Clinical trials: Diuretic Effect
Healthy Participants
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Drug Effects of BMS-986308 in Healthy Participants
The purpose of this study is to evaluate the safety, tolerability, drug levels, and drug effects of BMS-986308 compared to placebo in healthy participants.
- Trial name
- NCT04763226
- Testing
- BMS-986308, Furosemide
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Hypertension
Diuretics In the Management of Essential Hypertension (DIME) Study
The purpose of DIME is to evaluate the safety (i.e. new onset of diabetes and other metabolic adverse events), efficacy and cost-effectiveness of antihypertensive treatment with low dose diuretics.
- Trial name
- NCT00131846
- Testing
- Thiazide diuretics, No diuretics
- Where
- Japan
- Volunteers
- 1,130 people
- Sponsor
- Kyoto University
Heart Failure, Congestive
PROTECT-1: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function
The study is being conducted to examine whether KW-3902IV will result in greater improvement in signs and symptoms of heart failure, with less treatment failure than standard therapy, when it is added to IV loop diuretics in…
- Trial name
- NCT00328692
- Testing
- rolofylline
- Volunteers
- 932 people
- Sponsor
- NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
ADHF
Troponin I Release After High Diuretic Doses
High values of cardiac troponin (Ct) in acute heart failure (ADHF) identify patients (pts) at higher risk and worsened prognosis.
- Trial name
- Tra-HSS-Fur (NCT01419132)
- Testing
- Furosemide
- Where
- 3 sites in Italy
- Volunteers
- 60 people
- Sponsor
- University of Palermo
Urine Output Decreased
"Effect of Albumin Combined With Furosemide in Critically Ill Patients With Fluid Overload: Impact on Urine Output and Renal Function"
This study aims to compare the effectiveness of furosemide alone versus the combination of furosemide plus albumin in critically ill adult patients with fluid overload.
- Trial name
- FANTASTIC (NCT07417969)
- Testing
- Furosemide plus albumin, Furosemide (Diuretic)
- Where
- Mexico
- Volunteers
- 56 people
- Sponsor
- Jose J Zaragoza, MD MSc
Heart Failure, Congestive
Placebo-Controlled Randomized Study of KW-3902 for Subjects Hospitalized With Worsening Renal Function and Heart Failure Requiring IV Therapy
To evaluate the effect of KW-3902IV, in addition to standard therapy, on the proportion of worsening heart failure and worsening renal function, and on the proportion of deaths or rehospitalizations for heart failure or worsening…
- Trial name
- REACH UP (NCT00443690)
- Testing
- rolofylline
- Volunteers
- 480 people
- Sponsor
- NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Hypertension
Efficacy and Safety of Valsartan/Hydrochlorothiazide Combination Therapy in Patients With Hypertension
This study will assess the efficacy and safety of valsartan/hydrochlorothiazide combination therapy in patients with hypertension not controlled with hydrochlorothiazide monotherapy.
- Trial name
- NCT00277472
- Testing
- Valsartan/Hydrochlorothiazide, HCTZ
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Novartis
Heart Failure
Ertugliflozin in Chronic Heart Failure
The purpose of this study is to determine the effects on heart failure signs and symptoms of the use of either ertugliflozin, metolazone or placebo, in conjunction with intravenous loop diuretic use in acute settings and chronic…
- Trial name
- NCT04438213
- Testing
- Ertugliflozin, Metolazone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Cardiac Failure, Renal Failure
Protocolized Diuretic Strategy in Cardiorenal Failure
This research study is a randomized clinical trial to evaluate if taking diuretics (medications that increase urine production and help with fluid removal from the body) in a standardized fashion (using a guideline for adjusting…
- Conditions
- Cardiac Failure, Renal Failure, Kidney Failure
- Trial name
- ProDiuS (NCT01921829)
- Testing
- Protocolized Diuretic Strategy
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Kelly V. Liang, MD
Acute Decompensated Heart Failure, Volume Overload
Acetazolamide in Decompensated Heart Failure With Volume OveRload (ADVOR)
This clinical research study is being conducted in multiple hospitals in Belgium and approximately 519 patients with acute decompensated heart failure are expected to participate.
