releasing Hormone in Pregnant Women With Threatened Premature Delivery
OBJECTIVES: I. Evaluate the effect of thyrotropin-releasing hormone (TRH) on the severity of initial lung disease and occurrence of chronic lung disease when given antenatally to women with threatened premature delivery. II.
- Trial name
- NCT00004778
- Testing
- betamethasone, dexamethasone, thyrotropin-releasing hormone
- Volunteers
- 1,090 people
- Sponsor
- National Center for Research Resources (NCRR)
Pulmonary Hypertension, Bronchopulmonary Dysplasia
Study of the Effect of Four Methods of Cardiopulmonary Resuscitation Instruction on Psychosocial Response of Parents With Infants at Risk of Sudden Death
OBJECTIVES: I. Describe the psychosocial response of parents and caretakers who learn cardiopulmonary resuscitation (CPR) techniques for infants at high risk for respiratory or cardiac arrest. II.
- Conditions
- Pulmonary Hypertension, Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
- Trial name
- NCT00004805
- Testing
- CPR instruction
- Volunteers
- 500 people
- Sponsor
- National Center for Research Resources (NCRR)
Respiratory Distress Syndrome
Study of Antenatal Thyrotropin-Releasing Hormone in Women in Premature Labor to Prevent Lung Disease in Preterm Infants
OBJECTIVES: I. Assess the efficacy and safety of antenatal administration of thyrotropin-releasing hormone to women in premature labor to improve pulmonary outcomes in preterm infants.
- Trial name
- NCT00004840
- Testing
- thyrotropin-releasing hormone
- Volunteers
- 996 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Study of the Pathobiology of Bronchopulmonary Dysplasia in Newborns
OBJECTIVES: I. Create a clinical sample bank of neonates with lung disease to test hypotheses regarding the pathogenesis of bronchopulmonary dysplasia (BPD). II.
- Trial name
- NCT00006058
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Center for Research Resources (NCRR)
Respiratory Distress Syndrome
Study of Energy Requirements in Critically Ill Newborns
OBJECTIVES: I. Determine the total energy expenditure in term and preterm infants in both well and ill states using the doubly labeled water method.
- Trial name
- NCT00006274
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)