Clinical trials: Disuse Atrophy
Healthy
A Study of the Effect of BIIB023 on Muscle Atrophy in Healthy Male Volunteers
The primary objective of this study is to determine whether muscle atrophy induced by immobilization of the lower limb can be attenuated by BIIB023 in healthy male volunteers.
- Trial name
- NCT01943513
- Testing
- BIIB023
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Biogen
Knee Osteoarthritis, Disuse Atrophy
Effects of Kneehab 12-week Peri-operative Total Knee Arthroplasty
Determine the efficacy of neuromuscular electrical stimulation (NMES, Kneehab) in promoting accelerated recovery of quadriceps function in patients recovering from total knee arthroplasty (TKA) as measured by increases in…
- Trial name
- KneehabTKA (NCT01096524)
- Testing
- Standard Physiotherapy, Kneehab
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Bio-Medical Research, Ltd.
Muscle Atrophy, Disuse Atrophy
Effect of Knee Position on Muscle Loss During Leg Immobilization
This study looks at what happens to leg muscles when the knee is kept straight or bent during five days of wearing a brace. We want to find out if keeping the knee bent (so the thigh muscle is stretched) helps prevent muscle loss…
- Conditions
- Muscle Atrophy, Disuse Atrophy, Immobilization
- Trial name
- NCT07690150
- Testing
- Knee immobilization brace (0°) for 5 days, Knee immobilization brace (60°) for 5 days
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Aging, Oxidative Stress
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse
Prolonged periods of reduced activity are associated with decreased vascular function and muscle atrophy. Physical inactivity due to acute hospitalization is also associated with impaired recovery, hospital readmission, and…
- Conditions
- Aging, Oxidative Stress, Vascular Endothelium, Skeletal Muscle
- Trial name
- NCT04351113
- Testing
- MITO-AO, PB-125, Passive Leg Movement (PLM)
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Joel Trinity
Chronic Kidney Disease (CKD)
Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength
The aging Veteran population has more frequent inpatient hospitalization than non-Veterans. In addition, older Veterans have an inability to fully recover muscle mass and function after hospital-acquired weakness.
- Trial name
- EMPHASIS (NCT06607913)
- Testing
- Exercise
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- VA Office of Research and Development
Immobilization, Muscle Disuse Atrophy
Neuromuscular Electrical Stimulation During Immobilization Due to Ankle Fractures
Rationale: Situations such as fractures of the lower extremity can necessitate a prolonged period of immobilization in otherwise healthy individuals.
- Trial name
- ANKL-ES (NCT02469506)
- Testing
- Neuromuscular Electrical Stimulation (NMES)
- Where
- Netherlands
- Volunteers
- 1 people
- Sponsor
- Maastricht University Medical Center
Muscle Loss, Disuse Atrophy
Preventing Bed-rest Induced Muscle Loss in the Elderly
Episodes of inactivity due to hospitalisation, as short as 5 days, are associated with rapid muscle and strength loss in the elderly.
- Conditions
- Muscle Loss, Disuse Atrophy, Protein Metabolism, Prehabilitation
- Trial name
- NCT04422665
- Testing
- Resistance exercise
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Muscle Atrophy, Postoperative Complications
Postoperative Electrical Muscle Stimulation (POEMS)
Patients lose a significant amount of muscle following major abdominal surgery. This is partly due to a catabolic response to the surgical insult and inflammation, but is also probably due to a lack of muscle use secondary to…
- Trial name
- POEMS (NCT04199936)
- Testing
- Electrical Muscle stimulation
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Nottingham
Atrophy, Disuse, Atrophy, Muscular
Effects of Resistance Training Preconditioning on Skeletal Muscle Recovery From a Period of Disuse in Young Adults
The goal of this clinical trial is to compare the effects of resistance training (RT) preconditioning vs no training on disuse-induced atrophy and post-disuse resistance training in young healthy individuals.
