Clinical trials: Diuretics
Congestive Heart Failure
Ultrafiltration Versus Intravenous (IV) Diuretics for Patients Hospitalized for Acute Decompensated Heart Failure: (UNLOAD)
The purpose of this study is to compare patients who are suffering from heart failure and who are fluid overloaded to determine if ultrafiltration (UF) can remove more of the extra fluid as measured by weight loss while in the…
- Trial name
- NCT00124137
- Testing
- Aquadex system, IV diuretic
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Nuwellis, Inc.
Urine Output Decreased
"Effect of Albumin Combined With Furosemide in Critically Ill Patients With Fluid Overload: Impact on Urine Output and Renal Function"
This study aims to compare the effectiveness of furosemide alone versus the combination of furosemide plus albumin in critically ill adult patients with fluid overload.
- Trial name
- FANTASTIC (NCT07417969)
- Testing
- Furosemide plus albumin, Furosemide (Diuretic)
- Where
- Mexico
- Volunteers
- 56 people
- Sponsor
- Jose J Zaragoza, MD MSc
Pre-hypertension, Pre-diabetes
Losartan Versus Hydrochlorothiazide in Reversing Remodeling of Small Arteries in Pre-Hypertensive Pre-Diabetic Subjects
This randomized, double-blind, parallel group, two-centre pilot study will test the hypothesis that subjects who are otherwise healthy but fulfill the criteria for a diagnosis of pre-hypertension and pre-diabetes will have…
- Trial name
- NCT00388388
- Testing
- losartan, hydrochlorothiazide
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Renal Insufficiency, Acute
Determination of the "Tissue Transit Time" (TTT)
Determination of Tissue Transit Time (TTT) as a parameter with high prognostic value to predict the functional course of the differential renal function and the development of the differential renal function after pyeloplasty
- Trial name
- NCT03311256
- Testing
- Tissue Transit Time
- Where
- 9 sites in Germany, Switzerland
- Volunteers
- 119 people
- Sponsor
- University Hospital Tuebingen
Congestive Heart Failure
BioImpedentiometry, Lung UltraSound and cONgestion in Heart Failure
The purpose of this study is to validate non-invasive and user-friendly methods to monitor systemic and pulmonary congestion in heart failure patients.
- Trial name
- BLUEMOON (NCT02394470)
- Testing
- Deuterium oxide dilution, Bioimpedentiometry, Lung and subcutaneous ultrasound
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Niguarda Hospital
Chronic Kidney Disease, End Stage Renal Disease
Efficacy of Diuretics in Kidney Disease
This study will determine the efficacy of diuretics in patients with chronic kidney disease.
- Trial name
- NCT04542304
- Testing
- Metolazone
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Stanford University
Heart Failure
Efficacy and Safety of Tolvaptan in Japanese Patients With Acute Heart Failure
The aims of the present study are to investigate prospectively the clinical course and outcome of the hospitalized heart failure patients treated with tolvaptan for management of fluid retention and serum sodium levels of less…
- Trial name
- MT FUJI (NCT01635517)
- Where
- Japan
- Volunteers
- 274 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Renal Function Disorder, Glucose Metabolism Disorders
Phthalates Exposure in Type 2 Diabetic Patients and Diuretic Therapy
In this open clinical trial, 30 subjects with inadequately controlled T2D and eligible, as per good clinical practice, for therapy with SGLT-2 inhibitor, will be randomized to receive a SGLT-2 inhibitor vs other oral-antidiabetic…
- Trial name
- PURITY (NCT04242758)
- Testing
- Dapagliflozin 10 MG, Hydrochlorothiazide 12.5mg
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Pisa
Heart Failure; With Decompensation
A Study of Ultra High Dose Diuretics to Treat Heart Failure
The purpose of this study is to determine the safety and effectiveness of ultrahigh dose diuretics compared to standard dose diuretics over 24 hours in patients with decompensated heart failure.
- Trial name
- NCT06036914
- Testing
- Bumetanide, Furosemide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Hypertension
Salt Loading and Thiazide Intervention Study
The investigators of this study propose to examine the relationships between STK39 (Serine Threonine Kinase 39) genotypes and responses to salt loading and to thiazide diuretics, hydrochlorothiazide.