- Trial name
- Advor (NCT03505788)
- Testing
- Acetazolamide
- Where
- Belgium
- Volunteers
- 519 people
- Sponsor
- Ziekenhuis Oost-Limburg
Ascitic Cirrhosis, Hyperactivation of Sympathetic Nervous System
The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients
To examine the effects of the addition of clonidine to diuretics on the mobilization of ascites at short-term (diuretic response and requirement of diuretics) and long-term (readmissions for tense ascites and requirement of…
- Trial name
- NCT00356226
- Testing
- clonidine
- Where
- Belgium
- Volunteers
- 64 people
- Sponsor
- CHU de Charleroi
Prediabetic State
Antihypertensive Medication Exposure as Risk for Impaired Glucose Tolerance: A PEAR Sub-Study
The purpose of this study is to determine if, in a subset of patients treated with a beta-blocker and diuretic, prediabetes is detectable to a greater extent through a 2-hour oral glucose tolerance test (OGTT) compared to fasting…
- Trial name
- NCT01099397
- Testing
- Oral glucose tolerance test
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Florida
Heart Failure
Bumetanide Versus Furosemide in Heart Failure
Patients with NYHA FC II-III heart failure will be randomized in a cross-over fashion to 8 weeks of bumetanide versus furosemide therapy (equipotent dose), to test whether bumetanide therapy has a superior effect on insulin…
- Trial name
- NCT00372762
- Testing
- Furosemide, Bumetanide
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Acute Heart Failure, Acute Renal Failure
Recombinant BNP on Heart and Renal Function in Acute Heart Failure
The purpose of this study is to evaluate the efficacy and safety of recombinant human B-type natriuretic peptide (rhBNP) on heart and renal function in patients with acute decompensated heart failure (ADHF) and acute renal injury…
- Trial name
- NCT01625403
- Testing
- rhBNP, standard of care
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Chest Hospital
Cardiac Edema
A Study of OPC-41061 in Subjects With Cardiac-induced Edema (Congestive Heart Failure)
To investigate the plasma drug level, efficacy, and safety of 7-day repeated oral administration of OPC-41061 at 15 mg/day (treatment period 1) and subsequent 7-day repeated administration of OPC-41061 at 15 mg/day or 30 mg/day…
- Trial name
- NCT00544869
- Testing
- OPC-41061 （Tolvaptan)
- Where
- 6 sites in Japan
- Volunteers
- 52 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Essential Hypertension
Effects of Angiotensin II Receptor Blocker Compared With Diuretics in High-risk Hypertensive Patients
The aim of the study is to investigate the optimized treatment strategy of hypertension, so as to make more patients to reach the blood pressure goals and to reduce cardio-cerebrovascular events.
- Trial name
- CHIEF (NCT01011660)
- Testing
- Amlodipine, Telmisartan, Amiloride Compound , Simvastatin
- Where
- China
- Volunteers
- 13,542 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Hypertension
Preventing Metabolic Side Effects of Thiazide Diuretics With KMgCitrate
Chlorthalidone (CTD) may produce various metabolic disturbances, including hypokalemia, activation of Renin-Angiotensin- Aldosterone (RAA) system, oxidative stress, dyslipidemia, Fibroblast growth factor 23 (FGF23) synthesis, and…
- Trial name
- NCT02665117
- Testing
- Potassium Magnesium Citrate (KMgCit), Potassium Chloride (KCl), Chlorthalidone
- Where
- 3 sites in United States
- Volunteers
- 61 people
- Sponsor
- University of Texas Southwestern Medical Center
Hypertension
A Clinical Study to Evaluate the Effects of Darusentan on Safety and Efficacy in Subjects With Resistant Systolic Hypertension Receiving Combination Therapy With Three or More Blood Pressure Lowering Drugs
This is a research study of a new experimental drug called darusentan. Darusentan is not currently approved by the U.S. Food and Drug Administration (FDA) for use in the United States, which means that a doctor cannot prescribe…
- Trial name
- NCT00364026
- Testing
- darusentan
- Sponsor
- Gilead Sciences
Heart Diseases
Effect of Thiamin Supplementation on Thiamin Status in Children With Heart Disease Receiving Diuretic Drugs
The purpose of this study is to determine effect of thiamin supplementation on thiamin status by measuring thiamin pyrophosphate effect in children with heart disease receiving diuretic drugs.
- Trial name
- NCT03989700
- Testing
- Thiamine Mononitrate
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Bioavailability Heathy Volunteers
A Study to Evaluate the Effect of Food or no Food on the Bioavailability of an Extended Release (ER) Torsemide and Spironolactone Fixed Dose Combination (FDC) Tablet in Healthy Adult Subjects
This study will examine comparative bioavailability of single dose of a fixed dose combination (FDC) of extended release Torsemide and Spironolactone given with or without food in healthy adult subjects.
- Trial name
- NCT07043634
- Testing
- FDC (24 mg ER torsemide and 30 mg Spironolactone) without food, FDC (24 mg ER torsemide and 30 mg Spironolactone) with food
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sarfez Pharmaceuticals, Inc.