Clinical trials: Diuretics
Heart Failure
A Pilot Study of Dietary Chloride Supplementation on Cardiorenal Function in Heart Failure
The purpose of this study is to determine if administration of supplemental chloride in the form of lysine chloride to patients with congestive heart failure will affect their neurohormonal profile as well as response to…
- Trial name
- NCT02031354
- Testing
- Lysine Chloride
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Yale University
Hypertension
Calcium Channel Blockers (CCBs) or Diuretics as an Add-on to Olmesartan Medoxomil in Hypertension
The purpose of the study is to test the efficacy and safety of the combination of Calcium Channel Blockers (CCBs)(of the dihydropyridine class) or Diuretics (of the thiazide class) and olmesartan medoxomil in essential…
- Trial name
- NCT00858702
- Testing
- olmesartan medoxomil and a CCB, olmesartan medoxomil and a diuretic
- Where
- Japan
- Volunteers
- 105 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Fluid Overload, Heart Failure Acute
Diuretic Effect of Metolazone Pre-dosing Versus Concurrent Dosing
The purpose of this study is to examine whether administering metolazone 60 minutes prior to furosemide increases urine output compared with administering metolazone and furosemide concomitantly.
- Trial name
- NCT03746002
- Testing
- Metolazone 60 minutes prior to furosemide, Metolazone concurrently with furosemide
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Maryland, Baltimore
Ascites, Liver Cirrhosis
Satavaptan for the Prevention of Ascites Recurrence in Patients With Ascites Due to Cirrhosis of the Liver
Primary: To evaluate the efficacy of satavaptan in the absence of concomitant diuretic drugs in reducing the recurrence of ascites.
- Trial name
- SPARe-2 (NCT00366795)
- Testing
- Satavaptan
- Where
- 21 sites in United States, Argentina and 19 more
- Volunteers
- 241 people
- Sponsor
- Sanofi
Hypertension, COVID-19
Coronavirus (COVID-19) ACEi/ARB Investigation
Coronavirus disease 2019 (COVID-19) is a pandemic infection caused by a virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Trial name
- CORONACION (NCT04330300)
- Testing
- Thiazide or Thiazide-like diuretics, Calcium Channel Blockers, ACE inhibitor
- Where
- Ireland
- Volunteers
- 2,414 people
- Sponsor
- National University of Ireland, Galway, Ireland
Thiazide Associated Hyponatremia
Validation of New Diagnostic Indices to Simplify Hyponatremia Therapy Assessment in Patients on Thiazide Diuretics
This study is looking at two new parameters, aSID and ChU, to see if these can help physicians to distinguish between different causes of low sodium levels (hyponatremia) in Patients taking a medicament against high blood…
- Trial name
- NCT06381934
- Testing
- Standard Care, aSID/ChU Guided Therapy
- Where
- Switzerland
- Volunteers
- 136 people
- Sponsor
- University Hospital, Basel, Switzerland
Essential Hypertension
Pharmacosurveillance and Pharmacogenetics of First-line Diuretics in Hypertension: The StayOnDiur Study
Background: The use of thiazide diuretics in the treatment of hypertension (HT) is widely considered a first line treatment, given the efficacy and low cost of this class of drugs.
- Trial name
- stayondiur (NCT00408512)
- Testing
- thiazides, Non thiazidic treatment
- Where
- Italy
- Volunteers
- 2,500 people
- Sponsor
- Federico II University
Heart Failure, Heart Failure Acute
Nitroglycerin vs. Furosemide Using Lung Ultrasound Pilot Trial
Nearly 80% of acute heart failure (AHF) patients admitted to the hospital are initially treated in the emergency department (ED). Once admitted, within 30 days post-discharge, 27% of patients are re-hospitalized or die.
- Conditions
- Heart Failure, Heart Failure Acute, Acute Cardiac Failure, Acute Cardiac Pulmonary Edema
- Trial name
- N-FURIOUS (NCT03259165)
- Testing
- Nitrates, Loop Diuretics
- Where
- 3 sites in United States
- Volunteers
- 52 people
- Sponsor
- Indiana University
Heart Failure
OUTpatient Intravenous LASix Trial in Reducing Hospitalization for Acute Decompensated Heart Failure
Single-center, prospective double-blinded randomized control trial to evaluate the the feasibility, efficacy and safety of outpatient IV diuretic therapy in treatment of heart failure.
- Trial name
- OUTLAST (NCT04691687)
- Testing
- Furosemide, IV Solution
- Volunteers
- 100 people
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
Precapillary Pulmonary Hypertension
Adherence of Diuretics in Pulmonary Hypertension
In this prospective study, the investigators will implement a systematic assessment of adherence to diuretics in a cohort of patients with precapillary pulmonary hypertension.