- Trial name
- SALTI (NCT00896389)
- Testing
- Salt loading, Hydrochlorothiazide (HCTZ)
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Critical Illness, Pediatrics
Effect of Giving Reduced Fluid in Children After Trauma
This study is designed to help decide how much intravenous (IV) fluid should be given to pediatric trauma patients. No standard currently exists for managing fluids in critically ill pediatric trauma patients, and many fluid…
- Conditions
- Critical Illness, Pediatrics, General Surgery, Fluid Therapy
- Trial name
- NCT04201704
- Testing
- Balanced crystalloid solution volume administration, Packed Erythrocytes Units, Blood Product Unit volume, Plasma volume
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- Columbia University
Fluid Shifts, Critical Care
Effects of Fluid Balance Control in Critically Ill Patients
Most ICU patients develop a positive fluid balance, mainly during the two first weeks of their stay. The causes are multifactorial: a reduced urine output subsequent to shock state, positive pressure mechanical ventilation, acute…
- Trial name
- POINCARE (NCT02765009)
- Testing
- diuretics, albumin, fluid restriction
- Where
- 11 sites in France
- Volunteers
- 1,411 people
- Sponsor
- Central Hospital, Nancy, France
Heart Failure
Evaluation of the Effects of Sauna Therapy on Congestion and Loop Diuretic Use in Patients With Heart Failure With Reduced or Moderately Reduced Ejection Fraction
This study aims to evaluate the effect of sauna therapy on congestion levels during cardiac rehabilitation in patients with heart failure who have an impaired or moderately impaired ejection fraction, compared to standard cardiac…
- Trial name
- SAUNA-HF RCT (NCT07468344)
- Testing
- Sauna
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Central Hospital, Nancy, France
Congestive Heart Failure
Study to Evaluate Cardiac Hemodynamics and Safety of SLV320 in Subjects With Congestive Heart Failure
The study is a randomized, placebo controlled, multi-center, single dose study to evaluate cardiac hemodynamics and safety of iv SLV320 in 110 subjects with congestive heart failure requiring diuretic treatment.
- Trial name
- NCT00160134
- Testing
- SLV320
- Where
- Germany
- Sponsor
- Solvay Pharmaceuticals
ADHF
Troponin I Release After High Diuretic Doses
High values of cardiac troponin (Ct) in acute heart failure (ADHF) identify patients (pts) at higher risk and worsened prognosis.
- Trial name
- Tra-HSS-Fur (NCT01419132)
- Testing
- Furosemide
- Where
- 3 sites in Italy
- Volunteers
- 60 people
- Sponsor
- University of Palermo
Heart Failure, Diuretics
Spot Analysis of Natriuresis to Guide up- or Down-titration of Diuretic Therapy in Ambulatory Patients With Chronic Heart Failure
Heart failure is a chronic condition that causes congestion and frequent hospitalizations. Diuretic doses are usually adjusted based on clinical judgment without an objective measure of response.
- Trial name
- SAND-HF (NCT07369856)
- Testing
- Natriuresis-Guided Up-Titration, Standard care, Natriuresis-Guided Down-Titration
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Cardiology Research UBC
Chronic Kidney Disease
DD-study: Diet or Diuretics for Salt-sensitivity in Chronic Kidney Disease
In this clinical study the anti-hypertensive response to dietary salt restriction is compared with the anti-hypertensive response to the diuretics hydrochlorothiazide/amiloride in adult patients with chronic kidney disease.
- Trial name
- DD (NCT02875886)
- Testing
- Amiloride, Hydrochlorothiazide, Low-sodium diet
- Where
- Netherlands
- Volunteers
- 28 people
- Sponsor
- Erasmus Medical Center
Heart Failure, Volume Overload
Safety & Feasibility of DSR TherApy in Heart FAiluRe pAtients With Persistent Congestion
Feasibility and safety study of the alfapump DSR system in the treatment of volume overloaded heart failure subjects receiving high doses of loop diuretics.
- Trial name
- SAHARA (NCT04882358)
- Testing
- ALFAPUMP DSR (DIRECT SODIUM REMOVAL) SYSTEM, SGLT2 inhibitor
- Where
- 2 sites in Georgia
- Volunteers
- 24 people
- Sponsor
- Sequana Medical N.V.
Diuretics Drug Reactions, Heart Failure; With Decompensation
PREVENTION OF WORSENING RENAL FUNCTION OF INTRAVENUS ALBUMIN IN HEART FAILURE PATIENTS
Patients hospitalized for acute decompensation of CHF are usually complicated by worsening renal function (WRF) which leads to diuretic resistance and inadequate decongestion as well as poor prognosis.
- Conditions
- Diuretics Drug Reactions, Heart Failure; With Decompensation, Albumin; Double
- Trial name
- NCT06630923
- Testing
- Human albumin
- Where
- Greece
- Volunteers
- 250 people
- Sponsor
- Democritus University of Thrace
Chronic Kidney Disease, Hypertension
Diuretics and Volume Overload in Early CKD
Almost 15% of Americans have chronic kidney disease (CKD), with an even higher rate in Veterans due to common risk factors such as high blood pressure and diabetes.
- Trial name
- DOCK (NCT05171686)
- Testing
- Diuretic augmentation (hydrochlorothiazide, chlorthalidone, furosemide, torsemide, or bumetanide)
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- VA Office of Research and Development