- Trial name
- NCT05760066
- Testing
- Resistance Training Preconditioning, Control
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Auburn University
Multifidus Disuse Atrophy
Short Arc Multifidus Study
Patients will be performing Logan short arc banding protocols to see the effect on multifidus size
- Trial name
- NCT00846664
- Testing
- Logan Short Arc Banding
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Logan College of Chiropractic
Muscle Disuse Atrophy
Strength Training Augmenting Rehabilitation
This project aims to determine whether a novel strength training rehabilitation protocol can diminish the negative consequences of limb immobilization and expedite the restoration of muscle function during retraining in healthy…
- Trial name
- STAR (NCT05097092)
- Testing
- Orthopedic immobilization, Unilateral resistance training, Bilateral resistance training
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Texas Christian University
Muscle Atrophy, Muscle Weakness
FIT Exercise in 30d of ULLS-induced Muscle Disuse
This study aims to determine how flywheel-based inertial training (FIT) implemented according to principles of velocity-based training (VBT) and High-Intensity Interval Training (HIIT) affects disuse-induced physical…
- Trial name
- NCT06631053
- Testing
- velocity-based FIT (VBFIT), No Exercise
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Lance Bollinger
Hip Fractures, Muscle Atrophy
The Role of Blood Flow Restriction Therapy in Postoperative Elderly Patients With Hip Fracture
The investigators aim to study the use of blood flow restriction therapy (BFR) to augment routine post-operative physical therapy in elderly patients (age >= 65) after recovering from surgical treatment of hip fractures.
- Trial name
- NCT04809714
- Testing
- Blood Flow Restriction with Delfi Tourniquet System Cuff, Routine Post-operative Physical Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Proteomics, Exercise
Dynamic Proteomics and Integrated Rates of Muscle Protein Synthesis During an Acute Period of Loading and Unloading
Skeletal muscle plays several different roles in the promotion and maintenance of health and well-being. The loss of muscle mass that occurs with aging, chronic muscle wasting diseases, and physical inactivity puts people at an…
- Conditions
- Proteomics, Exercise, Atrophy, Disuse, Hypertrophy
- Trial name
- HYPAT (NCT04514744)
- Testing
- Knee bracing, Unilateral Resistance Exercise Training
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscle Atrophy, Muscle Disuse Atrophy
n3 PUFA and Muscle-disuse Atrophy in Older Women
This study will examine the influence of n3 PUFA supplementation on the rate of muscle atrophy in older women undergoing 1 week of unilateral limb immobilization.
- Conditions
- Muscle Atrophy, Muscle Disuse Atrophy, Sarcopenia
- Trial name
- NCT03808519
- Testing
- n3 PUFA-enriched fish oil
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscle Atrophy
Protein Ingestion and Skeletal Muscle Atrophy
The effect of different protein intakes on skeletal muscle atrophy during short term unilateral leg immobilisation.
- Trial name
- NCT03797781
- Testing
- Lower limb immobilisation (leg brace) with varying levels of protein intake
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Muscle Disuse Atrophy, Nutrition, Healthy
Effect of a Natural Source Supplementation on Muscle Mass
Periods of muscle disuse are commonly experienced in young and elderly individuals as a result of short-term hospitalization or leg casting after injury.
- Trial name
- NCT05369026
- Testing
- Single leg immobilization
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscle Disuse Atrophy
Muscle Damage and Disuse Atrophy
Limb injury generally requires a period of recovery during which time the limb is often immobilised (e.g. with a cast or brace) resulting in a rapid loss of skeletal muscle.
- Trial name
- NCT03559452
- Testing
- Eccentric exercise
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Disuse Atrophy
The Efficacy of Protein Supplementation on Attenuating Muscle Atrophy Following Disuse in the Collegiate Population
Following orthopedic surgery and/or injury, a significant loss of muscle mass is generally observed. While this loss of muscle mass appears to be the norm, it causes significant problems in both the athletic and general…
- Trial name
- NCT03454347
- Testing
- Profile Perform, Lower Limb Suspension
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- South Dakota State University
Muscular Atrophy
A Study of LY2495655 in Older Participants Undergoing Elective Total Hip Replacement
The primary objective of this study is to test the hypothesis that appendicular lean body mass (aLBM) will increase after 12 weeks of LY2495655 treatment versus placebo in older participants undergoing elective total hip…
- Trial name
- NCT01369511
- Testing
- LY2495655
- Where
- 45 sites in United States, Austria and 9 more
- Volunteers
- 400 people
- Sponsor
- Eli Lilly and Company