- Trial name
- PHARE (NCT05167968)
- Testing
- No intervention (Observational cohort)
- Where
- France
- Volunteers
- 227 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cirrhosis, Liver, Volume Overload
Compare the Diuretic Effect With Furosemide vs Furosemide and Albumin Combined in Cirrhotic Patients
A common complication of the progression of cirrhosis is fluid retention (ascites, edema, or pleural effusion). Loop diuretics are the treatment of choice for fluid retention in cirrhotic patients; however, many of these patients…
- Conditions
- Cirrhosis, Liver, Volume Overload, Fluid Overload
- Trial name
- NCT04216784
- Testing
- Furosemide Injection, Albumin Human
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Rush University Medical Center
Hypertension, Hyperuricemia
Reversal of an Unfavorable Effect of Hydrochlorothiazide Compared to Angiotensin Converting Enzyme Inhibitor on Serum Uric Acid and Oxypurines Levels by Estrogen-progestin Therapy in Hypertensive Postmenopausal Women.
The aim was to assess the effect of estrogen-progestin therapy (EPT) on serum levels of uric acid (SUA) and its precursors: xanthine (X) and hypoxanthine (HX) and on uric acid (UA) renal excretion in hypertensive postmenopausal…
- Conditions
- Hypertension, Hyperuricemia, Menopause
- Trial name
- NCT03921736
- Testing
- Perindopril, Hydrochlorothiazide, Estracomb TTS
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Anna Posadzy-Małaczyńska
Acute Decompensated Heart Failure, Diuretics Resistance
Exploring Diuretics Effective Management in Acute Decompensated Heart Failure, EDEMA Trial
1. Evaluate efficacy and safety of continuous infusion of IV Frusemide compared to IV shots in acute decompensated heart failure ADHF 2.
- Trial name
- EDEMA (NCT03863626)
- Testing
- Frusemide IV shots, Frusemide IV infusion
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Cairo University
Acute Heart Failure, Acute Kidney Injury
Early Sequential Nephron Blockade in Acute Heart Failure Patients: A Randomised, Controlled Study
This study aims to demonstrate the efficacy of sequential nephron blockade by adding hydrochlorothiazide or spironolactone on intravenous furosemide compared to intravenous furosemide alone in the treatments of volume overload in…
- Trial name
- NEB-HF (NCT04465123)
- Testing
- Spironolactone or hydrochlorothiazide
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Chiang Mai University
Hypertension, Blood Pressure, High
Ramipril and Hydrochlorothiazide Alone and in Combination for the Treatment of Essential Hypertension
The purpose of this study is to determine if there is greater blood pressure reduction using ramipril or hydrochlorothiazide alone or ramipril and hydrochlorothiazide together.
- Trial name
- NCT00355589
- Testing
- Ramipril and hydrochlorothiazide
- Where
- 60 sites in United States
- Sponsor
- Pfizer
Heart Failure
Comparing Diuretic Strategies in Hospitalized Heart Failure
We will conduct a pragmatic randomized trial comparing whether using a combination of two types of diuretics (loop + thiazide) compared with using a single diuretic (loop only) will result in shorter hospital stays for patients…
- Trial name
- NCT03999216
- Testing
- Loop Diuretics vs. loop + thiazide diuretics
- Where
- United States
- Sponsor
- Stanford University
Hypertension
DORADO-AC-EX - A Long-Term Safety Extension Study to the Phase 3 DORADOC-AC Study (Protocol DAR-312) of Darusentan in Resistant Hypertension
This is a double-blind, active-controlled, long-term study of a new experimental drug called darusentan. Darusentan in not currently approved by the United States Food and Drug Administration (FDA), which means that a doctor…
- Trial name
- Darusentan (NCT00389675)
- Testing
- Darusentan, Guanfacine
- Where
- 99 sites in United States, Argentina and 2 more
- Volunteers
- 661 people
- Sponsor
- Gilead Sciences
Heart Failure, Congestive
Diuretic Efficacy of Dexamethasone in Heart Failure
The purpose of this study is to determine whether glucocorticoids have potent diuretic effects in patients with congestive heart failure.
- Trial name
- NCT00263302
- Testing
- dexamethasone
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Hebei Medical University
Heart Failure, Congestive
PROTECT-2: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function
The study is being conducted to examine whether KW-3902IV will result in greater improvement in signs and symptoms of heart failure, with less treatment failure than standard therapy, when it is added to IV loop diuretics in…
- Trial name
- NCT00354458
- Testing
- rolofylline
- Volunteers
- 1,102 people
- Sponsor
- NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Heart Failure
Weight-Based Torsemide Dosing in Subjects With Heart Failure
This study will be a randomized open-label pilot study. The purpose of the study is to compare standard of care outpatient heart failure management versus a weight based torsemide regimen.
- Trial name
- NCT03187509
- Testing
- Torsemide, Standard Outpatient Heart Failure Management
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- New York City Health and Hospitals Corporation